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1. 发明授权

US08557956B2 Aligned polymers including bonded substrates 有权
标题翻译：对准的聚合物包括粘合的基材
公开(公告)号：US08557956B2
公开(公告)日：2013-10-15
申请号：US12813834
申请日：2010-06-11
申请人： Xingguo Cheng , Vasiliki Z. Poenitzsch
发明人： Xingguo Cheng , Vasiliki Z. Poenitzsch
IPC分类号： C07K14/00
CPC分类号： C25B7/00
摘要： The present disclosure relates to the present disclosure relates to a method of fabricating an aligned polymer containing a bonded substrate and related compositions. The method involved placing a polymer in solution which is capable of alignment wherein the polymer is also bound to a selected substrate. This may then be followed by placing the polymer solution in an electrochemical cell wherein the polymer solution is in contact with at least one electrode and applying an electric field/voltage to the polymer solution and generating a pH gradient wherein the polymer and bonded substrate positions at the isoelectric point of the polymer in solution.
摘要翻译：本公开内容涉及本公开内容涉及制备包含键合衬底和相关组合物的取向聚合物的方法。该方法包括将聚合物置于能够取向的溶液中，其中聚合物也结合到所选择的底物上。然后可以将聚合物溶液放置在电化学电池中，其中聚合物溶液与至少一个电极接触并向聚合物溶液施加电场/电压并产生pH梯度，其中聚合物和键合的衬底位于溶液中聚合物的等电点。

2. 发明申请

US20100311949A1 ALIGNED COLLAGEN AND METHOD THEREFOR 审中-公开
标题翻译：对准的胶原蛋白及其方法
公开(公告)号：US20100311949A1
公开(公告)日：2010-12-09
申请号：US12745362
申请日：2008-11-26
申请人： Ozan Akkus , Alyssa Panitch , Xingguo Cheng
发明人： Ozan Akkus , Alyssa Panitch , Xingguo Cheng
IPC分类号： C07K14/78
CPC分类号： A61L27/24 , A61L27/38 , A61L2430/32 , C25B7/00
摘要： Compositions and methods of preparing a graft construct comprising aligned collagen fibrils, wherein the construct is anisotropic, are described. The construct is prepared by application of an electrochemical field and a pH gradient to solutions containing collagen. In accordance with this method, collagen aligns at its isoelectric point to form anisotropic constructs.
摘要翻译：描述了制备包含对准的胶原纤维的接枝构建体的组合物和方法，其中所述构建体是各向异性的。通过将电化学场和pH梯度应用于含有胶原的溶液来制备构建体。根据该方法，胶原蛋白在其等电点处排列以形成各向异性构造。

3. 发明申请

US20140044643A1 Magnetic Calcium Phosphate Nanoparticles, Applications And Methods Of Preparation Thereof 有权
标题翻译：磁性磷酸钙纳米颗粒，应用及其制备方法
公开(公告)号：US20140044643A1
公开(公告)日：2014-02-13
申请号：US13568644
申请日：2012-08-07
申请人： Xingguo CHENG , Qingwen Ni , Thomas B. POTTER
发明人： Xingguo CHENG , Qingwen Ni , Thomas B. POTTER
IPC分类号： A61K33/42 , A61K49/00 , G01N33/53
CPC分类号： A61K33/42 , A61K49/1818 , A61N1/403 , B82Y5/00
摘要： Magnetic calcium phosphate particles are provided including particles comprising iron oxide and calcium phosphate. A chitosan coating is present on the particles, wherein the particles are less than or equal to 1,000 nm, are magnetic and exhibit a positive charge in the range of 1 mVolts to 60 mVolts. The particles are provided by preparing a calcium hydroxide solution and filtering the calcium hydroxide solution in a membrane filter. An iron chloride solution is formed and combined with the filtered calcium hydroxide solution. In addition, the phosphoric acid solution is combined with the combined solutions of iron chloride and calcium hydroxide, forming a mixture including particles comprising iron oxide and calcium phosphate.
摘要翻译：提供了包含氧化铁和磷酸钙的颗粒的磁性磷酸钙颗粒。在颗粒上存在壳聚糖涂层，其中颗粒小于或等于1000nm，是磁性的，并且在1mV至60mV的范围内呈现正电荷。通过制备氢氧化钙溶液并过滤膜过滤器中的氢氧化钙溶液来提供颗粒。形成氯化铁溶液并与过滤的氢氧化钙溶液组合。此外，将磷酸溶液与氯化铁和氢氧化钙的组合溶液组合，形成包含氧化铁和磷酸钙的颗粒的混合物。

4. 发明授权

US08652505B2 Coating for medical implants 有权
标题翻译：医疗植入物涂层
公开(公告)号：US08652505B2
公开(公告)日：2014-02-18
申请号：US12717666
申请日：2010-03-04
申请人： Xingguo Cheng , Nitin Nitin , Jorge G. Rossini , Stephen T. Wellinghoff
发明人： Xingguo Cheng , Nitin Nitin , Jorge G. Rossini , Stephen T. Wellinghoff
IPC分类号： A61F2/00 , A61F13/00 , A61L33/00
CPC分类号： A61F2/02 , B05D1/36
摘要： A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.
摘要翻译：一种用于药物递送的医用植入物，其包括分散在其中的药物的内层，其中包含药物的内层，然后外层可以以可控的方式调节药物的释放。外层可以粘附和/或穿透下面的层并且提供保护性涂层以及改善的机械强度以及水合和变得透水并允许药物释放的能力。

5. 发明授权

US09675640B2 Magnetic calcium phosphate nanoparticles, applications and methods of preparation thereof 有权
公开(公告)号：US09675640B2
公开(公告)日：2017-06-13
申请号：US13568644
申请日：2012-08-07
申请人： Xingguo Cheng , Qingwen Ni , Thomas B. Potter
发明人： Xingguo Cheng , Qingwen Ni , Thomas B. Potter
IPC分类号： A61K33/42 , A61K49/18 , A61N1/40 , B82Y5/00
CPC分类号： A61K33/42 , A61K49/1818 , A61N1/403 , B82Y5/00
摘要： Magnetic calcium phosphate particles are provided including particles comprising iron oxide and calcium phosphate. A chitosan coating is present on the particles, wherein the particles are less than or equal to 1,000 nm, are magnetic and exhibit a positive charge in the range of 1 mVolts to 60 mVolts. The particles are provided by preparing a calcium hydroxide solution and filtering the calcium hydroxide solution in a membrane filter. An iron chloride solution is formed and combined with the filtered calcium hydroxide solution. In addition, the phosphoric acid solution is combined with the combined solutions of iron chloride and calcium hydroxide, forming a mixture including particles comprising iron oxide and calcium phosphate.

6. 发明申请

US20110306754A1 Aligned Polymers Including Bonded Substrates 有权
标题翻译：对接聚合物包括粘合基材
公开(公告)号：US20110306754A1
公开(公告)日：2011-12-15
申请号：US12813834
申请日：2010-06-11
申请人： Xingguo Cheng , Vasiliki Z. Poenitzsch
发明人： Xingguo Cheng , Vasiliki Z. Poenitzsch
IPC分类号： C07K14/78 , C25B1/00
CPC分类号： C25B7/00
摘要： The present disclosure relates to the present disclosure relates to a method of fabricating an aligned polymer containing a bonded substrate and related compositions. The method involved placing a polymer in solution which is capable of alignment wherein the polymer is also bound to a selected substrate. This may then be followed by placing the polymer solution in an electrochemical cell wherein the polymer solution is in contact with at least one electrode and applying an electric field/voltage to the polymer solution and generating a pH gradient wherein the polymer and bonded substrate positions at the isoelectric point of the polymer in solution.
摘要翻译：本公开内容涉及本公开内容涉及制备包含键合衬底和相关组合物的取向聚合物的方法。该方法包括将聚合物置于能够取向的溶液中，其中聚合物也结合到所选择的底物上。然后可以将聚合物溶液放置在电化学电池中，其中聚合物溶液与至少一个电极接触并向聚合物溶液施加电场/电压并产生pH梯度，其中聚合物和键合的衬底位于溶液中聚合物的等电点。

7. 发明申请

US20110217351A1 COATING FOR MEDICAL IMPLANTS 有权
标题翻译：医用植绒涂层
公开(公告)号：US20110217351A1
公开(公告)日：2011-09-08
申请号：US12717666
申请日：2010-03-04
申请人： Xingguo CHENG , Nitin NITIN , Jorge G. ROSSINI , Stephen T. WELLINGHOFF
发明人： Xingguo CHENG , Nitin NITIN , Jorge G. ROSSINI , Stephen T. WELLINGHOFF
IPC分类号： B05D1/36 , A61F2/02
CPC分类号： A61F2/02 , B05D1/36
摘要： A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.
摘要翻译：一种用于药物递送的医用植入物，其包括分散在其中的药物的内层，其中包含药物的内层，然后外层可以以可控的方式调节药物的释放。外层可以粘附和/或穿透下面的层并且提供保护性涂层以及改善的机械强度以及水合和变得透水并允许药物释放的能力。

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