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1. 发明授权

US5821065A Immunoassay for the detection of collagen I 失效
标题翻译：免疫测定检测胶原蛋白I
公开(公告)号：US5821065A
公开(公告)日：1998-10-13
申请号：US576039
申请日：1995-12-21
申请人： Werner Naser , Brigitte Drager , Ulrich Essig , Christa Hubner-Parajsz , Erasmus Huber
发明人： Werner Naser , Brigitte Drager , Ulrich Essig , Christa Hubner-Parajsz , Erasmus Huber
IPC分类号： G01N33/53 , A61K39/395 , A61K49/00 , C07K14/78 , C07K16/00 , C07K16/06 , C07K16/18 , C07K19/00 , G01N33/563
CPC分类号： C07K16/18 , C07K14/78 , Y10S435/81
摘要： A method for determining collagen degradation products in a body fluid sample using a non-competitive or competitive immunoassay is disclosed, the method comprising incubating the body fluid sample with an amount of antibody which specifically reacts with the amino acid sequence of SEQ ID NO. 2 of collagen l or a fragment thereof, and determining the collagen degradation products bound to the amount of the antibody. A kit for such a method is also disclosed.
摘要翻译：公开了一种使用非竞争性或竞争性免疫测定方法测定体液样品中的胶原降解产物的方法，该方法包括将体液样品与一定量的与SEQ ID NO：1的氨基酸序列特异性反应的抗体孵育。 2的胶原蛋白I或其片段，并测定与抗体量结合的胶原降解产物。还公开了用于这种方法的试剂盒。

2. 发明授权

US5763272A Hybridoma for producing antibody for collagen I 失效
标题翻译：用于产生胶原I抗体的杂交瘤
公开(公告)号：US5763272A
公开(公告)日：1998-06-09
申请号：US678552
申请日：1996-07-09
申请人： Werner Naser , Brigitte Drager , Ulrich Essig , Christa Hubner-Parajsz , Erasmus Huber
发明人： Werner Naser , Brigitte Drager , Ulrich Essig , Christa Hubner-Parajsz , Erasmus Huber
IPC分类号： A61K39/00 , C07K14/25 , C07K14/78 , C07K16/18 , C12N5/00 , C07K16/00
CPC分类号： C07K16/18 , C07K14/25 , C07K14/78 , A61K39/00 , C07K2317/34
摘要： Disclosed are antibodies which specifically bind the amino acid sequence of SEQ ID NO. 1 of collagen I. A hybridoma cell line which produces the antibodies is also disclosed.
摘要翻译：公开了特异性结合SEQ ID NO：1的氨基酸序列的抗体。还公开了产生抗体的杂交瘤细胞系。

3. 发明授权

US07863040B2 Ready-to-use whole blood collection vessel 有权
标题翻译：即用型全血采集器
公开(公告)号：US07863040B2
公开(公告)日：2011-01-04
申请号：US12327854
申请日：2008-12-04
申请人： Werner Naser , Thomas Duelffer , Rupert Herrmann , Uwe Kobold , Herbert von der Eltz
发明人： Werner Naser , Thomas Duelffer , Rupert Herrmann , Uwe Kobold , Herbert von der Eltz
IPC分类号： C12M1/33 , C12M3/08
CPC分类号： G01N33/5002
摘要： The present invention relates to a sampling tube for collecting and processing a whole blood sample. The sampling tube contains a reagent for differential hemolysis of whole blood, wherein said reagent for differential hemolysis comprises a chemical for differential hemolysis and an anti-coagulant, and wherein said sampling tube is a ready-to-use and single-use sampling tube. It also relates to the use of said sampling tube in the processing of a whole blood sample for liquid chromatography and also to the use of a blood sample processed in such sampling tube in a liquid chromatography-based analysis.
摘要翻译：本发明涉及一种用于收集和处理全血样本的取样管。采样管含有用于全血差异溶血的试剂，其中所述用于差异溶血的试剂包括用于差异溶血的化学药剂和抗凝血剂，并且其中所述采样管是即用型和一次性采样管。它还涉及在液相色谱法的全血样品的处理中使用所述采样管以及在基于液相色谱的分析中使用在这种采样管中处理的血液样品。

4. 发明授权

US5935780A Method for the qualitative or/and quantitative detection of an analyte 失效
标题翻译：分析物的定性或定量检测方法
公开(公告)号：US5935780A
公开(公告)日：1999-08-10
申请号：US531838
申请日：1995-09-21
申请人： Werner Naser
发明人： Werner Naser
IPC分类号： G01N33/53 , G01N33/543 , G01N33/533
CPC分类号： G01N33/54393 , G01N33/54306 , Y10S435/962 , Y10S435/969 , Y10S436/823 , Y10S436/825
摘要： For the qualitative or/and quantitative detection of a substance to be determined in a test sample with the aid of an immunoassay or nucleic acid hybridization assay the following components are used:a) a capture reagent which enables a specific detection of the substance to be determined by means of two different binding sites 1) if desired together with further test components and 2) is bound or is capable of binding to an active solid phase via a specific binding pair one partner of which is linked to the capture reagent and the second partner of which is coupled to an active solid phaseb) an active solid phase andc) an inactive solid phase which substantially corresponds to the active solid phase but to which the capture reagent cannot bind,wherein the test sample is either firstly brought into contact with the inactive solid phase alone and only later with the active solid phase, or is simultaneously brought into contact with the active and inactive solid phase during which the capture reagent and if desired further test components are either present from the start or are only added later and the substance to be determined is detected.
摘要翻译：为了通过免疫测定或核酸杂交测定法在待测样品中定性或定量检测待测物质，使用以下组分：a）使物质特异性检测的捕获试剂通过两个不同的结合位点确定1）如果需要，连同另外的测试组分，和2）结合或能够通过特异性结合对结合活性固相，其中一个配偶体与捕获试剂连接，第二个其配合物与活性固相偶联b）活性固相，和c）基本上对应于活性固相但不与捕获试剂结合的惰性固相，其中测试样品首先接触单独使用无活性固相，仅在随后的活性固相中，或者同时与活性和非活性固相接触，在此期间 e捕获试剂，如果需要，进一步的测试组分从一开始就存在或者仅在后面加入，并且检测待测物质。

5. 发明授权

US5441869A Method for the determination of fibrin 失效
标题翻译：纤维蛋白测定方法
公开(公告)号：US5441869A
公开(公告)日：1995-08-15
申请号：US944691
申请日：1992-09-14
申请人： Andreas Dessauer , Helmut Lill , Werner Naser , Beatus Ofenloch-Hahnle
发明人： Andreas Dessauer , Helmut Lill , Werner Naser , Beatus Ofenloch-Hahnle
IPC分类号： G01N33/53 , G01N33/48 , G01N33/531 , G01N33/68 , G01N33/86 , G01N33/536 , G01N33/577
CPC分类号： G01N33/6857 , G01N33/86 , G01N2333/75
摘要： The present invention concerns an improved method for the determination of fibrin in body fluids in which before the actual determination the sample solution containing fibrin is incubated in the presence of thiocyanate, iodide, magnesium or/and guanidinium ions.
摘要翻译：本发明涉及一种用于测定体液中纤维蛋白的改进方法，其中在实际测定之前，含有血纤蛋白的样品溶液在硫氰酸盐，碘化物，镁或/和胍离子存在下孵育。

6. 发明申请

US20090246866A1 READY-TO-USE WHOLE BLOOD COLLECTION VESSEL 有权
标题翻译：准备使用完整的血液收集血管
公开(公告)号：US20090246866A1
公开(公告)日：2009-10-01
申请号：US12327854
申请日：2008-12-04
申请人： Werner Naser , Thomas Duelffer , Rupert Herrmann , Uwe Kobold , Herbert von der Eltz
发明人： Werner Naser , Thomas Duelffer , Rupert Herrmann , Uwe Kobold , Herbert von der Eltz
IPC分类号： C12M3/08
CPC分类号： G01N33/5002
摘要： The present invention relates to a sampling tube for collecting and processing a whole blood sample. The sampling tube contains a reagent for differential hemolysis of whole blood, wherein said reagent for differential hemolysis comprises a chemical for differential hemolysis and an anti-coagulant, and wherein said sampling tube is a ready-to-use and single-use sampling tube. It also relates to the use of said sampling tube in the processing of a whole blood sample for liquid chromatography and also to the use of a blood sample processed in such sampling tube in a liquid chromatography-based analysis.
摘要翻译：本发明涉及一种用于收集和处理全血样本的取样管。采样管含有用于全血差异溶血的试剂，其中所述用于差异溶血的试剂包括用于差异溶血的化学药剂和抗凝血剂，并且其中所述采样管是即用型和一次性采样管。它还涉及在液相色谱法的全血样品的处理中使用所述采样管以及在基于液相色谱的分析中使用在这种采样管中处理的血液样品。

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