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1. 发明授权

US09110022B2 Acoustic methods and systems for detecting terahertz radiation 有权
标题翻译：用于检测太赫兹辐射的声学方法和系统
公开(公告)号：US09110022B2
公开(公告)日：2015-08-18
申请号：US13643871
申请日：2011-04-29
申请人： Benjamin Clough , Jingle Liu , Xi-Cheng Zhang
发明人： Benjamin Clough , Jingle Liu , Xi-Cheng Zhang
IPC分类号： G01N21/63 , G01N21/3504 , G01N21/3581
CPC分类号： G01N21/63 , G01N21/3504 , G01N21/3581
摘要： Methods and systems for detecting radiation for example, terahertz radiation, with the aid of acoustic signal generation and detection include: directing an optical beam into a volume of gas; ionizing at least a portion of the volume of gas with the optical beam to produce a plasma; and detecting an acoustic signal produced from an interaction of a radiation wave with the plasma. The methods and systems are particularly adapted for remote detection of chemicals, biological substances, and explosives, among others. The capability of the methods and systems can be enhanced by employing multi-color laser excitation to produce the plasma and varying the time delay between the multi-color pulses.
摘要翻译：借助于声信号产生和检测，用于检测辐射的方法和系统，例如太赫兹辐射，包括：将光束引导到一定体积的气体中; 用光束电离至少一部分体积的气体以产生等离子体; 以及检测由辐射波与等离子体的相互作用产生的声信号。这些方法和系统特别适用于远程检测化学品，生物物质和爆炸物等。可以通过采用多色激光激发产生等离子体并改变多色脉冲之间的时间延迟来增强方法和系统的能力。

2. 发明授权

US08299435B2 Tunable broadband anti-relfection apparatus 有权
标题翻译：可调式宽带抗再感器
公开(公告)号：US08299435B2
公开(公告)日：2012-10-30
申请号：US12855332
申请日：2010-08-12
申请人： Xi-Cheng Zhang , Pengyu Han , Yuting W. Chen
发明人： Xi-Cheng Zhang , Pengyu Han , Yuting W. Chen
IPC分类号： G01J5/08
CPC分类号： G02B1/118
摘要： A broadband anti-reflection apparatus for use with terahertz radiation includes a layer having an outer surface comprising a plurality of pyramid structures having about a 30 μm to about a 110 μm period, and wherein reflectance of the terahertz radiation is reduced compared to a layer comprising a planar outer surface. Also disclosed is a method for modifying terahertz radiation which includes receiving terahertz radiation on a device having an anti-reflection layer having an outer surface comprising a plurality of pyramid structures having about a 30 μm to a 110 μm period, and modifying the terahertz radiation passing through the device or processing the terahertz radiation in the device.
摘要翻译：一种与太赫兹辐射一起使用的宽带抗反射装置包括具有外表面的层，该层具有包括大约30μm至大约110μm周期的多个金字塔结构，并且与包括以下的层相比，太赫兹辐射的反射率降低：平面外表面。还公开了一种用于修改太赫兹辐射的方法，其包括在具有抗反射层的装置上接收太赫兹辐射，所述抗反射层具有外表面，该外表面包括具有约30μm至110μm周期的多个金字塔结构，并且修改太赫兹辐射通过通过设备或处理设备中的太赫兹辐射。

3. 发明授权

US07718969B2 Methods and systems for generating amplified terahertz radiation for analyzing remotely-located objects 有权
标题翻译：用于生成放大太赫兹辐射的方法和系统，用于分析远程位置的物体
公开(公告)号：US07718969B2
公开(公告)日：2010-05-18
申请号：US11756243
申请日：2007-05-31
申请人： Xi-Cheng Zhang , Jianming Dai , Xu Xie
发明人： Xi-Cheng Zhang , Jianming Dai , Xu Xie
IPC分类号： G01N21/35
CPC分类号： G01N21/3581 , G01N21/3563 , G01N21/636 , G01S7/4802 , G01S13/887 , G01S17/026
摘要： A method for generating amplified terahertz radiation includes inducing a first volume of a gas to produce a seed plasma and emit pulsed seed terahertz radiation by focusing an optical seed beam in the first volume. The seed terahertz radiation is then amplified by focusing an optical gain beam to produce a gain plasma in a second volume overlapping with the pulsed seed terahertz radiation remote from the seed plasma. The method may be implemented in a system for detecting and analyzing a remotely-located object such as an explosive material, a biological agent, and a chemical agent.
摘要翻译：用于产生放大的太赫兹辐射的方法包括：通过将光学种子束聚焦在第一体积中来诱导第一体积的气体以产生种子等离子体并发射脉冲种子太赫兹辐射。然后通过聚焦光学增益束来放大种子太赫兹辐射，以产生与远离种子等离子体的脉冲种子太赫兹辐射重叠的第二体积中的增益等离子体。该方法可以在用于检测和分析诸如爆炸物质，生物制剂和化学试剂的远程定位物体的系统中实现。

4. 发明授权

US06977379B2 T-ray Microscope 有权
标题翻译： T型显微镜
公开(公告)号：US06977379B2
公开(公告)日：2005-12-20
申请号：US10434329
申请日：2003-05-08
申请人： Xi-Cheng Zhang , Jingzhou Xu , Tao Yuan
发明人： Xi-Cheng Zhang , Jingzhou Xu , Tao Yuan
IPC分类号： G01N21/35 , G02B21/00
CPC分类号： G01N21/3581 , G01N21/3563 , G02B21/00
摘要： A microscope for producing an image of a target using THz radiation. The microscope comprises a source for providing an optical pump pulse and an optical probe pulse; a THz emitter for activation by pump pulse to emit a THz pulse that irradiates the target to form a target-modified THz pulse; a THz detector for modulating the probe pulse with the target-modified THz pulse to create a modulated optical probe pulse characteristic of the target; an optical detection system for modifying and detecting the modulated optical probe pulse and converting the modulated optical probe pulse to electronic information; and a processor for receiving the electronic information and producing an image of the sample using the electronic information. The THz emitter and detector comprise one or more EO crystals. The target is positioned on one of the EO crystals in a near-field of the THz pulse.
摘要翻译：用于使用太赫兹辐射产生目标图像的显微镜。显微镜包括用于提供光泵浦脉冲和光探针脉冲的源; 用于通过泵浦脉冲激活的THz发射器发射照射目标以形成目标修正的THz脉冲的THz脉冲; THz检测器，用于用目标修正的THz脉冲调制探针脉冲，以产生目标的调制光探针脉冲特性; 光学检测系统，用于修改和检测调制的光探针脉冲并将调制的光探针脉冲转换成电子信息; 以及处理器，用于接收电子信息并使用电子信息产生样本的图像。太赫兹发射器和检测器包括一个或多个EO晶体。目标位于太赫兹脉冲的近场中的一个EO晶体上。

5. 发明授权

US06573700B2 Method of characterizing free-space radiation using a chirped optical pulse 有权
公开(公告)号：US06573700B2
公开(公告)日：2003-06-03
申请号：US10164454
申请日：2002-06-06
申请人： Xi-Cheng Zhang , Zhiping Jiang
发明人： Xi-Cheng Zhang , Zhiping Jiang
IPC分类号： G01R3100
CPC分类号： G01R29/0885
摘要： Characterization of free-space electromagnetic energy pulses (15) using a chirped optical probe beam is provided. An electro-optic or magneto-optic crystal (14) is positioned such that the free-space radiation and chirped optical probe signal co-propagate, preferably in a co-linear common direction, through the crystal where a temporal waveform of the free-space radiation is linearly encoded onto a wavelength spectrum of the chirped optical probe signal. The temporal waveform of the free-space radiation is then reconstructed using, for example, a dynamic subtraction of the spectral distribution of the chirped optical probe signal without modulation from the spectral distribution of the chirped optical probe signal with modulation by the free-space radiation.

6. 发明授权

US5952818A Electro-optical sensing apparatus and method for characterizing free-space electromagnetic radiation 失效
标题翻译：用于表征自由空间电磁辐射的电光感测装置和方法
公开(公告)号：US5952818A
公开(公告)日：1999-09-14
申请号：US739099
申请日：1996-10-25
申请人： Xi-Cheng Zhang , Louis Francis Libelo , Qi Wu
发明人： Xi-Cheng Zhang , Louis Francis Libelo , Qi Wu
IPC分类号： G01R29/08 , G01R31/00
CPC分类号： G01R29/0885
摘要： Apparatus and methods for characterizing free-space electromagnetic energy, and in particular, apparatus/method suitable for real-time two-dimensional far-infrared imaging applications are presented. The sensing technique is based on a non-linear coupling between a low-frequency electric field and a laser beam in an electro-optic crystal. In addition to a pratical counter-propagating sensing technique, a co-linear approach is described which provides longer radiated field--optical beam interaction length, thereby making imaging applications practical.
摘要翻译：提出了表征自由空间电磁能的装置和方法，特别是适用于实时二维远红外成像应用的装置/方法。感测技术基于电光晶体中低频电场与激光束之间的非线性耦合。除了实际的反向传播感测技术之外，还描述了提供更长的辐射场 - 光束相互作用长度的共线方法，从而使成像应用成为实用的。

7. 发明授权

US5420595A Microwave radiation source 失效
标题翻译：微波辐射源
公开(公告)号：US5420595A
公开(公告)日：1995-05-30
申请号：US144724
申请日：1993-10-28
申请人： Xi-Cheng Zhang , David H. Auston
发明人： Xi-Cheng Zhang , David H. Auston
IPC分类号： H01Q3/26 , H01Q3/44 , H01Q3/22 , H01Q1/06 , H01Q3/24
CPC分类号： H01Q3/44 , H01Q3/2676
摘要： A source of collimated beam or beams of microwave electromagnetic radiation pulses comprises a photoconductor substrate having a major surface and an optical radiation source providing a beam of optical radiation pulses for illuminating at least a relatively large aperture region of the major surface. A static electric field, intrinsic or applied, is present at the major surface for driving transient photocurrents generated by the beam of optical radiation pulses. Each beam of microwave electromagnetic radiation pulses emitted from the photoconductor substrate may be steered by varying the angle of incidence of the beam of optical radiation pulses illuminating the major surface, by varying the period of the spatial variation of a static electric field applied to the major surface by means of electrodes, or by varying the period or direction of a periodic intensity variation of a spatially modulated beam of optical radiation pulses on the major surface.
摘要翻译：微波电磁辐射脉冲的准直光束或光束的源包括具有主表面的光电导体基底和提供用于照射主表面的至少相对大的开口区域的光辐射脉冲束的光辐射源。固有或应用的静电场存在于主表面上，用于驱动由光辐射脉冲束产生的瞬态光电流。通过改变施加到主表面的静电场的空间变化的周期，可以通过改变照射主表面的光辐射脉冲束的入射角来控制从感光体基板发射的每束微波电磁辐射脉冲或通过改变在主表面上的空间调制光束的光辐射脉冲的周期性强度变化的周期或方向。

8. 发明授权

US08637013B2 Treatment of drug-related side effect and tissue damage by targeting the CD24-HMGB1-Siglec10 axis 有权
标题翻译：通过靶向CD24-HMGB1-Siglec10轴治疗药物相关的副作用和组织损伤
公开(公告)号：US08637013B2
公开(公告)日：2014-01-28
申请号：US13426392
申请日：2012-03-21
申请人： Yang Liu , Pan Zheng , Guo-Yun Chen , Xincheng Zheng , Xi Cheng , Steve Kunkel
发明人： Yang Liu , Pan Zheng , Guo-Yun Chen , Xincheng Zheng , Xi Cheng , Steve Kunkel
IPC分类号： A61K39/395 , A61K39/00 , A61K38/16
CPC分类号： C07K16/18 , A61K31/351 , A61K38/177 , A61K45/06 , A61K2039/505 , C07K14/70596 , C07K16/2803 , C07K16/2896 , C07K2319/30 , A61K2300/00
摘要： The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.
摘要翻译：本技术提供了通过施用包含一种或多种CD24的组合物来治疗组织损伤相关免疫失调调节的方法和组合物; CD24片段，变体和衍生物，CD24Fc融合蛋白; HMBG1结合蛋白，HMBG1盒B结合蛋白; HMGB1的多肽，单克隆，重组，嵌合，人源化scFv抗体和HMGB1抗体片段或HMGB1片段的抗体以及结合并抑制HMGB1盒B活性的抗体的拮抗剂; Siglec 10激动剂如抗Siglec 10抗体; 及其组合。

9. 发明申请

US20120193535A1 PLASMA DIAGNOSTIC METHOD USING TERAHERTZ-WAVE-ENHANCED FLUORESCENCE 有权
标题翻译：使用TERAHERTZ-WAVE增强荧光的等离子体诊断方法
公开(公告)号：US20120193535A1
公开(公告)日：2012-08-02
申请号：US13097866
申请日：2011-04-29
申请人： Xi-Cheng ZHANG , Jingle LIU
发明人： Xi-Cheng ZHANG , Jingle LIU
IPC分类号： G01J5/10
CPC分类号： G01N21/64 , G01N21/1702 , G01N21/3577 , G01N21/3586 , G01N2021/1704
摘要： Methods and systems for characterizing a plasma with radiation, particularly, terahertz (THz) radiation, are disclosed. The disclosed method of characterizing a plasma includes directing THz radiation into the plasma; and detecting an emission due to interaction of the THz radiation with the plasma to characterize the plasma. A disclosed plasma characterizing device includes a means for directing THz radiation into a plasma; and a detector adapted to detect an emission emitted by the plasma due to interaction of the THz radiation with the plasma to characterize the plasma. A plasma characterizing system is also disclosed. The emission detected may be a fluorescence, a variation in fluorescence and/or an acoustic emission.
摘要翻译：公开了用于表征具有辐射特别是太赫兹（THz）辐射的等离子体的方法和系统。所公开的表征等离子体的方法包括将THz辐射引入等离子体; 并且检测由于THz辐射与等离子体的相互作用引起的发射以表征等离子体。公开的等离子体表征装置包括用于将太赫兹辐射引导到等离子体中的装置; 以及检测器，其适于检测由于THz辐射与等离子体的相互作用而发射的等离子体的发射以表征等离子体。还公开了等离子体表征系统。检测到的发射可以是荧光，荧光和/或声发射的变化。

10. 发明授权

US07595491B2 Methods and systems for the enhancement of terahertz wave generation for analyzing a remotely-located object 有权
标题翻译：用于增强太赫兹波生成的方法和系统，用于分析远程位置的物体
公开(公告)号：US07595491B2
公开(公告)日：2009-09-29
申请号：US11756230
申请日：2007-05-31
申请人： Xi-Cheng Zhang , Jianming Dai , Xu Xie
发明人： Xi-Cheng Zhang , Jianming Dai , Xu Xie
IPC分类号： G01N21/17
CPC分类号： G01N21/3581 , G01N21/3563 , G01N21/636 , G01N2021/1793
摘要： A method for generating terahertz radiation includes inducing a background plasma in a volume of a gas by focusing a first optical beam in the volume, and generating pulsed terahertz radiation with enhanced generation efficiency by focusing a second time-delayed optical beam in the background plasma. The method may be implemented in a system for detecting and analyzing a remotely-located object.
摘要翻译：一种用于产生太赫兹辐射的方法包括通过将第一光束聚焦在体积中来引入一定体积的气体中的背景等离子体，以及通过将第二时间延迟的光束聚焦在背景等离子体中来产生具有增强的发生效率的脉冲太赫兹辐射。该方法可以在用于检测和分析位于远程的对象的系统中实现。

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