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1. 发明授权

US07449598B2 Methods for the preparation, formulation and use of lithium valproate 失效
标题翻译：制备，制备和使用丙戊酸锂的方法
公开(公告)号：US07449598B2
公开(公告)日：2008-11-11
申请号：US11725414
申请日：2007-03-19
申请人： Navdeep B. Malkar , Deanna Jean Nelson , Walter C. Holberg, III
发明人： Navdeep B. Malkar , Deanna Jean Nelson , Walter C. Holberg, III
IPC分类号： C07C53/00
CPC分类号： A61K31/19 , C07C51/412 , C07C53/128
摘要： The present invention relates to methods for preparing lithium valproate and administering this compound to a subject in need of treatment with lithium and/or valproate. Pharmaceutical compositions are also provided that are useful therapies for the treatment of neurological, immunological, and viral-mediated disorders in warm-blooded mammals.
摘要翻译：本发明涉及制备丙戊酸锂并将该化合物施用于需要用锂和/或丙戊酸酯处理的受试者的方法。还提供了药物组合物，其是用于治疗温血哺乳动物中神经学，免疫学和病毒介导的疾病的有用治疗方法。

2. 发明授权

US08324191B2 Combined calcium, magnesium and vitamin D supplements 有权
标题翻译：组合钙，镁和维生素D补充剂
公开(公告)号：US08324191B2
公开(公告)日：2012-12-04
申请号：US12218067
申请日：2008-07-11
申请人： Deanna Jean Nelson , Walter C. Holberg, III
发明人： Deanna Jean Nelson , Walter C. Holberg, III
IPC分类号： A01N37/36 , A01N45/00
CPC分类号： A61K31/59
摘要： The present invention relates to oral nutritional and therapeutic products which are useful for providing vitamins and minerals required for bone health. The present invention is an oral nutritional and therapeutic composition of calcium succinate, magnesium R-(+)-alpha-lipoate, and Vitamin D for use in the maintenance of bone health, the optimization of bone growth, reducing the risk of bone fracture, and the prevention and treatment of osteoporosis. The pharmaceutical products and methods of the present invention are particularly useful in building bone mass, quality, and density during growth, maintaining bone mass, quality, and density over time, reducing bone fracture risk, and treating osteoporosis in men and women.
摘要翻译：本发明涉及可用于提供骨骼健康所需的维生素和矿物质的口服营养和治疗产品。本发明是一种用于维持骨骼健康，优化骨骼生长，降低骨折风险的琥珀酸钙，R - （+） - α-硫辛酸镁和维生素D的口服营养和治疗组合物，并预防和治疗骨质疏松症。本发明的药物产品和方法特别可用于在生长期间建立骨量，质量和密度，保持骨质量，质量和随时间的密度，降低骨折风险，并治疗男性和女性的骨质疏松症。

3. 发明授权

US07790921B2 Methods for the preparation, formulation and use of lithium valproate 失效
标题翻译：制备，制备和使用丙戊酸锂的方法
公开(公告)号：US07790921B2
公开(公告)日：2010-09-07
申请号：US12082878
申请日：2008-04-15
申请人： Navdeep B. Malkar , Deanna Jean Nelson , Walter C. Holberg, III
发明人： Navdeep B. Malkar , Deanna Jean Nelson , Walter C. Holberg, III
IPC分类号： C07B53/00
CPC分类号： A61K31/19 , C07C51/412 , C07C53/128
摘要： The present invention relates to methods for preparing lithium valproate and administering this compound to a subject in need of treatment with lithium and/or valproate. Pharmaceutical compositions are also provided that are useful therapies for the treatment of neurological, immunological, and viral-mediated disorders in warm-blooded mammals.
摘要翻译：本发明涉及制备丙戊酸锂并将该化合物施用于需要用锂和/或丙戊酸酯处理的受试者的方法。还提供了药物组合物，其是用于治疗温血哺乳动物中神经学，免疫学和病毒介导的疾病的有用治疗方法。

4. 发明申请

US20100009948A1 Combined calcium, magnesium and vitamin D supplements 有权
标题翻译：组合钙，镁和维生素D补充剂
公开(公告)号：US20100009948A1
公开(公告)日：2010-01-14
申请号：US12218067
申请日：2008-07-11
申请人： Deanna Jean Nelson , Walter C. Holberg, III
发明人： Deanna Jean Nelson , Walter C. Holberg, III
IPC分类号： A61K31/59 , A61P19/00 , A61P19/10 , C07D339/04
CPC分类号： A61K31/59
摘要： The present invention relates to oral nutritional and therapeutic products which are useful for providing vitamins and minerals required for bone health. The present invention is an oral nutritional and therapeutic composition of calcium succinate, magnesium R-(+)-alpha-lipoate, and Vitamin D for use in the maintenance of bone health, the optimization of bone growth, reducing the risk of bone fracture, and the prevention and treatment of osteoporosis. The pharmaceutical products and methods of the present invention are particularly useful in building bone mass, quality, and density during growth, maintaining bone mass, quality, and density over time, reducing bone fracture risk, and treating osteoporosis in men and women.
摘要翻译：本发明涉及可用于提供骨骼健康所需的维生素和矿物质的口服营养和治疗产品。本发明是一种用于维持骨骼健康，优化骨骼生长，降低骨折风险的琥珀酸钙，R - （+） - α-硫辛酸镁和维生素D的口服营养和治疗组合物，并预防和治疗骨质疏松症。本发明的药物产品和方法特别可用于在生长期间建立骨量，质量和密度，保持骨质量，质量和随时间的密度，降低骨折风险，并治疗男性和女性骨质疏松症。

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