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1. 发明授权

US07763466B2 Mesoderm and definitive endoderm cell populations 有权
标题翻译：中胚层和确定的内胚层细胞群
公开(公告)号：US07763466B2
公开(公告)日：2010-07-27
申请号：US10514759
申请日：2003-05-19
申请人： Gordon M. Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
发明人： Gordon M. Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
IPC分类号： C12N5/00 , C12N15/00
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/16 , C12N2501/415 , C12N2506/02 , G01N33/5073
摘要： The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
摘要翻译：本发明提供富集中内胚层和中胚层的细胞群以及富含内胚层的细胞群。本发明的细胞群可用于产生用于细胞替代疗法的细胞。

2. 发明申请

US20080226558A1 Mesoderm and definitive endoderm cell populations 有权
标题翻译：中胚层和确定的内胚层细胞群
公开(公告)号：US20080226558A1
公开(公告)日：2008-09-18
申请号：US12077976
申请日：2008-03-24
申请人： Gordon M. Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
发明人： Gordon M. Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
IPC分类号： C12N5/06 , C12Q1/68 , C12P21/00 , A01K67/027
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/16 , C12N2501/415 , C12N2506/02 , G01N33/5073
摘要： The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
摘要翻译：本发明提供富集中内胚层和中胚层的细胞群以及富含内胚层的细胞群。本发明的细胞群可用于产生用于细胞替代疗法的细胞。

3. 发明授权

US5675060A Transgenic arthritic mice expressing a T-cell receptor transgene 失效
标题翻译：表达T细胞受体转基因的转基因关节炎小鼠
公开(公告)号：US5675060A
公开(公告)日：1997-10-07
申请号：US246242
申请日：1994-05-19
申请人： Christophe O. Benoist , Diane J. Mathis , Valerie Kouskoff
发明人： Christophe O. Benoist , Diane J. Mathis , Valerie Kouskoff
IPC分类号： A01K67/027 , A61K38/00 , A61K48/00 , A61K49/00 , A61P29/00 , C07K14/705 , C07K14/725 , C12N5/10 , C12N9/22 , C12N15/00 , C12N15/02 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/577 , C12N5/00 , C12P15/00
CPC分类号： A01K67/0278 , A01K67/0275 , C07K14/705 , C07K14/7051 , C12N15/8509 , C12N9/22 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , A01K2267/0368
摘要： A transgenic animal model for arthritis is disclosed. The arthritic condition results from genetic (or immunologic) manipulations that result in the T cell receptor (TCR) repertoire of the animal being substantially limited relative to the TCR repertoire of a wildtype control animal. The TCR repertoire of the arthritic animal, albeit limited, is functionally viable. In a preferred embodiment, the invention relates to transgenic arthritic mice wherein arthritis results from (1) a transgenic allele which encodes and expresses TCR .alpha. and .beta. subunits that combine in T lymphocytes of the transgenic animal to form a TCR that recognizes an antigen comprising one or more epitopes of an oligopeptide derived from amino acids 41-61 of bovine pancreatic ribonuclease and/or (2) polypeptide arthritogenic self antigens derived from endogenous proteins. The transgenic arthritic mice of the invention provides an animal model which faithfully mimics rheumatoid arthritis and by which human arthritogenic and therapeutic anti-arthritic compositions are evaluated. Also provided herein are therapeutic oligopeptides derived from the variable regions of the TCRs of the transgenes of the invention and/or from the amino acid sequence of proteins comprising endogenous polypeptide arthritogenic antigens.
摘要翻译：公开了一种用于关节炎的转基因动物模型。遗传（或免疫）操作导致关节炎病症导致动物的T细胞受体（TCR）谱系相对于野生型对照动物的TCR谱系基本上受限制。关节炎动物的TCR谱系尽管有限，但在功能上是可行的。在优选的实施方案中，本发明涉及转基因关节炎小鼠，其中关节炎来自（1）编码和表达在转基因动物的T淋巴细胞中结合的TCRα和β亚基的转基因等位基因，以形成识别包含一个或更多的衍生自牛胰腺核糖核酸酶的氨基酸41-61的寡肽的表位和/或（2）衍生自内源蛋白的多肽关节炎自身抗原。本发明的转基因关节炎小鼠提供了忠实地模仿类风湿性关节炎的动物模型，并且通过该动物模型评价人类关节炎和治疗性抗关节炎组合物。本文还提供衍生自本发明的转基因的TCR的可变区和/或包含内源多肽关节炎抗原的蛋白质的氨基酸序列的治疗性寡肽。

4. 发明授权

US08748171B2 Cell population enriched for endoderm cells 有权
标题翻译：细胞种群富含内胚层细胞
公开(公告)号：US08748171B2
公开(公告)日：2014-06-10
申请号：US12836275
申请日：2010-07-14
申请人： Gordon M Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
发明人： Gordon M Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
IPC分类号： C12N5/00 , C12N15/00
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/16 , C12N2501/415 , C12N2506/02 , G01N33/5073
摘要： The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
摘要翻译：本发明提供富集中内胚层和中胚层的细胞群以及富含内胚层的细胞群。本发明的细胞群可用于产生用于细胞替代疗法的细胞。

5. 发明申请

US20110070203A1 MESENDODERM AND MESODERM CELL POPULATIONS 审中-公开
标题翻译： MESENDODERM和MESODERM细胞群体
公开(公告)号：US20110070203A1
公开(公告)日：2011-03-24
申请号：US12836277
申请日：2010-07-14
申请人： Gordon M. Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
发明人： Gordon M. Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
IPC分类号： A61K35/12 , C12N5/0735 , C12Q1/02 , A61P17/00
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/16 , C12N2501/415 , C12N2506/02 , G01N33/5073
摘要： The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
摘要翻译：本发明提供富集中内胚层和中胚层的细胞群以及富含内胚层的细胞群。本发明的细胞群可用于产生用于细胞替代疗法的细胞。

6. 发明申请

US20120114613A1 DEFINITIVE ENDODERM CELL POPULATIONS 有权
标题翻译：定义细胞群体
公开(公告)号：US20120114613A1
公开(公告)日：2012-05-10
申请号：US12836275
申请日：2010-07-14
申请人： GORDON M. KELLER , VALERIE KOUSKOFF , ATSUSHI KUBO , HANS JOERG FEHLING
发明人： GORDON M. KELLER , VALERIE KOUSKOFF , ATSUSHI KUBO , HANS JOERG FEHLING
IPC分类号： A61K35/12 , G01N33/53 , C12Q1/68 , C12N5/071 , C12Q1/02
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/16 , C12N2501/415 , C12N2506/02 , G01N33/5073
摘要： The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
摘要翻译：本发明提供富集中内胚层和中胚层的细胞群以及富含内胚层的细胞群。本发明的细胞群可用于产生用于细胞替代疗法的细胞。

7. 发明授权

US07955849B2 Method of enriching a mammalian cell population for mesoderm cells 有权
标题翻译：富集中胚层细胞哺乳动物细胞群的方法
公开(公告)号：US07955849B2
公开(公告)日：2011-06-07
申请号：US12077976
申请日：2008-03-24
申请人： Gordon M. Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
发明人： Gordon M. Keller , Valerie Kouskoff , Atsushi Kubo , Hans Joerg Fehling
IPC分类号： C12N5/00 , C12N15/00
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/16 , C12N2501/415 , C12N2506/02 , G01N33/5073
摘要： The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
摘要翻译：本发明提供富集中内胚层和中胚层的细胞群以及富含内胚层的细胞群。本发明的细胞群可用于产生用于细胞替代疗法的细胞。

8. 发明申请

US20060276420A1 Mesoderm and definitive endoderm cell populations 有权
标题翻译：中胚层和确定的内胚层细胞群
公开(公告)号：US20060276420A1
公开(公告)日：2006-12-07
申请号：US10514759
申请日：2003-05-19
申请人： Gordon Keller , Valerie Kouskoff , Atsushi Kubo , Hans Fehling
发明人： Gordon Keller , Valerie Kouskoff , Atsushi Kubo , Hans Fehling
IPC分类号： A61K48/00 , C12Q1/68 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/16 , C12N2501/415 , C12N2506/02 , G01N33/5073
摘要： The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
摘要翻译：本发明提供富集中内胚层和中胚层的细胞群以及富含内胚层的细胞群。本发明的细胞群可用于产生用于细胞替代疗法的细胞。

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