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1. 发明授权

US5728873A Process for the preparation of cyclopropanamine 失效
标题翻译：制备环丙胺的方法
公开(公告)号：US5728873A
公开(公告)日：1998-03-17
申请号：US663989
申请日：1996-06-14
申请人： Wolfgang Kleemiss , Thomas Kalz
发明人： Wolfgang Kleemiss , Thomas Kalz
IPC分类号： C07C209/56 , C07C211/35
CPC分类号： C07C209/56 , C07C2101/02
摘要： A process for the preparation of cyclopropanamine by Hofmann degradation of cyclopropanecarboxamide, comprising the following steps: (1) suspending cyclopropanecarboxamide, either (A) in 1.1 to 4 mol of sodium hydroxide, in solution whose concentration is 10 to 50%, per mol of amide, or (B) in a sparing amount of water, (2) adding 1 to 1.5 mol of hypochlorite, per mol of amide, from a 5 to 15% strength hypochlorite solution at a temperature of 0.degree. to 20.degree. C., (3) adding 1.1 to 4 mol of sodium hydroxide, in solution whose concentration is 10 to 50%, per mol of amide, in the case where a suspension has been formed according to step (1)(B), (4) reacting the amide, hypochlorite, and sodium hydroxide for 10 to 60 minutes to form a homogeneous reaction mixture, (5) continuously passing the homogeneous reaction mixture through a tubular reactor at a temperature of 45.degree. to 260.degree. C., (6) feeding the reaction output from the tubular reactor into a distillation column and keeping it under reflux with water, wherein cyclopropanamine is distilled off.
摘要翻译：包括以下步骤：（1）将环丙烷甲酰胺（浓度为10〜50％）中的（A）悬浮于1.1〜4mol氢氧化钠中，每摩尔浓度为10〜50％的溶液中，将环丙烷甲酰胺（A）悬浮于环丙烷甲醛中，酰胺或（B），（2）在0〜20℃的温度下，从5〜15％的强酸性次氯酸盐溶液中加入1〜1.5摩尔次氯酸盐/每摩尔酰胺，（3）在根据步骤（1）（B）形成悬浮液的情况下，在每摩尔酰胺浓度为10至50％的溶液中加入1.1至4mol氢氧化钠，（4）使酰胺，次氯酸盐和氢氧化钠反应10至60分钟以形成均匀的反应混合物，（5）将均匀的反应混合物连续通过管式反应器，温度为45至260℃，（6）反应从管状反应器输出到蒸馏塔中并将其保持在下面与水回流，其中蒸馏出环丙胺。

2. 发明授权

US06399809B1 Process for the preparation of amino acid derivatives 失效
标题翻译：制备氨基酸衍生物的方法
公开(公告)号：US06399809B1
公开(公告)日：2002-06-04
申请号：US09557413
申请日：2000-04-21
申请人： Wolfgang Kleemiss , Marcel Feld
发明人： Wolfgang Kleemiss , Marcel Feld
IPC分类号： C07C20500
CPC分类号： C07C269/00 , C07C273/18 , C07C271/22 , C07C275/16 , C07C275/24
摘要： Process for the preparation of amino acid derivatives of the general formula I where R1-R4 are as defined herein, from the corresponding malonic acid monoester amides of the general formula II by Hofmann degradation using a hypohalite in an aqueously basic medium, which comprises carrying out the reaction in the presence of an alcohol or amine and using the hypohalite in amounts of from 1.0 to 1.5 equivalents and the base in amounts of from 0.8 to 4.0 equivalents per mole of starting material II.
摘要翻译：由通式II的相应的丙二酸单酯酰胺制备通式Ⅰ的氨基酸衍生物的方法，其通过霍夫曼降解，使用碱性介质中的次卤酸盐，其包括进行在醇或胺的存在下反应，并使用量为1.0至1.5当量的次卤酸盐和碱的量为每摩尔原料II为0.8至4.0当量。

3. 发明授权

US5767326A Process for preparing hydroxymethylcyclopropane 失效
标题翻译：制备羟甲基环丙烷的方法
公开(公告)号：US5767326A
公开(公告)日：1998-06-16
申请号：US813593
申请日：1997-03-07
申请人： Wolfgang Kleemiss , Marcel Feld
发明人： Wolfgang Kleemiss , Marcel Feld
IPC分类号： B01J23/26 , B01J23/80 , B01J23/86 , C07B61/00 , C07C29/141 , C07C31/133 , C07C27/10
CPC分类号： C07C29/141 , C07C2101/02
摘要： A process for preparing hydroxymethylcyclopropane, in which formylcyclopropane is hydrogenated over copper chromite, zinc chromite and/or copper/zinc catalysts. The process may be batchwise or continuous.
摘要翻译：甲基环丙烷的制备方法，其中甲基环丙烷在亚铬酸铜，亚铬酸铬和/或铜/锌催化剂上氢化。该方法可以是分批的或连续的。

4. 发明授权

US06500980B1 Process for preparing amino derivatives of C-H-acid compounds 失效
标题翻译：制备C-H酸化合物的氨基衍生物的方法
公开(公告)号：US06500980B1
公开(公告)日：2002-12-31
申请号：US09863253
申请日：2001-05-24
申请人： Guenther Koehler , Wolfgang Kleemiss , Frank Bauer
发明人： Guenther Koehler , Wolfgang Kleemiss , Frank Bauer
IPC分类号： C07C22924
CPC分类号： C07C231/10 , C07C233/45 , C07C233/47
摘要： A process for preparing amino derivatives of C—H-acid compounds of the general formula I where R is an alkyl group, a cycloaliphatic radical, an aryl radical, an alkylaryl radical or an aralkyl radical, and X1 and X2 are identical or different electron-withdrawing groups, by reacting compounds of the general formula II with nitrous acid, where the nitrosation is carried out in the presence of from 1 to 10 mol of a carboxylic anhydride, and the reaction product is subjected to catalytic hydrogenation, where appropriate after removing the salts derived from the reaction. Compounds of the general formula I are useful intermediates for compounds which can be used in the pharmaceutical and agricultural sectors.
摘要翻译：制备通式I的CH-酸化合物的氨基衍生物的方法，其中R是烷基，脂环族基，芳基，烷基芳基或芳烷基，X1和X2是相同或不同的吸电子基团通过使通式II的化合物与亚硝酸反应，其中亚硝化在1-10摩尔羧酸酐存在下进行，并且在除去衍生自反应。通式I的化合物是可用于制药和农业领域的化合物的有用中间体。

5. 发明授权

US06248917B1 Process for the preparation of 2-hydroxybenzonitrile 失效
标题翻译： 2-羟基苄腈的制备方法
公开(公告)号：US06248917B1
公开(公告)日：2001-06-19
申请号：US08663661
申请日：1996-06-14
申请人： Wolfgang Kleemiss
发明人： Wolfgang Kleemiss
IPC分类号： C07C25320
CPC分类号： C07C253/20 , C07C255/53
摘要： 2-Hydroxybenzonitrile is prepared by passing 2-hydroxybenzamide in the gas phase over a heterogeneous catalyst thereby effecting dehydration of the 2-hydroxybenzamide to produce 2-hydroxybenzonitrile.
摘要翻译：通过使气相中的2-羟基苯甲酰胺在非均相催化剂上通过2-羟基苯甲酰胺脱水制备2-羟基苄腈来制备2-羟基苄腈。

6. 发明授权

US6143920A Process for the preparation of methoxyacetic acid esters 失效
标题翻译：制备甲氧基乙酸酯的方法
公开(公告)号：US6143920A
公开(公告)日：2000-11-07
申请号：US179189
申请日：1998-10-27
申请人： Wolfgang Kleemiss , Klaus-Dieter Steffen , Marcel Feld
发明人： Wolfgang Kleemiss , Klaus-Dieter Steffen , Marcel Feld
IPC分类号： B01J31/02 , C07B61/00 , C07C67/03 , C07C67/30 , C07C67/31 , C07C69/708 , C07C69/66 , C07C67/02
CPC分类号： C07C67/03 , C07C67/31
摘要： The invention relates to a process for the preparation of methoxyacetic acid esters in which a chloroacetic acid ester is reacted with an alkali metal methoxide to give the methoxyacetic acid ester.
摘要翻译：本发明涉及一种制备甲氧基乙酸酯的方法，其中氯乙酸酯与碱金属甲醇盐反应得到甲氧基乙酸酯。

7. 发明授权

US6107522A Process for the preparation of cyclopropylamine 失效
标题翻译：制备环丙胺的方法
公开(公告)号：US6107522A
公开(公告)日：2000-08-22
申请号：US350289
申请日：1999-07-09
申请人： Wolfgang Kleemiss , Marcel Feld , Manfred Kaufhold
发明人： Wolfgang Kleemiss , Marcel Feld , Manfred Kaufhold
IPC分类号： C07C209/56 , C07B61/00 , C07C51/363 , C07C67/00 , C07C67/333 , C07C69/74 , C07C209/58 , C07C211/17 , C07C211/35 , C07C231/02 , C07C233/58 , C07L209/00
CPC分类号： C07C231/02 , C07C209/58 , C07C51/363 , C07C67/00 , C07C2101/02
摘要： Cyclopropylamine is prepared from butyrolactone by a process comprising:(a) reacting butyrolactone with hydrogen chloride, thereby yielding chlorobutyric acid, (b) esterifying said chlorobutyric acid with a primary or secondary alcohol having 4-8 carbon atoms, (c) cyclizing the ester with an alkali metal alcoholate of a primary alcohol having 1-3 carbon atoms to give a mixture of cyclopropanecarboxylic acid esters, (d) converting the cyclopropanecarboxylic acid ester mixture into cyclopropanecarboxylic acid amide by reacting the ester mixture with ammonia, and (e) reacting said cyclopropanecarboxylic acid amide with hypohalite ion in a basic medium, thereby forming cyclopropylamine.
摘要翻译：环丙胺由丁内酯制备，包括：（a）使丁内酯与氯化氢反应，从而产生氯代丁酸，（b）用具有4-8个碳原子的伯或仲醇酯化所述氯代丁酸，（c）使酯与具有1-3个碳原子的伯醇的碱金属醇化物反应得到环丙烷羧酸酯的混合物，（d）通过使酯混合物与氨反应将环丙烷羧酸酯混合物转化为环丙烷羧酸酰胺，和（e）使所述环丙烷羧酸酰胺与碱式介质中的次卤酸离子形成环丙胺。

8. 发明授权

US6100424A Process for the preparation of amino acetic acid esters with a tertiary hydrocarbon radical in the .alpha.-position 失效
标题翻译：在α-位上用叔烃基制备氨基乙酸酯的方法
公开(公告)号：US6100424A
公开(公告)日：2000-08-08
申请号：US350102
申请日：1999-07-09
申请人： Wolfgang Kleemiss
发明人： Wolfgang Kleemiss
IPC分类号： C07C227/04 , C07C229/08 , C07C229/00 , C07C69/74
CPC分类号： C07C227/04
摘要： Aminoacetic acid esters of formula I in which R.sup.1, R.sup.2 and R.sup.3 are identical or different hydrocarbon radicals, or any two of these radicals form a carbon ring with the carbon atom to which they are attached and R.sup.4 is hydrogen or an alkyl radical having 1-4 carbon atoms, are prepared by reacting an .alpha.-substituted malonic acid monoamide ester of formula II ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings above, by the Hofmann degradation reaction, with a hypohalite in an amount of up to 1.5 equivalents in an aqueous-basic medium containing base in an amount of 0.8-1.5 equivalents per mol. of starting malonic acid monoamide ester II.
摘要翻译：其中R 1，R 2和R 3是相同或不同的烃基，或这些基团中的任何两个与它们所连接的碳原子形成碳环，并且R 4是氢或具有1-甲基的烷基的式I的氨基乙酸酯， 4个碳原子通过霍夫曼降解反应使式II的α-取代的丙二酸单酰胺（其中R 1，R 2，R 3和R 4具有上述含义）与低至1.5当量的次卤酸盐反应制备含有0.8-1.5当量/摩尔碱的碱水溶液。开始丙二酸单酰胺酯II。

9. 发明授权

US6045662A Process for preparing high-purity cyclopropyl methyl ketone 失效
标题翻译：制备高纯度环丙基甲基酮的方法
公开(公告)号：US6045662A
公开(公告)日：2000-04-04
申请号：US033071
申请日：1998-03-02
申请人： Wolfgang Kleemiss , Guenther Koehler , Manfred Neumann
发明人： Wolfgang Kleemiss , Guenther Koehler , Manfred Neumann
IPC分类号： C07C45/82 , C07C49/293 , C07D307/28 , B01D3/00
CPC分类号： C07D307/28 , C07C45/82 , Y10S203/20
摘要： A process for preparing high-purity cyclopropyl methyl ketone from compositions which contain cyclopropyl methyl ketone, 4,5-dihydro-2-methylfuran, addition products of 4,5-dihydro-2-methylfuran by a continuous rectification process in which at least a portion of the composition to be purified is introduced into a rectification apparatus via a side feed located above the bottom portion of the apparatus.
摘要翻译：从含有环丙基甲基酮，4,5-二氢-2-甲基呋喃，通过连续精馏方法的4,5-二氢-2-甲基呋喃的加成产物的组合物制备高纯度环丙基甲基酮的方法，其中至少一种要净化的组合物的部分经由位于装置的底部上方的侧进料引入精馏装置。

10. 发明授权

US5659081A Process for the preparation of cyclopropanecarboxamide 失效
标题翻译：制备环丙烷甲酰胺的方法
公开(公告)号：US5659081A
公开(公告)日：1997-08-19
申请号：US669832
申请日：1996-06-26
申请人： Wolfgang Kleemiss
发明人： Wolfgang Kleemiss
IPC分类号： C07C231/02 , C07C233/58
CPC分类号： C07C233/58 , C07C231/02 , C07C2101/02
摘要： In a process for the preparation of cyclopropanecarboxamide by amidating cyclopropanecarboxylic esters with ammonia in alcoholic solution at from 60.degree. to 200.degree. C., the reaction being catalyzed by an alcoholate of a monohydric alcohol, high yields are achieved even in the absence of a hydrocarbon solvent when a cyclopropanecarboxylic ester of the formula ##STR1## in which R is C.sub.1 - to C.sub.3 -alkyl or cyclopropyl, is employed.
摘要翻译：在环戊烷甲酰胺的制备过程中，通过在60至200℃的醇溶液中将氨基环丙烷羧酸酯与氨反应，该反应由一元醇的醇化物催化，甚至在不存在烃使用其中R为C 1 -C 3 - 烷基或环丙基的式“IMAGE”的环丙烷羧酸酯的溶剂。

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