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1. 发明授权

US08377667B2 Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto 有权
标题翻译：用于生产1,4-丁二醇，4-羟基丁醛，4-羟基丁酰辅酶A，腐胺及相关化合物的微生物及其相关方法
公开(公告)号：US08377667B2
公开(公告)日：2013-02-19
申请号：US13109732
申请日：2011-05-17
申请人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
发明人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
IPC分类号： C12P7/02 , C12N1/21 , C12P21/00 , C12N15/00 , C12N9/02
CPC分类号： C12P7/18 , C12P7/24 , C12P7/42 , C12P13/001 , C12P19/40
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A，表达量足以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的β-羟基丁酸或腐胺途径酶，并进一步优化BDO的表达。本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

2. 发明授权

US08377666B2 Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto 有权
标题翻译：用于生产1,4-丁二醇，4-羟基丁醛，4-羟基丁酰辅酶，腐胺及相关化合物的微生物及其相关方法
公开(公告)号：US08377666B2
公开(公告)日：2013-02-19
申请号：US12904130
申请日：2010-10-13
申请人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
发明人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
IPC分类号： C12P7/02 , C12N1/21 , C12P21/00 , C12N9/02 , C12N15/00
CPC分类号： C12P7/18 , C12P7/24 , C12P7/42 , C12P13/001 , C12P19/40
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A，表达量足以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的β-羟基丁酸或腐胺途径酶，并进一步优化BDO的表达。本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

3. 发明申请

US20120225463A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：US20120225463A1
公开(公告)日：2012-09-06
申请号：US13361799
申请日：2012-01-30
申请人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
发明人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
IPC分类号： C12P7/18 , C12N1/19 , C12N1/15 , C12N1/21
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化用于BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

4. 发明申请

US20120094345A1 COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS 有权
标题翻译： 1,4-丁二醇及其前体的生物合成的组合物和方法
公开(公告)号：US20120094345A1
公开(公告)日：2012-04-19
申请号：US13286135
申请日：2011-10-31
申请人： Mark J. Burk , Stephen J. Van Dien , Anthony P. Burgard , Wei Niu
发明人： Mark J. Burk , Stephen J. Van Dien , Anthony P. Burgard , Wei Niu
IPC分类号： C12P7/18 , C12N15/63 , C12N1/19 , C12N15/53 , C12N1/21 , C12N1/15
CPC分类号： C12N15/52 , B01D3/002 , C12N9/0006 , C12N9/0008 , C12N9/88 , C12N9/93 , C12N15/70 , C12N15/81 , C12P7/18 , C12P7/42 , C12P7/52 , C12P17/04 , C12Y101/01061 , C12Y102/01076 , C12Y401/01071 , C12Y602/01004 , Y02P20/52
摘要： The invention provides a non-naturally occurring microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (1,4-BDO) biosynthetic pathways. The pathways include exogenous nucleic acids encoding a) an α-ketoglutarate decarboxylase; b) a 4-hydroxybutanoate dehydrogenase; c) a 4-hydroxybutyryl-CoA:acetyl-CoA transferase or a butyrate kinase and a phosphotransbutyrylase; d) an aldehyde dehydrogenase, and e) an alcohol dehydrogenase, wherein the exogenous nucleic acids are expressed in sufficient amounts to produce 1,4-butanediol (1,4-BDO). Also provide is a method for the production of 1,4-BDO. The method includes culturing the non-naturally occurring microbial organism having 4-HB and 1,4-BDO biosynthetic pathways substantially anaerobic conditions for a sufficient period of time to produce 1,4-BDO.
摘要翻译：本发明提供了具有4-羟基丁酸（4-HB）和1,4-丁二醇（1,4-BDO）生物合成途径的非天然存在的微生物生物。途径包括编码a）α-酮戊二酸脱羧酶的外源核酸; b）4-羟基丁酸脱氢酶; c）4-羟基丁酰-CoA：乙酰-CoA转移酶或丁酸酯激酶和磷酸转磷酸化酶; d）醛脱氢酶，和e）醇脱氢酶，其中外源核酸以足够的量表达以产生1,4-丁二醇（1,4-BDO）。还提供了用于生产1,4-BDO的方法。该方法包括培养具有4-HB和1,4-BDO生物合成途径的非天然存在的微生物生物合成途径，基本上是厌氧条件足够的时间以产生1,4-BDO。

5. 发明授权

US08067214B2 Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors 有权
标题翻译： 1,4-丁二醇及其前体的生物合成的组合物和方法
公开(公告)号：US08067214B2
公开(公告)日：2011-11-29
申请号：US12049256
申请日：2008-03-14
申请人： Mark J. Burk , Stephen J. Van Dien , Anthony P. Burgard , Wei Niu
发明人： Mark J. Burk , Stephen J. Van Dien , Anthony P. Burgard , Wei Niu
IPC分类号： C12P7/18 , C12N1/21
CPC分类号： C12N15/52 , B01D3/002 , C12N9/0006 , C12N9/0008 , C12N9/88 , C12N9/93 , C12N15/70 , C12N15/81 , C12P7/18 , C12P7/42 , C12P7/52 , C12P17/04 , C12Y101/01061 , C12Y102/01076 , C12Y401/01071 , C12Y602/01004 , Y02P20/52
摘要： The invention provides a non-naturally occurring microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (1,4-BDO) biosynthetic pathways. The pathways include exogenous nucleic acids encoding a) an α-ketoglutarate decarboxylase; b) a 4-hydroxybutanoate dehydrogenase; c) a 4-hydroxybutyryl-CoA:acetyl-CoA transferase or a butyrate kinase and a phosphotransbutyrylase; d) an aldehyde dehydrogenase, and e) an alcohol dehydrogenase, wherein the exogenous nucleic acids are expressed in sufficient amounts to produce 1,4-butanediol (1,4-BDO). Also provide is a method for the production of 1,4-BDO. The method includes culturing the non-naturally occurring microbial organism having 4-HB and 1,4-BDO biosynthetic pathways substantially anaerobic conditions for a sufficient period of time to produce 1,4-BDO.
摘要翻译：本发明提供了具有4-羟基丁酸（4-HB）和1,4-丁二醇（1,4-BDO）生物合成途径的非天然存在的微生物生物。途径包括编码a）α-酮戊二酸脱羧酶的外源核酸; b）4-羟基丁酸脱氢酶; c）4-羟基丁酰-CoA：乙酰-CoA转移酶或丁酸酯激酶和磷酸转磷酸化酶; d）醛脱氢酶，和e）醇脱氢酶，其中外源核酸以足够的量表达以产生1,4-丁二醇（1,4-BDO）。还提供了用于生产1,4-BDO的方法。该方法包括培养具有4-HB和1,4-BDO生物合成途径的非天然存在的微生物生物合成途径，基本上是厌氧条件足够的时间以产生1,4-BDO。

6. 发明申请

US20110217742A1 MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE 有权
标题翻译：共聚1,4-丁二醇和γ-丁内酯的微生物和方法
公开(公告)号：US20110217742A1
公开(公告)日：2011-09-08
申请号：US12940021
申请日：2010-11-04
申请人： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
发明人： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
IPC分类号： C12P17/04
CPC分类号： C12P17/04 , C12N1/20 , C12N15/52 , C12P7/18
摘要： The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
摘要翻译：本发明提供包含1,4-丁二醇（14-BDO）和γ-丁内酯（GBL）途径的非天然存在的微生物生物，其包含至少一种编码14-BDO和GBL途径酶的外源核酸，其以足够的量表达，生产14-BDO和GBL。本发明另外提供了使用这种微生物生物来生产14-BDO和GBL的方法。

7. 发明授权

US08530210B2 Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone 有权
公开(公告)号：US08530210B2
公开(公告)日：2013-09-10
申请号：US12940021
申请日：2010-11-04
申请人： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
发明人： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
IPC分类号： C12P7/18 , C12P7/04
CPC分类号： C12P17/04 , C12N1/20 , C12N15/52 , C12P7/18
摘要： The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.

8. 发明申请

US20130196397A1 COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS 有权
标题翻译： 1,4-丁二醇及其前体的生物合成的组合物和方法
公开(公告)号：US20130196397A1
公开(公告)日：2013-08-01
申请号：US13717350
申请日：2012-12-17
申请人： Mark J. BURK , Stephen J. VAN DIEN , Anthony P. BURGARD , Wei NIU
发明人： Mark J. BURK , Stephen J. VAN DIEN , Anthony P. BURGARD , Wei NIU
IPC分类号： C12P7/42 , C12P7/18
CPC分类号： C12N15/52 , B01D3/002 , C12N9/0006 , C12N9/0008 , C12N9/88 , C12N9/93 , C12N15/70 , C12N15/81 , C12P7/18 , C12P7/42 , C12P7/52 , C12P17/04 , C12Y101/01061 , C12Y102/01076 , C12Y401/01071 , C12Y602/01004 , Y02P20/52
摘要： The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (BDO). Additionally provided are methods for the production of 4-HB and BDO.
摘要翻译：本发明提供了一种非天然存在的微生物生物催化剂，其包括具有4-羟基丁酸（4-HB）生物合成途径的微生物生物，其具有至少一种编码4-羟基丁酸脱氢酶的外源核酸，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸半醛脱氢酶或α-酮戊二酸脱羧酶，其中外源核酸以足够的量表达以产生单体4-羟基丁酸（4-HB）。还提供了非天然存在的微生物生物催化剂，其包括具有4-羟基丁酸（4-HB）和1,4-丁二醇（BDO）生物合成途径的微生物生物，该途径包括至少一种编码4-羟基丁酸脱氢酶的外源核酸，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸半醛脱氢酶，4-羟基丁酸酯：CoA转移酶，4-丁酸酯激酶，磷酸转移酶，α-酮戊二酸脱羧酶，醛脱氢酶，醇脱氢酶或醛/醇脱氢酶，其中外源核酸为以足够的量表示产生1,4-丁二醇（BDO）。另外提供了用于生产4-HB和BDO的方法。

9. 发明申请

US20130189751A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产1,4-丁二醇，4-羟基吡啶，4-羟基丁酰氯，聚氨酯和相关化合物的微生物及其相关方法
公开(公告)号：US20130189751A1
公开(公告)日：2013-07-25
申请号：US13737866
申请日：2013-01-09
申请人： Robert HASELBECK , John D. TRAWICK , Wei NIU , Anthony P. BURGARD
发明人： Robert HASELBECK , John D. TRAWICK , Wei NIU , Anthony P. BURGARD
IPC分类号： C12P7/24
CPC分类号： C12P7/18 , C12P7/24 , C12P7/42 , C12P13/001 , C12P19/40
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A，表达量足以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的β-羟基丁酸或腐胺途径酶，并进一步优化BDO的表达。本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

10. 发明申请

US20110076730A1 MICROBIAL SYNTHESIS OF D-1,2,4-BUTANETRIOL 审中-公开
标题翻译： D-1,2,4-BUTANETRIOL的微观合成
公开(公告)号：US20110076730A1
公开(公告)日：2011-03-31
申请号：US12374367
申请日：2007-07-19
申请人： John W. Frost , Wei Niu
发明人： John W. Frost , Wei Niu
IPC分类号： C12P13/04 , C12P7/18 , C07C201/02 , C12N9/04 , C07H21/04 , C12N15/63 , C12N9/88 , C12N5/10 , C12N1/00 , C12P7/58 , C12P7/52 , C12N9/02 , C12N9/10 , C07K16/40 , C07K16/44 , G01N33/53
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/88
摘要： Improved enzyme systems, recombinant cells, and processes employing the same to produce biosynthetic D-1,2,4-butanetriol; D-1,2,4-butanetriol prepared thereby and derivatives thereof; D-1,2,4-butanetriol trinitrate prepared therefrom; and enzymes and genes useful in the enzyme systems and recombinant cells.
摘要翻译：改进的酶系统，重组细胞和使用其的方法产生生物合成D-1,2,4-丁三醇的方法; 由此制备的D-1,2,4-丁三醇及其衍生物; 由其制备的D-1,2,4-丁三醇三硝酸酯; 以及可用于酶系统和重组细胞的酶和基因。

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