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1. 发明申请

US20090182013A1 Derivatives of 5-Thioxylopyranose and Use of Same for Treatment 失效
标题翻译： 5-噻吩多糖的衍生物及其用途
公开(公告)号：US20090182013A1
公开(公告)日：2009-07-16
申请号：US12411783
申请日：2009-03-26
申请人： Veronique Barberousse , Didier Thomas , Michel Bondoux
发明人： Veronique Barberousse , Didier Thomas , Michel Bondoux
IPC分类号： A61K31/4436 , C07D409/12 , A61P7/02
CPC分类号： C07H17/02
摘要： The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.
摘要翻译：本发明涉及5-硫代二糖的新化合物，优选5-硫代吡喃葡糖型衍生物及其制备方法及其作为主要用于治疗或抑制血栓形成或心力衰竭或血栓栓塞性疾病的药物活性成分的用途。

2. 发明申请

US20080293768A1 Novel Compounds Derived From 5-Thioxylose And Their Use In Therapeutics 失效
标题翻译：来自5-硫代木糖的新型化合物及其在治疗中的应用
公开(公告)号：US20080293768A1
公开(公告)日：2008-11-27
申请号：US11909489
申请日：2006-03-24
申请人： Veronique Barberousse , Michel Bondoux , Didier Thomas , Vincent Peyrou
发明人： Veronique Barberousse , Michel Bondoux , Didier Thomas , Vincent Peyrou
IPC分类号： A61K31/4545 , C07D409/12 , C07D409/14 , A61P9/00 , A61K31/4436
CPC分类号： C07H15/203 , C07H17/02
摘要： The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the process for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thrombosis or cardiac insufficiency.
摘要翻译：本发明涉及新的5-硫代木糖化合物，优选5-羟基吡喃糖型衍生物，其制备方法及其作为特别用于治疗或预防血栓形成或心脏功能不全的药物的活性成分的用途。

3. 发明授权

US5169838A Benzopyranone-.beta.-D-thioxylosides and their use in therapy 失效
标题翻译：苯并吡喃酮（BETA）-D-硫氧化物及其在治疗中的应用
公开(公告)号：US5169838A
公开(公告)日：1992-12-08
申请号：US579702
申请日：1990-09-10
申请人： Soth Samreth , Veronique Barberousse , Patrice Renaut , Francois Bellamy , Jean Millet
发明人： Soth Samreth , Veronique Barberousse , Patrice Renaut , Francois Bellamy , Jean Millet
IPC分类号： C07H17/065 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P7/02 , C07D311/06 , C07D311/08 , C07D311/12 , C07D311/14 , C07D311/16 , C07D311/18 , C07D311/22 , C07D311/80 , C07D311/86 , C07H5/10 , C07H17/04 , C07H17/07 , C07H17/075
CPC分类号： C07H17/04 , C07D311/12 , C07D311/14 , C07D311/16 , C07D311/18 , C07D311/22 , C07H17/07 , C07H17/075
摘要： The present invention relates, by way of novel industrial products which are useful in therapy, to the benzopyranone-.beta.-D-thioxyloside compounds of the formula ##STR1## in which: one of the substituents R or R' is an oxygen atom double-bonded to the corresponding cyclic carbon atom and the other is a group R.sub.1,the symbol represents a double bond conjugated to the CO group provided by one of the substituents R or R',X is a sulfur atom or an oxygen atom,R.sub.1 and R.sub.2, which are identical or different, are each a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a halogen atom, a trifluoromethyl group or a phenyl group, it being possible for R.sub.1 and R.sub.2, taken together, to form a 7,8,9,10-tetrahydrodibenzo[b,d]pyran-6-one group or a 1,2,3,4-tetrahydro-9H-xanthen-9-one group with the benzopyranone group to which they are bonded, andY is the hydrogen atom or an aliphatic acyl group.
摘要翻译：本发明通过新颖的可用于治疗的新型工业产品涉及下式（I）的苯并吡喃酮-β-D-硫代西洛昔康化合物，其中：取代基R或R'之一是氧原子与相应的环状碳原子双键连接，另一个为基团R 1，符号表示与一个取代基R或R'，X为硫原子或氧原子提供的与CO基团共轭的双键， R1和R2相同或不同，分别为氢原子，C1-C4烷基，卤素原子，三氟甲基或苯基，R1和R2可以一起形成7 ，8,9,10-四氢二苯并[b，d]吡喃-6-酮基或与其结合的苯并吡喃酮基团的1,2,3,4-四氢-9H-呫吨-9-酮基，以及 Y是氢原子或脂肪族酰基。

4. 发明申请

US20090186840A1 5-Thioxylopyranose Compounds 失效
标题翻译： 5-噻吩基吡喃糖化合物
公开(公告)号：US20090186840A1
公开(公告)日：2009-07-23
申请号：US12411765
申请日：2009-03-26
申请人： Veronique BARBEROUSSE , Didier Thomas , Michel Bondoux
发明人： Veronique BARBEROUSSE , Didier Thomas , Michel Bondoux
IPC分类号： C07H15/20 , A61K31/7034 , A61P9/00
CPC分类号： C07H15/203
摘要： Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.
摘要翻译： 5-硫代羟基吡喃糖的化合物，优选5-硫代吡喃葡萄糖型的衍生物，制备这些化合物的方法，以及这些化合物作为有效成分在药物组合物中的用途，其特别用于治疗或抑制血栓形成或心力衰竭或血栓栓塞性疾病状态。

5. 发明申请

US20090118325A1 5-Thioxylopyranose Compounds 有权
标题翻译： 5-噻吩基吡喃糖化合物
公开(公告)号：US20090118325A1
公开(公告)日：2009-05-07
申请号：US12352382
申请日：2009-01-12
申请人： Didier THOMAS , Michel Bondoux , Veronique Barberousse , Vincent Peyrou
发明人： Didier THOMAS , Michel Bondoux , Veronique Barberousse , Vincent Peyrou
IPC分类号： A61K31/437 , C07D409/02 , A61K31/428 , A61K31/423 , C07D471/02
CPC分类号： C07H1/00 , C07H17/00
摘要： 5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses. The compounds correspond to formula I: in which the pentapyranosyl group represents a free or substituted 5-thio-β-D-xylopyranosyl group; R′, R″ and R′″ each independently represent a hydrogen atom, a C2-C6 acyl group, or two adjacent ones of them form a 1-methylethylidene bridge; X1 and X2 each represent carbon or nitrogen; Y1 and Y2 each independently represent carbon, nitrogen, sulfur or oxygen, with the proviso that if Y2 represents oxygen or sulfur, then Y1 represents carbon or nitrogen; R1, R2, R3, R4 and R5 each independently represent hydrogen, a COOR6 group where R6 represents hydrogen or a C1-C4 alkyl group optionally substituted by a phenyl ring, a halogen atom or a —COOR6 group; a C1-C4 alkoxy group; a C1-C6 acyl group; a benzoyl group or a phenyl ring; and the addition salts and/or active metabolites of such compounds.
摘要翻译： 5-硫代羟基化合物，特别是5-羟基吡喃糖化合物，其制备方法及其用于治疗和/或抑制血栓形成，特别是静脉血栓形成的用途。化合物对应于式I：其中五草酰基代表游离或取代的5-硫代-β-D-吡喃木糖基; R'，R“和R”'各自独立地表示氢原子，C 2 -C 6酰基或其两个相邻的一个形成1-甲基亚乙基桥; X1和X2各自表示碳或氮; Y1和Y2各自独立地表示碳，氮，硫或氧，条件是如果Y2表示氧或硫，则Y1表示碳或氮; R 1，R 2，R 3，R 4和R 5各自独立地表示氢，COOR 6基团，其中R 6表示氢或任选被苯环，卤素原子或-COOR 6基团取代的C 1 -C 4烷基; C1-C4烷氧基; C1-C6酰基; 苯甲酰基或苯环; 和这些化合物的加成盐和/或活性代谢物。

6. 发明申请

US20070054955A1 Novel thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therepeutics. 失效
标题翻译：新型硫代羟基化合物，其制备方法，含有该组合物的药物组合物及其用途。
公开(公告)号：US20070054955A1
公开(公告)日：2007-03-08
申请号：US10572999
申请日：2004-09-24
申请人： Veronique Barberousse , Soth Samreth , Benaissa Boubia , Francois Bellamy , Vincent Peyrou
发明人： Veronique Barberousse , Soth Samreth , Benaissa Boubia , Francois Bellamy , Vincent Peyrou
IPC分类号： A01N43/18
CPC分类号： C07H17/02
摘要： The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the method for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thromboses or cardiac insufficiency.
摘要翻译：本发明涉及新的5-硫代羟基化合物，优选5-羟基吡喃糖型衍生物，其制备方法及其用作特别用于治疗或预防血栓形成或心脏功能不全的药物的活性成分。

7. 发明授权

US06291433B1 Derivatives of &agr;-D-Thioxyloside and their use against atheroma 失效
标题翻译： alpha-D-thioxyloside的衍生物及其对动脉粥样化的影响
公开(公告)号：US06291433B1
公开(公告)日：2001-09-18
申请号：US09486226
申请日：2000-02-24
申请人： Veronique Barberousse , Christiane Legendre , Soth Samreth , Alan Dunlap Edgar
发明人： Veronique Barberousse , Christiane Legendre , Soth Samreth , Alan Dunlap Edgar
IPC分类号： A61K317034
CPC分类号： C07H15/203
摘要： The present invention concerns, as new industrial products, the &agr;-D-xylose compounds of formula I: wherein X and Y represent, independently of one another, an oxygen atom or a sulphur atom, R1 represents a CN, CF3 or SO2CH3 group, and R represents a hydrogen atom or an aliphatic acyl group containing 2 to 5 carbon atoms. It also concerns a method for the preparation and the use in therapeutics of said compounds of the formula I.
摘要翻译：作为新的工业产品，本发明涉及式I的α-D-木糖化合物：其中X和Y彼此独立地表示氧原子或硫原子，R1表示CN，CF3或SO2CH3基，R表示R 表示氢原子或含有2至5个碳原子的脂族酰基。它还涉及用于制备和用于所述式I化合物的治疗剂的方法。

8. 发明授权

US5101048A .beta.-D-phenylthioxylosides, their method of preparation and their use as therapeutic agents 失效
标题翻译：（BETA）-D-苯乙基硫醚，它们的制备方法及其作为治疗剂的使用
公开(公告)号：US5101048A
公开(公告)日：1992-03-31
申请号：US423958
申请日：1989-10-18
申请人： Jerzy Bajgrowicz , Patrice Renaut , Veronique Barberousse , Soth Samreth , Jean Millet , Francois Bellamy
发明人： Jerzy Bajgrowicz , Patrice Renaut , Veronique Barberousse , Soth Samreth , Jean Millet , Francois Bellamy
IPC分类号： C07H5/02 , A61K31/70 , A61K31/7024 , A61K31/7028 , A61K31/7034 , A61P7/02 , C07C323/09 , C07C323/62 , C07C333/04 , C07H5/10 , C07H13/00 , C07H13/04 , C07H15/14 , C07H15/203
CPC分类号： C07H13/04 , C07C323/09 , C07C323/62 , C07C333/04 , C07H13/00 , C07H15/14 , C07H15/203
摘要： The present invention relates, by way of novel industrial products, to the .beta.-D-phenylthioxyloside compounds of the formula ##STR1## in which: X represents a sulfur atom or an oxygen atom;R.sub.1, R.sub.2 and R.sub.3, which are identical or different, each represent a hydrogen atom, a nitro group, a cyano group, a group --CO--R (in which R represents a C.sub.1 -C.sub.4 alkyl group or a trifluoromethyl group), an amino group, an acetamido group (NHCOCH.sub.3), a C.sub.1 -C.sub.4 alkoxy group, a trifluoromethyl group or a phenyl group substituted by one or more cyano, nitro or trifluoromethyl groups, it being possible for R.sub.1 and R.sub.2, taken together, to form, with the phenyl group to which they are bonded, a .beta.-naphthalenyl group which is unsubstituted or substituted by one or more cyano, nitro or trifluoromethyl groups; andY represents the hydrogen atom or an aliphatic acyl group.These compounds are useful as therapeutic agents, especially as venous antithrombotics.
摘要翻译：本发明通过新工业产品涉及式（I）的β-D-苯硫噻酰氯化合物，其中：X表示硫原子或氧原子; R 1，R 2和R 3相同或不同，各自表示氢原子，硝基，氰基，-CO-R基（其中R表示C1-C4烷基或三氟甲基），氨基，乙酰氨基（NHCOCH 3），C 1 -C 4烷氧基，三氟甲基或被一个或多个氰基，硝基或三氟甲基取代的苯基，可以将R 1和R 2一起形成，与它们所键合的苯基，未被取代或被一个或多个氰基，硝基或三氟甲基取代的β-萘基; Y表示氢原子或脂肪族酰基。这些化合物可用作治疗剂，特别是静脉抗血栓药。

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