专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070276140A1 Chiral 1,8-Diarylnaphthalenes, Methods of Making Them, and Their Use as Sensors 有权
标题翻译：手性1,8-二芳基萘，其制备方法及其用作传感器
公开(公告)号：US20070276140A1
公开(公告)日：2007-11-29
申请号：US10576567
申请日：2004-11-01
申请人： Christian Wolf , Xuefeng Mei
发明人： Christian Wolf , Xuefeng Mei
IPC分类号： C07D219/02
CPC分类号： C07D213/06 , C07D213/89 , C07D219/02 , C07D221/18 , C07D307/00 , G01N33/52
摘要： One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acridyl group. In certain embodiments, a compound of the invention is a single steroisomer. In certain embodiments, a compound of the invention is a single enantiomer. Another aspect of the present invention relates to a method of detecting the presence of an analyte in a sample by monitoring the fluorescence of a compound of the invention in a sample. In certain embodiments, the analyte is a metal ion. Another aspect of the present invention relates to a method of determining the enantiomeric purity of an analyte by monitoring the fluorescence of a compound of the invention in the presence of the analyte. In certain embodiments, the analyte is a compound that is capable of hydrogen bonding.
摘要翻译：本发明的一个方面涉及1,8-二芳基萘化合物。在某些实施方案中，本发明的化合物是1,8-二芳基萘的N-氧化物。在某些实施方案中，芳基是任选取代的吖啶基。在某些实施方案中，本发明的化合物是单一的立体异构体。在某些实施方案中，本发明的化合物是单一的对映异构体。本发明的另一方面涉及通过监测样品中本发明化合物的荧光来检测样品中分析物的存在的方法。在某些实施方案中，分析物是金属离子。本发明的另一方面涉及通过在分析物的存在下监测本发明化合物的荧光来测定分析物的对映体纯度的方法。在某些实施方案中，分析物是能够氢键合的化合物。

2. 发明申请

US20200181121A1 Cocrystal of Telmisartan and Hydrochlorothiazide 审中-公开
公开(公告)号：US20200181121A1
公开(公告)日：2020-06-11
申请号：US16791916
申请日：2020-02-14
申请人： Xuefeng Mei , Jianrong Wang , Qihui Yu
发明人： Xuefeng Mei , Jianrong Wang , Qihui Yu
IPC分类号： C07D403/10 , C07D285/20
摘要： The present disclosure relates to a cocrystal of telmisartan and hydrochlorothiazide, a preparation method and use thereof. In the cocrystal, the molar ratio of telmisartan and hydrochlorothiazide is 1:1. The cocrystal of telmisartan and hydrochlorothiazide was characterized by X-ray powder diffraction (XRPD), proton nuclear magnetic resonance spectra (1H-NMR), thermal gravimetric analysis (TG), scanning differential calorimetry (DSC) and infrared (IR) spectra, and it was found that the maximum plasma concentration of the cocrystal in SD rats was higher than that of any one of hydrochlorothiazide and telmisartan itself. The cocrystal of telmisartan and hydrochlorothiazide has a simple preparation method and good physical and chemical properties.

3. 发明授权

US07888509B2 Chiral 1,8-diarylnaphthalenes, methods of making them, and their use as sensors 有权
标题翻译：手性1,8-二芳基萘，其制备方法及其作为传感器的用途
公开(公告)号：US07888509B2
公开(公告)日：2011-02-15
申请号：US10576567
申请日：2004-11-01
申请人： Christian Wolf , Xuefeng Mei
发明人： Christian Wolf , Xuefeng Mei
IPC分类号： C07D401/02 , C07D215/02 , C07D217/02
CPC分类号： C07D213/06 , C07D213/89 , C07D219/02 , C07D221/18 , C07D307/00 , G01N33/52
摘要： One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acridyl group. In certain embodiments, a compound of the invention is a single steroisomer. In certain embodiments, a compound of the invention is a single enantiomer. Another aspect of the present invention relates to a method of detecting the presence of an analyte in a sample by monitoring the fluorescence of a compound of the invention in a sample. In certain embodiments, the analyte is a metal ion. Another aspect of the present invention relates to a method of determining the enantiomeric purity of an analyte by monitoring the fluorescence of a compound of the invention in the presence of the analyte. In certain embodiments, the analyte is a compound that is capable of hydrogen bonding.
摘要翻译：本发明的一个方面涉及1,8-二芳基萘化合物。在某些实施方案中，本发明的化合物是1,8-二芳基萘的N-氧化物。在某些实施方案中，芳基是任选取代的吖啶基。在某些实施方案中，本发明的化合物是单一的立体异构体。在某些实施方案中，本发明的化合物是单一的对映异构体。本发明的另一方面涉及一种通过监测样品中本发明化合物的荧光来检测样品中分析物的存在的方法。在某些实施方案中，分析物是金属离子。本发明的另一方面涉及通过在分析物的存在下监测本发明化合物的荧光来测定分析物的对映体纯度的方法。在某些实施方案中，分析物是能够氢键合的化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式