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1. 发明授权

US07622612B2 Tricyclic derivatives and their use 失效
标题翻译：三环衍生物及其用途
公开(公告)号：US07622612B2
公开(公告)日：2009-11-24
申请号：US11482855
申请日：2006-07-10
申请人： Dong Jo Chang , Eun Young Yoon , Gun Bong Lee , Soon Ok Kim , Wan Joo Kim
发明人： Dong Jo Chang , Eun Young Yoon , Gun Bong Lee , Soon Ok Kim , Wan Joo Kim
IPC分类号： C07C233/65 , A61K31/165
CPC分类号： C07C49/755 , C07C69/78 , C07C203/10 , C07C233/32 , C07C233/41 , C07C233/76 , C07C235/14 , C07C235/42 , C07C271/24 , C07C323/41 , C07C323/42 , C07C2603/34 , C07D307/93
摘要： The present invention relates to tricyclic colchicine derivatives represented by the formulas (I) or (II), pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an anti-inflammatory effect or a method for treating cancer comprising administering to a patient an effective amount of one or more colchicine derivatives:
摘要翻译：本发明涉及由式（I）或（II）表示的三环秋水仙碱衍生物及其药学上可接受的盐，以及提供免疫抑制或免疫调节作用，抗增殖作用，抗炎作用效果或治疗癌症的方法包括向患者施用有效量的一种或多种秋水仙碱衍生物：

2. 发明授权

US5677456A Quinolone derivatives and processes for the preparation thereof 失效
标题翻译：喹诺酮衍生物及其制备方法
公开(公告)号：US5677456A
公开(公告)日：1997-10-14
申请号：US438886
申请日：1995-05-10
申请人： Wan Joo Kim , Tae Ho Park , Moon Hwan Kim , Jewn Giew Park , Bong Jin Kim
发明人： Wan Joo Kim , Tae Ho Park , Moon Hwan Kim , Jewn Giew Park , Bong Jin Kim
IPC分类号： A61K31/435 , A61P31/04 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , Y02P20/55
摘要： The present invention relates to optical isomers of quinoline compounds of Formula (IA) or Formula (IA'), their pharmaceutically acceptable salts and their intermediates: ##STR1## In the above formulae, A represent nitrogen or ##STR2## in which Y represents hydrogen, halogen such as fluorine or chlorine, lower alkyl or lower alkoxy such as methoxy, or together with R.sub.1 forms --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH(CH.sub.3)--, --OCH.sub.2 CH.sub.2 --, --OCH.sub.2 CH(CH.sub.3)--, --SCH.sub.2 CH.sub.2 -- or --SCH.sub.2 CH(CH.sub.3)--; R.sub.1 is as defined above or represents straight chain or cyclic lower alkyl group having 1 to 3 carbon atoms, a straight chain or cyclic lower alkyl group having 1 to 3 carbon atoms which is substituted with a halogen atom, a phenyl group or a phenyl group substituted with one or two halogen atoms, such as ethyl, cyclopropyl or 2,4-difluorophenyl; R.sup.4 represents hydrogen, lower alkyl, lower alkoxy, or an amino-protecting group, such as methyl, ethyl or butoxycarbonyl; R.sub.5, R.sub.6, R.sub.7 and R.sub.8 may be the same or different and represent independently hydrogen, lower alkyl optionally substituted by amino, hydroxy or halogen, such as methyl or ethyl; and X represents hydrogen, halogen such as fluorine or chlorine, amino or lower alkyl such as methyl.
摘要翻译：本发明涉及式（IA）或式（IA'）喹啉化合物及其药学上可接受的盐及其中间体的光学异构体：其中A表示氮或其中Y表示氢的卤素，例如氟或氯的卤素，低级烷基或低级烷氧基如甲氧基，或与R 1一起形成-CH 2 CH 2 CH 2 - ， - CH 2 CH 2 CH（CH 3） - ， - OCH 2 CH 2 - ， - OCH 2 CH（ CH 3） - ， - SCH 2 CH 2 - 或-SCH 2 CH（CH 3） - ; R1如上所定义，或表示具有1至3个碳原子的直链或环状低级烷基，被卤素原子，苯基或苯基取代的具有1至3个碳原子的直链或环状低级烷基被一个或两个卤素原子取代，例如乙基，环丙基或2,4-二氟苯基; R4表示氢，低级烷基，低级烷氧基或氨基保护基，例如甲基，乙基或丁氧基羰基; R5，R6，R7和R8可以相同或不同，独立地表示氢，任意被氨基，羟基或卤素取代的低级烷基如甲基或乙基; X表示氢，卤素如氟或氯，氨基或低级烷基如甲基。

3. 发明授权

US06600025B1 Intermediates, process for preparing macrolide antibiotic agent therefrom 失效
标题翻译：中间体，其制备大环内酯类抗生素的方法
公开(公告)号：US06600025B1
公开(公告)日：2003-07-29
申请号：US09856383
申请日：2001-09-06
申请人： Tae Suk Lee , Chang Hyun Yoo , Kyoung Soo Kim , Hyun Suk An , Jung Young Kim , Wan Joo Kim
发明人： Tae Suk Lee , Chang Hyun Yoo , Kyoung Soo Kim , Hyun Suk An , Jung Young Kim , Wan Joo Kim
IPC分类号： C07H100
CPC分类号： C07H17/08 , Y02P20/55
摘要： An erythromycin A 9-O-benzodithiol oxime intermediate represented by the following formula (III) useful for synthesis of clarthromycin and crystalline solvate thereof: Wherein, Y1 and Y2 are independently a hydrogen atoms or trimethylsilyl groups. And, a process for the preparation of clarithromycin using the erythromycin A 9-O-benzodithiol oxime intermediate as described in the specification.
摘要翻译：用于合成克拉霉素及其结晶溶剂化物的下式（III）表示的红霉素A 9-O-苯并二硫醇肟中间体：其中Y1和Y2独立地为氢原子或三甲基甲硅烷基。而且，如本说明书所述，使用红霉素A 9-O-苯并二硫醇肟中间体制备克拉霉素的方法。

4. 发明授权

US08048800B2 Fabrication method of two-terminal semiconductor component using trench technology 有权
标题翻译：使用沟槽技术的二端子半导体元件的制造方法
公开(公告)号：US08048800B2
公开(公告)日：2011-11-01
申请号：US12603766
申请日：2009-10-22
申请人： Jin-Koo Rhee , Seong-Dae Lee , Mi-Ra Kim , Dae-Hong Min , Wan-Joo Kim
发明人： Jin-Koo Rhee , Seong-Dae Lee , Mi-Ra Kim , Dae-Hong Min , Wan-Joo Kim
IPC分类号： H01L21/44 , H01L21/311
CPC分类号： H01L29/6609 , H01L21/30625 , H01L29/66083 , H01L29/66166 , H01L29/66174
摘要： A method of fabricating a two-terminal semiconductor component using a trench technique is disclosed that includes forming a trench by etching an etching pattern formed on a substrate on which an active layer having impurities added is grown, forming a front metal layer on a front upper surface of the substrate by using an evaporation method or a sputtering method after removing the etching pattern, forming a metal plated layer on the front surface of the substrate on which the front metal layer is formed, polishing a lower surface of the substrate by using at least one of a mechanical polishing method and a chemical polishing method until the front metal layer is exposed, forming a rear metal layer on the polished substrate, and removing each component by using at least one of a dry etching method and a wet etching method.
摘要翻译：公开了一种使用沟槽技术制造二端子半导体部件的方法，包括通过蚀刻形成在其上生长有杂质添加的有源层的基板上形成的蚀刻图案来形成沟槽，在正面上方形成前金属层在去除蚀刻图案之后，通过使用蒸镀法或溅射法形成基板的表面，在其上形成有前金属层的基板的前表面上形成金属镀层，使用在至少一种机械抛光方法和化学抛光方法，直到暴露前金属层，在抛光的基底上形成后金属层，并且通过使用干蚀刻方法和湿蚀刻方法中的至少一种来去除每个部件。

5. 发明授权

US5770597A Quinolone derivatives and processes for preparing the same 失效
标题翻译：喹诺酮衍生物及其制备方法
公开(公告)号：US5770597A
公开(公告)日：1998-06-23
申请号：US492086
申请日：1995-10-11
申请人： Wan Joo Kim , Tae Ho Park , Moon Hwan Kim , Bong Jin Kim , Neil D. Pearson
发明人： Wan Joo Kim , Tae Ho Park , Moon Hwan Kim , Bong Jin Kim , Neil D. Pearson
IPC分类号： A61K31/435 , A61K31/445 , A61K31/47 , A61P31/04 , C07D471/04 , C07D519/00 , C07D215/56
CPC分类号： C07D471/04
摘要： The present invention relates to quinoline derivatives substituted in the 7-position by a trans-2,8-diazabicyclo�4.3.0!nonan-8-yl group having a broad antibacterial spectrum and to processes for preparing the same.
摘要翻译： PCT No.PCT / KR94 / 00005 Sec。 371 1995年10月11日第 102（e）日期1995年10月11日PCT 1994年1月18日PCT PCT。公开号WO94 / 15938 日期：1994年7月21日本发明涉及具有宽抗菌谱的反式-2,8-二氮杂双环[4.3.0]壬烷-8-基取代的7-位喹啉衍生物及其制备方法。

6. 发明授权

US07119229B2 Alkaloid derivative and a pharmaceutical composition containing the same 有权
标题翻译：生物碱衍生物和含有它们的药物组合物
公开(公告)号：US07119229B2
公开(公告)日：2006-10-10
申请号：US10479057
申请日：2002-05-27
申请人： Wan Joo Kim , Kyoung Soo Kim , Myung Hwa Kim , Jong Yek Park , Jung Min Jang , Jae Won Choi , Dong Hoo Kim
发明人： Wan Joo Kim , Kyoung Soo Kim , Myung Hwa Kim , Jong Yek Park , Jung Min Jang , Jae Won Choi , Dong Hoo Kim
IPC分类号： C07C233/05 , A61K31/165
CPC分类号： C07C69/78 , C07C49/755 , C07C203/10 , C07C233/32 , C07C233/41 , C07C233/76 , C07C235/14 , C07C235/42 , C07C271/24 , C07C323/41 , C07C323/42 , C07C2603/34 , C07D307/93
摘要： Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the same as effective components are also described. The colchicine derivatives were found to have anticancer, anti-proliferous and immunosuppressive function. Methods for preparing the colchicines derivatives are also provided.
摘要翻译：描述了由式（I）表示的秋水仙碱衍生物与卤素或硝酸酯基或其药学上可接受的盐。还描述了含有与有效成分相同的药物组合物。发现秋水仙素衍生物具有抗癌，抗增殖和免疫抑制功能。还提供了制备秋水仙碱衍生物的方法。

7. 发明授权

US06506886B1 Method of preparing form II crystals of clarithromycin 失效
标题翻译：制备克拉霉素II型晶体的方法
公开(公告)号：US06506886B1
公开(公告)日：2003-01-14
申请号：US09786636
申请日：2001-03-07
申请人： Tae-Suk Lee , Ju-Cheol Lee , Kyoung-Ik Lee , Gwan-Sun Lee , Wan-Joo Kim
发明人： Tae-Suk Lee , Ju-Cheol Lee , Kyoung-Ik Lee , Gwan-Sun Lee , Wan-Joo Kim
IPC分类号： C07M100
CPC分类号： C07H17/08
摘要： Form II crystals of clarithromycin can be easily prepared by treating clarithromycin of different crystal forms with water or with a mixture of water and a water-immiscible organic solvent and isolating treated crystals by filtration.
摘要翻译：克拉霉素II型晶体可以通过用水或水与水不混溶的有机溶剂的混合物处理不同晶型的克拉霉素并通过过滤分离处理的晶体来容易地制备。

8. 发明授权

US6130336A Process for preparing paclitaxel 失效
标题翻译：制备紫杉醇的方法
公开(公告)号：US6130336A
公开(公告)日：2000-10-10
申请号：US242736
申请日：1999-02-23
申请人： Kyoung Soo Kim , Ki Byung Chai , Young Ho Moon , Kwang Ok Lee , Nam Du Kim , Tae Hee Ha , Jung Ae Shin , Gwan Sun Lee , Wan Joo Kim
发明人： Kyoung Soo Kim , Ki Byung Chai , Young Ho Moon , Kwang Ok Lee , Nam Du Kim , Tae Hee Ha , Jung Ae Shin , Gwan Sun Lee , Wan Joo Kim
IPC分类号： C07D305/14 , C07D263/04 , C07D263/06 , C07D413/12 , C07D263/02 , C07D305/00
CPC分类号： C07D263/04 , C07D305/14 , C07D413/12 , Y02P20/55
摘要： The present invention elates to a process for preparing paclitaxel represented by formula (1) characterized in that: (a) an oxazolidine derivative represented by formula (2) or its salt in which X represents halogen, is coupled with a 7-trihaloacetyl-baccatin III represented by formula (3) in which R.sub.1 represents trihaloacetyl, in a solvent in the presence of a condensing agent to produce an oxazolidine substituent-containing taxane represented by formula (4) in which X and R.sub.1 are each as previously defined; (b) the oxazolidine ring is opened in a solvent in the presence of an acid, and the product thus obtained is reacted with benzoyl chloride in the presence of a base to produce a protected paclitaxel wherein the hydroxy group at 7-position is protected with trihaloacetyl group represented by formula (5) in which R.sub.1 is as previously defined; (c) then the protecting group at 7-position is removed by ammonia or a salt of ammonia with a weak acid in a solvent.
摘要翻译： PCT No.PCT / KR97 / 00157 Sec。 371日期1999年2月23日 102（e）1999年2月23日PCT PCT 1997年8月25日PCT公布。出版物WO98 / 08832 1998年3月5日本发明涉及一种制备式（1）表示的紫杉醇的方法，其特征在于：（a）式（2）表示的恶唑烷衍生物或其中X表示卤素的盐与由式（3）表示的7-三卤乙酰基浆果赤霉素III，其中R 1表示三卤代乙酰基，在溶剂中，在缩合剂存在下制备由式（4）表示的含恶唑烷取代基的紫杉烷，其中X和R 1各自为以前定义; （b）在酸存在下，在溶剂中打开恶唑烷环，将得到的产物与苯甲酰氯在碱的存在下反应，得到保护的紫杉醇，其中7位的羟基被由式（5）表示的三卤代乙酰基，其中R 1如前所定义; （c）然后在溶剂中用氨或氨与弱酸将7位保护基除去。

9. 发明授权

US5817820A Quinolone derivatives and processes for the preparation thereof 失效
标题翻译：新型喹诺酮衍生物及其制备方法
公开(公告)号：US5817820A
公开(公告)日：1998-10-06
申请号：US277601
申请日：1994-07-20
申请人： Wan Joo Kim , Tae Ho Park , Moon Hwan Kim , Jewn Giew Park , Bong Jin Kim
发明人： Wan Joo Kim , Tae Ho Park , Moon Hwan Kim , Jewn Giew Park , Bong Jin Kim
IPC分类号： A61K31/435 , A61P31/04 , C07D471/04 , C07D519/00 , C07D215/56
CPC分类号： C07D471/04 , Y02P20/55
摘要： The present invention relates to optical isomers of quinoline compounds of Formula (IA) or Formula (IA'), their pharmaceutically acceptable salts and their intermediates: ##STR1## In the above formulae, A represent nitrogen or ##STR2## in which Y represents hydrogen, halogen such as fluorine or chlorine, lower alkyl or lower alkoxy such as methoxy, or together with R.sub.1 forms --CH.sub.2 CH.sub.2 CH.sub.2 --, CH.sub.2 CH.sub.2 CH(CH.sub.3)--, --OCH.sub.2 CH.sub.2 --, --OCH.sub.2 CH(CH.sub.3)--, --SCH.sub.2 CH.sub.2 -- or --SCH.sub.2 CH(CH.sub.3)--; R.sub.1 is as defined above or represents straight chain or cyclic lower alkyl group having 1 to 3 carbon atoms, a straight chain or cyclic lower alkyl group having 1 to 3 carbon atoms which is substituted with a halogen atom, a phenyl group or a phenyl group substituted with one or two halogen atoms, such as ethyl, cyclopropyl or 2,4-difluorophenyl; R.sub.4 represents hydrogen, lower alkyl, lower alkoxy, or an amino-protecting group, such as methyl, ethyl or butoxycarbonyl; R.sub.5, R.sub.6, R.sub.7 and R.sub.8 may be the same or different and represent independently hydrogen, lower alkyl optionally substituted by amino, hydroxy or halogen, such as methyl or ethyl; and X represents hydrogen, halogen such as fluorine or chlorine, amino or lower alkyl such as methyl.
摘要翻译：本发明涉及式（IA）或式（IA'）喹啉化合物及其药学上可接受的盐及其中间体的光学异构体：其中A表示氮或其中Y代表氢，卤素如氟或氯，低级烷基或低级烷氧基如甲氧基，或与R 1一起形成-CH 2 CH 2 CH 2 - ，CH 2 CH 2 CH（CH 3） - ， - OCH 2 CH 2 - ， - OCH 2 CH（CH 3）） - ， - SCH 2 CH 2 - 或-SCH 2 CH（CH 3） - ; R1如上所定义，或表示具有1至3个碳原子的直链或环状低级烷基，被卤原子，苯基或苯基取代的具有1至3个碳原子的直链或环状低级烷基被一个或两个卤素原子取代，例如乙基，环丙基或2,4-二氟苯基; R4表示氢，低级烷基，低级烷氧基或氨基保护基，例如甲基，乙基或丁氧基羰基; R5，R6，R7和R8可以相同或不同，独立地表示氢，任意被氨基，羟基或卤素取代的低级烷基如甲基或乙基; X表示氢，卤素如氟或氯，氨基或低级烷基如甲基。

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