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1. 发明授权

US5780055A Cushioning beads and tablet comprising the same capable of forming a suspension 失效
标题翻译：包括能形成悬浮液的缓冲珠和片剂
公开(公告)号：US5780055A
公开(公告)日：1998-07-14
申请号：US709415
申请日：1996-09-06
申请人： Yacoub S. Habib , Ralph Shangraw , Larry L. Augsburger
发明人： Yacoub S. Habib , Ralph Shangraw , Larry L. Augsburger
IPC分类号： A61K9/20 , A61K9/26 , B01J13/02
CPC分类号： A61K9/2081 , B01J13/02 , A61K9/2054
摘要： Cushioning beads comprising microcrystalline cellulose and a disintegrant (preferably croscarmellose sodium) are disclosed. The cushioning beads are prepared by extrusion-spheronization, followed by freeze-drying. Also disclosed, are water-dispersible tablets having high tensile strength, comprising the cushioning beads and biologically active ingredient-loaded beads, wherein optionally, the tablets can contain a viscosity enhancer in the form of separate beads, or as a component of the biologically active ingredient-loaded beads such that viscosity is rapidly generated when the tablets come in contact with water, and a homogenous suspension is formed, which can be easily swallowed by children and the elderly, with minimal effect of the biologically active ingredient release properties. The tablets are useful for sustained delivery of large doses of biologically active ingredients where swallowing of a large tablet or capsule poses a problem.
摘要翻译：公开了包含微晶纤维素和崩解剂（优选交联羧甲纤维素钠）的缓冲珠。缓冲珠通过挤出滚圆法制备，然后冷冻干燥。还公开了具有高拉伸强度的水分散性片剂，其包含缓冲珠粒和生物活性成分负载珠粒，其中任选地，片剂可以含有分离珠粒形式的粘度增强剂，或作为生物活性成分的组分成分负载的珠子，使得当片剂与水接触时，粘度迅速产生，并且形成均匀的悬浮液，其可以容易地被儿童和老年人吞咽，同时具有最小的生物活性成分释放性质的影响。片剂可用于持续递送大剂量的生物活性成分，其中吞咽大片剂或胶囊引起问题。

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