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1. 发明授权

US09360476B2 Microfluidic system and method to test for target molecules in a biological sample 有权
标题翻译：微流体系统和测试生物样品中靶分子的方法
公开(公告)号：US09360476B2
公开(公告)日：2016-06-07
申请号：US12520295
申请日：2007-12-19
申请人： Qing Xiang , Warren Che Wor Chan , Jesse M. Klostranec
发明人： Qing Xiang , Warren Che Wor Chan , Jesse M. Klostranec
IPC分类号： B82Y15/00 , G01N33/543 , G01N21/64 , G01N33/58
CPC分类号： G01N33/54366 , B82Y15/00 , G01N21/645 , G01N33/54346 , G01N33/587 , G01N33/588 , G01N2021/6421 , G01N2021/6441 , Y02A50/53 , Y02A50/58 , Y02A90/26
摘要： A system and method to test for the presence of target molecules in a biological test sample includes test molecules, a microfluidic chip, and irradiating and detection devices. The test molecules include bio-recognition molecules conjugable with the target molecules, and the corresponding conjugates. The microfluidic chip includes sample channels and flow focusing channels adjoining the sample channels. A buffer exiting from the focusing channels directs a single-file stream of the test molecules through one of the sample channels. The irradiating device delivers radiation for absorption by the test molecules in the single-file stream. After absorption, the test molecules emit fluorescence of a distinct fluorescent spectrum for each of the conjugates. The detection device monitors identifies the presence of the conjugates by monitoring for the distinct fluorescent spectrum. Thus, the test system and method identifies the presence of the target molecules in the test sample.
摘要翻译：用于测试生物测试样品中靶分子存在的系统和方法包括测试分子，微流体芯片以及照射和检测装置。测试分子包括与靶分子共轭的生物识别分子和相应的缀合物。微流体芯片包括与样品通道相邻的样品通道和流动聚焦通道。从聚焦通道出来的缓冲器通过一个样品通道引导测试分子的单文件流。照射装置在单个文件流中传递用于测试分子吸收的辐射。吸收后，测试分子发射每种缀合物的不同荧光光谱的荧光。检测装置监视器通过监测不同的荧光光谱来识别缀合物的存在。因此，测试系统和方法识别测试样品中靶分子的存在。

2. 发明申请

US20100021937A1 METHOD FOR DETECTING PATHOGENS USING MICROBEADS CONJUGATED TO BIORECOGNITION MOLECULES 审中-公开
标题翻译：使用与生物分解分子结合的微生物检测病原体的方法
公开(公告)号：US20100021937A1
公开(公告)日：2010-01-28
申请号：US12279639
申请日：2007-02-13
申请人： Michael Mordinson Greenberg , Kevin Charles Kain , Warren Che Wor Chan
发明人： Michael Mordinson Greenberg , Kevin Charles Kain , Warren Che Wor Chan
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/569 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/02 , B01L2300/025 , B01L2300/0627 , G01N21/6428 , G06F16/29 , G16H50/20 , H04W4/021 , Y02A50/53 , Y02A50/58 , Y02A90/26
摘要： A method and system are provided for the simultaneous detection and identification of multiple pathogens in a patient sample. The sample is combined with microbeads, which have been injected with quantum dots or fluorescent dye and conjugated to pathogen-specific biorecognition molecules, such as antibodies and oligonucleotides. Treatment options may be determined based on the identities of the pathogens detected in the sample.
摘要翻译：提供了一种用于同时检测和鉴定患者样品中多种病原体的方法和系统。将样品与已经注入量子点或荧光染料并与病原体特异性生物识别分子（例如抗体和寡核苷酸）缀合的微珠组合。治疗选择可以基于样品中检测到的病原体的身份来确定。

3. 发明申请

US20190195883A1 DIAGNOSTIC SEQUENCING VIA TABLETS 审中-公开
公开(公告)号：US20190195883A1
公开(公告)日：2019-06-27
申请号：US16181679
申请日：2018-11-06
申请人： Warren Che Wor CHAN , Buddhisha Nayantara UDUGAMA , Pranav Karthike KADHIRESAN
发明人： Warren Che Wor CHAN , Buddhisha Nayantara UDUGAMA , Pranav Karthike KADHIRESAN
IPC分类号： G01N33/58 , G01N33/543
CPC分类号： G01N33/588 , B82Y15/00 , G01N33/54393
摘要： A solid diagnostic product comprising reagents necessary for a protein-based test or genetic test and method of using said solid diagnostic product in detecting targets of interest in a fluid sample.

4. 发明授权

US08597729B2 Systems and methods for manufacturing quantum dot-doped polymer microbeads 有权
标题翻译：制造量子点掺杂聚合物微珠的系统和方法
公开(公告)号：US08597729B2
公开(公告)日：2013-12-03
申请号：US12666112
申请日：2008-06-23
申请人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
发明人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
IPC分类号： B05D1/02 , B05D1/26 , B05D1/34 , B05D1/42 , B05B1/34 , B05B7/26 , B32B5/16
CPC分类号： C40B20/04 , B01J2219/005 , B01J2219/00551 , B01J2219/00576 , C08L25/14 , C08L35/06
摘要： In a method and system for forming microbeads, a polymer solution includes particles and a polymer dissolved in a solvent. A stream of the polymer solution flows into a chamber. A focusing fluid contacts and focuses the polymer stream in the chamber. The focusing fluid and the focused polymer stream flow, as a single flow stream, out from the chamber. Pendant droplets detach from a leading end of the single flow stream to form the microbeads. The focusing fluid reacts with the polymer solution to form functional groups at a surface of the microbeads for binding with biorecognition molecules. In the system, a flow focusing apparatus includes a flow focusing body shaped to define the chamber. Microbeads formed according to the methods and systems are also disclosed.
摘要翻译：在用于形成微珠的方法和系统中，聚合物溶液包括溶解在溶剂中的颗粒和聚合物。聚合物溶液流流入室中。聚焦流体将聚合物流接触并聚焦在室中。聚焦流体和聚焦聚合物流作为单一流动流从腔室流出。悬滴从单流流的前端分离形成微珠。聚焦流体与聚合物溶液反应以在微珠的表面形成官能团，用于与生物识别分子结合。在该系统中，流动聚焦装置包括成形为限定腔室的流动聚焦体。还公开了根据方法和系统形成的微珠。

5. 发明授权

US08360321B2 System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology 有权
标题翻译：通过量子点光学编码技术生成的多重荧光光谱信号的去卷积系统和方法
公开(公告)号：US08360321B2
公开(公告)日：2013-01-29
申请号：US12594430
申请日：2008-04-02
申请人： Jeongjin Lee , Warren Che Wor Chan , Qing Xiang , Jesse Klostranec
发明人： Jeongjin Lee , Warren Che Wor Chan , Qing Xiang , Jesse Klostranec
IPC分类号： G06K7/10
CPC分类号： C40B20/04 , G01J3/4406 , G01N2021/6417 , G01N2021/6441 , G01N2201/1293
摘要： A method deconvolves a multiplexed fluorescence spectral signal into its component single-color fluorescence spectra emitted by contributing fluorophore types. A spectral database contains a parameter set for each of the component spectra. Optical codes are received as the multiplexed signals. A sliding window technique estimates a number and location of local peaks for the component spectra. Allowable variation ranges are assigned for the corresponding parameter sets. Each multiplexed signal is deconvolved into a sum of parametric values to generate a list of its component spectra. Encoded and received optical codes, in the form of multiplexed signals, are decoded and identified by their component spectra and contributing fluorophore types. A system for deconvolving the multiplexed signals includes a spectral database containing the parameter sets, a detection element receiving the optical codes, and a signal processor encoded to analyze and deconvolve the multiplexed signals.
摘要翻译：一种方法将多路复用的荧光光谱信号去卷积成由贡献荧光团类型发射的组分单色荧光光谱。光谱数据库包含每个分量光谱的参数集。作为复用信号接收光码。滑动窗口技术估计分量光谱的局部峰值的数量和位置。为相应的参数集分配允许的变化范围。每个复用的信号被去卷积成参数值的和以产生其分量谱的列表。以多路复用信号的形式编码和接收的光学代码通过其分量光谱和贡献的荧光团类型进行解码和识别。用于对多路复用信号进行解卷积的系统包括包含参数集的频谱数据库，接收光学代码的检测元件以及被编码为对多路复用信号进行解卷积的信号处理器。

6. 发明授权

US08551763B2 Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto 有权
标题翻译：用于形成集中体积的微珠的流动聚焦方法和系统，以及进一步形成的微珠
公开(公告)号：US08551763B2
公开(公告)日：2013-10-08
申请号：US12682710
申请日：2008-10-10
申请人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
发明人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
IPC分类号： B01J13/08 , B01F13/08 , C12M1/02 , G01N33/545
CPC分类号： C12Q1/706 , B01F3/0807 , B01F13/0062 , B01F13/0827 , B01F13/0863 , B01J13/04 , B29C47/0813 , C08J3/14 , C08J3/21 , C12Q1/701
摘要： In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so &s to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath. Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in die fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn from the fluid bath.
摘要翻译：在用于形成浓缩体积的微珠的方法和系统中，聚合物溶液和/或悬浮液包括溶解和/或分散在介质中的聚合物。聚焦流体和聚合物溶液和/或悬浮液的液流流向流体浴，并且彼此相交，因此聚焦聚合物溶液和/或悬浮液。聚合物溶液和/或悬浮液流在流体浴中形成微珠。一些聚焦流体从流体浴中抽出，以将微珠浓缩在流体液体中。该系统包括流动聚焦装置和含液体池。聚焦装置包括聚合物和聚焦喷嘴。电池包含流体槽，并具有出口端口，聚焦流体通过该出口端口从流体槽中抽出。

7. 发明申请

US20110284639A1 SYSTEM AND METHOD OF DECONVOLVING MULTIPLEXED FLUORESCENCE SPECTRAL SIGNALS GENERATED BY QUANTUM DOT OPTICAL CODING TECHNOLOGY 有权
标题翻译：消除量子光学编码技术产生的多重荧光光谱信号的系统和方法
公开(公告)号：US20110284639A1
公开(公告)日：2011-11-24
申请号：US12594430
申请日：2008-04-02
申请人： Jeongjin Lee , Warren Che Wor Chan
发明人： Jeongjin Lee , Warren Che Wor Chan
IPC分类号： G06K7/10 , G01N21/64
CPC分类号： C40B20/04 , G01J3/4406 , G01N2021/6417 , G01N2021/6441 , G01N2201/1293
摘要： A method deconvolves a multiplexed fluorescence spectral signal into its component single-color fluorescence spectra emitted by contributing fluorophore types. A spectral database contains a parameter set for each of the component spectra. Optical codes are received as the multiplexed signals. A sliding window technique estimates a number and location of local peaks for the component spectra. Allowable variation ranges are assigned for the corresponding parameter sets. Each multiplexed signal is deconvolved into a sum of parametric values to generate a list of its component spectra. Encoded and received optical codes, in the form of multiplexed signals, are decoded and identified by their component spectra and contributing fluorophore types. A system for deconvolving the multiplexed signals includes a spectral database containing the parameter sets, a detection element receiving the optical codes, and a signal processor encoded to analyze and deconvolve the multiplexed signals.
摘要翻译：一种方法将多路复用的荧光光谱信号去卷积成由贡献荧光团类型发射的组分单色荧光光谱。光谱数据库包含每个分量光谱的参数集。作为复用信号接收光码。滑动窗口技术估计分量光谱的局部峰值的数量和位置。为相应的参数集分配允许的变化范围。每个复用的信号被解卷积成参数值的和以产生其分量谱的列表。以多路复用信号的形式编码和接收的光学代码通过其分量光谱和贡献的荧光团类型进行解码和识别。用于对多路复用信号进行解卷积的系统包括包含参数集的频谱数据库，接收光学代码的检测元件以及被编码为对多路复用信号进行解卷积的信号处理器。

8. 发明申请

US20100151443A1 MICROFLUID SYSTEM AND METHOD TO TEST FOR TARGET MOLECULES IN A BIOLOGICAL SAMPLE 有权
标题翻译：微生物系统和生物样品中目标分子测试方法
公开(公告)号：US20100151443A1
公开(公告)日：2010-06-17
申请号：US12520295
申请日：2007-12-19
申请人： Qing Xiang , Warren Che Wor Chan , Jesse M. Klostranec
发明人： Qing Xiang , Warren Che Wor Chan , Jesse M. Klostranec
IPC分类号： C12Q1/70 , G01N27/00 , C12M1/34 , G01N21/64 , G01N33/53 , G01N33/544 , G01N27/447
CPC分类号： G01N33/54366 , B82Y15/00 , G01N21/645 , G01N33/54346 , G01N33/587 , G01N33/588 , G01N2021/6421 , G01N2021/6441 , Y02A50/53 , Y02A50/58 , Y02A90/26
摘要： A system and method to test for the presence of target molecules in a biological test sample includes test molecules, a microfluidic chip, and irradiating and detection devices. The test molecules include bio-recognition molecules conjugable with the target molecules, and the corresponding conjugates. The microfluidic chip includes sample channels and flow focusing channels adjoining the sample channels. A buffer exiting from the focusing channels directs a single-file stream of the test molecules through one of the sample channels. The irradiating device delivers radiation for absorption by the test molecules in the single-file stream. After absorption, the test molecules emit fluorescence of a distinct fluorescent spectrum for each of the conjugates. The detection device monitors identifies the presence of the conjugates by monitoring for the distinct fluorescent spectrum. Thus, the test system and method identifies the presence of the target molecules in the test sample.
摘要翻译：用于测试生物测试样品中靶分子存在的系统和方法包括测试分子，微流体芯片以及照射和检测装置。测试分子包括与靶分子共轭的生物识别分子和相应的缀合物。微流体芯片包括与样品通道相邻的样品通道和流动聚焦通道。从聚焦通道出来的缓冲器通过一个样品通道引导测试分子的单文件流。照射装置在单个文件流中传递用于测试分子吸收的辐射。吸收后，测试分子发射每种缀合物的不同荧光光谱的荧光。检测装置监视器通过监测不同的荧光光谱来识别缀合物的存在。因此，测试系统和方法识别测试样品中靶分子的存在。

9. 发明授权

US08551786B2 Systems and methods for enhancing fluorescent detection of target molecules in a test sample 有权
标题翻译：用于增强测试样品中靶分子的荧光检测的系统和方法
公开(公告)号：US08551786B2
公开(公告)日：2013-10-08
申请号：US12668264
申请日：2008-07-09
申请人： Warren Che Wor Chan , Travis Leon Jennings , Jesse M. Klostranec
发明人： Warren Che Wor Chan , Travis Leon Jennings , Jesse M. Klostranec
IPC分类号： G01N21/76 , G01N21/75 , G01N33/53 , G01N33/543
CPC分类号： G01N33/588 , B82Y15/00 , C12Q1/6818 , C40B30/10 , C40B70/00 , G01N33/542 , G01N2021/6432 , C12Q2563/155 , C12Q2563/107
摘要： Systems and methods for enhancing fluorescent detection of target molecules in a test sample are for use with an irradiating device. First fluorophores are provided for absorption of EMF radiation, and emission of a first signal. Second fluorophores are provided for partial absorption of the first signal, and emission of a second signal distinguishable from the first signal. The fluorophores are combined with the test sample, and secured to the target molecules and relative to one another. After the first fluorophores receive the EMF radiation from the irradiating device, the first signal is detected, together with the second spectral signal if the target molecules are present in the test sample.
摘要翻译：用于增强测试样品中靶分子的荧光检测的系统和方法用于照射装置。提供第一荧光团用于吸收EMF辐射和发射第一信号。提供第二荧光团用于部分吸收第一信号，以及发射与第一信号可区分的第二信号。将荧光团与测试样品组合，并固定到靶分子并相对于彼此。在第一荧光团从照射装置接收EMF辐射之后，如果目标分子存在于测试样品中，则与第二光谱信号一起检测第一信号。

10. 发明申请

US20120156490A1 SYSTEMS AND METHODS FOR MANUFACTURING QUANTUM DOT-DOPED POLYMER MICROBEADS 有权
标题翻译：制造量子聚合物微粒的系统和方法
公开(公告)号：US20120156490A1
公开(公告)日：2012-06-21
申请号：US12666112
申请日：2008-06-23
申请人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
发明人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
IPC分类号： B32B5/16 , B29B9/00
CPC分类号： C40B20/04 , B01J2219/005 , B01J2219/00551 , B01J2219/00576 , C08L25/14 , C08L35/06
摘要： In a method and system for forming microbeads, a polymer solution includes particles and a polymer dissolved in a solvent. A stream of the polymer solution flows into a chamber. A focusing fluid contacts and focuses the polymer stream in the chamber. The focusing fluid and the focused polymer stream flow, as a single flow stream, out from the chamber. Pendant droplets detach from a leading end of the single flow stream to form the microbeads. The focusing fluid reacts with the polymer solution to form functional groups at a surface of the microbeads for binding with biorecognition molecules. In the system, a flow focusing apparatus includes a flow focusing body shaped to define the chamber. Microbeads formed according to the methods and systems are also disclosed.
摘要翻译：在用于形成微珠的方法和系统中，聚合物溶液包括溶解在溶剂中的颗粒和聚合物。聚合物溶液流流入室中。聚焦流体将聚合物流接触并聚焦在室中。聚焦流体和聚焦聚合物流作为单一流动流从腔室流出。悬滴从单流流的前端分离形成微珠。聚焦流体与聚合物溶液反应以在微珠的表面形成官能团，用于与生物识别分子结合。在该系统中，流动聚焦装置包括成形为限定腔室的流动聚焦体。还公开了根据方法和系统形成的微珠。

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