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1. 发明申请

US20080281091A1 Process for the Preparation of Porphyrin Derivatives as Antimicrobial Agents by Photodynamic Therapy (Pdt) 审中-公开
标题翻译：通过光动力疗法制备卟啉衍生物作为抗微生物剂的方法（Pdt）
公开(公告)号：US20080281091A1
公开(公告)日：2008-11-13
申请号：US12158779
申请日：2006-12-22
申请人： Derek Brundish , William Love , William Rhys-Williams , Xiang Dong Feng , Frederic Naud , Hans Meier
发明人： Derek Brundish , William Love , William Rhys-Williams , Xiang Dong Feng , Frederic Naud , Hans Meier
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： There is provided a process for the preparation of 5,15-bis-[4-(3-trimethylammonio-propyloxy)-phenyl]-porphyrin dihalide, wherein the process comprises step (a) of providing 4-(3-bromopropyloxy)benzaldehyde, step (b) of providing dipyrrolmethane, step (c) of reacting the 4-(3-bromopropyloxy)benzaldehyde with the dipyrrol-methane, together with trifluoro acetic acid, in the presence of an oxidation reagent to produce 5,15-bis-[4-(3-bromo-propyloxy)-phenyl]-porphyrin which is purified by Soxhlet extraction from the adsorbed state on a bed of alumina under highly controlled conditions; and step (d) of reacting the 5,15-bis-[4-(3-bromo-propyloxy)-phenyl]-porphyrin with trimethylamine in the presence of dry dimethylformamide to produce 5,15-bis-[4-(3-trimethylammonio-propyl-oxy)-phenyl]-porphyrin dibromide. In a preferred embodiment, the process further comprises step (e) of passing the 5,15-bis-[4-(3-trimethylammonio-propyloxy)-phenyl]-porphyrin dibromide produced in step (d) through an anion exchanger to produce 5,15-bis-[4-(3-trimethylammonio-propyloxy)-phenyl]-porphyrin dichloride. There is provided a process for the preparation of 5,15-bis-(4-{3-[(3-dimethylamino-propyl)-dimethyl-ammonio]-propyloxy}-phenyl]-porphyrin dihalide.
摘要翻译：提供了制备5,15-双 - [4-（3-三甲基铵 - 丙氧基） - 苯基] - 卟啉二卤化物的方法，其中该方法包括步骤（a）提供4-（3-溴丙氧基）苯甲醛，提供二吡咯甲烷的步骤（b），步骤（c）在氧化试剂存在下使4-（3-溴丙氧基）苯甲醛与二吡咯甲烷一起与三氟乙酸一起反应，生成5,15-双 - [4-（3-溴 - 丙氧基） - 苯基] - 卟啉，其在高度控制的条件下通过索氏提取从氧化铝床上的吸附状态提纯; 和步骤（d）使5,15-双 - [4-（3-溴 - 丙氧基） - 苯基] - 卟啉与三甲胺在无水二甲基甲酰胺存在下反应，生成5,15-双 - [4-（3 - 三甲基铵 - 丙基 - 氧基） - 苯基 - 卟啉二溴化物。在优选的实施方案中，该方法还包括步骤（e）使步骤（d）中产生的5,15-双 - [4-（3-三甲基铵 - 丙氧基） - 苯基 - - 卟啉二溴化物通过阴离子交换剂以产生 5,15-双 - [4-（3-三甲基铵 - 丙氧基） - 苯基] - 卟啉二氯化物。提供了制备5,15-双 - （4- {3 - [（3-二甲基氨基 - 丙基） - 二甲基 - 氨基] - 丙氧基} - 苯基] - 卟啉二卤化物的方法。

2. 发明授权

US5632645A Wire nut with self locking hot wire insert 失效
标题翻译：线螺母带自锁热丝插件
公开(公告)号：US5632645A
公开(公告)日：1997-05-27
申请号：US694037
申请日：1996-08-08
申请人： William Love
发明人： William Love
IPC分类号： H01R4/22 , H01R4/48 , H01R4/26
CPC分类号： H01R4/22 , H01R4/4827
摘要： A new Wire Nut With Self Locking Hot Wire Insert for providing a connector which allows an electric wire to be safely removed from other wires for testing without disturbing the electrical bond needed by the branch wires. The inventive device includes an insert wire socket, a release wire socket, an insulating means, a conductive means, a retainer means and an insulating pad means. In use, an electrical supply 11 is electrically connected to an electrical circuit having any number of typical components such as a control means 15, like a switch 16, and branch circuit wires 14 which are typically held together by wire nuts 17. A typical application for this electrical circuit is in a house where a "neutral" wire 18 (usually white in insulation color) and the hot wire 12 (usually black in insulation color) are employed for transfer of electrical power from the electrical supply 11 to the electrical circuit. The inventive device is the self locking wire nut 13 which, referring to FIGS. 5 and 6, allows for easy wire assembly 50 or easy wire disassembly 60 with the additional use of a removal means 62 such as a flat head screw driver.
摘要翻译：具有自锁热丝插头的新型螺纹插件，用于提供一个连接器，允许将电线从其他电线安全地移除以进行测试，而不会干扰分支电线所需的电接合。本发明的装置包括插入线插座，释放线插座，绝缘装置，导电装置，保持装置和绝缘垫装置。在使用中，电源11电连接到具有任何数量的典型部件的电路，例如诸如开关16的控制装置15和通常由线螺母17保持在一起的分支电路线14.典型的应用因为这个电路是在一个房屋里，这样一个房子里，采用“中性线”18（绝缘颜色通常为白色）和热丝12（通常是绝缘颜色为黑色），用于将电力从电源11传送到电路。本发明的装置是自锁线螺母13，其参考图1和2。如图5和图6所示，通过额外使用诸如平头螺丝刀的移除装置62，允许容易的线组件50或容易的线拆卸60。

3. 发明申请

US20100275423A1 SYSTEM FOR PRELOADING PIEZOELECTRIC ACTUATORS AND METHOD 有权
标题翻译：用于推进压电致动器和方法的系统
公开(公告)号：US20100275423A1
公开(公告)日：2010-11-04
申请号：US12786575
申请日：2010-05-25
申请人： Jayaraman Venkataraghavan , William Love , Stephen R. Lewis , Zhenlong Xu
发明人： Jayaraman Venkataraghavan , William Love , Stephen R. Lewis , Zhenlong Xu
IPC分类号： H01L41/22
CPC分类号： H01L41/0533 , F02M2200/21 , H01L41/083 , Y10T29/42
摘要： A system for preloading piezoelectric actuators includes a fixture, a preloading mechanism configured to apply a mechanical force to a piezoelectric element supported by the fixture, and a sensor configured to sense an electrical property induced by the mechanical force in an electrical circuit having the piezoelectric element therein. A control device is coupled with the sensor and configured to generate a signal based on the sensed electrical property. A method of setting or testing preload includes applying a mechanical force to a piezoelectric element, and correlating an electrical property induced by the mechanical force with a magnitude of the mechanical force. Closed loop control allows preload to be set highly accurately.
摘要翻译：一种用于预压压电致动器的系统包括固定装置，配置成将机械力施加到由固定装置支撑的压电元件的预加载机构，以及构造成感测由具有压电元件的电路中的机械力引起的电特性的传感器其中。控制装置与传感器耦合并被配置为基于感测到的电气特性产生信号。设置或测试预载荷的方法包括对压电元件施加机械力，并将由机械力引起的电特性与机械力的大小相关联。闭环控制允许高精度地设定预载荷。

4. 发明授权

US07765877B2 System for preloading piezoelectric actuators and method 失效
标题翻译：压电致动器预压系统及方法
公开(公告)号：US07765877B2
公开(公告)日：2010-08-03
申请号：US11998531
申请日：2007-11-30
申请人： Jayaraman Venkataraghavan , Stephen R. Lewis , William Love , Zhenlong Xu
发明人： Jayaraman Venkataraghavan , Stephen R. Lewis , William Love , Zhenlong Xu
IPC分类号： G01B7/16
CPC分类号： H01L41/0533 , F02M2200/21 , H01L41/083 , Y10T29/42
摘要： A system for preloading piezoelectric actuators includes a fixture, a preloading mechanism configured to apply a mechanical force to a piezoelectric element supported by the fixture, and a sensor configured to sense an electrical property induced by the mechanical force in an electrical circuit having the piezoelectric element therein. A control device is coupled with the sensor and configured to generate a signal based on the sensed electrical property. A method of setting or testing preload includes applying a mechanical force to a piezoelectric element, and correlating an electrical property induced by the mechanical force with a magnitude of the mechanical force. Closed loop control allows preload to be set highly accurately.
摘要翻译：一种用于预压压电致动器的系统包括固定装置，配置成将机械力施加到由固定装置支撑的压电元件的预加载机构，以及构造成感测由具有压电元件的电路中的机械力引起的电特性的传感器其中。控制装置与传感器耦合并被配置为基于感测到的电气特性产生信号。设置或测试预载荷的方法包括对压电元件施加机械力，并将由机械力引起的电特性与机械力的大小相关联。闭环控制允许高精度地设定预载荷。

5. 发明申请

US20090140610A1 System for preloading piezoelectric actuators and method 失效
标题翻译：压电致动器预压系统及方法
公开(公告)号：US20090140610A1
公开(公告)日：2009-06-04
申请号：US11998531
申请日：2007-11-30
申请人： Jayaraman Venkataraghavan , Stephen R. Lewis , William Love , Zhenlong Xu
发明人： Jayaraman Venkataraghavan , Stephen R. Lewis , William Love , Zhenlong Xu
IPC分类号： G01L1/00 , G01L1/16 , H01L41/113
CPC分类号： H01L41/0533 , F02M2200/21 , H01L41/083 , Y10T29/42
摘要： A system for preloading piezoelectric actuators includes a fixture, a preloading mechanism configured to apply a mechanical force to a piezoelectric element supported by the fixture, and a sensor configured to sense an electrical property induced by the mechanical force in an electrical circuit having the piezoelectric element therein. A control device is coupled with the sensor and configured to generate a signal based on the sensed electrical property. A method of setting or testing preload includes applying a mechanical force to a piezoelectric element, and correlating an electrical property induced by the mechanical force with a magnitude of the mechanical force. Closed loop control allows preload to be set highly accurately.
摘要翻译：一种用于预压压电致动器的系统包括：固定装置，被配置为对由固定装置支撑的压电元件施加机械力的预加载机构;以及传感器，其构造成感测由具有压电元件的电路中的机械力引起的电特性其中。控制装置与传感器耦合并被配置为基于感测到的电气特性产生信号。设置或测试预载荷的方法包括对压电元件施加机械力，并将由机械力引起的电特性与机械力的大小相关联。闭环控制允许高精度地设定预载荷。

6. 发明授权

US07244841B2 Porphyrin derivatives and their use in photodynamic therapy 有权
标题翻译：卟啉衍生物及其在光动力疗法中的应用
公开(公告)号：US07244841B2
公开(公告)日：2007-07-17
申请号：US10744863
申请日：2003-12-23
申请人： William Love , Derek Brundish , William Rhys-Williams , Xiang Dong Feng , Benoit Pugin
发明人： William Love , Derek Brundish , William Rhys-Williams , Xiang Dong Feng , Benoit Pugin
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： C07D487/22
摘要： A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilizing solutions comprising a compound of the invention, and the use thereof, are also disclosed.
摘要翻译：式I的化合物：其中X 1，X 2，X 3，X 4，Y，SUB Y 1，Y 3，Y 3，Y 4和Z具有在说明书中给出的含义，并且这样的金属化形式化合物，其可用于治疗其中指示光动力学化合物的医学病症。还公开了治疗指示光动力剂的医疗状况的药物制剂和方法。还公开了包含本发明化合物的灭菌溶液及其用途。

7. 发明申请

US20050188107A1 Redundant pipelined file transfer 审中-公开
标题翻译：冗余流水线文件传输
公开(公告)号：US20050188107A1
公开(公告)日：2005-08-25
申请号：US11034852
申请日：2005-01-14
申请人： Benjamin Piercey , Marc Vachon , Henry Bailey , William Love , Ian Gough
发明人： Benjamin Piercey , Marc Vachon , Henry Bailey , William Love , Ian Gough
IPC分类号： G06F15/173 , H04L1/24 , H04L12/28 , H04L12/54
CPC分类号： H04L12/2854
摘要： A mechanism for point-to-multipoint file transfer utilizes a pipeline architecture established through a set of networking messages to transfer a file from a source node to a plurality of recipient nodes. Each node in the pipeline can utilize a redundant connection to a next nearest neighbor in the pipeline to decrease the time required to recover from a node failure.
摘要翻译：用于点对多点文件传输的机制利用通过一组网络消息建立的流水线架构，以将文件从源节点传送到多个接收节点。流水线中的每个节点可以利用到管道中的下一个最近邻居的冗余连接，以减少从节点故障中恢复所需的时间。

8. 发明授权

US08806505B1 Service and project request processing within a business enterprise 有权
标题翻译：企业内部的服务和项目请求处理
公开(公告)号：US08806505B1
公开(公告)日：2014-08-12
申请号：US12164639
申请日：2008-06-30
申请人： Ryan Sherry , David Palmieri , William Love , Donald Curtis
发明人： Ryan Sherry , David Palmieri , William Love , Donald Curtis
IPC分类号： G06F9/30 , G06F9/50 , G06Q10/06
CPC分类号： G06F9/505 , G06Q10/0631
摘要： A system and method for request processing management that includes receiving requests for tasks from a plurality of sources; reviewing the requests by a review group comprising representatives from different functional areas; and identifying at least one functional area for each request for handling the associated request. The requests for tasks from the plurality of sources are received at a single entry point.
摘要翻译：一种用于请求处理管理的系统和方法，包括从多个源接收对任务的请求; 审查由不同职能领域的代表组成的审查组的要求; 以及为处理相关联的请求的每个请求识别至少一个功能区。在单个入口点处接收来自多个源的任务的请求。

9. 发明授权

US08084602B2 Porphyrin derivatives and their use in photodynamic therapy 有权
标题翻译：卟啉衍生物及其在光动力疗法中的应用
公开(公告)号：US08084602B2
公开(公告)日：2011-12-27
申请号：US11562183
申请日：2006-11-21
申请人： William Love , Derek Brundish , William Rhys-Williams , Xiang Dong Feng , Benoit Pugin
发明人： William Love , Derek Brundish , William Rhys-Williams , Xiang Dong Feng , Benoit Pugin
IPC分类号： C07D487/22 , C07B47/00
CPC分类号： C07D487/22
摘要： A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilizing solutions comprising a compound of the invention, and the use thereof, are also disclosed.
摘要翻译：式I的化合物：其中X 1，X 2，X 3，X 4，Y 1，Y 2，Y 3，Y 4和Z具有说明书中给出的含义，以及这些化合物的金属化形式，其可用于治疗其中指示光动力学化合物。还公开了治疗指示光动力剂的医疗状况的药物制剂和方法。还公开了包含本发明化合物的灭菌溶液及其用途。

10. 发明授权

US07997145B2 System for preloading piezoelectric actuators and method 有权
标题翻译：压电致动器预压系统及方法
公开(公告)号：US07997145B2
公开(公告)日：2011-08-16
申请号：US12786575
申请日：2010-05-25
申请人： Jayaraman Venkataraghavan , William Love , Stephen R. Lewis , Zhenlong Xu
发明人： Jayaraman Venkataraghavan , William Love , Stephen R. Lewis , Zhenlong Xu
IPC分类号： G01B7/16
CPC分类号： H01L41/0533 , F02M2200/21 , H01L41/083 , Y10T29/42
摘要： A system for preloading piezoelectric actuators includes a fixture, a preloading mechanism configured to apply a mechanical force to a piezoelectric element supported by the fixture, and a sensor configured to sense an electrical property induced by the mechanical force in an electrical circuit having the piezoelectric element therein. A control device is coupled with the sensor and configured to generate a signal based on the sensed electrical property. A method of setting or testing preload includes applying a mechanical force to a piezoelectric element, and correlating an electrical property induced by the mechanical force with a magnitude of the mechanical force. Closed loop control allows preload to be set highly accurately.
摘要翻译：一种用于预压压电致动器的系统包括固定装置，配置成将机械力施加到由固定装置支撑的压电元件的预加载机构，以及构造成感测由具有压电元件的电路中的机械力引起的电特性的传感器其中。控制装置与传感器耦合并被配置为基于感测到的电气特性产生信号。设置或测试预载荷的方法包括对压电元件施加机械力，并将由机械力引起的电特性与机械力的大小相关联。闭环控制允许高精度地设定预载荷。

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