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1. 发明授权

US5807678A Identification of gene mutations associated with congenital lipoid adrenal hyperplasia 失效
标题翻译：鉴定与先天性类脂肾上腺增生相关的基因突变
公开(公告)号：US5807678A
公开(公告)日：1998-09-15
申请号：US410540
申请日：1995-03-23
申请人： Walter L. Miller , Dong Lin , Jerome F. Strauss, III
发明人： Walter L. Miller , Dong Lin , Jerome F. Strauss, III
IPC分类号： C12N15/09 , C07H21/04 , C07K14/47 , C12N5/10 , C12N15/85 , C12P21/02 , C12Q1/68 , C12R1/91 , C07H21/02
CPC分类号： C07K14/4702 , C12N15/85 , C12Q1/6883 , C12N2830/00 , C12N2830/85 , C12Q2600/156
摘要： Method for diagnosis of congenital lipoid adrenal hyperplasia and for the detection of the presence of a mutated gene for steroidogenesis acute regulatory protein (StAR) by analyzing nucleic acid obtained from a patient. The nucleic acid can be analyzed by restriction fragment length polymorphism analysis, nucleic acid hybridization, or nucleotide sequencing, among other techniques. A mutation may result in premature termination of the protein, or it may result in the StAR gene not being transcribed or translated, or it may result in a change in the amino acid sequence of the StAR gene product.
摘要翻译：通过分析从患者获得的核酸，诊断先天性脂质肾上腺增生的方法和用于检测类固醇生成急性调节蛋白（StAR）突变基因的存在的方法。核酸可以通过限制性片段长度多态性分析，核酸杂交或核苷酸测序等进行分析。突变可能导致蛋白质过早终止，否则可能导致StAR基因不被转录或翻译，或者可能导致StAR基因产物的氨基酸序列发生变化。

2. 发明授权

US4675297A Genes encoding bovine prolactin 失效
标题翻译：编码牛催乳素的基因
公开(公告)号：US4675297A
公开(公告)日：1987-06-23
申请号：US532107
申请日：1983-09-14
申请人： John D. Baxter , Walter L. Miller , Joseph A. Martial
发明人： John D. Baxter , Walter L. Miller , Joseph A. Martial
IPC分类号： C07K14/575 , C12N1/20 , C07H21/04 , C12N1/00 , C12N15/00 , C12P19/34 , C12P21/00 , C12P21/02
CPC分类号： C07K14/57554 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： A DNA sequence encoding bovine prolactin and optionally including condons for the preceding 10 amino acids is used to construct expression systems to obtain recombinant production of these proteins.
摘要翻译：使用编码牛催乳素并任选地包含前10个氨基酸的宽带的DNA序列构建表达系统以获得这些蛋白质的重组产生。

3. 发明授权

US07942754B1 Golf green for a patio 有权
标题翻译：高尔夫绿色的露台
公开(公告)号：US07942754B1
公开(公告)日：2011-05-17
申请号：US12555862
申请日：2009-09-09
申请人： Walter L. Miller, Jr.
发明人： Walter L. Miller, Jr.
IPC分类号： A63B69/36
CPC分类号： A63B57/40 , A63B57/357 , A63B69/3676 , A63B71/04
摘要： A golf green for a patio, deck, floor, substrate or supporting surface with access from below to cut a hole therein includes a U-shaped cup retaining structure mounted to the substrate underside adjacent the hole and into which a cup is slidably inserted and seated in alignment with the hole and the cup having a passageway into which a plug is inserted with the plug having a through hole for receiving the lower end of the golf flag staff, a plurality of ring inserts for placement within the cup to alter the cup diameter and refine golf putting practice, a cover for placement over the cup to conceal the hole so that the substrate, such as the patio, can be safely traversed, and a ball collection apparatus disposed underneath the substrate and into which balls fall by gravity for collection and eventual retrieval.
摘要翻译：用于露天，甲板，地板，基底或支撑表面的高尔夫球绿色，从下方进入以切割孔，其中包括U形杯保持结构，其安装在邻近孔的基底下侧，杯可滑动地插入和坐着与所述孔对准并且所述杯具有通道，所述插头插入所述通道中，所述插头具有用于容纳所述高尔夫球杆工作人员的下端的通孔;多个环形插入件，用于放置在所述杯内以改变所述杯直径并优化高尔夫球练习，盖子放置在杯子上以隐藏孔，使得诸如天井的基底能够被安全地穿过;以及设置在基底下方的球收集装置，并且通过重力落入球中用于收集并最终检索。

4. 发明授权

US07796526B2 Versatile communication network test apparatus and methods 有权
标题翻译：多功能通信网络测试仪器及方法
公开(公告)号：US07796526B2
公开(公告)日：2010-09-14
申请号：US10978698
申请日：2004-11-01
申请人： Walter L. Miller
发明人： Walter L. Miller
IPC分类号： G01R31/08 , H04J3/14
CPC分类号： H04L43/50
摘要： An analysis device includes a connector, a display, a digital communication circuit and a processing circuit. The connector is configured to connect to a coaxial cable of a communication system, the communication system including a connection to a network employing internet protocol communications. The digital communication circuit is operably connected to the connector and configured to communicate information signals within the communication system via the connector. The digital communication circuit is operable to establish at least two types of connections through the communication system. The first type of data connection employs an internet protocol, while the second type of internet data connection employs a voice over internet protocol. The processing circuit is connected to the digital communication circuit. The processing circuit is operable to obtain diagnostic data relating to each of the first type of connection and the second type of connection. The processing circuit is further operable to cause the display to display information representative of the diagnostic data.
摘要翻译：分析装置包括连接器，显示器，数字通信电路和处理电路。连接器被配置为连接到通信系统的同轴电缆，该通信系统包括与使用因特网协议通信的网络的连接。数字通信电路可操作地连接到连接器并且被配置为经由连接器在通信系统内传送信息信号。数字通信电路可操作以通过通信系统建立至少两种类型的连接。第一种类型的数据连接采用互联网协议，而第二种类型的因特网数据连接采用互联网语音协议。处理电路连接到数字通信电路。处理电路可操作以获得与第一类型连接和第二类型连接中的每一种有关的诊断数据。处理电路还可操作以使显示器显示表示诊断数据的信息。

5. 发明授权

US06692941B1 Bovine growth hormone 失效
标题翻译：牛生长激素
公开(公告)号：US06692941B1
公开(公告)日：2004-02-17
申请号：US07480745
申请日：1990-02-15
申请人： Walter L. Miller , Joseph Augustin Martial , John D. Baxter
发明人： Walter L. Miller , Joseph Augustin Martial , John D. Baxter
IPC分类号： C12N1500
CPC分类号： C12N15/71 , C07K14/61 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： A DNA comprising a deoxynucleotide sequence coding for bovine growth hormone is described. A transfer vector and an expression vector containing this DNA and microorganisms transformed by these vectors are also described.
摘要翻译：描述了包含编码牛生长激素的脱氧核苷酸序列的DNA。还描述了转移载体和含有该DNA的表达载体和由这些载体转化的微生物。

6. 发明授权

US4169542A Dispenser for cup holders 失效
标题翻译：杯架分配器
公开(公告)号：US4169542A
公开(公告)日：1979-10-02
申请号：US828336
申请日：1977-08-29
申请人： Walter L. Miller
发明人： Walter L. Miller
IPC分类号： G07F11/16 , A47F1/08
CPC分类号： G07F11/16
摘要： A dispenser for cup holders for flexible cup liners, in which the cup holders are stacked one on top of the other in a tube having a slot in the side thereof for receiving the handles of the stacked cup holders and the slot having an inlet slot portion for receiving the handles, an offset slot portion in which the handle of the lowest cup can rotate, and a discharge slot portion for discharging the lowest cup from the bottom opening of the tube after rotation of its handle.
摘要翻译：一种用于柔性杯衬套的杯保持器的分配器，其中杯保持器在一侧的管中彼此堆叠，在其侧面具有狭槽，用于接收堆叠的杯保持器的手柄，并且具有入口狭缝部分的狭槽用于接收把手的最小杯的手柄可以旋转的偏移槽部分和用于在其手柄转动之后将最下面的杯子从管的底部开口排出的排放槽部分。

7. 发明授权

US3996809A Drive chain having a disengaging link 失效
标题翻译：具有脱离连杆的驱动链
公开(公告)号：US3996809A
公开(公告)日：1976-12-14
申请号：US616924
申请日：1975-09-26
申请人： Walter L. Miller
发明人： Walter L. Miller
IPC分类号： F16G13/06 , F16H7/22 , F16H7/06
CPC分类号： F16G13/06 , F16H7/22 , Y10T74/1884
摘要： A chain of the type that is used in a reciprocating chain drive. The majority of the chain is constructed of conventional links that mesh with and are driven by rotating sprockets. A specially constructed link is included in the chain to disengage from the sprockets if the reversal controls of the chain drive mechanism malfunction. The special disengaging link is provided with an inclined plate which cams against the sprocket teeth to divert the chain off to the side of the sprocket if the disengaging link reaches the sprocket due to a control malfunction.
摘要翻译：一种用于往复式链条传动的链条。大多数链条由常规链条构成，与常用链轮啮合并由旋转链轮驱动。如果链条驱动机构的反转控制故障，链条中包含特殊构造的连杆，以与链轮脱离接合。特殊的脱离连杆设置有倾斜板，其如果脱离连杆由于控制故障而到达链轮而凸轮抵靠链轮齿，以将链转移到链轮的侧面。

8. 发明授权

US07101981B1 Bovine growth hormone recombinantly produced in E. coli 失效
标题翻译：在大肠杆菌中重组产生的牛生长激素
公开(公告)号：US07101981B1
公开(公告)日：2006-09-05
申请号：US08487312
申请日：1995-06-07
申请人： Walter L. Miller , Joseph Augustin Martial , John D. Baxter
发明人： Walter L. Miller , Joseph Augustin Martial , John D. Baxter
IPC分类号： C07K14/61
CPC分类号： C07K14/61
摘要： Recombinant materials have been obtained which permit the production of bovine growth hormone in E. coli.
摘要翻译：已经获得了允许在大肠杆菌中生产牛生长激素的重组材料。

9. 发明授权

US5939318A Cholesterol disposal fusion enzymes 失效
标题翻译：胆固醇处理融合酶
公开(公告)号：US5939318A
公开(公告)日：1999-08-17
申请号：US564090
申请日：1996-02-05
申请人： Walter L. Miller , Jennifer A. Harikrishna , Stephen M. Black
发明人： Walter L. Miller , Jennifer A. Harikrishna , Stephen M. Black
IPC分类号： C12N1/15 , C12N1/21 , C12N9/02 , C12P33/00 , C12N5/10 , C12N15/62 , C12N15/79
CPC分类号： C12N9/0081 , C12N9/0095 , C12P33/005 , C12Y114/15006 , C12Y118/01002 , C07K2319/00
摘要： Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring electrons to P450scc are described along with genetic constructs for production of such enzymes and methods for their use. Methods for their use include cholesterol degradation in vitro or in vivo as well as conversion of cholesterol to other useful steroidal products including pregnenolone.
摘要翻译： PCT No.PCT / US94 / 06698 Sec。 371日期：1996年2月5日 102（e）日期1996年2月5日PCT提交1994年6月9日PCT公布。出版物WO94 / 29434 PCT 1994年12月22日的日期描述了具有不同生物学活性的多个片段的融合酶，包括具有P450scc活性的一个片段和至少一个具有用于将电子转移至P450scc的电子转移活性的片段以及用于生产这些酶的遗传构建体及其方法使用。其使用方法包括体外或体内的胆固醇降解以及胆固醇转化为其他有用的甾体产物，包括孕烯醇酮。

10. 发明授权

US5045471A Cloned DNA for P450scc and expression thereof 失效
标题翻译：克隆DNA为P450scc及其表达
公开(公告)号：US5045471A
公开(公告)日：1991-09-03
申请号：US936883
申请日：1986-12-02
申请人： Walter L. Miller
发明人： Walter L. Miller
IPC分类号： A61K38/00 , C12N9/02
CPC分类号： C12N9/0081 , C12Y114/15006 , A61K38/00
摘要： A polynucleotide sequence encoding human P450scc is disclosed along with techniques for utilizing the P450scc expressed by this gene to reduce in vivo cholesterol levles.
摘要翻译：公开了编码人P450scc的多核苷酸序列以及利用由该基因表达的P450scc以降低体内胆固醇水平的技术。

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