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1. 发明申请

US20130172588A1 CONTINUOUS PHOTOLYTIC PROCESS FOR THE PREPARATION OF VITAMIN D RELATED SUBSTANCES 审中-公开
标题翻译：用于制备维生素D相关物质的连续光刻法
公开(公告)号：US20130172588A1
公开(公告)日：2013-07-04
申请号：US13821686
申请日：2011-09-01
申请人： William Edward Bauta , Bruce Girard Anderson , William R. Cantrell, JR.
发明人： William Edward Bauta , Bruce Girard Anderson , William R. Cantrell, JR.
IPC分类号： C07C401/00
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24 , C07F7/1804
摘要： The present application provides a novel method for generation of a vitamin D2 compound using a continuous flow photoisomerization reactor. A compound represented by formula I: [structure] as further defined herein, is mixed with a solvent and a sensitizer, and is then passed through the continuous flow photoisomerization reactor. If X3 and X4 of formula II is tert-butyldimethylsilyl, then formula II is mixed with a deprotection reagent to obtain the vitamin D2 analog.
摘要翻译：本申请提供了使用连续流动光异构化反应器产生维生素D2化合物的新方法。由式I表示的化合物：如本文进一步定义的[结构]与溶剂和敏化剂混合，然后通过连续流光致异构化反应器。如果式II的X 3和X 4是叔丁基二甲基甲硅烷基，则将式II与去保护试剂混合以获得维生素D 2类似物。

2. 发明授权

US07528247B2 Process for preparing purine nucleosides 有权
标题翻译：制备嘌呤核苷的方法
公开(公告)号：US07528247B2
公开(公告)日：2009-05-05
申请号：US10755005
申请日：2004-01-09
申请人： William E. Bauta , Brian D. Burke , Brian E. Schulmeier , William R. Cantrell, Jr. , Dennis P. Lovett , Jose Puente
发明人： William E. Bauta , Brian D. Burke , Brian E. Schulmeier , William R. Cantrell, Jr. , Dennis P. Lovett , Jose Puente
IPC分类号： C07H19/16 , C07H19/073
CPC分类号： C07H19/16
摘要： The present invention for the stereoselective preparation of 2-deoxy-β-D-adenine nucleosides wherein a blocked 2-deoxy-α-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative.
摘要翻译：用于2-脱氧-β-D-腺嘌呤核苷立体选择性制备的本发明，其中封闭的2-脱氧-α-D-阿拉伯呋喃糖基卤与腺嘌呤衍生物的盐偶合。

3. 发明授权

US06680382B2 Process for preparing purine nucleosides 有权
标题翻译：制备嘌呤核苷的方法
公开(公告)号：US06680382B2
公开(公告)日：2004-01-20
申请号：US10209808
申请日：2002-08-01
申请人： William E. Bauta , Brian D. Burke , Brian E. Schulmeier , William R. Cantrell, Jr. , Dennis P. Lovett , Jose Puente
发明人： William E. Bauta , Brian D. Burke , Brian E. Schulmeier , William R. Cantrell, Jr. , Dennis P. Lovett , Jose Puente
IPC分类号： C07H1916
CPC分类号： C07H19/16
摘要： The present invention provides for the preparation &bgr;-adenine nucleosides by coupling an adenine derivative containing an unprotected exocyclic amino group at the C-6 position and a blocked arabinofuranosyl derivative, in the presence of a base and solvent. The present invention also provides for the stereoselective preparation of 2-deoxy-&bgr;-D-adenine nucleosides wherein a blocked 2-deoxy-&agr;-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative. The forgoing aspects of the present invention are utilized in the preparation of a clofarabine composition wherein the ratio of &bgr; to &agr;-anomer is at least 99:1.
摘要翻译：本发明提供了在碱性和溶剂存在下，通过偶联含有C-6位未被保护的环外氨基的腺嘌呤衍生物和封闭的阿拉伯呋喃糖苷衍生物来制备β-腺嘌呤核苷。本发明还提供2-脱氧-β-D-腺嘌呤核苷的立体选择性制备，其中封闭的2-脱氧-α-D-阿拉伯呋喃糖基卤与腺嘌呤衍生物的盐偶合。本发明的前述方面用于制备克拉菲滨组合物，其中β与α-端基异构体的比例为至少99:1。

4. 发明授权

US5646330A Production of enantiomerically enriched ortho-substituted .alpha.,.alpha.-diaromatic methanols 失效
标题翻译：生产对映体富集的邻位取代的α，α-二芳族甲醇
公开(公告)号：US5646330A
公开(公告)日：1997-07-08
申请号：US390255
申请日：1995-02-17
申请人： Wen-Chung Shieh , William R. Cantrell , John Alan Carlson
发明人： Wen-Chung Shieh , William R. Cantrell , John Alan Carlson
IPC分类号： C07B41/02 , C07C29/143 , C07C37/00 , C07C39/12 , C07C213/00 , C07C213/08 , C07C215/68 , C07C231/18 , C07C233/56 , C07C229/34
CPC分类号： C07C231/18 , C07C213/08 , C07C233/56 , C07C37/002 , C07B2200/07
摘要： A method of producing compounds of formula I ##STR1## wherein one of R.sub.1 and R.sub.2 is selected from --OH, --SH, and --NHR.sub.7 ; and the other of R.sub.1 and R.sub.2 is selected from H, --OH, --SH, --NHR.sub.7, and R.sub.8 ; R.sub.3 and R.sub.4 are each independently selected from R.sub.8 ; n and m are each independently 3; and each R.sub.5 and each R.sub.6 is independently selected from --OH, --SH, --NHR.sub.7, and R.sub.8 ; and R.sub.8 is as detailed in the specification;in enantiomerically enriched form, comprising reducing a compound of formula II ##STR2## wherein R.sub.1 -R.sub.6 are defined as in formula I, in the presence of B-haloisopinocampheylborane.
摘要翻译：一种制备式I化合物的方法，其中R 1和R 2之一选自-OH，-SH和-NHR 7; R 1和R 2中的另一个选自H，-OH，-SH，-NHR 7和R 8; R3和R4各自独立地选自R8; n和m各自独立地为3; 并且每个R 5和R 6各自独立地选自-OH，-SH，-NHR 7和R 8; R8如说明书所述; 包括在B-卤代异蒎烷oc基硼烷存在下还原其中R 1 -R 6如式I中定义的式II化合物（II）。

5. 发明授权

US07947824B2 Process for preparing purine nucleosides 有权
标题翻译：制备嘌呤核苷的方法
公开(公告)号：US07947824B2
公开(公告)日：2011-05-24
申请号：US12435326
申请日：2009-05-04
申请人： William E. Bauta , Brian D. Burke , Brian E. Schulmeier , William R. Cantrell, Jr. , Dennis P. Lovett , Jose Puente
发明人： William E. Bauta , Brian D. Burke , Brian E. Schulmeier , William R. Cantrell, Jr. , Dennis P. Lovett , Jose Puente
IPC分类号： C07H19/16 , C07H19/073
CPC分类号： C07H19/16
摘要： The present invention for the stereoselective preparation of 2-deoxy-β-D-adenine nucleosides wherein a blocked 2-deoxy-α-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative.
摘要翻译：用于2-脱氧-β-D-腺嘌呤核苷的立体选择性制备的本发明，其中封闭的2-脱氧-α-D-阿拉伯呋喃糖基卤与腺嘌呤衍生物的盐偶合。

6. 发明申请

US20090286971A1 PROCESS FOR PREPARING PURINE NUCLEOSIDES 有权
标题翻译：制备嘌呤核苷酸的方法
公开(公告)号：US20090286971A1
公开(公告)日：2009-11-19
申请号：US12435326
申请日：2009-05-04
申请人： William E. Bauta , Brian D. Burke , Brian E. Schulmeier , William R. Cantrell, JR. , Dennis P. Lovett , Jose Puente
发明人： William E. Bauta , Brian D. Burke , Brian E. Schulmeier , William R. Cantrell, JR. , Dennis P. Lovett , Jose Puente
IPC分类号： C07H19/173
CPC分类号： C07H19/16
摘要： The present invention for the stereoselective preparation of 2-deoxy-β-D-adenine nucleosides wherein a blocked 2-deoxy-α-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative.
摘要翻译：用于2-脱氧-β-D-腺嘌呤核苷立体选择性制备的本发明，其中封闭的2-脱氧-α-D-阿拉伯呋喃糖基卤与腺嘌呤衍生物的盐偶合。

7. 发明授权

US06797838B2 Process for preparing homophthalate derivatives 失效
标题翻译：邻苯二甲酸酯衍生物的制备方法
公开(公告)号：US06797838B2
公开(公告)日：2004-09-28
申请号：US10628736
申请日：2003-07-28
申请人： William E. Bauta , William R. Cantrell, Jr. , Dennis P. Lovett
发明人： William E. Bauta , William R. Cantrell, Jr. , Dennis P. Lovett
IPC分类号： C07C6976
CPC分类号： C07D311/76 , C07C67/475 , Y02P20/125 , C07C69/92
摘要： The present invention provides a process for the preparation of homophthlate esters useful in the preparation of homophthalic anhydride reactants.
摘要翻译：本发明提供了制备用于制备高邻苯二甲酸酐反应物的高分子酯的方法。

8. 发明授权

US06664401B2 Process for preparing isocoumarins 失效
标题翻译：制备异香豆素的方法
公开(公告)号：US06664401B2
公开(公告)日：2003-12-16
申请号：US10188556
申请日：2002-07-02
申请人： William E. Bauta , William R. Cantrell, Jr. , Dennis P. Lovett
发明人： William E. Bauta , William R. Cantrell, Jr. , Dennis P. Lovett
IPC分类号： C07D31102
CPC分类号： C07D311/76 , C07C67/475 , Y02P20/125 , C07C69/92
摘要： The present invention provides a process from preparing isocoumarin-3-yl derivatives comprising reacting a homophthalic anhydride derivative with a carbonyl compound, wherein the carbonyl group is substituted with an acyl activating group, in the presence of a reaction medium comprising a solvent and a base. The invention also encompasses a process for the preparation of homophthalate esters useful in the preparation of homophthalic anhydride reactants as well as an integrated process wherein the twp reactions are carried out sequentially to afford the desired isocoumarin derivative.
摘要翻译：本发明提供了制备异香豆素-3-基衍生物的方法，其包括使均苯二甲酸酐衍生物与羰基化合物反应，其中羰基被酰基活化基团取代，在包含溶剂和碱的反应介质存在下。本发明还包括制备用于制备高邻苯二甲酸酐反应物的均相邻二酸酯的方法以及其中相继进行twp反应以提供所需的异香豆素衍生物的整合方法。

9. 发明授权

US4773436A Pot and pan washing machines 失效
标题翻译：锅和锅洗衣机
公开(公告)号：US4773436A
公开(公告)日：1988-09-27
申请号：US23145
申请日：1987-03-09
申请人： John W. Cantrell , Thomas D. Gault , William R. Cantrell
发明人： John W. Cantrell , Thomas D. Gault , William R. Cantrell
IPC分类号： A47L15/08 , A47L15/00 , A47L15/02 , B08B3/04
CPC分类号： A47L15/02 , A47L15/0092
摘要： Improvements in pot and pan washing machines (as opposed to dishwashing machines and drinking glass washing machines); a device adapted to receive large pots and pans used in cooking operations in a restaurant or the like which is downstream, typically, in the work process of cleaning pots and pans, from an initial scraping and scrapping tank, then, typically, is followed by a rinsing tank, the latter then followed by a sanitizer tank; a pot and pan washer tank utilizing a multiplicity of relatively high velocity, underwater, spaced apart water input jets on one wall thereof which provide a tank-wide circulating flow from upper back to lower front and then upwards and back within the tank from the front wall, the jet nozzles being positioned below the operating water level, there preferably being an overflow opening above the jet nozzles and pipes associated therewith, a pump circulating water from a lower portion of the tank at one side thereof to the noted jet nozzles, a faucet being preferably provided above said overflow opening for intially filling or refilling the tank and controlling the level of water therewithin for various purposes involved in the carrying out of the washing of the pots and pans; improvements in pot and pan washing devices where relatively unclean pots and pans from a scraping and scrapping tank or operation may be continuously fed into such device which continuously operates, the clean or more clean pots and pans, after an interval therewithin; continuously being removed from said tank to be passed to a rinsing step.

10. 发明申请

US20160130264A1 Synthesis of Fatostatin Based Polycyclic Compounds 有权
标题翻译：基于脂肪肝的多环化合物的合成
公开(公告)号：US20160130264A1
公开(公告)日：2016-05-12
申请号：US14934279
申请日：2015-11-06
申请人： William R. Cantrell, JR.
发明人： William R. Cantrell, JR.
IPC分类号： C07D417/04
CPC分类号： C07D417/04
摘要： The present invention relates to methods and strategies for large-scale synthesis of compounds having the chemical structure: The R substituents are H, methyl, isopropyl, benzyl, cyclohexyl, cyclopropylmethyl, methoxy, tert-butyloxycarbonyl, methanesulfonyl, p-toluenesulfonyl, quinolinesulfonyl, or thiophenesulfonyl groups. The method comprises condensing prothionamide with a halo nitroacetophenone to form a nitrophenyl substituted thiazole, reducing the nitro group to form an amine and derivatizing the amine to produce the compound.
摘要翻译：本发明涉及大规模合成具有化学结构的化合物的方法和策略：R取代基是H，甲基，异丙基，苄基，环己基，环丙基甲基，甲氧基，叔丁氧基羰基，甲磺酰基，对甲苯磺酰基，喹啉磺酰基，或噻吩磺酰基。该方法包括将丙硫酰胺与卤代硝基苯乙酮缩合以形成硝基苯基取代的噻唑，还原硝基以形成胺并衍生化胺以产生化合物。

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