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1. 发明申请

US20060206160A1 Process and electrostimulation device for treating obesity and/or gastroesophageal reflux disease 审中-公开
标题翻译：用于治疗肥胖症和/或胃食管反流病的过程和电刺激装置
公开(公告)号：US20060206160A1
公开(公告)日：2006-09-14
申请号：US10154012
申请日：2002-05-23
申请人： Valerio Cigaina , Claudia Knippig
发明人： Valerio Cigaina , Claudia Knippig
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/32
摘要： An improved process using electrostimulation for treating obesity and/or related motor disorders is provided. The improved method of this invention provides electrostimulation on the lesser curvature of the stomach. Preferably, the electrostimulation or pacemaker device provides electrostimulation to the lower or distal end of the lesser curvature (i.e., towards the pylorus) for the treatment or control of obesity. Preferably, the electrostimulation or pacemaker device provides electrostimulation to the upper or proximal end of the lesser curvature for the treatment or control of gastroesophageal reflux disease. In one embodiment, the process employs stimulation of the lesser curvature at a rate of about 2 to about 14 pulses/minute with each pulse lasting about 0.5 to about 4 seconds such that there is a pause of about 3 to about 30 seconds between the pulses.
摘要翻译：提供了使用电刺激治疗肥胖症和/或相关运动障碍的改进方法。本发明的改进方法提供对胃较小曲率的电刺激。优选地，电刺激或起搏器装置向较小曲率（即朝向幽门）的下端或远端提供电刺激以用于治疗或控制肥胖症。优选地，电刺激或起搏器装置向较小曲率的上端或近端提供电刺激用于治疗或控制胃食管反流疾病。在一个实施例中，该过程以约2至约14个脉冲/分钟的速率刺激较小的曲率，每个脉冲持续约0.5至约4秒，使得在脉冲之间存在约3至约30秒的暂停。

2. 发明申请

US20060058851A1 Treatment of the autonomic nervous system 失效
标题翻译：治疗自主神经系统
公开(公告)号：US20060058851A1
公开(公告)日：2006-03-16
申请号：US11175626
申请日：2005-07-06
申请人： Valerio Cigaina
发明人： Valerio Cigaina
IPC分类号： A61N1/18
CPC分类号： A61N1/36139 , A61B5/02405 , A61B5/0456 , A61B5/4035 , A61N1/36085
摘要： Systems and methods are provided for modulating the autonomic nervous system by the electrical stimulation of the neuro-muscular system of a patient, and include an implantable electrical system for gastrointestinal stimulation which incorporates a heart rate sensor to indicate the neurovegetative patient condition, to initiate and terminate stimulation at specific locations, and an algorithm to automatically control electrical stimulation frequency, interval, amplitude, or a combination of such parameters for adaptive treatment of obesity, anorexia, other eating disorders, diseases related with the so called “metabolic syndrome” (e.g., impaired glucose tolerance and diabetes type 2, GERD, systemic hypertension, early arterovascular degeneration, early senility, and the like), and disorders related to a pathologic inbalance of the autonomic nervous system.
摘要翻译：提供了系统和方法，用于通过对患者的神经 - 肌肉系统的电刺激来调节自主神经系统，并且包括用于胃肠刺激的可植入电气系统，其包括心率传感器以指示神经递质患者状况，以启动和在特定位置终止刺激，以及自动控制电刺激频率，间隔，幅度或这些参数的组合的算法，用于适应性治疗肥胖症，厌食症，其他进食障碍，与所谓的“代谢综合征”相关的疾病（例如，，糖耐量异常和2型糖尿病，GERD，全身高血压，早期动脉血管变性，早衰等），以及与自主神经系统的病理性失衡相关的疾病。

3. 发明授权

US06606518B1 Apparatus and process for stimulation of a state of complete continence in the neospincter in the preparation of continent neostomies 失效
标题翻译：在大陆新生物体的制备过程中刺激完全控制状态的装置和过程
公开(公告)号：US06606518B1
公开(公告)日：2003-08-12
申请号：US09632834
申请日：2000-08-04
申请人： Valerio Cigaina
发明人： Valerio Cigaina
IPC分类号： A61N136
CPC分类号： A61N1/36007
摘要： The present invention provides an apparatus and process which can stimulate a state of complete continence of the neosphincter in the preparation of continent neostomies. More specifically, the present invention provides an apparatus and process for the stimulation of a state of complete continence of the neosphincter in the preparation of continent neostomies, comprising an electrocatheter with an electrode inserted above the neostomy near, and in electrical contact with, transplanted muscle tissue (i.e., a strip of antral gastric musculature) which has been transplanted to the distal segment of the intestine or other organ where an ostomy has been created. The apparatus and process can restore the organic continence in a subject who has undergone therapeutic alteration of an indispensable segment of the visceral anatomy (i.e., the anus or the urinary bladder), thereby significantly improving quality of life.
摘要翻译：本发明提供了一种能够刺激大脑新生儿准备中的新近视矫正器的完全控制状态的装置和方法。更具体地，本发明提供了一种用于刺激大脑新生儿制备中的新近视矫正器的完全连续状态的装置和方法，该装置和方法包括电导体，其中插入电极插入瘤体附近并与移植的肌肉电接触已经移植到已经产生造口术的肠或其他器官的远端部分的组织（即，胃窦胃肌肉条）。该装置和方法可以恢复已经经历了内脏解剖结构（即肛门或膀胱）不可或缺部分的治疗性改变的受试者的有机控制，从而显着改善生活质量。

4. 发明申请

US20160375256A1 Set Comprising A Totally Implantable Device For Electroneuromodulation And An Implantation Tool Of Said Device 审中-公开
标题翻译：包括用于电子调节的完全植入装置和所述装置的植入工具
公开(公告)号：US20160375256A1
公开(公告)日：2016-12-29
申请号：US15038767
申请日：2014-11-28
申请人： Valerio CIGAINA
发明人： Valerio CIGAINA , Paolo FABRIS , Simone CIGAINA
IPC分类号： A61N1/372 , A61B17/34 , A61N1/05 , A61N1/36 , A61N1/378 , A61N1/375
摘要： The set comprises a totally implantable device (1) for electroneuromodulation for the electric stimulation of the nervous tissue of the wall of the stomach and/or another neuroreceptive biological tissue and an implantation tool (2) of the device (1), the tool (2) comprising an axially hollow longitudinal containment body (6) for said device (1) and a needle (12) incorporated into said containment body (6) and having a tip (13) that projects forwards to a sharp front end (7) of the containment body (6), said needle (12) being connected to a supply conduit (15) of a fluid injectable from said needle (12) into the tissue for the creation of a localised tissue swelling (4) in which said device (1) can be positioned.
摘要翻译：该组包括用于电刺激胃壁和/或另一神经受体生物组织的神经组织和装置（1）的植入工具（2）的电可调谐装置（1），该工具 2）包括用于所述装置（1）的轴向中空的纵向容纳体（6）和结合到所述容纳体（6）中并具有向前突出到锋利前端（7）的尖端（13）的针（12）所述针头（12）连接到可从所述针头（12）注射到所述组织中的流体的供应管道（15），用于产生局部组织肿胀（4），其中所述装置（1）可以定位。

5. 发明授权

US06615084B1 Process for electrostimulation treatment of morbid obesity 有权
标题翻译：电刺激治疗病态肥胖的方法
公开(公告)号：US06615084B1
公开(公告)日：2003-09-02
申请号：US09713556
申请日：2000-11-15
申请人： Valerio Cigaina
发明人： Valerio Cigaina
IPC分类号： A61N108
CPC分类号： A61N1/36007
摘要： An improved process using electrostimulation for treating obesity, especially morbid obesity, and other syndromes related to motor disorders of the stomach is provided. The improved method of this invention provides electrostimulation on the lesser curvature of the stomach, preferably on the lower or distal end of the lesser curvature, which provides improved control of obesity and other syndromes related to motor disorders of the stomach. In one embodiment, the process employs stimulation of the lesser curvature at a rate of about 2 to about 14 pulses/minute with each pulse lasting about 0.5 to about 4 seconds such that there is a pause of about 3 to about 30 between the pulses. Preferably, the pulse rate is about 12 pulses/minute with each pulse lasting about 2 seconds with a pause of about 3 seconds between pulses. Preferably, the pulse amplitude is about 0.5 to about 15 milliamps. More preferable, each pulse consists of a train of micro-bursts with a frequency of about 5 to about 100 sec−1.
摘要翻译：提供了使用电刺激治疗肥胖症，特别是病态肥胖症和与胃运动障碍相关的其他综合征的改进方法。本发明的改进方法提供了胃较小曲率上的电刺激，优选在较小曲率的较低或远端上进行电刺激，这提供了与胃运动障碍相关的肥胖症和其它综合征的改善的控制。在一个实施例中，该过程以约2至约14个脉冲/分钟的速率刺激较小曲率，每个脉冲持续约0.5至约4秒，使得在脉冲之间存在约3至约30的暂停。优选地，脉冲速率为约12脉冲/分钟，每个脉冲持续约2秒，脉冲间隔约3秒。优选地，脉冲振幅为约0.5至约15毫安。更优选地，每个脉冲由具有约5至约100sec -1的频率的微阵列组成。

6. 发明授权

US06411842B1 Implant device for internal-external electromyographic recording, particularly for the in vivo study of electromotor activity of the digestive system 有权
标题翻译：用于内外部肌电图记录的植入装置，特别用于体内研究消化系统的电动机活动
公开(公告)号：US06411842B1
公开(公告)日：2002-06-25
申请号：US09449165
申请日：1999-11-24
申请人： Valerio Cigaina , Francesco Ferraro
发明人： Valerio Cigaina , Francesco Ferraro
IPC分类号： A61B50488
CPC分类号： A61B5/42 , A61B5/0031 , A61B5/04884
摘要： Implant device for internal-external electromyographic recording of the electromotor activity of the digestive system, being of the type that comprises at least one sensor implanted in the viscera to record its electric activity and to provide a device for analysis in vivo of the electric activity of the tract, capable of giving the patient normal freedom of movement.
摘要翻译：用于消除系统的电动机活动的内部外部肌电图记录的植入装置，其包括植入内脏中的至少一个传感器以记录其电活动并提供用于在体内分析电活动的装置该道能够给予患者正常的运动自由。

7. 发明授权

US07664551B2 Treatment of the autonomic nervous system 失效
标题翻译：治疗自主神经系统
公开(公告)号：US07664551B2
公开(公告)日：2010-02-16
申请号：US11175626
申请日：2005-07-06
申请人： Valerio Cigaina
发明人： Valerio Cigaina
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/02405 , A61B5/0456 , A61B5/4035 , A61N1/36085
摘要： Systems and methods are provided for modulating the autonomic nervous system by the electrical stimulation of the neuro-muscular system of a patient, and include an implantable electrical system for gastrointestinal stimulation which incorporates a heart rate sensor to indicate the neurovegetative patient condition, to initiate and terminate stimulation at specific locations, and an algorithm to automatically control electrical stimulation frequency, interval, amplitude, or a combination of such parameters for adaptive treatment of obesity, anorexia, other eating disorders, diseases related with the so called “metabolic syndrome” (e.g., impaired glucose tolerance and diabetes type 2, GERD, systemic hypertension, early arterovascular degeneration, early senility, and the like), and disorders related to a pathologic imbalance of the autonomic nervous system.
摘要翻译：提供了系统和方法，用于通过对患者的神经 - 肌肉系统的电刺激来调节自主神经系统，并且包括用于胃肠刺激的可植入电气系统，其包括心率传感器以指示神经递质患者状况，以启动和在特定位置终止刺激，以及自动控制电刺激频率，间隔，幅度或这些参数的组合的算法，用于适应性治疗肥胖症，厌食症，其他进食障碍，与所谓的“代谢综合征”相关的疾病（例如，，糖耐量异常和2型糖尿病，GERD，全身性高血压，早期动脉血管变性，早衰等），以及与自主神经系统的病理失衡相关的疾病。

8. 发明授权

US06165180A Medical device handle for use in laparoscopic surgery 失效
标题翻译：医疗器械手柄用于腹腔镜手术
公开(公告)号：US06165180A
公开(公告)日：2000-12-26
申请号：US482369
申请日：2000-01-13
申请人： Valerio Cigaina , David Jenkins
发明人： Valerio Cigaina , David Jenkins
IPC分类号： A61N1/05 , A61N1/36 , A61M31/00
CPC分类号： A61N1/05
摘要： An improved handle for a medical device used in laparoscopic surgery is provided. This handle is especially adapted for use with an implant device specifically for electrostimulation and/or electrical monitoring of endo-abdominal tissue or viscera is provided. The implant device has an elongated body equipped with devices to secure it to the tissue to be treated and two or more electric poles that are electrically connected to an electric connection terminal for connection to a power source, means to penetrate the tissue to be treated, and quick-release connecting devices to separate the penetration device from the elongated body. The handle, which is an elongated body, is attached to the proximal end of the implant device or other medical device and has a grasping means at its opposite end for manipulation with laparoscopic forceps.
摘要翻译：提供了用于腹腔镜手术中的医疗装置的改进的手柄。该手柄特别适用于专门用于电刺激和/或内部腹部组织或内脏的电监测的植入装置。植入装置具有细长体，其配备有将其固定到要处理的组织的装置，以及电连接到用于连接到电源的电连接端子的两个或更多个电极，穿透待治疗组织的装置，和快速释放连接装置以将穿透装置与细长体分开。作为细长主体的手柄附接到植入装置或其他医疗装置的近端，并且在其相对端具有抓握装置，以用腹腔镜钳进行操作。

9. 发明授权

US6146391A Laparoscopic forceps 失效
标题翻译：腹腔镜钳
公开(公告)号：US6146391A
公开(公告)日：2000-11-14
申请号：US358955
申请日：1999-07-22
申请人： Valerio Cigaina
发明人： Valerio Cigaina
IPC分类号： A61B17/04 , A61B17/06 , A61B17/28 , A61B17/00
CPC分类号： A61B17/0482 , A61B17/0469 , A61B17/06066 , A61B2017/2926
摘要： The present invention provides laparoscopic forceps which can grasp surgical and/or laparoscopic implements and automatically orient the surgical and/or laparoscopic implements to a predetermined orientation. The forceps are fashioned specifically for grasping the laparoscopic implement, and include grasping mechanisms located at one end of the shaft. The grasping mechanisms include orienting mechanisms effective to orient the implement in a predetermined orientation with respect to the forceps. In favorable embodiments, the grasping mechanism is effective to orient the implement automatically in the predetermined orientation, and consists of two jaws, each jaw including a flat surface and a recessed seat for receiving a portion of the implement defined on the flat surface of at least one of the jaws.
摘要翻译：本发明提供了能够掌握外科手术和/或腹腔镜手术并自动地将外科手术和/或腹腔镜器具定向到预定取向的腹腔镜钳。镊子专门用于抓握腹腔镜器具，并且包括位于轴的一端的抓握机构。把持机构包括有效地将工具相对于镊子定向在预定取向上的定向机构。在有利的实施例中，抓握机构有效地将工具以预定的方向自动定位，并且由两个夹爪组成，每个夹爪包括平坦表面和凹入的座，用于接收至少在平坦表面上限定的工具的一部分颚之一。

10. 发明授权

US08792986B2 Treatment of the autonomic nervous system 有权
标题翻译：治疗自主神经系统
公开(公告)号：US08792986B2
公开(公告)日：2014-07-29
申请号：US12706608
申请日：2010-02-16
申请人： Valerio Cigaina
发明人： Valerio Cigaina
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/02405 , A61B5/0456 , A61B5/4035 , A61N1/36085
摘要： Systems and methods are provided for modulating the autonomic nervous system by the electrical stimulation of the neuro-muscular system of a patient, and include an implantable electrical system for gastrointestinal stimulation which incorporates a heart rate sensor to indicate the neurovegetative patient condition, to initiate and terminate stimulation at specific locations, and an algorithm to automatically control electrical stimulation frequency, interval, amplitude, or a combination of such parameters for adaptive treatment of obesity, anorexia, other eating disorders, diseases related with the so called “metabolic syndrome” (e.g., impaired glucose tolerance and diabetes type 2, GERD, systemic hypertension, early arterovascular degeneration, early senility, and the like), and disorders related to a pathologic inbalance of the autonomic nervous system.
摘要翻译：提供了系统和方法，用于通过对患者的神经 - 肌肉系统的电刺激来调节自主神经系统，并且包括用于胃肠刺激的可植入电气系统，其包括心率传感器以指示神经递质患者状况，以启动和在特定位置终止刺激，以及自动控制电刺激频率，间隔，幅度或这些参数的组合的算法，用于适应性治疗肥胖症，厌食症，其他进食障碍，与所谓的“代谢综合征”相关的疾病（例如，，糖耐量异常和2型糖尿病，GERD，全身高血压，早期动脉血管变性，早衰等），以及与自主神经系统的病理性失衡相关的疾病。

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