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1. 发明授权

US08586755B2 Substituted nicotinamides as KCNQ2/3 modulators 失效
标题翻译：取代烟酰胺作为KCNQ2 / 3调节剂
公开(公告)号：US08586755B2
公开(公告)日：2013-11-19
申请号：US13434915
申请日：2012-03-30
申请人： Sven Kühnert , Beatrix Merla , Gregor Bahrenberg , Wolfgang Schröder
发明人： Sven Kühnert , Beatrix Merla , Gregor Bahrenberg , Wolfgang Schröder
IPC分类号： A61K31/44 , C07D211/72
CPC分类号： C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Substituted nicotinamides, processes for their preparation, medicaments comprising these compounds and methods of using these compounds to treat pain, epilepsy, urinary incontinence, anxiety, dependency, mania, bipolar disorders, migraine, cognitive diseases, and/or dystonia-associated dyskinesias.
摘要翻译：取代的烟酰胺，其制备方法，包含这些化合物的药物和使用这些化合物治疗疼痛，癫痫，尿失禁，焦虑症，依赖性，躁狂症，双相情感障碍，偏头痛，认知疾病和/或肌张力障碍相关运动障碍的方法。

2. 发明授权

US08552200B2 Substituted 6-amino-nicotinamides as KCNQ2/3 modulators 有权
公开(公告)号：US08552200B2
公开(公告)日：2013-10-08
申请号：US13276464
申请日：2011-10-19
申请人： Sven Kühnert , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder , Simon Lucas
发明人： Sven Kühnert , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder , Simon Lucas
IPC分类号： C07D213/72 , A61K31/44
CPC分类号： C07D401/04 , C07D213/82 , C07D401/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Substituted 6-amino-nicotinamides, pharmaceutical compositions containing these compounds and also use of these compounds in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

3. 发明授权

US08399673B2 Substituted 2-mercaptoquinoline-3-carboxamides as KCNQ2/3 modulators 有权
标题翻译：取代的2-巯基喹啉-3-甲酰胺作为KCNQ2 / 3调节剂
公开(公告)号：US08399673B2
公开(公告)日：2013-03-19
申请号：US13523955
申请日：2012-06-15
申请人： Sven Kühnert , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder
发明人： Sven Kühnert , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder
IPC分类号： C07D215/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D409/12 , C07D215/54
摘要： The invention relates to substituted 2-mercaptoquinoline-3-carboxamides, methods for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
摘要翻译：本发明涉及取代的2-巯基喹啉-3-甲酰胺，其制备方法，含有这些化合物的药物以及这些化合物在制备药物中的用途。

4. 发明授权

US08357705B2 Substituted cyclohexyldiamines 有权
标题翻译：取代的环己基二胺
公开(公告)号：US08357705B2
公开(公告)日：2013-01-22
申请号：US12410923
申请日：2009-03-25
申请人： Saskia Zemolka , Bert Nolte , Klaus Linz , Derek John Saunders , Wolfgang Schröder , Werner Englberger , Fritz Theil , Hans Schick , Jens Kaufmann , Julian Gebauer , Helmut Sonnenschein
发明人： Saskia Zemolka , Bert Nolte , Klaus Linz , Derek John Saunders , Wolfgang Schröder , Werner Englberger , Fritz Theil , Hans Schick , Jens Kaufmann , Julian Gebauer , Helmut Sonnenschein
IPC分类号： A61K31/41 , C07D271/12
CPC分类号： C07D209/20 , C07D403/06 , C07D413/06 , C07D417/06
摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain or other conditions.
摘要翻译：本发明涉及对μ-阿片受体和ORL1-受体具有亲和力的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛或其它病症的用途。

5. 发明授权

US08293758B2 Substituted spirocyclic cyclohexane derivatives 有权
标题翻译：取代的螺环环己烷衍生物
公开(公告)号：US08293758B2
公开(公告)日：2012-10-23
申请号：US12410544
申请日：2009-03-25
申请人： Saskia Zemolka , Bert Nolte , Sven Frormann , Claudia Hinze , Klaus Linz , Wolfgang Schröder , Werner Englberger , Hans Schick , Helmut Sonnenschein
发明人： Saskia Zemolka , Bert Nolte , Sven Frormann , Claudia Hinze , Klaus Linz , Wolfgang Schröder , Werner Englberger , Hans Schick , Helmut Sonnenschein
IPC分类号： A61K31/438 , A61K31/407 , A61P25/00 , C07D491/052 , C07D471/04
CPC分类号： C07D471/04 , C07D471/14 , C07D491/052 , C07D491/147
摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
摘要翻译：本发明涉及对μ-阿片受体和ORL1-受体具有亲和力的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛和其它病症的用途。

6. 发明授权

US07977370B2 (Hetero)aryl cyclohexane derivatives 有权
标题翻译：（杂芳基）环己烷衍生物
公开(公告)号：US07977370B2
公开(公告)日：2011-07-12
申请号：US12410692
申请日：2009-03-25
申请人： Saskia Zemolka , Stefan Schunk , Bert Nolte , Klaus Linz , Wolfgang Schröder , Werner Englberger , Hans Schick , Helmut Sonnenschein , Birgitta Henkel , József Bálint
发明人： Saskia Zemolka , Stefan Schunk , Bert Nolte , Klaus Linz , Wolfgang Schröder , Werner Englberger , Hans Schick , Helmut Sonnenschein , Birgitta Henkel , József Bálint
IPC分类号： A01N43/38
CPC分类号： C07D209/30 , C07D401/06 , C07D417/08
摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
摘要翻译：本发明涉及对μ-阿片受体和ORL1-受体具有亲和力的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛和其它病症的用途。

7. 发明授权

US07488371B2 Degassing device for degassing matrix material in order to produce fiber-reinforced components 有权
标题翻译：用于脱气基质材料的脱气装置，以便产生纤维增强部件
公开(公告)号：US07488371B2
公开(公告)日：2009-02-10
申请号：US10902091
申请日：2004-07-30
申请人： Thomas Lippert , Hans-Wolfgang Schröder , Franz Stadler , Stefan Utecht
发明人： Thomas Lippert , Hans-Wolfgang Schröder , Franz Stadler , Stefan Utecht
IPC分类号： B01D19/00
CPC分类号： B29C70/54 , B29B15/08
摘要： Degassing device for degassing matrix material in the manufacture of fiber-composite components with a support device, a distribution fabric, a gate device, a discharge device, a matrix-material-impermeable barrier layer, which is sealed with respect to the support device by a seal and thus forms a first chamber of the degassing device located around the gate device, as well as a degassing device for degassing matrix material in the manufacture of fiber-composite components with a first connection, for conducting the matrix material to be degassed into the degassing device, a second connection for conducting the degassed fluid out of the same, and a third connection for applying negative pressure to the interior of the same, an inner body, a resin-impermeable and air-permeable film, and an outer housing.
摘要翻译：在具有支撑装置，分配织物，浇口装置，放电装置，基质材料不可渗透阻挡层的纤维复合材料部件的制造中脱气基质材料的脱气装置，其通过相对于支撑装置被密封密封件并因此形成位于浇口装置周围的脱气装置的第一室，以及用于在具有第一连接的纤维复合材料部件的制造中对基体材料进行脱气的脱气装置，用于将要脱气的基质材料导入脱气装置，用于将脱气流体从其外部引出的第二连接件和用于向其内部施加负压的第三连接件，内部主体，树脂不可渗透和透气膜以及外部壳体。

8. 发明授权

US06718652B2 Rotary particle-drying drum 失效
标题翻译：旋转颗粒干燥鼓
公开(公告)号：US06718652B2
公开(公告)日：2004-04-13
申请号：US10093075
申请日：2002-03-07
申请人： Andreas Klug , Wolfgang Schröder
发明人： Andreas Klug , Wolfgang Schröder
IPC分类号： F26B1102
CPC分类号： F26B11/0477 , F26B2210/16
摘要： A rotary particle dryer has a shaft extending along an axis and a hollow drum coaxially and spacedly surrounding the shaft and rotatable about the axis in a direction. A set of axially extending inner baffles fixed to the shaft extend radially outward therefrom and each form at least one angularly open inner pocket. A set of axially extending outer baffles fixed to the drum extend radially inward therefrom and each form at least two angularly open outer pockets. Structure mechanically connects the inner baffles directly with the outer baffles.
摘要翻译：旋转颗粒干燥器具有沿轴线延伸的轴和中空鼓，其同轴并且间隔开地围绕轴并且可绕轴线在一个方向上旋转。固定在轴上的一组轴向延伸的内部挡板从其径向向外延伸，并且每个形成至少一个有角度的开口内袋。固定到鼓的一组轴向延伸的外挡板从其上径向向内延伸，并且每个形成至少两个有角度开口的外袋。结构将内挡板与外挡板直接机械连接。

9. 发明授权

US06316396B1 Amphiphilic compounds with at least two hydrophilic and at least two hydrophobic groups based on di-, oligo- or polyolethers 失效
标题翻译：具有至少两个亲水性和至少两个基于二，寡或多脂肪族的疏水基的两亲化合物
公开(公告)号：US06316396B1
公开(公告)日：2001-11-13
申请号：US09288632
申请日：1999-04-09
申请人： Klaus Kwetkat , Wolfgang Schröder
发明人： Klaus Kwetkat , Wolfgang Schröder
IPC分类号： A61K7075
CPC分类号： A61Q19/10 , A61K8/466 , A61K8/90 , A61Q5/02 , B01F17/0021 , B01F17/0057 , C07C305/10 , C11D1/12
摘要： The invention relates to amphiphilic compounds of the general formula (I) with at least two hydrophilic and at least two hydrophobic groups based on di, oligo or polyolethers. The amphiphilic compounds of this invention are highly surface active and are suitable as emulsifiers, demulsifiers, detergents, dispersants and hydrotropes for industrial and domestic purposes, e.g. in the fields of metalworking, ore separation, surface treatment, washing and cleaning, cosmetics, medicine and food processing and preparation.
摘要翻译：本发明涉及通式（I）的两亲化合物与至少两个基于二，寡聚或多烯烃的亲水和至少两个疏水基团。本发明的两亲性化合物是高度表面活性的，并且适用于工业和家用目的的乳化剂，破乳剂，洗涤剂，分散剂和水溶助长剂。在金属加工，矿石分离，表面处理，洗涤和清洁，化妆品，医药和食品加工和制备领域。

10. 发明授权

US09168259B2 Substituted 6-amino-nicotinamides as KCNQ2/3 modulators 有权
标题翻译：取代的6-氨基烟酰胺作为KCNQ2 / 3调节剂
公开(公告)号：US09168259B2
公开(公告)日：2015-10-27
申请号：US13449472
申请日：2012-04-18
申请人： Sven Kühnert , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder , Simon Lucas
发明人： Sven Kühnert , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder , Simon Lucas
IPC分类号： A61K31/5377 , C07D413/04 , A61K31/541 , C07D213/82 , C07D401/04 , C07D401/14 , C07D405/12 , C07D413/14 , A61K31/455 , C07D401/12 , C07D417/04
CPC分类号： A61K31/541 , A61K31/455 , A61K31/5377 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： Substituted 6-amino-nicotinamides, pharmaceutical compositions containing these compounds and also use of these compounds in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译：取代的6-氨基烟酰胺，含有这些化合物的药物组合物，以及这些化合物在治疗和/或预防疼痛和其它疾病和/或病症中的用途。

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