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1. 发明申请

US20050043545A1 4-(5-Membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors 审中-公开
标题翻译： 4-（5-成员） - 杂芳基酰基吡咯烷衍生物作为hcv抑制剂
公开(公告)号：US20050043545A1
公开(公告)日：2005-02-24
申请号：US10494114
申请日：2002-10-30
申请人： Gianpalol Bravi , Helene Goodland , David Haigh , Charles Hartley , Victoria Lovegrove , Pritom Shah , Martin Slater
发明人： Gianpalol Bravi , Helene Goodland , David Haigh , Charles Hartley , Victoria Lovegrove , Pritom Shah , Martin Slater
IPC分类号： A61K31/4196 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61P1/16 , A61P31/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D43/02
CPC分类号： C07D409/14 , C07D413/14 , C07D417/14
摘要： Novel anti-viral agents of Formula wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 5-membered heterocyclic ring; E represents hydrogen or C1-6alkyl; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts and solvates thereof, processes for their preparation and methods of using them in HCV treatment are provided.
摘要翻译：新型的式的抗病毒剂其中：A表示OR 1，NR 1 R 2或R 1，其中R 1和R 2是氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; B表示C（O）R 3，其中R 3是C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; C代表C 1-6烷基，芳基，杂芳基或杂环基; D表示饱和或不饱和的任选取代的5元杂环; E表示氢或C 1-6烷基; F表示氢，C 1-6烷基，芳基或杂芳基; 和G表示氢，C 1-6烷基，杂环基烷基，芳基烷基或杂芳基烷基; 并提供其盐和溶剂化物，其制备方法及其在HCV治疗中的使用方法。

2. 发明申请

US20050043390A1 4-(6-membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors 失效
标题翻译： 4-（6-元） - 杂芳基酰基吡咯烷衍生物作为hcv抑制剂
公开(公告)号：US20050043390A1
公开(公告)日：2005-02-24
申请号：US10494127
申请日：2002-10-30
申请人： Gianpaolo Bravi , Rossella Guidetti , David Haigh , Charles Hartley , Peter Howes , Deborah Jackson , Victoria Lovegrove , Pritom Shah , Martin Slater , Katrina Wareing
发明人： Gianpaolo Bravi , Rossella Guidetti , David Haigh , Charles Hartley , Peter Howes , Deborah Jackson , Victoria Lovegrove , Pritom Shah , Martin Slater , Katrina Wareing
IPC分类号： A61K31/4439 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61P1/16 , A61P31/12 , A61P31/14 , C07D401/14 , C07D403/04 , C07D409/14 , C07D417/14 , A61K31/4025 , A61K31/401 , C07D43/02
CPC分类号： C07D401/14 , C07D403/04 , C07D409/14 , C07D417/14
摘要： Novel anti-viral agents of Formula wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 6-membered heterocyclic ring; E represents hydrogen or C1-6-alkyl; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof, processes for their preparation and methods of using them in HCV treatment are provided.
摘要翻译：新型的式的抗病毒剂其中：A表示OR 1，NR 1 R 2或R 1，其中R 1和R 2是氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; B表示C（O）R 3，其中R 3是C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; C代表C 1-6烷基，芳基，杂芳基或杂环基; D表示饱和或不饱和的任选取代的6元杂环; E表示氢或C 1-6 - 烷基; F表示氢，C 1-6烷基，芳基或杂芳基; 和G表示氢，C 1-6烷基，杂环基烷基，芳基烷基或杂芳基烷基; 提供其盐，溶剂合物和酯，其制备方法及其用于HCV治疗的方法。

3. 发明申请

US20050009873A1 Acyl dihydro pyrrole derivatives as hcv inhibitors 审中-公开
标题翻译：酰基二氢吡咯衍生物作为hcv抑制剂
公开(公告)号：US20050009873A1
公开(公告)日：2005-01-13
申请号：US10494121
申请日：2002-10-30
申请人： Gianpaolo Bravi , Peter Howes , Victoria Lovegrove , Pritom Shah , Martin Slater
发明人： Gianpaolo Bravi , Peter Howes , Victoria Lovegrove , Pritom Shah , Martin Slater
IPC分类号： A61K31/4025 , A61P31/12 , A61P31/14 , A61P31/20 , C07D417/04 , C07 , A61K31/401 , A61K31/454
CPC分类号： C07D417/04
摘要： Novel anti-viral agents of Formula (I) wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; D represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; E represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts and solvates thereof, processes for their preparation and methods of using them in HCV treatment are provided.
摘要翻译：式（I）的新型抗病毒剂，其中：A表示OR 1，NR 1 R 2或R 1，其中R 1和R 2为氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; B表示C（O）R 3，其中R 3是C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; D表示C 1-6烷基，芳基，杂芳基或杂环基; E表示OR 1，NR 1 R 2或R 1，其中R 1和R 2是氢，C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; F表示氢，C 1-6烷基，芳基或杂芳基; 和G表示氢，C 1-6烷基，杂环基烷基，芳基烷基或杂芳基烷基; 并提供其盐和溶剂化物，其制备方法及其在HCV治疗中的使用方法。

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