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1. 发明申请

US20100120678A1 NOVEL INHIBITORS OF THE EGFR KINASE TARGETING THE ASYMMETRIC ACTIVATING DIMER INTERFACE 有权
标题翻译： EGFR激酶抑制剂不对称激活二聚体界面的新型抑制剂
公开(公告)号：US20100120678A1
公开(公告)日：2010-05-13
申请号：US12444914
申请日：2007-10-15
申请人： John Kuriyan , Xuewu Zhang , Philip Cole
发明人： John Kuriyan , Xuewu Zhang , Philip Cole
IPC分类号： A61K38/17 , C07K7/08 , C07K14/435 , C12N9/99 , G01N33/573 , A61K38/10
CPC分类号： G01N33/74 , A61K38/00 , C07K14/4703 , C12Q1/045 , G01N2500/00
摘要： The invention provides methods and compositions for the modulation of EGFR activity, in particular, inhibition of EGFR activation through an allosteric mechanism is discloses, as is a method for targeted drug discovery and design based on models of the three dimensional structure of the kinase domains of the protein dimers.
摘要翻译：本发明提供了用于调节EGFR活性的方法和组合物，特别是通过变构机制抑制EGFR激活，公开了基于靶向药物发现和设计的方法，其基于激酶结构域的三维结构模型蛋白二聚体。

2. 发明授权

US08125523B2 Device and method for ultrasonic video display 有权
标题翻译：超声波视频显示装置及方法
公开(公告)号：US08125523B2
公开(公告)日：2012-02-28
申请号：US12257255
申请日：2008-10-23
申请人： Xuewu Zhang , Song Chen
发明人： Xuewu Zhang , Song Chen
IPC分类号： H04N5/66 , H04N7/01
CPC分类号： H04N9/642 , A61B8/461 , G09G5/36
摘要： An ultrasonic video display device may comprise a memory; a programmable logic device, which may comprise a VGA signal receiving module for receiving and demodulating digital video signals and a video signal processing module including a memory controller, a gamma correcting unit, a scaling processing unit, a filtering unit, a chrominance space converting unit, a chrominance sampling unit and an interleaved sampling controller. The ultrasonic video display may also include a first digital-to-analog converter having an input coupled to an output of the VGA signal receiving module to convert the digital video signals into VGA analog signals and to output the VGA analog signals. A second digital-to-analog converter may receive video digital signals, convert the video digital signals into video analog signals, and output the video analog signals.
摘要翻译：超声波视频显示装置可以包括存储器; 可编程逻辑器件，其可以包括用于接收和解调数字视频信号的VGA信号接收模块和包括存储器控制器，伽马校正单元，缩放处理单元，滤波单元，色度空间转换单元的视频信号处理模块，色度采样单元和交错采样控制器。超声波视频显示器还可以包括第一数模转换器，其具有耦合到VGA信号接收模块的输出的输入，以将数字视频信号转换成VGA模拟信号并输出VGA模拟信号。第二数模转换器可以接收视频数字信号，将视频数字信号转换为视频模拟信号，并输出视频模拟信号。

3. 发明授权

US08242080B2 Inhibitors of the EGFR kinase targeting the asymmetric activating dimer interface 有权
标题翻译：靶向不对称活化二聚体界面的EGFR激酶抑制剂
公开(公告)号：US08242080B2
公开(公告)日：2012-08-14
申请号：US12444914
申请日：2007-10-15
申请人： John Kuriyan , Xuewu Zhang , Philip Cole
发明人： John Kuriyan , Xuewu Zhang , Philip Cole
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： G01N33/74 , A61K38/00 , C07K14/4703 , C12Q1/045 , G01N2500/00
摘要： The invention provides methods and compositions for the modulation of EGFR activity. In particular, inhibition of EGFR activation through an allosteric mechanism is discloses, as is a method for targeted drug discovery and design based on models of the three dimensional structure of the kinase domains of the protein dimers.
摘要翻译：本发明提供了调节EGFR活性的方法和组合物。特别地，通过变构机制抑制EGFR激活是公开的，也是基于蛋白质二聚体的激酶结构域的三维结构模型的靶向药物发现和设计的方法。

4. 发明申请

US20100323957A1 NOVEL ASSAY FOR INHIBITORS OF EGFR 审中-公开
标题翻译： EGFR抑制剂的新方法
公开(公告)号：US20100323957A1
公开(公告)日：2010-12-23
申请号：US12743218
申请日：2008-11-19
申请人： John Kuriyan , Xuewu Zhang , Natalia Jura
发明人： John Kuriyan , Xuewu Zhang , Natalia Jura
IPC分类号： A61K38/16 , G01N33/566 , C12N9/99 , A61P35/00
CPC分类号： C12Q1/485 , G01N2333/485 , G01N2500/04
摘要： The invention provides methods and compositions for screening for modulators of EGFR activity. In particular, an assay for such modulators is provided, which includes methods of screening for modulators using models of the three dimensional structure of EGFR kinase domains.
摘要翻译：本发明提供用于筛选EGFR活性调节剂的方法和组合物。特别地，提供了这种调节剂的测定法，其包括使用EGFR激酶结构域的三维结构模型筛选调节剂的方法。

5. 发明申请

US20090268087A1 DEVICE AND METHOD FOR ULTRASONIC VIDEO DISPLAY 有权
标题翻译：超声视频显示装置及方法
公开(公告)号：US20090268087A1
公开(公告)日：2009-10-29
申请号：US12257255
申请日：2008-10-23
申请人： Xuewu ZHANG , Song Chen
发明人： Xuewu ZHANG , Song Chen
IPC分类号： H04N7/01 , H04N5/66
CPC分类号： H04N9/642 , A61B8/461 , G09G5/36
摘要： An ultrasonic video display device may comprise a memory; a programmable logic device, which may comprise a VGA signal receiving module for receiving and demodulating digital video signals and a video signal processing module including a memory controller, a gamma correcting unit, a scaling processing unit, a filtering unit, a chrominance space converting unit, a chrominance sampling unit and an interleaved sampling controller. The ultrasonic video display may also include a first digital-to-analog converter having an input coupled to an output of the VGA signal receiving module to convert the digital video signals into VGA analog signals and to output the VGA analog signals. A second digital-to-analog converter may receive video digital signals, convert the video digital signals into video analog signals, and output the video analog signals.
摘要翻译：超声波视频显示装置可以包括存储器; 可编程逻辑器件，其可以包括用于接收和解调数字视频信号的VGA信号接收模块和包括存储器控制器，伽马校正单元，缩放处理单元，滤波单元，色度空间转换单元的视频信号处理模块，色度采样单元和交错采样控制器。超声波视频显示器还可以包括第一数模转换器，其具有耦合到VGA信号接收模块的输出的输入，以将数字视频信号转换成VGA模拟信号并输出VGA模拟信号。第二数模转换器可以接收视频数字信号，将视频数字信号转换为视频模拟信号，并输出视频模拟信号。

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