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1. 发明授权

US07462495B2 Methods and compositions for use in diagnosing and characterizing chronic immune disease 有权
标题翻译：用于诊断和表征慢性免疫疾病的方法和组合物
公开(公告)号：US07462495B2
公开(公告)日：2008-12-09
申请号：US10963981
申请日：2004-10-12
申请人： Simon Adriaan Michiel Roelens , Patrick Englebienne , Anne Marie Yvonne Robert D'Haese , Charles Vincent Taylor Herst
发明人： Simon Adriaan Michiel Roelens , Patrick Englebienne , Anne Marie Yvonne Robert D'Haese , Charles Vincent Taylor Herst
IPC分类号： G01N33/564
CPC分类号： G01N33/6887 , C12Q1/34 , C12Q1/37 , G01N33/564 , G01N2333/4712 , G01N2333/922 , Y10T436/10 , Y10T436/105831 , Y10T436/141111 , Y10T436/25125 , Y10T436/25375
摘要： Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the presence of low molecular actin fragments. The assay results are used to diagnose the presence of chronic immune disease activity and/or characterize chronic immune disease activity in the subject, e.g. to confirm an initial chronic immune disease diagnosis, to determine the stage of the disease, to monitor disease progression, to predict disease attacks, and the like. Also provided by the subject invention are kits for practicing the methods.
摘要翻译：提供了用于诊断和/或表征受试者的慢性免疫疾病活动的方法。在本发明方法中，从疑似患有或已知具有慢性免疫疾病的受试者获得样品。然后测定样品的低分子肌动蛋白片段的存在。测定结果用于诊断受试者的慢性免疫疾病活动的存在和/或表征慢性免疫疾病活动，例如，确定初始慢性免疫疾病诊断，确定疾病的阶段，监测疾病进展，预测疾病发作等。本发明还提供了用于实施该方法的试剂盒。

2. 发明申请

US20150132398A1 VACCINE FORMULATION OF MANNOSE COATED PEPTIDE PARTICLES 审中-公开
标题翻译：疫苗制剂的MANNOSE涂层肽颗粒
公开(公告)号：US20150132398A1
公开(公告)日：2015-05-14
申请号：US14601849
申请日：2015-01-21
申请人： CHARLES VINCENT TAYLOR HERST , REID M. RUBSAMEN
发明人： CHARLES VINCENT TAYLOR HERST , REID M. RUBSAMEN
IPC分类号： A61K9/16 , A61K39/00
CPC分类号： A61K9/167 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/1647 , A61K9/5015 , A61K39/00 , A61K39/39 , A61K2039/55555 , A61K2039/575 , A61K2039/64
摘要： A vaccine formulation as disclosed which is comprised of a pharmaceutically acceptable carrier in a plurality of particles with mannose on their surface. The particles are comprised of a biocompatible polymer which maybe a co-polymer such as PLGA combined with a peptide of a sequence which corresponds to a sequence on a surface of a pathogen. A plurality of different groups of particles are provided in the formulation wherein the particles within any single group include peptides of identical amino acid sequence. The particles are sized such that they are sufficiently large so as to prevent more than a single particle from being presented to a single immune system cell.
摘要翻译：所公开的疫苗制剂，其由在其表面上具有甘露糖的多个颗粒中的药学上可接受的载体组成。颗粒由生物相容性聚合物组成，其可以是共聚物如PLGA与对应于病原体表面上的序列的序列的肽结合。在制剂中提供多个不同组的颗粒，其中任何单一组中的颗粒包括相同氨基酸序列的肽。这些颗粒的尺寸使得它们足够大，以便防止多于单个颗粒被提供给单个免疫系统细胞。

3. 外观设计

USD693237S1 Food package 有权
公开(公告)号：USD693237S1
公开(公告)日：2013-11-12
申请号：US29426574
申请日：2012-07-06
申请人： Peter Bates , Kristin Heist , Christine Horan , Julie King , Elizabeth Kneen , Jason Robertson , David M. Sokolsky , Jung Geun Tak , Vincent Taylor , Craig Ziemkiewicz
设计人： Peter Bates , Kristin Heist , Christine Horan , Julie King , Elizabeth Kneen , Jason Robertson , David M. Sokolsky , Jung Geun Tak , Vincent Taylor , Craig Ziemkiewicz

4. 发明申请

US20120231044A1 VACCINE FORMULATION OF MANNOSE COATED PEPTIDE PARTICLES 审中-公开
标题翻译：疫苗制剂的MANNOSE涂层肽颗粒
公开(公告)号：US20120231044A1
公开(公告)日：2012-09-13
申请号：US13417996
申请日：2012-03-12
申请人： Charles Vincent Taylor Herst , Reid M. Rubsamen
发明人： Charles Vincent Taylor Herst , Reid M. Rubsamen
IPC分类号： A61K31/765 , A61P37/04 , A61K9/14
CPC分类号： A61K9/167 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/1647 , A61K9/5015 , A61K39/00 , A61K39/39 , A61K2039/55555 , A61K2039/575 , A61K2039/64
摘要： A vaccine formulation as disclosed which is comprised of a pharmaceutically acceptable carrier in a plurality of particles with mannose on their surface. The particles are comprised of a biocompatible polymer which maybe a co-polymer such as PLGA combined with a peptide of a sequence which corresponds to a sequence on a surface of a pathogen. A plurality of different groups of particles are provided in the formulation wherein the particles within any single group include peptides of identical amino acid sequence. The particles are sized such that they are sufficiently large so as to prevent more than a single particle from being presented to a single immune system cell.
摘要翻译：所公开的疫苗制剂，其由在其表面上具有甘露糖的多个颗粒中的药学上可接受的载体组成。颗粒由生物相容性聚合物组成，其可以是共聚物如PLGA与对应于病原体表面上的序列的序列的肽结合。在制剂中提供多个不同组的颗粒，其中任何单一组中的颗粒包括相同氨基酸序列的肽。这些颗粒的尺寸使得它们足够大，以便防止多于单个颗粒被提供给单个免疫系统细胞。

5. 发明申请

US20080103510A1 BIO-ABSORBABLE TISSUE CLOSURE SYSTEM 审中-公开
标题翻译：生物可吸收组织闭合系统
公开(公告)号：US20080103510A1
公开(公告)日：2008-05-01
申请号：US11923656
申请日：2007-10-25
申请人： Thomas Vincent Taylor , John Edward Parazynski , Scott Parazynski
发明人： Thomas Vincent Taylor , John Edward Parazynski , Scott Parazynski
IPC分类号： A61B17/064
CPC分类号： A61B17/08 , A61B17/083 , A61B17/10 , A61B17/105 , A61B2017/081
摘要： A surgical fastening system, utilizing surgical clips made from bio-absorbable materials, for use in the rapid closing of deep internal wounds in humans or animals is disclosed. Elements of the system include surgical clips, applicators of surgical clips and dispensers of surgical clips. The surgical clips may contain small amounts of prophylactic antibiotic medication, long-acting time-release pain medication, radio-opaque markers, small amounts of radioactive material, colors, and/or patterns.
摘要翻译：公开了一种利用由生物可吸收材料制成的手术夹具用于快速关闭人或动物深部内部伤口的手术紧固系统。该系统的元件包括外科夹子，手术夹子的施用器和手术夹具的分配器。手术夹可能含有少量预防性抗生素药物，长效释药止痛药，不透射线标记物，少量放射性物质，颜色和/或图案。

6. 发明授权

US3662852A Air cushion vehicle 失效
标题翻译： AIR CUSHION VEHICLE
公开(公告)号：US3662852A
公开(公告)日：1972-05-16
申请号：US3662852D
申请日：1971-01-04
申请人： ROBERT VINCENT TAYLOR
发明人： TAYLOR ROBERT VINCENT
IPC分类号： B60V1/00 , B60V1/04 , B60V1/06 , B60V1/16
CPC分类号： B60V1/043
摘要： An air cushion vehicle of the type wherein air at superatmospheric pressure in a plenum supports a vehicle and the vehicle is provided with an inflatable bag skirt, there being a duct extending between a blower on the one hand and both the bag skirt and the plenum on the other, the plenum containing a door which can be opened or closed to control pressure differential between the inflatable skirt and the plenum whereby the vehicle may be lifted to take-off point with the plenum door closed, and take-off can be achieved by opening of the plenum door.
摘要翻译：一种气垫车辆，其中在大气压力下的空气支撑车辆，并且车辆设置有可充气的袋子裙部，其中一个管道在鼓风机和鼓风机之间延伸，两个袋子裙部和气室在另一方面，所述增压室包含可以打开或关闭的门，以控制可膨胀裙部与气室之间的压力差，由此车辆可以在通风门关闭时被提升到起飞点，起飞可以通过开通通风门。

7. 发明授权

US08844767B1 Food containment and delivery system 有权
标题翻译：食品遏制和分娩系统
公开(公告)号：US08844767B1
公开(公告)日：2014-09-30
申请号：US13543624
申请日：2012-07-06
申请人： Peter Bates , Kristin Heist , Christine Horan , Julie King , Elizabeth Kneen , Jason Robertson , David M. Sokolsky , Jung Geun Tak , Vincent Taylor , Craig Ziemkiewicz
发明人： Peter Bates , Kristin Heist , Christine Horan , Julie King , Elizabeth Kneen , Jason Robertson , David M. Sokolsky , Jung Geun Tak , Vincent Taylor , Craig Ziemkiewicz
IPC分类号： B65D35/00
CPC分类号： B65D47/2031 , B65D35/10 , B65D75/5883
摘要： An inverted flexible food containment and delivery system is disclosed. Embodiments disclosed herein include a flexible pouch that is configured to contain a food product. A spout fitment is coupled to the flexible pouch proximate a dispensing end. The spout fitment supports a cap assembly that includes a valve. An exterior support surface of the cap assembly is configured to support the flexible food containment and delivery system and the food product in an inverted/cap-down orientation.
摘要翻译：公开了一种倒置的柔性食品包装和输送系统。本文公开的实施例包括被配置为容纳食品的柔性袋。喷嘴配件在分配端附近耦合到柔性袋。喷嘴配件支撑包括阀的盖组件。帽组件的外部支撑表面构造成以倒置/封顶方向支撑柔性食品容纳和输送系统和食品。

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