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1. 发明授权

US5043158A Immunogenic compositions containing ordered carriers 失效
标题翻译：含有有序载体的免疫原性组合物
公开(公告)号：US5043158A
公开(公告)日：1991-08-27
申请号：US487729
申请日：1990-03-02
申请人： Uwe B. Sleytr , Wolfgang Mundt , Paul Messner , Richard H. Smith , Frank M. Unger
发明人： Uwe B. Sleytr , Wolfgang Mundt , Paul Messner , Richard H. Smith , Frank M. Unger
IPC分类号： A61K38/00 , A61K39/385 , A61K47/48 , C07K14/32 , C07K14/33 , C07K17/02
CPC分类号： A61K39/385 , A61K47/4833 , C07K14/32 , C07K14/33 , C07K17/02 , A61K2039/6068 , A61K2039/6087 , A61K38/00 , Y10S530/81
摘要： Superior pharmaceutical compositions which comprise carriers coupled to epitope-bearing moieties are described. The carriers are crystalline or paracrystalline glycoproteins, especially those derived from S-layers of microbial cell walls. These conjugates are capable of eliciting the formation of antibodies as well as a T-cell response.
摘要翻译：描述了包含与表位承担部分偶联的载体的优质药物组合物。载体是结晶或副晶体糖蛋白，特别是衍生自微生物细胞壁S层的那些。这些缀合物能够引发抗体的形成以及T细胞应答。

2. 发明授权

US07262281B2 Method of depositing S-layer proteins on a carrier to immobilize functional molecules 失效
标题翻译：在载体上沉积S层蛋白以固定功能性分子的方法
公开(公告)号：US07262281B2
公开(公告)日：2007-08-28
申请号：US10722962
申请日：2003-11-26
申请人： Uwe B. Sleytr , Margit Sara , Wolfgang Kautek
发明人： Uwe B. Sleytr , Margit Sara , Wolfgang Kautek
IPC分类号： C07K1/04 , C07K17/00 , C07K17/02 , C12N11/00 , C12N11/02 , G01N33/543 , G01N33/544
CPC分类号： C07K17/00 , Y10S530/81 , Y10S530/812
摘要： On a carrier surface, a layer of S-layer proteins is produced as a carrier of functional molecules. A solution containing S-layer proteins in the form of monomers or oligomers is brought into contact with the carrier surface. Electrochemical conditions are produced in the solution such that the S-layer proteins (SU) have an electrical net charge by establishing an electrochemical potential difference between the solution and the carrier surface such that the S-layer proteins accumulate on the carrier surface. A two-dimensional crystalline structure is formed in the layer, and this can occur at a time separate from the deposition of the S-layer proteins, and under different electrochemical conditions.
摘要翻译：在载体表面上，产生一层S层蛋白质作为功能分子的载体。使含有单体或低聚物形式的S层蛋白质的溶液与载体表面接触。在溶液中产生电化学条件，使得S层蛋白质（SU）通过在溶液和载体表面之间建立电化学电势差而具有电网电荷，使得S层蛋白质积聚在载体表面上。在该层中形成二维晶体结构，并且这可以在与S层蛋白沉积不同的时间和不同的电化学条件下发生。

3. 发明授权

US07125707B2 Use of secondary cell wall polymer of procaryotic microorganisms 失效
标题翻译：使用原核微生物的二次细胞壁聚合物
公开(公告)号：US07125707B2
公开(公告)日：2006-10-24
申请号：US10258803
申请日：2001-04-24
申请人： Uwe B. Sleytr , Margit Sara , Christoph Mader , Bernhard Schuster , Frank M. Unger
发明人： Uwe B. Sleytr , Margit Sara , Christoph Mader , Bernhard Schuster , Frank M. Unger
IPC分类号： C12N9/58 , B01D61/00
CPC分类号： B01D71/74 , C07K17/10
摘要： A compound body can be constructed, using secondary cell wall polymers of prokaryotic microorganisms as bonding agent to anchor a monomolecular lattice to a support, with or without functional groups attached to the lattice. The lattice may be comprised of lipid or crystalline cell surface layer proteins. The support is illustrated by a micro-filtration membrane, a cell surface ultra-filtration membrane (SUM), and a micelle, respectively.
摘要翻译：可以构建复合体，使用原核微生物的二次细胞壁聚合物作为粘合剂，将单分子晶格锚定到载体上，具有或不具有连接到晶格的官能团。晶格可以由脂质或结晶细胞表面层蛋白组成。支持物分别由微滤膜，细胞表面超滤膜（SUM）和胶束示出。

4. 发明授权

US06296700B1 Method of producing a structured layer 失效
标题翻译：生产结构层的方法
公开(公告)号：US06296700B1
公开(公告)日：2001-10-02
申请号：US09388289
申请日：1999-09-01
申请人： Uwe B. Sleytr , Dietmar Pum , Hans Loschner
发明人： Uwe B. Sleytr , Dietmar Pum , Hans Loschner
IPC分类号： C30B2954
CPC分类号： G03F7/40 , G03F7/004 , G03F7/26
摘要： The invention relates to a method for producing a structured layer of defined functional molecules on the surface of a flat substrate, on the surface of which structures having different surface properties, at least as regards their hydrophobicity, are produced. A monolayer of a protein-containing crystalline cell surface layer (S layer) is deposited by recrystallization on said structured surface. Said S Layer binds only to those structured areas of the surface characterized by raised hydrophobicity. Alternatively, a structured S-layer may also be produced on the basis of a monolayer of an S layer deposited on a substrate by irradiating predefined sections of said layer to be structured with radiation of a predetermined intensity and energy. In the irradiated sections of the S-layer this suppresses the binding or intercalating ability of at least one surface. Functional molecules can bind to or become intercalated in the surface or the intermediate spaces of the crystal lattice, for example for use as bio-sensors.
摘要翻译：本发明涉及一种在平坦基材的表面上制造具有规定功能性分子的结构化层的方法，其表面至少具有与其疏水性有关的表面性能不同的结构。通过在所述结构化表面上重结晶沉积含蛋白质的结晶细胞表面层（S层）的单层。所述S层仅结合表征为具有提高的疏水性的表面的那些结构化区域。或者，还可以通过用预定的强度和能量的辐射照射待构造的所述层的预定部分，基于沉积在衬底上的S层的单层来生产结构化的S层。在S层的照射部分中，这抑制了至少一个表面的结合或嵌入能力。功能分子可以结合或嵌入在晶格的表面或中间空间中，例如用作生物传感器。

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