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1. 发明授权

US07008765B1 PCA3, PCA3 genes, and methods of use 有权
公开(公告)号：US07008765B1
公开(公告)日：2006-03-07
申请号：US09402713
申请日：1998-04-09
申请人： Marion J. G. Bussemakers , William B. Isaacs
发明人： Marion J. G. Bussemakers , William B. Isaacs
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/11 , C12N15/63
CPC分类号： C12Q1/6886 , A01K2217/05 , A61K38/00 , C07K14/47 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.

2. 发明授权

US09534256B2 Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer 有权
标题翻译：将遗传标记与侵袭性前列腺癌风险相关联的方法和组合物
公开(公告)号：US09534256B2
公开(公告)日：2017-01-03
申请号：US13344907
申请日：2012-01-06
申请人： Jianfeng Xu , William B. Isaacs , Henrik Grönberg
发明人： Jianfeng Xu , William B. Isaacs , Henrik Grönberg
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/156 , G06F19/22 , G06F19/28
摘要： The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer.
摘要翻译：本发明提供了鉴定受试者具有增加或侵袭性前列腺癌风险增加的方法，其包括在受试者中检测与具有或发展侵袭性前列腺癌的风险增加相关的各种多态性的存在。

3. 发明授权

US08192928B2 Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease 失效
标题翻译：巨噬细胞清道夫受体1基因的突变改变前列腺癌，哮喘和心血管疾病的风险
公开(公告)号：US08192928B2
公开(公告)日：2012-06-05
申请号：US12504034
申请日：2009-07-16
申请人： Jianfeng Xu , Deborah Meyers , Sigun Zheng , Patrick C. Walsh , William B. Isaacs , Eugene Bleecker , David Herrington
发明人： Jianfeng Xu , Deborah Meyers , Sigun Zheng , Patrick C. Walsh , William B. Isaacs , Eugene Bleecker , David Herrington
IPC分类号： C12Q1/68
CPC分类号： C07K14/705 , C12Q1/6886 , C12Q2600/172
摘要： The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.
摘要翻译：本发明公开了筛选受试者增加某些疾病或病症的可能性或风险的方法。该方法包括检测MSR1基因中存在或不存在至少一个突变，其中这种突变的存在或不存在表明某些疾病如癌症哮喘和/或心血管疾病的风险增加。

4. 发明申请

US20090226912A1 METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH PROSTATE CANCER RISK 审中-公开
标题翻译：用于相关遗传标记与前列腺癌风险的方法和组合
公开(公告)号：US20090226912A1
公开(公告)日：2009-09-10
申请号：US12339653
申请日：2008-12-19
申请人： Jianfeng Xu , S. Lilly Zheng , Henrik Gronberg , William B. Isaacs
发明人： Jianfeng Xu , S. Lilly Zheng , Henrik Gronberg , William B. Isaacs
IPC分类号： C12Q1/68 , G06F17/30
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/172
摘要： The present invention provides a method of identifying a subject as having an increased risk of developing prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of developing prostate cancer.
摘要翻译：本发明提供了将受试者鉴定为具有增加的前列腺癌风险的方法，其包括在受试者中检测与发展中的前列腺癌的风险增加相关的各种多态性的存在。

5. 发明申请

US20120178082A1 METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH RISK OF AGGRESSIVE PROSTATE CANCER 有权
标题翻译：用于与遗传性前列腺癌风险相关的遗传标记物的方法和组合物
公开(公告)号：US20120178082A1
公开(公告)日：2012-07-12
申请号：US13344907
申请日：2012-01-06
申请人： Jianfeng Xu , William B. Isaacs , Henrik Grönberg
发明人： Jianfeng Xu , William B. Isaacs , Henrik Grönberg
IPC分类号： C12Q1/68 , H01J49/40 , G06F17/30
CPC分类号： C12Q1/6886 , C12Q2600/156 , G06F19/22 , G06F19/28
摘要： The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer.
摘要翻译：本发明提供了鉴定受试者具有增加或侵袭性前列腺癌风险增加的方法，其包括在受试者中检测与具有或发展侵袭性前列腺癌的风险增加相关的各种多态性的存在。

6. 发明授权

US07632643B2 PCA3, PCA3 genes, and methods of use 有权
标题翻译： PCA3，PCA3基因和使用方法
公开(公告)号：US07632643B2
公开(公告)日：2009-12-15
申请号：US11260282
申请日：2005-10-28
申请人： Marion J. G. Bussemakers , William B. Isaacs
发明人： Marion J. G. Bussemakers , William B. Isaacs
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A01K2217/05 , A61K38/00 , C07K14/47 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
摘要翻译：本发明一般涉及前列腺特异性抗原PCA3。特别地，本发明涉及编码PCA3蛋白的核酸分子; 纯化的PCA3蛋白和多肽; 重组核酸分子; 含有重组核酸分子的细胞; 具有与PCA3蛋白和多肽特异性结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测编码PCA3蛋白质的核酸的核酸探针; 检测样品中编码PCA3蛋白或多肽的核酸的方法; 含有核酸探针或抗体的试剂盒; 使用本发明的核酸序列，蛋白质或抗体的生物测定来诊断，评估或预测患有前列腺癌的哺乳动物; 治疗用途; 以及预防动物中前列腺癌的方法。

7. 发明授权

US07579147B2 Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease 失效
标题翻译：巨噬细胞清道夫受体1基因的突变改变前列腺癌，哮喘和心血管疾病的风险
公开(公告)号：US07579147B2
公开(公告)日：2009-08-25
申请号：US10426262
申请日：2003-04-30
申请人： Jianfeng Xu , Deborah Meyers , Sigun Zheng , Patrick C. Walsh , William B. Isaacs , Eugene Bleecker , David Herrington
发明人： Jianfeng Xu , Deborah Meyers , Sigun Zheng , Patrick C. Walsh , William B. Isaacs , Eugene Bleecker , David Herrington
IPC分类号： C12Q1/68
CPC分类号： C07K14/705 , C12Q1/6886 , C12Q2600/172
摘要： The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.
摘要翻译：本发明公开了筛选受试者增加某些疾病或病症的可能性或风险的方法。该方法包括检测MSR1基因中存在或不存在至少一个突变，其中这种突变的存在或不存在表明某些疾病如癌症哮喘和/或心血管疾病的风险增加。

8. 发明授权

US6043088A Prostate/colon tumor suppressor gene located on human chromosome 8 失效
标题翻译：位于人类8号染色体上的前列腺/结肠肿瘤抑制基因
公开(公告)号：US6043088A
公开(公告)日：2000-03-28
申请号：US445515
申请日：1995-05-22
申请人： Robert Bookstein , William B. Isaacs
发明人： Robert Bookstein , William B. Isaacs
IPC分类号： C07K14/47 , C07K16/18 , C12N5/08 , C12N15/12 , C07H21/04 , C12N1/00 , C12N15/63
CPC分类号： C07K14/4703 , C07K16/18
摘要： This invention provides a novel nucleic acid molecule encoding a prostate/colon tumor suppressor gene product. The means and methods for detecting mutations and/or loss of prostate/colon tumor suppressor gene are provided. Also included within the scope of this invention are methods of suppressing the neoplastic phenotype of cancer cells having a defect in the prostate/colon tumor suppressor gene product. The invention also includes the means and methods for treating the cancer by administering the prostate/colon tumor suppressor gene.
摘要翻译：本发明提供了编码前列腺/结肠肿瘤抑制基因产物的新型核酸分子。提供了用于检测前列腺/结肠肿瘤抑制基因突变和/或丧失的方法和方法。也包括在本发明范围内的是抑制前列腺/结肠肿瘤抑制基因产物缺陷的癌细胞的肿瘤表型的方法。本发明还包括通过施用前列腺/结肠肿瘤抑制基因治疗癌症的方法和方法。

9. 发明授权

US08551699B2 PCA3, PCA3 genes, and methods of use 有权
标题翻译： PCA3，PCA3基因和使用方法
公开(公告)号：US08551699B2
公开(公告)日：2013-10-08
申请号：US12609483
申请日：2009-10-30
申请人： Marion J. G. Bussemakers , William B. Isaacs
发明人： Marion J. G. Bussemakers , William B. Isaacs
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A01K2217/05 , A61K38/00 , C07K14/47 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
摘要翻译：本发明一般涉及前列腺特异性抗原PCA3。特别地，本发明涉及编码PCA3蛋白的核酸分子; 纯化的PCA3蛋白和多肽; 重组核酸分子; 含有重组核酸分子的细胞; 具有与PCA3蛋白和多肽特异性结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测编码PCA3蛋白质的核酸的核酸探针; 检测样品中编码PCA3蛋白或多肽的核酸的方法; 含有核酸探针或抗体的试剂盒; 使用本发明的核酸序列，蛋白质或抗体的生物测定来诊断，评估或预测患有前列腺癌的哺乳动物; 治疗用途; 以及预防动物中前列腺癌的方法。

10. 发明申请

US20100267024A1 MUTATIONS IN THE MACROPHAGE SCAVENGER RECEPTOR 1 GENE ALTER RISK OF PROSTATE CANCER, ASTHMA, AND CARDIOVASCULAR DISEASE 失效
标题翻译：大鼠SCAVENGER受体1基因突变与前列腺癌，哮喘和心血管疾病的风险
公开(公告)号：US20100267024A1
公开(公告)日：2010-10-21
申请号：US12504034
申请日：2009-07-16
申请人： Jianfeng Xu , Deborah Meyers , Sigun Zheng , Patrick C. Walsh , William B. Isaacs , Eugene Bleecker , David Herrington
发明人： Jianfeng Xu , Deborah Meyers , Sigun Zheng , Patrick C. Walsh , William B. Isaacs , Eugene Bleecker , David Herrington
IPC分类号： C12Q1/68 , C07K14/435 , C12N5/10 , C07H21/04
CPC分类号： C07K14/705 , C12Q1/6886 , C12Q2600/172
摘要： The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.
摘要翻译：本发明公开了筛选受试者增加某些疾病或病症的可能性或风险的方法。该方法包括检测MSR1基因中存在或不存在至少一个突变，其中这种突变的存在或不存在表明某些疾病如癌症哮喘和/或心血管疾病的风险增加。

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