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1. 发明授权

US09434964B2 Microorganisms for the production of 1,4-butanediol and related methods 有权
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：US09434964B2
公开(公告)日：2016-09-06
申请号：US13361799
申请日：2012-01-30
申请人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
发明人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
IPC分类号： C12N1/21 , C12P7/18
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化用于BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

2. 发明申请

US20110045575A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS 有权
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：US20110045575A1
公开(公告)日：2011-02-24
申请号：US12794700
申请日：2010-06-04
申请人： STEPHEN J. VAN DIEN , ANTHONY P. BURGARD , ROBERT HASELBECK , CATHERINE J. PUJOL-BAXLEY , WEI NIU , JOHN D. TRAWICK , HARRY YIM , MARK J. BURK , ROBIN E. OSTERHOUT , JUN SUN
发明人： STEPHEN J. VAN DIEN , ANTHONY P. BURGARD , ROBERT HASELBECK , CATHERINE J. PUJOL-BAXLEY , WEI NIU , JOHN D. TRAWICK , HARRY YIM , MARK J. BURK , ROBIN E. OSTERHOUT , JUN SUN
IPC分类号： C12N1/21 , C12N1/00
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化用于BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

3. 发明授权

US08470566B2 Microorganisms and methods for conversion of syngas and other carbon sources to useful products 有权
公开(公告)号：US08470566B2
公开(公告)日：2013-06-25
申请号：US13371278
申请日：2012-02-10
申请人： John D. Trawick , Mark J. Burk , Anthony P. Burgard
发明人： John D. Trawick , Mark J. Burk , Anthony P. Burgard
IPC分类号： C12P7/42 , C12P7/04 , C12P7/16 , C12P21/06 , C12N1/00 , C12N1/20 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/02 , C07C29/00 , C07C29/74
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/10 , C12N9/1029 , C12N9/88 , C12N15/52 , C12P7/04 , C12P7/42
摘要： A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway enzyme expressed in a sufficient amount to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. The aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol.

4. 发明授权

US08377667B2 Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto 有权
标题翻译：用于生产1,4-丁二醇，4-羟基丁醛，4-羟基丁酰辅酶A，腐胺及相关化合物的微生物及其相关方法
公开(公告)号：US08377667B2
公开(公告)日：2013-02-19
申请号：US13109732
申请日：2011-05-17
申请人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
发明人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
IPC分类号： C12P7/02 , C12N1/21 , C12P21/00 , C12N15/00 , C12N9/02
CPC分类号： C12P7/18 , C12P7/24 , C12P7/42 , C12P13/001 , C12P19/40
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A，表达量足以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的β-羟基丁酸或腐胺途径酶，并进一步优化BDO的表达。本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

5. 发明授权

US08377666B2 Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto 有权
标题翻译：用于生产1,4-丁二醇，4-羟基丁醛，4-羟基丁酰辅酶，腐胺及相关化合物的微生物及其相关方法
公开(公告)号：US08377666B2
公开(公告)日：2013-02-19
申请号：US12904130
申请日：2010-10-13
申请人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
发明人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
IPC分类号： C12P7/02 , C12N1/21 , C12P21/00 , C12N9/02 , C12N15/00
CPC分类号： C12P7/18 , C12P7/24 , C12P7/42 , C12P13/001 , C12P19/40
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A，表达量足以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的β-羟基丁酸或腐胺途径酶，并进一步优化BDO的表达。本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

6. 发明申请

US20120225463A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：US20120225463A1
公开(公告)日：2012-09-06
申请号：US13361799
申请日：2012-01-30
申请人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
发明人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
IPC分类号： C12P7/18 , C12N1/19 , C12N1/15 , C12N1/21
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化用于BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

7. 发明申请

US20110223637A1 METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL 有权
标题翻译：使用合成气或其他气态碳源和甲醇的方法和有机体
公开(公告)号：US20110223637A1
公开(公告)日：2011-09-15
申请号：US13106764
申请日：2011-05-12
申请人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
发明人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
IPC分类号： C12P19/40 , C12N1/00
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
摘要： The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
摘要翻译：本发明提供具有乙酰-CoA途径的非天然存在的微生物生物体，以及利用合成气或合成气和甲醇的能力。在一个实施方案中，本发明提供非天然存在的微生物，其包含一种或多种外源蛋白质，赋予微生物将CO，CO 2和/或H 2转化为乙酰辅酶A（乙酰辅酶A），甲基四氢叶酸（甲基 -THF）或其它所需产物，其中微生物缺乏在不存在一种或多种外源蛋白的情况下将CO或CO 2和H 2转化为乙酰辅酶A或甲基-THF的能力。例如，微生物生物体可以含有至少一种编码乙酰辅酶A途径中的酶或蛋白质的外源核酸。微生物生物能够单独或与甲醇组合使用包含CO，CO 2和/或H 2的合成气体，以产生乙酰辅酶A。本发明另外提供了生产乙酰辅酶A的方法，例如通过培养产生乙酰辅酶A的微生物，其中微生物生物体表达至少一种编码乙酰辅酶A途径酶或蛋白质的外源核酸，其量足够在条件下和足够的时间内产生乙酰辅酶A产生乙酰辅酶A。

8. 发明申请

US20110217742A1 MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE 有权
标题翻译：共聚1,4-丁二醇和γ-丁内酯的微生物和方法
公开(公告)号：US20110217742A1
公开(公告)日：2011-09-08
申请号：US12940021
申请日：2010-11-04
申请人： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
发明人： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
IPC分类号： C12P17/04
CPC分类号： C12P17/04 , C12N1/20 , C12N15/52 , C12P7/18
摘要： The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
摘要翻译：本发明提供包含1,4-丁二醇（14-BDO）和γ-丁内酯（GBL）途径的非天然存在的微生物生物，其包含至少一种编码14-BDO和GBL途径酶的外源核酸，其以足够的量表达，生产14-BDO和GBL。本发明另外提供了使用这种微生物生物来生产14-BDO和GBL的方法。

9. 发明授权

US08691553B2 Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol 有权
标题翻译：利用合成气或其他气态碳源和甲醇的方法和生物
公开(公告)号：US08691553B2
公开(公告)日：2014-04-08
申请号：US12863978
申请日：2009-01-22
申请人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
发明人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
IPC分类号： C12N1/20 , C12N9/00 , C12N1/00 , C12P7/42 , C12P7/20 , C07H21/04
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
摘要： The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
摘要翻译：本发明提供具有乙酰-CoA途径的非天然存在的微生物生物体，以及利用合成气或合成气和甲醇的能力。在一个实施方案中，本发明提供非天然存在的微生物，其包含一种或多种外源蛋白质，赋予微生物将CO，CO 2和/或H 2转化为乙酰辅酶A（乙酰辅酶A），甲基四氢叶酸（甲基 -THF）或其它所需产物，其中微生物缺乏在不存在一种或多种外源蛋白的情况下将CO或CO 2和H 2转化为乙酰辅酶A或甲基-THF的能力。例如，微生物生物体可以含有至少一种编码乙酰辅酶A途径中的酶或蛋白质的外源核酸。微生物生物能够单独或与甲醇组合使用包含CO，CO 2和/或H 2的合成气体，以产生乙酰辅酶A。本发明另外提供了生产乙酰辅酶A的方法，例如通过培养产生乙酰辅酶A的微生物，其中微生物生物体表达至少一种编码乙酰辅酶A途径酶或蛋白质的外源核酸，其量足够在条件下和足够的时间内产生乙酰辅酶A产生乙酰辅酶A。

10. 发明申请

US20130029381A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO 审中-公开
公开(公告)号：US20130029381A1
公开(公告)日：2013-01-31
申请号：US13447094
申请日：2012-04-13
申请人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
发明人： Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
IPC分类号： C12P19/32 , C12P13/00 , C12N1/19 , C12P7/24 , C12N1/21 , C12N1/15
CPC分类号： C12P7/18 , C12P7/24 , C12P7/42 , C12P13/001 , C12P19/40
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.

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