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1. 发明申请

US20070105222A1 In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby 有权
标题翻译：适合于由此形成骨和骨形成组织的组织的体外生长
公开(公告)号：US20070105222A1
公开(公告)日：2007-05-10
申请号：US11518566
申请日：2006-09-11
申请人： Lloyd Wolfinbarger , Xiaofei Qin
发明人： Lloyd Wolfinbarger , Xiaofei Qin
IPC分类号： C12N5/02 , C12N5/00 , C12N5/08
CPC分类号： C12N5/0654 , A61L27/3608 , A61L27/3683 , A61L2430/02 , C12M21/08 , C12M25/14 , C12M29/16 , C12M35/02 , C12M35/04
摘要： The present invention is directed to a device for the growth of new bone or bone-like tissue under in vitro cell culture conditions.
摘要翻译：本发明涉及一种用于在体外细胞培养条件下生长新骨或骨样组织的装置。

2. 发明授权

US09951112B2 BMP-4 peptides and methods of use 有权
公开(公告)号：US09951112B2
公开(公告)日：2018-04-24
申请号：US13636870
申请日：2011-03-24
申请人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
发明人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
IPC分类号： A61K38/17 , A61K38/18 , A61K38/48 , C07K14/51 , C07K1/00 , C12N9/48 , C12N5/077 , C12N5/071 , A61K38/00
CPC分类号： C07K14/51 , A61K38/00 , A61K38/1875 , A61K38/48 , C12N5/0602 , C12N5/0658 , C12N9/48 , C12N2501/155
摘要： The invention relates to truncated BMP-4 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-4 growth factors.

3. 发明授权

US09809635B2 BMP-2 peptides and methods of use 有权
公开(公告)号：US09809635B2
公开(公告)日：2017-11-07
申请号：US13636016
申请日：2011-03-21
申请人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James A. Clagett
发明人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James A. Clagett
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/43 , A61K38/48 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/475 , C07K14/51 , C12N9/00 , C12N9/48 , C12N5/077
CPC分类号： C07K14/51 , C12N5/0654 , C12N2501/155 , C12N2506/1323
摘要： The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.

4. 发明授权

US07494811B2 In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby 有权
标题翻译：适合于由此形成骨和骨形成组织的组织的体外生长
公开(公告)号：US07494811B2
公开(公告)日：2009-02-24
申请号：US10835529
申请日：2004-04-30
申请人： Lloyd Wolfinbarger, Jr. , XiaoFei Qin
发明人： Lloyd Wolfinbarger, Jr. , XiaoFei Qin
IPC分类号： C12N5/00 , C12N5/02 , C12N5/04
CPC分类号： C12N5/0654 , A61L27/3608 , A61L27/3683 , A61L2430/02 , C12M21/08 , C12M25/14 , C12M29/16 , C12M35/02 , C12M35/04
摘要： The present invention is directed to a method of growing new bone, bone-like tissue or extracellular matrix under in vitro cell culture conditions. The method utilizes a bioreactor allowing for the flow of nutrient solutions into, through, and out of the bioreactor, wherein ground demineralized bone and bone-forming cells are present in the bioreactor. The resulting bone, bone-like tissue or extracellular matrix produced by the invention are within the scope of the present invention. In addition, the present invention is directed to the bioreactor device used to grow the new bone, bone-like tissue, or extracellular matrix.
摘要翻译：本发明涉及在体外细胞培养条件下生长新骨，骨样组织或细胞外基质的方法。该方法利用生物反应器，允许营养液流入生物反应器，通过和流出生物反应器，其中在生物反应器中存在研磨的软化骨和骨形成细胞。由本发明产生的所得骨，骨样组织或细胞外基质在本发明的范围内。此外，本发明涉及用于生长新骨，骨样组织或细胞外基质的生物反应器装置。

5. 发明申请

US20090024229A1 Devitalization and recellularization of cartilage 有权
标题翻译：软骨的破坏和收缩
公开(公告)号：US20090024229A1
公开(公告)日：2009-01-22
申请号：US11826523
申请日：2007-07-16
申请人： Silvia S. Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger, JR. , Mark Moore , Rony Thomas , Alyce Linthurst Jones
发明人： Silvia S. Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger, JR. , Mark Moore , Rony Thomas , Alyce Linthurst Jones
IPC分类号： A61F2/02
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/3094 , A61F2/38 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30224 , A61F2002/30751 , A61F2002/30759 , A61F2002/30764 , A61F2002/4646 , A61F2002/4648 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61L27/3612 , A61L27/3683 , A61L27/3804 , A61L27/3852 , A61L2430/06
摘要： The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps. The present invention is directed to both recellularized cartilage grafts as well as a process for recellularizing cartilage grafts.
摘要翻译：本发明涉及在体内，原位或体外将活细胞软骨移植物活化的可细胞细胞移植，以使组织至关重要。本发明还涉及修复软骨缺损并将软骨移植物植入人或动物中，通过将软骨基质制成单独的移植物，消毒和清洁软骨移植物，将预处理溶液施用于软骨移植物，使用用于产生失活的软骨移植物的提取溶液，使失活的软骨移植物收缩，将软骨移植物植入到具有或不具有插入装置的软骨缺损中，以及用植入物组织密封植入的软骨移植物。灭活的软骨移植物任选地存储在去除细胞碎片和再生细胞步骤之间。本发明涉及两种受体结合的软骨移植物以及用于软骨移植物的再结合的方法。

6. 发明申请

US20090024223A1 Crafting of cartilage 有权
标题翻译：软骨手术
公开(公告)号：US20090024223A1
公开(公告)日：2009-01-22
申请号：US11826518
申请日：2007-07-16
申请人： Silvia S. Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger, JR.
发明人： Silvia S. Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger, JR.
IPC分类号： A61F2/28
CPC分类号： A61F2/30756 , A61B17/1604 , A61B17/1635 , A61B17/1675 , A61F2/28 , A61F2/30749 , A61F2/3094 , A61F2/38 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30224 , A61F2002/30235 , A61F2002/30751 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/4646 , A61F2002/4648 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3804 , A61L2430/06
摘要： The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps.
摘要翻译：本发明涉及生产从人或动物分离的成形软骨基质，其中已经制备了软骨以促进植入后的消毒，清洁，失活，再结晶和/或整合。本发明涉及一种通过将软骨基质成形为单个移植物，消毒和清洁软骨移植物，将预处理溶液施用于软骨移植物，去除细胞碎片的方法来修复软骨缺损和软骨移植物植入人或动物的方法使用提取溶液来产生失活的软骨移植物，将软骨移植物植入到具有或不具有插入装置的软骨缺损中，以及用植入物组织密封植入的软骨移植物。灭活的软骨移植物任选地在体外，体内或原位与活细胞接触，以在植入之前或之后使组织至关重要。灭活的软骨移植物也任选地存储在去除细胞碎片和再结晶步骤之间。

7. 发明申请

US20130030528A1 Implantation of Cartilage 审中-公开
标题翻译：软骨植入
公开(公告)号：US20130030528A1
公开(公告)日：2013-01-31
申请号：US13537194
申请日：2012-06-29
申请人： Silvia S. Chen , Xiaofei Qin , Jingson Chen , Lloyd Wolfinbarger, JR.
发明人： Silvia S. Chen , Xiaofei Qin , Jingson Chen , Lloyd Wolfinbarger, JR.
IPC分类号： A61F2/02
CPC分类号： A61F2/30756 , A61B17/1604 , A61B17/1635 , A61B17/1675 , A61F2/28 , A61F2/30749 , A61F2/3094 , A61F2/38 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30224 , A61F2002/30235 , A61F2002/30751 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/4646 , A61F2002/4648 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3804 , A61L2430/06
摘要： The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal. The invention is further directed toward a repaired cartilage defect.
摘要翻译：本发明涉及将软骨移植物植入软骨缺损并用接受者组织密封植入的软骨移植物的方法。本发明还涉及修复软骨缺损并将软骨移植物植入人或动物的方法。本发明进一步针对修复的软骨缺损。

8. 发明申请

US20090024224A1 Implantation of cartilage 审中-公开
标题翻译：植入软骨
公开(公告)号：US20090024224A1
公开(公告)日：2009-01-22
申请号：US11826530
申请日：2007-07-16
申请人： Silvia S. Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger, JR.
发明人： Silvia S. Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger, JR.
IPC分类号： A61F2/02 , A61F2/28
CPC分类号： A61F2/30756 , A61B17/1604 , A61B17/1635 , A61B17/1675 , A61F2/28 , A61F2/30749 , A61F2/3094 , A61F2/38 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30224 , A61F2002/30235 , A61F2002/30751 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/4646 , A61F2002/4648 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3804 , A61L2430/06
摘要： The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, cleaning and disinfecting the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. The invention is further directed toward a repaired cartilage defect.
摘要翻译：本发明涉及一种用于将软骨移植物植入软骨缺损并通过产生向下到软骨缺损的骨部分的第一孔的方式将植入的软骨移植物与受体组织密封的方法，产生与软骨缺损同心的第二形状的孔在第一孔的顶部，以匹配软骨移植物的形状和尺寸，用粘合剂处理缺损部位处的第一孔和第二形状孔，用粘合剂处理软骨移植物的周边区域，软骨移植到缺损部位，其中软骨移植物的表面与周围的软骨表面处于相同的高度。可以通过施加刺激剂来诱导第一和第二粘合剂来诱导受体组织的流体动力学环境的密封，整合和恢复。本发明还涉及一种修复软骨缺损并将软骨移植物植入人或动物的方法，该软骨移植物通过将软骨基质制成单独的移植物，清洁和消毒软骨移植物，将预处理溶液施用于软骨移植物，去除细胞碎片使用提取溶液以产生失活的软骨移植物，将软骨移植物植入软骨缺损带有或不具有插入装置，以及用接受者组织密封植入的软骨移植物。灭活的软骨移植物任选地在体外，体内或原位与活细胞接触，以在植入之前或之后使组织至关重要。灭活的软骨移植物也任选地存储在去除细胞碎片和再结晶步骤之间。本发明进一步针对修复的软骨缺损。

9. 发明申请

US20080077251A1 Cleaning and devitalization of cartilage 审中-公开
标题翻译：软骨的清洁和失活
公开(公告)号：US20080077251A1
公开(公告)日：2008-03-27
申请号：US11826522
申请日：2007-07-16
申请人： Silvia Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger
发明人： Silvia Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger
IPC分类号： A61F2/02 , C12N5/08
CPC分类号： A61F2/30756 , A01N1/02 , A01N1/0215 , A61F2/28 , A61F2/30749 , A61F2/3094 , A61F2/38 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30224 , A61F2002/30751 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/4646 , A61F2002/4648 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61L2/0088 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/38 , A61L2430/06 , A61L2430/40
摘要： The invention is further directed to producing a cleaned, disinfected, and devitalized cartilage graft by optionally cleaning and disinfecting the cartilage graft; treating the cartilage graft in a pretreatment solution; treating the cartilage graft in an extracting solution; washing the extracted cartilage graft with a rinsing solution; and subsequently soaking the devitalized cartilage graft in a storage solution. The devitalized cartilage graft is essentially free from metabolically viable and/or reproductively viable cells and the rinsing solution is hypotonic solution or isotonic solution. The present invention is further directed to a cleaned, disinfected, and devitalized cartilage graft and a process for cleaning, disinfecting, and devitalizing cartilage grafts. The invention also relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps.
摘要翻译：本发明进一步旨在通过任选地清洁和消毒软骨移植物来生产清洁的，消毒的和失活的软骨移植物; 在预处理溶液中处理软骨移植物; 在提取液中处理软骨移植物; 用冲洗溶液洗涤提取的软骨移植物; 随后将失活的软骨移植物浸泡在储存溶液中。失活的软骨移植物基本上没有代谢活力和/或再生活细胞，冲洗溶液是低渗溶液或等渗溶液。本发明还涉及清洁，消毒和失活的软骨移植物以及用于清洁，消毒和失活软骨移植物的方法。本发明还涉及一种通过将软骨基质成形为单独的移植物，消毒和清洁软骨移植物，将预处理溶液施用于软骨移植物，去除细胞的方法来修复软骨缺损和软骨移植物植入人或动物的方法碎片使用提取溶液以产生失活的软骨移植物，将软骨移植物植入软骨缺损带有或不具有插入装置，以及用接受者组织密封植入的软骨移植物。灭活的软骨移植物任选地在体外，体内或原位与活细胞接触，以在植入之前或之后使组织至关重要。灭活的软骨移植物也任选地存储在去除细胞碎片和再结晶步骤之间。

10. 发明授权

US10881515B2 Implantation of cartilage 有权
公开(公告)号：US10881515B2
公开(公告)日：2021-01-05
申请号：US13537194
申请日：2012-06-29
申请人： Silvia S. Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger, Jr.
发明人： Silvia S. Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger, Jr.
IPC分类号： A61F2/38 , A61F2/30 , A61B17/16 , A61F2/28 , A61F2/46 , A61L27/36 , A61L27/38
摘要： The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal. The invention is further directed toward a repaired cartilage defect.

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