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1. 发明申请

US20100119457A1 COMPOSITION OF LABELED AND NON-LABELED MONOCLONAL ANTIBODIES 审中-公开
标题翻译：标签和非标签单克隆抗体的组成
公开(公告)号：US20100119457A1
公开(公告)日：2010-05-13
申请号：US12593621
申请日：2008-03-27
申请人： Helmut Lenz , Wemer Scheuer
发明人： Helmut Lenz , Wemer Scheuer
IPC分类号： A61K49/00 , A61P35/00
CPC分类号： A61K49/0058 , A61K49/0032
摘要： This invention relates to a composition of labeled and non-labeled monoclonal antibodies directed to a human transmembrane protein for the simultaneous treatment and diagnosis of diseases which are associated with an overexpression of such a protein especially of cancer. The invention further relates to a method of first administering said composition, determine the change of labeled antibody concentration and afterwards administering the non-labeled monoclonal antibodies only such that the minimum required concentration of such non-labeled antibody for a favorable therapeutical effect is achieved and maintained in the treatment, while unfavorable side effects are minimized due to the lower systemic antibody concentration.
摘要翻译：本发明涉及针对人跨膜蛋白的标记和非标记的单克隆抗体的组合物，用于同时治疗和诊断与这种特别是癌症的蛋白质的过度表达有关的疾病。本发明还涉及首先施用所述组合物的方法，确定标记的抗体浓度的变化，然后仅施用非标记的单克隆抗体，使得达到有利治疗效果的这种非标记抗体的最低要求浓度，维持治疗，而由于较低的全身抗体浓度，不利的副作用被最小化。

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