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1. 发明授权

US5983735A Method and apparatus for analyzing particulate matter 有权
标题翻译：分析颗粒物的方法和装置
公开(公告)号：US5983735A
公开(公告)日：1999-11-16
申请号：US144716
申请日：1998-09-01
申请人： Wieland E. Von Behrens , Roger Bourree , George Chappell , James G. Young
发明人： Wieland E. Von Behrens , Roger Bourree , George Chappell , James G. Young
IPC分类号： G01N15/14 , G01N27/00
CPC分类号： G01N15/1404
摘要： An apparatus for analyzing particulates including solutes in a sample liquid suspension in which the sample liquid suspension flows through an aperture into a first region of a reservoir containing particle free liquid to form a jet which entrains particle free liquid to ensheathe the jet. The jet passes through a muffler which includes a funnel and a throat into a second region of said reservoir where the particle free liquid and particulates are mixed. The throat is configured to prevent regurgitation of liquid from the second region back into the first region. A return passage connects the second region of the reservoir to the first region. The energy of the jet stream causes liquid to flow from the second region to the first region to provide particle free liquid to the first region. The return passage is configured or contains means to continuously mix the advancing liquid to prevent central streamers and the peripheral Coanda effect. This assures that during particle analysis only clean liquid reaches the first region, and that during cleanout particle free liquid admitted into the first region displaces all analyzed sample liquid without carryover.
摘要翻译：一种用于分析包括样品液体悬浮液中的溶质的微粒的装置，其中样品液体悬浮液通过孔流入含有无颗粒液体的储存器的第一区域中，以形成夹带无颗粒液体以使其入射的射流。喷射器通过包括漏斗和喉部的消音器进入所述储存器的第二区域，其中混合无颗粒的液体和微粒。喉部构造成防止液体从第二区域返回到第一区域。返回通道将储存器的第二区域连接到第一区域。喷射流的能量使液体从第二区域流动到第一区域，以向第一区域提供无颗粒液体。返回通道配置或包含连续混合前进液体以防止中央拖缆和周边柯恩达效应的装置。这确保在颗粒分析期间，仅清洁液体到达第一区域，并且在清洁期间允许进入第一区域的无颗粒液体置换所有分析的样品液体而不残留。

2. 发明授权

US5378633A Method for accurately enumerating and sensitively qualifying heterogenous cell populations in cytolytic processing conditions 失效
标题翻译：在细胞溶解处理条件下准确地枚举和敏感鉴定异源细胞群体的方法
公开(公告)号：US5378633A
公开(公告)日：1995-01-03
申请号：US197575
申请日：1994-02-16
申请人： Wieland E. von Behrens , Sherry Haiflich , John Glazier , John M. Roche , Bruce A. Director
发明人： Wieland E. von Behrens , Sherry Haiflich , John Glazier , John M. Roche , Bruce A. Director
IPC分类号： G01N33/49 , C12M1/34 , G01N15/14 , G01N33/50 , G01N33/48
CPC分类号： G01N33/5094 , G01N15/1434 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2015/1413 , G01N2015/1477 , Y10T436/107497
摘要： A method for identifying, characterizing, categorizing and enumerating cells within a cell population. The survivorship characteristics of the different cell populations is used to obtain quantitative and qualitative information about the cell populations initially present in the sample solution before conditions were imposed on the sample solution to elicit a response. The monitored cell survivorship response may be either direct disappearance of intact cells or the appearance of cell structures, carcasses, ghosts or residuum. In a preferred embodiment, a leukocyte cell decay rate in the presence of an erythrolytic agent is determined by monitoring leukocyte counts at several time intervals after the addition of the erythrolytic agent to the sample solution. The leukocyte decay rate is then used to indicate the presence of a fragile leukocyte population, and to accurately estimate the number of leukocytes initially present in the whole blood sample. The use of stronger erythrolytic agents in samples with lyse-resistant erythrocytes while preserving the accuracy of leukocyte counts is allowed. The present method permits calculation of a leukocyte decay rate which can be back extrapolated to time zero to provide an accurate estimate of the leukocyte count initially present in the whole blood sample.
摘要翻译：用于识别，表征，分类和枚举细胞群体中的细胞的方法。不同细胞群体的存活特征用于获得关于样品溶液中最初存在的细胞群的定量和定性信息，然后再对样品溶液施加条件以引发反应。受监测的细胞存活应答可能是完整细胞的直接消失或细胞结构，胴体，幽灵或残渣的出现。在优选的实施方案中，在将红细胞溶解剂加入到样品溶液中之后，通过在几个时间间隔监测白细胞计数来确定在存在红血球分解剂的情况下的白血球细胞衰变速率。然后使用白细胞衰减速率来指示脆性白细胞群的存在，并准确估计最初存在于全血样品中的白细胞数。允许在具有抗裂红细胞的样品中使用更强的红血球，同时保持白细胞计数的准确性。本方法允许计算白细胞衰减速率，其可以反向外推到时间零，以提供最初存在于全血样品中的白细胞计数的准确估计。

3. 发明授权

US4710021A Particulate matter analyzing apparatus and method 失效
标题翻译：颗粒物分析装置及方法
公开(公告)号：US4710021A
公开(公告)日：1987-12-01
申请号：US837875
申请日：1986-03-05
申请人： Wieland E. von Behrens
发明人： Wieland E. von Behrens
IPC分类号： G01N15/12 , G01N15/14 , G01N21/85
CPC分类号： G01N15/1245
摘要： A method and apparatus for jetting a measured volume of a suspension of particulates such as blood cells or colloids into a single fluid-primed incompletely partitioned transducer chamber in such a way that the dynamic relationship between the priming liquid and the inflowing jet imparts to the suspended particulates the properties of a stable stream line monofile which reliably traverses one or more particulate-identifying and/or analyzing sensing zones. Said transducer chamber has one or more of the following three sources of energy for moving the contained fluids: an easily maintained non-critical pressure differential between the suspension inflow port and an exit line, potential energy stored within the transducer chamber during the priming step, a pump mechanism to propel particulate-free fluid. The measurement period in all such transducers may be defined by monitoring the volume of either the inflowing or displaced outflowing liquid.
摘要翻译：将测量体积的诸如血细胞或胶体的颗粒悬浮液喷射到单个流体填充的不完全分隔的换能器室中的方法和装置，使得起动液体和流入喷射器之间的动态关系赋予悬浮液颗粒化可靠地穿过一个或多个颗粒识别和/或分析感测区域的稳定流线单体的性质。所述传感器腔室具有用于移动所容纳流体的以下三种能量源中的一种或多种：在悬浮液流入口和出口管线之间容易维持的非临界压力差，在启动步骤期间存储在换能器室内的势能，泵机构，用于推进无颗粒流体。所有这些换能器中的测量周期可以通过监测流入或流出的流出液体的体积来定义。

4. 发明授权

US06646742B1 Optical device and method for multi-angle laser light scatter 失效
标题翻译：用于多角度激光散射的光学装置和方法
公开(公告)号：US06646742B1
公开(公告)日：2003-11-11
申请号：US09507431
申请日：2000-02-19
申请人： Mervin L. Gangstead , Wieland E. von Behrens , James R. Boyd , Jean-Charles Pina , Jerry B. West
发明人： Mervin L. Gangstead , Wieland E. von Behrens , James R. Boyd , Jean-Charles Pina , Jerry B. West
IPC分类号： G01N2100
CPC分类号： G01N15/1404 , G01N15/0205 , G01N21/532 , G01N2015/1413 , G01N2015/149
摘要： The present invention relates to an optical system for an apparatus for multi-part differential particle discrimination to facilitate analysis, classification, and sorting of various fluid components for presentation. The optical system is characterized by one or more of the following: a synchronized illumination beam and flow cell conduit, a flow cell arrangement to control back reflection, and light sensor arrangement to particularly gather a specific range of light scatter, such specific range of light scatter directly corresponding to at least one type of particle capable of being identified by the apparatus.
摘要翻译：本发明涉及一种用于多部分差分粒子鉴别的装置的光学系统，以便于用于呈现的各种流体部件的分析，分类和分类。光学系统的特征在于以下一个或多个：同步照明光束和流动池导管，用于控制反射反射的流动池装置和光传感器装置，以特别收集特定范围的光散射，这种特定范围的光直接对应于能够被该装置识别的至少一种类型的颗粒。

5. 发明授权

US5895869A Method and apparatus for analyzing particulate matter 失效
公开(公告)号：US5895869A
公开(公告)日：1999-04-20
申请号：US741980
申请日：1996-10-31
申请人： Wieland E. Von Behrens , Roger Bourree , George Chappell , James G. Young
发明人： Wieland E. Von Behrens , Roger Bourree , George Chappell , James G. Young
IPC分类号： G01N15/14 , G01N27/00
CPC分类号： G01N15/1404
摘要： An apparatus for analyzing particulates including solutes in a sample liquid suspension in which the sample liquid suspension flows through an aperture into a first region of a reservoir containing particle free liquid to form a jet which entrains particle free liquid to ensheathe the jet. The jet passes through a muffler which includes a funnel and a throat into a second region of said reservoir where the particle free liquid and particulates are mixed. The throat is configured to prevent regurgitation of liquid from the second region back into the first region. A return passage connects the second region of the reservoir to the first region. The energy of the jet stream causes liquid to flow from the second region to the first region to provide particle free liquid to the first region. The return passage is configured or contains means to continuously mix the advancing liquid to prevent central streamers and the peripheral Coanda effect. This assures that during particle analysis only clean liquid reaches the first region, and that during cleanout particle free liquid admitted into the first region displaces all analyzed sample liquid without carryover.

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