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1. 发明授权

US07090986B2 Protein for blocking platelet adhesion 有权
公开(公告)号：US07090986B2
公开(公告)日：2006-08-15
申请号：US11153433
申请日：2005-06-16
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： G01N33/53
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.

2. 发明授权

US06962801B2 Protein for blocking platelet adhesion 失效
标题翻译：用于阻断血小板粘附的蛋白质
公开(公告)号：US06962801B2
公开(公告)日：2005-11-08
申请号：US10846668
申请日：2004-05-17
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： G01N33/50 , A61K31/616 , A61K31/727 , A61K38/00 , A61K38/17 , A61K38/46 , A61L27/00 , A61P7/02 , C07K14/435 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/15 , G01N33/566 , C07H21/04 , C12N15/63
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to hard disease and diseases of the circulation system. Furthermore the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译：描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。公开了通过重组技术生产这种多肽的方法。重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与硬疾病和循环系统疾病有关的各种疾病。此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并防止细胞的活化。

3. 发明申请

US20050143305A1 Specific mechanism for inhibiting platelet adhesion to collagen 失效
标题翻译：抑制血小板粘附到胶原蛋白的具体机制
公开(公告)号：US20050143305A1
公开(公告)日：2005-06-30
申请号：US11016854
申请日：2004-12-21
申请人： Christopher Barnes , Matthias Frech , Uwe Hofmann , Johannes Gleitz , Wolfgang Strittmatter
发明人： Christopher Barnes , Matthias Frech , Uwe Hofmann , Johannes Gleitz , Wolfgang Strittmatter
IPC分类号： A61K38/00 , A61F2/84 , A61K38/17 , A61M25/00 , A61P7/02 , A61P9/10 , A61B17/20
CPC分类号： A61K38/1767 , A61M2025/0057
摘要： Use of the polypeptide Saratin for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or endarterectomy. The invention furthermore relates to a novel medical use of Saratin as an inhibitor of thrombosis and intimal hyperplasia, wherein said polypeptide may be used locally as a topical agent or as a coating on, or otherwise incorporated or associated with medical devices.
摘要翻译：多肽沙林定用于制造具有显着降低血管损伤或内膜剥离后血小板粘附和血小板聚集能力的药物的用途。本发明还涉及Saratin作为血栓形成和内膜增生的抑制剂的新型医疗用途，其中所述多肽可局部用作局部用药剂，或作为医疗器械上或其他方式并入或与医疗器械相关联的涂层。

4. 发明授权

US5798229A Bispecific molecules recognizing lymphocyte antigen CD2 and tumor antigens 失效
标题翻译：识别淋巴细胞抗原CD2和肿瘤抗原的双特异性分子
公开(公告)号：US5798229A
公开(公告)日：1998-08-25
申请号：US284947
申请日：1994-08-02
申请人： Wolfgang Strittmatter , Carlota-Silvia Jaggle , Stefan Meuer , Burkhart Shraven , Martin Wild
发明人： Wolfgang Strittmatter , Carlota-Silvia Jaggle , Stefan Meuer , Burkhart Shraven , Martin Wild
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K1/113 , C07K14/485 , C07K14/52 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/46 , C07K19/00 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/13 , C12N15/28 , C12P21/08 , C12R1/91 , G01N33/531 , G01N33/574
CPC分类号： C07K16/2806 , C07K16/30 , A61K38/00 , C07K2317/74
摘要： The present invention relates to novel and highly effective bispecific antibody fragments which recognize lymphocyte CD2 antigen and any variable tumor antigen. Moreover, the invention relates to two new monoclonal antibodies terms AICD2.M1 and AICD2.M2. A combination of these antibodies, whereby at least one of them is a bispecific antibody fragment, can be used successfully in tumor therapy and diagnostics.
摘要翻译：本发明涉及识别淋巴细胞CD2抗原和任何可变肿瘤抗原的新颖且高度有效的双特异性抗体片段。此外，本发明涉及两种新的单克隆抗体AICD2.M1和AICD2.M2。这些抗体的组合，其中至少一个是双特异性抗体片段，可以成功地用于肿瘤治疗和诊断。

5. 发明授权

US5824782A Immunoconjugates II 失效
标题翻译：免疫接种II
公开(公告)号：US5824782A
公开(公告)日：1998-10-20
申请号：US528523
申请日：1995-09-15
申请人： Wolfgang Holzer , Ilka von Hoegen , Wolfgang Strittmatter , Siegfried Matzku
发明人： Wolfgang Holzer , Ilka von Hoegen , Wolfgang Strittmatter , Siegfried Matzku
IPC分类号： C12N15/02 , A61K38/00 , A61K38/19 , A61K39/385 , A61K39/395 , A61K39/44 , A61K47/48 , A61P35/00 , A61P43/00 , C07K14/485 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C07K16/46 , C12N15/62 , C12P21/08 , C12R1/91 , C07K17/00 , C07K17/14
CPC分类号： A61K47/48415 , A61K47/48561 , Y02P20/582
摘要： The invention provides new immunoconjugates comprising a mono-clonal antibody or a fragment thereof specific for the human EGF-receptor molecule and a member of the chemokine family, preferably selected from the C-X-C family, e.g. lnterleukin-8 (IL-8). The immunoconjugates induce cytotoxic and chemotactic activity and are suitable for a targeted tumor therapy.
摘要翻译：本发明提供了新的免疫偶联物，其包含对人EGF受体分子特异的单克隆抗体或其片段和趋化因子家族成员，优选选自C-X-C家族，例如，白细胞介素-8（IL-8）。免疫偶联物诱导细胞毒性和趋化活性，适用于靶向肿瘤治疗。

6. 发明授权

US07943300B2 Method for improved protein expression in bacteria by monitoring and modulating protein folding 有权
标题翻译：通过监测和调节蛋白质折叠来改善细菌中蛋白质表达的方法
公开(公告)号：US07943300B2
公开(公告)日：2011-05-17
申请号：US10482728
申请日：2002-07-03
申请人： Uwe Horn , Ulrike Riesenberg , Wolfgang Strittmatter
发明人： Uwe Horn , Ulrike Riesenberg , Wolfgang Strittmatter
IPC分类号： C12Q1/68 , C12Q1/66 , C12N1/20
CPC分类号： C12Q1/6897
摘要： This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced by adding folding promoting agents and/or co-expression of the periplasmic chaperone (Skp). In this respect, the invention offers a technology to improve the yield of functionally expressed recombinant proteins.
摘要翻译：本发明涉及一种改善功能性蛋白质表达的新方法，其中通过在线测量监测折叠过程，如果需要，蛋白质折叠通过加入折叠促进剂和/或共表达周质伴侣（Skp）而受到影响。在这方面，本发明提供了一种提高功能表达的重组蛋白的产量的技术。

7. 发明授权

US07459438B2 Specific mechanism for inhibiting platelet adhesion to collagen 失效
标题翻译：抑制血小板粘附到胶原蛋白的具体机制
公开(公告)号：US07459438B2
公开(公告)日：2008-12-02
申请号：US11016854
申请日：2004-12-21
申请人： Christopher Barnes , Matthias Frech , Uwe Hofmann , Johannes Gleitz , Wolfgang Strittmatter
发明人： Christopher Barnes , Matthias Frech , Uwe Hofmann , Johannes Gleitz , Wolfgang Strittmatter
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K38/1767 , A61M2025/0057
摘要： The present invention relates to the polypeptide Saratin and its use for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or endarterectomy. The invention furthermore relates to a novel medical use of Saratin as an inhibitor of thrombosis and intimal hyperplasia, where the Saratin polypeptide may be used locally as a topical agent or as a coating on, or otherwise incorporated or associated with medical devices or vascular grafts.
摘要翻译：本发明涉及多肽Saratin及其用于制造具有显着降低血管损伤或内膜剥离术后血小板粘附和血小板聚集的能力的药物的用途。本发明还涉及Saratin作为血栓形成和内膜增生抑制剂的新型医疗用途，其中Saratin多肽可局部用作局部用药剂，或作为外用剂或其它方式并入或与医疗器械或血管移植物结合使用。

8. 发明授权

US06774107B1 Protein for blocking platelet adhesion 失效
标题翻译：用于阻断血小板粘附的蛋白质
公开(公告)号：US06774107B1
公开(公告)日：2004-08-10
申请号：US09936737
申请日：2001-09-17
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： A61K3817
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译：描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。公开了通过重组技术生产这种多肽的方法。重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与心脏病和循环系统疾病有关的各种病症。此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并阻止细胞的活化。

9. 发明申请

US20060094079A1 Protein for blocking platelet adhesion 有权
标题翻译：用于阻断血小板粘附的蛋白质
公开(公告)号：US20060094079A1
公开(公告)日：2006-05-04
申请号：US11153433
申请日：2005-06-16
申请人： Wolfgang Strittmatter , Detlef Gussow , Uwe Hofmann , Jurgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Gussow , Uwe Hofmann , Jurgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： C07H21/04 , C12N9/64
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译：描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。公开了通过重组技术生产这种多肽的方法。重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与心脏病和循环系统疾病有关的各种病症。此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并阻止细胞的活化。

10. 发明申请

US20050244421A1 Compositions and methods for modulating immune response 审中-公开
标题翻译：用于调节免疫应答的组合物和方法
公开(公告)号：US20050244421A1
公开(公告)日：2005-11-03
申请号：US11010748
申请日：2004-12-13
申请人： Wolfgang Strittmatter , Heidrun Moll , Burkhard Scharm
发明人： Wolfgang Strittmatter , Heidrun Moll , Burkhard Scharm
IPC分类号： C12N15/09 , A61K35/12 , A61K38/00 , A61K39/00 , A61K39/39 , A61P35/00 , A61P35/02 , A61P37/06 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/10 , C12P21/08 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/6845 , A61K2039/5156 , C12N15/1034 , G01N33/56977 , G01N33/574 , G01N2333/70539 , G01N2800/245 , G01N2800/56
摘要： A method of modulating reactivity of a T cell population of a mammal comprises contacting the T cell population with an immunogenic dose of an antigenic peptide having a sequence that derives from a tissue specific expressed allelic protein variant from an individual of a specific species, wherein the tissue specific expressed allelic protein is encoded by a DNA sequence containing at least one single nucleotide polymorphism (SNP) in the coding region and binds to a MHC class I protein complex inducing an immunogenic response.
摘要翻译：调节哺乳动物T细胞群体的反应性的方法包括使T细胞群体与免疫原性剂量的抗原肽接触，所述抗原肽具有源自特定物种个体的组织特异性表达的等位基因蛋白质变体的序列，其中组织特异性表达的等位基因蛋白由编码区中含有至少一个单核苷酸多态性（SNP）的DNA序列编码，并与诱导免疫原性应答的MHC I类蛋白复合物结合。

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