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1. 发明申请

US20070078281A1 Process for the Preparation of Iopamidol 有权
标题翻译：制备Iopamidol的方法
公开(公告)号：US20070078281A1
公开(公告)日：2007-04-05
申请号：US11464981
申请日：2006-08-16
申请人： Richard Lorenzini , Ashok Bhatia , Steven Chamberlin , Keith Drengler , John Hufnagel , Xiu Wang
发明人： Richard Lorenzini , Ashok Bhatia , Steven Chamberlin , Keith Drengler , John Hufnagel , Xiu Wang
IPC分类号： C07C237/20
CPC分类号： C07C231/12 , C07C237/46
摘要： The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.
摘要翻译：本发明公开了一种制备纯非离子造影剂的方法。本发明还包括纯化非离子造影剂的方法。

2. 发明授权

US5126513A Interactive display system 失效
标题翻译：互动显示系统
公开(公告)号：US5126513A
公开(公告)日：1992-06-30
申请号：US698520
申请日：1991-05-10
申请人： Xiu Wang , Henri E. M. Melotte
发明人： Xiu Wang , Henri E. M. Melotte
IPC分类号： G06F3/033 , G06F3/038 , G09F9/00 , H04B7/00
CPC分类号： G06F3/0354 , Y10S367/907
摘要： In an interactive display system, a transmitter is provided for transmitting a periodic signal to a plurality of receivers through the air. One or more phase differences are measured between the receiving at pairs of receivers. These phase differences control the coordinates of a locator on a display screen. Separate measured phase differences control the positions along different coordinate axes independently.

3. 发明申请

US20100246676A1 Method of downscale decoding MPEG-2 video 审中-公开
标题翻译：低分辨率MPEG-2视频解码方法
公开(公告)号：US20100246676A1
公开(公告)日：2010-09-30
申请号：US12591858
申请日：2009-12-03
申请人： Jian-Gen Cao , Cong-Xiu Wang , Ping Xiao , Chen Zhang
发明人： Jian-Gen Cao , Cong-Xiu Wang , Ping Xiao , Chen Zhang
IPC分类号： H04N7/48
CPC分类号： H04N19/59 , H04N19/61
摘要： A method of downscale decoding MPEG-2 video includes an Inverse Discrete Cosine Transformation (DCT) procedure for performing a ½ horizontal downscaling to convert DCT coefficients in a 8×8 array block of the video into a 4×8 array intra-block and performing a ½ vertical downscaling to convert the intra-block into an intra-coded picture having ¼ resolution of the original; and a downscaling motion compensation procedure for performing a motion compensation to the current intra-block to obtain a predictive block having ½ horizontal size of the original, adding the predictive block with a residual block produced by the same method applied to the intra-blocks to obtain a 4×8 array inter-block, and performing a ½ vertical downscaling to the inter-block for outputting a predictive-coded picture and a bidirectional predictive-coded picture having ¼ resolution of the original, so as to simplify the complexity of the decoding computation and enhance the decoding speed.
摘要翻译：一种缩减MPEG-2视频解码方法包括一个逆离散余弦变换（DCT）程序，用于执行1/2水平缩小，将视频的8×8阵列块中的DCT系数转换为4×8阵列块内块，并执行 ½垂直缩小，将块内转换为具有原始分辨率为1/4的帧内编码图像; 以及用于对当前帧内执行运动补偿以获得具有原始水平1/2的预测块的缩小运动补偿程序，将预测块与通过应用于块内的相同方法产生的残差块相加获得一个4×8阵列的块间数据，并且对该块进行1/2的垂直缩小以输出一个预测编码的图象和一个具有1/4分辨率的双向预测编码图象，从而简化了解码计算，提升解码速度。

4. 发明申请

US20170002008A1 BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 有权
标题翻译：具有选择性活性的双环胺取代的N-苯并呋喃胺化合物在电压筛选的钠通道中
公开(公告)号：US20170002008A1
公开(公告)日：2017-01-05
申请号：US15038805
申请日：2014-11-24
申请人： Dansu LI , Mark E. LAYTON , Anthony J. ROECKER , Melissa EGBERTSON , Kristen L. G. JONES , Xiu WANG , Xuanjia PENG , MERCK SHARP & DOHME CORP.
发明人： Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Dansu Li , Xiu Wang , Xuanjia Peng
IPC分类号： C07D487/04 , C07D487/10 , C07D471/04 , C07D285/135 , C07D213/76 , C07D239/42 , C07D237/20 , C07D491/20 , C07D277/52
CPC分类号： C07D487/04 , C07D213/76 , C07D237/20 , C07D239/42 , C07D277/52 , C07D285/135 , C07D471/04 , C07D487/10 , C07D491/20
摘要： Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
摘要翻译：公开了式A-a或其盐的化合物：其中“B1”和“R1”至“R5”如本文所定义，这些化合物具有阻断外周和交感神经元中的Nav 1.7离子通道的性质。还描述了包含式A-a化合物或其盐的药物制剂，以及使用其制备神经性疼痛病症的方法。

5. 发明申请

US20220305035A1 HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 有权
公开(公告)号：US20220305035A1
公开(公告)日：2022-09-29
申请号：US17615769
申请日：2020-06-08
申请人： Anthony J. ROECKER , Mark E. LAYTON , Deping WANG , Xiu WANG , Xuanjia PENG , Merck Sharp & Dohme Corp.
发明人： Anthony J. Roecker , Mark E. Layton , Deping Wang , Xiu Wang , Xuanjia Peng
IPC分类号： A61K31/635 , C07D417/12 , C07D417/14
摘要： Disclosed are compounds of Formula A, or a salt thereof: Wherein “A1”, R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch and neuropathic pain disorders using the same.

6. 发明申请

US20080064703A1 Fused bicycloheterocycle substituted quinuclidine derivatives 有权
标题翻译：稠合双环杂环取代的奎宁环衍生物
公开(公告)号：US20080064703A1
公开(公告)日：2008-03-13
申请号：US11789949
申请日：2007-04-26
申请人： Eric Stoner , Alan Christesen , Ahmad Sheikh , Xiu Wang , Agnes Pal , David Murphey , Jianguo Ji , Devalina Law , Daozhong Zou
发明人： Eric Stoner , Alan Christesen , Ahmad Sheikh , Xiu Wang , Agnes Pal , David Murphey , Jianguo Ji , Devalina Law , Daozhong Zou
IPC分类号： A61K31/501 , A61P25/34 , C07D401/14
CPC分类号： C07D453/02
摘要： Compounds of formula (II): known as: 5-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-yloxy]pyridazin-3-yl}-1-H-indole salt with (2R, 3R)-2,3-dihydroxybutanedioic acid (1:1).
摘要翻译：式（II）化合物：称为5- {6 - [（3R）-1-氮杂双环[2.2.2]辛-3-基氧基]哒嗪-3-基} -1H-吲哚盐与（2R ，3R）-2,3-二羟基丁二酸（1:1）。

8. 发明授权

US09586968B2 Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels 有权
标题翻译：在电压门控钠通道中具有选择性活性的双环胺取代的N-苯磺酰胺化合物
公开(公告)号：US09586968B2
公开(公告)日：2017-03-07
申请号：US15038805
申请日：2014-11-24
申请人： Merck Sharp & Dohme Corp. , Dansu Li , Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Xiu Wang , Xuanjia Peng
发明人： Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Dansu Li , Xiu Wang , Xuanjia Peng
IPC分类号： C07D487/04 , A61K31/407 , C07D471/04 , A61K31/4353 , C07D491/20 , C07D487/10 , C07D277/52 , C07D213/76 , C07D239/42 , C07D237/20 , C07D285/135
CPC分类号： C07D487/04 , C07D213/76 , C07D237/20 , C07D239/42 , C07D277/52 , C07D285/135 , C07D471/04 , C07D487/10 , C07D491/20
摘要： Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
摘要翻译：公开了式A-a或其盐的化合物：其中“B1”和“R1”至“R5”如本文所定义，这些化合物具有阻断外周和交感神经元中的Nav 1.7离子通道的性质。还描述了包含式A-a化合物或其盐的药物制剂，以及使用其制备神经性疼痛病症的方法。

9. 发明申请

US20070270383A1 Prodrugs of HIV protease inhibitors 有权
标题翻译： HIV蛋白酶抑制剂的前药
公开(公告)号：US20070270383A1
公开(公告)日：2007-11-22
申请号：US11170197
申请日：2005-06-29
申请人： David DeGoey , William Flosi , David Grampovnik , Larry Klein , Dale Kempf , Xiu Wang
发明人： David DeGoey , William Flosi , David Grampovnik , Larry Klein , Dale Kempf , Xiu Wang
IPC分类号： A61K31/675 , A61P31/18 , C07F9/09
CPC分类号： A61K45/06 , A61K31/661 , A61K2300/00
摘要： A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed.
摘要翻译：公开了式的化合物作为HIV蛋白酶抑制剂的前药。还公开了用于抑制HIV蛋白酶活性和治疗HIV感染的方法和组合物。

10. 发明申请

US20050192465A1 Process for the preparation of iopamidol 有权
标题翻译：碘帕醇的制备方法
公开(公告)号：US20050192465A1
公开(公告)日：2005-09-01
申请号：US11064779
申请日：2005-02-24
申请人： Richard Lorenzini , Ashok Bhatia , Steven Chamberlin , Keith Drengler , John Hufnagel , Xiu Wang
发明人： Richard Lorenzini , Ashok Bhatia , Steven Chamberlin , Keith Drengler , John Hufnagel , Xiu Wang
IPC分类号： C07C231/12 , C07C237/46 , C07C237/40
CPC分类号： C07C231/12 , C07C237/46
摘要： The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.
摘要翻译：本发明公开了一种制备纯非离子造影剂的方法。本发明还包括纯化非离子造影剂的方法。

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