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1. 发明授权

US07739053B2 System and process of determining a biological pathway based on a treatment of a biological specimen 失效
标题翻译：基于生物样本的处理确定生物学途径的系统和过程
公开(公告)号：US07739053B2
公开(公告)日：2010-06-15
申请号：US11035546
申请日：2005-01-14
申请人： Peter Palenchar , Dennis Shasha , Michael Chou , Marc Rejali , Yair Dorsett , Andrei Kouranov , Gloria Coruzzi
发明人： Peter Palenchar , Dennis Shasha , Michael Chou , Marc Rejali , Yair Dorsett , Andrei Kouranov , Gloria Coruzzi
IPC分类号： G01N33/48
CPC分类号： G06F19/12 , G06F19/20 , G06F19/28
摘要： Provided herein is a system and method for analyzing microarray data (transcriptome profiles), metabolite data (metabolome profiles), protein level data (proteome profiles), or any combination thereof to determine the biochemical pathways affected by a treatment. The system and method can be used to generate biochemical pathway information for any organism for which metabolic profile data can be obtained. The system and method may allow users to query the pathways generated and to filter the results of queries based on the -omic profile data, pathways involving molecules of interest, notions of biochemical importance, milestone molecules, and other factors. The system and method may also be suitable for discovery of regulatory sequences in genes. In an exemplary use, the system and method can be utilized to identify three genes involved in “de novo” ammonia “biosynthesis” that are induced by light, and was able to identify a putative cis-element, GWTTGTGG, that is likely involved in the regulation of those genes.
摘要翻译：本文提供了用于分析微阵列数据（转录组概况），代谢物数据（代谢组学谱），蛋白质水平数据（蛋白质组图谱）或其任何组合的系统和方法，以确定受治疗影响的生物化学途径。该系统和方法可以用于为可以获得代谢特征数据的任何生物体产生生物化学途径信息。该系统和方法可以允许用户查询所生成的途径，并且基于 - 个人资料数据，涉及分子的途径，生物化学重要性的概念，里程碑分子等因素来过滤查询结果。该系统和方法也可适用于发现基因中的调节序列。在一个示例性用途中，该系统和方法可以用于鉴定涉及由光诱导的“从头”氨“生物合成”中涉及的三个基因，并且能够鉴定可能涉及的推定的顺式元件GWTTGTGG 这些基因的调控。

2. 发明申请

US20050260615A1 System and process of determining a biological pathway based on a treatment of a biological specimen 失效
标题翻译：基于生物样本的处理确定生物学途径的系统和过程
公开(公告)号：US20050260615A1
公开(公告)日：2005-11-24
申请号：US11035546
申请日：2005-01-14
申请人： Peter Palenchar , Dennis Shasha , Michael Chou , Marc Rejali , Yair Dorsett , Andrei Kouranov , Gloria Coruzzi
发明人： Peter Palenchar , Dennis Shasha , Michael Chou , Marc Rejali , Yair Dorsett , Andrei Kouranov , Gloria Coruzzi
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G06F19/12 , G06F19/20 , G06F19/28
摘要： Provided herein is a system and method for analyzing microarray data (transcriptome profiles), metabolite data (metabolome profiles), protein level data (proteome profiles), or any combination thereof to determine the biochemical pathways affected by a treatment. The system and method can be used to generate biochemical pathway information for any organism for which metabolic profile data can be obtained. The system and method may allow users to query the pathways generated and to filter the results of queries based on the -omic profile data, pathways involving molecules of interest, notions of biochemical importance, milestone molecules, and other factors. The system and method may also be suitable for discovery of regulatory sequences in genes. In an exemplary use, the system and method can be utilized to identify three genes involved in “de novo” ammonia “biosynthesis” that are induced by light, and was able to identify a putative cis-element, GWTTGTGG, that is likely involved in the regulation of those genes.
摘要翻译：本文提供了用于分析微阵列数据（转录组概况），代谢物数据（代谢组学谱），蛋白质水平数据（蛋白质组图谱）或其任何组合的系统和方法，以确定受治疗影响的生物化学途径。该系统和方法可以用于为可以获得代谢特征数据的任何生物体产生生物化学途径信息。该系统和方法可以允许用户查询所生成的途径，并且基于 - 个人资料数据，涉及分子的途径，生物化学重要性的概念，里程碑分子等因素来过滤查询结果。该系统和方法也可适用于发现基因中的调节序列。在一个示例性用途中，该系统和方法可以用于鉴定涉及由光诱导的“从头”氨“生物合成”中涉及的三个基因，并且能够鉴定可能涉及的推定的顺式元件GWTTGTGG 这些基因的调控。

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