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1. 发明申请

US20140127172A1 METHODS OF PRESERVING FUNCTIONALITY OF AN ORGAN, PRESERVING FERTILITY OF A PATIENT UNDERGOING A TREATMENT EXPECTED TO CAUSE STERILITY AND ASSURING A SUPPLY OF VIABLE GAMETES FOR FUTURE USE 审中-公开
标题翻译：保护器官功能的方法，保护患者治疗预期导致无效的患者的健康状况，并确保为未来使用的可用游戏供应
公开(公告)号：US20140127172A1
公开(公告)日：2014-05-08
申请号：US14075101
申请日：2013-11-08
申请人： Amir ARAV , Yehudit NATAN , Saar YAVIN , Uri MEIR , Udi DAMARI
发明人： Amir ARAV , Yehudit NATAN , Saar YAVIN , Uri MEIR , Udi DAMARI
IPC分类号： A01N1/02
CPC分类号： A01N1/0284 , A01N1/02
摘要： A method of preserving functionality of an organ is disclosed herein, including removing a whole organ including vasculature from a donor, cryo-preserving the whole organ including vasculature, thawing the whole organ including vasculature so that at least a portion of cells contained therein resume biological activity, and introducing the whole organ including vasculature into a recipient so that a blood vessel in the vasculature is supplied with blood. Further disclosed herein is a method of preserving fertility of a patient undergoing a treatment expected to cause sterility, including removing at least one whole gonadal organ including vasculature from the patient, preserving functionality of the gonadal organ as described herein, conducting the treatment and waiting for an effect thereof to subside, and introducing the gonadal organ into the patient.
摘要翻译：本文公开了一种保护器官的功能的方法，包括从供体中除去包括脉管系统的整个器官，对包括脉管系统在内的整个器官进行低温保存，解冻包括脉管系统的整个器官，使得其中包含的至少一部分细胞恢复生物活动，并将包括脉管系统在内的整个器官引入接受者，使得脉管系统中的血管被供应血液。本文进一步公开的是保持经历预期引起不育的治疗的患者的生育能力的方法，包括从患者中除去至少一个包括脉管系统的整体性腺器官，保护本文所述的性腺器官的功能，进行治疗并等待其效果消退，并将性腺器官引入患者体内。

2. 发明申请

US20070099172A1 Methods and device for freezing and thawing biological samples 审中-公开
标题翻译：冷冻和解冻生物样品的方法和装置
公开(公告)号：US20070099172A1
公开(公告)日：2007-05-03
申请号：US11633431
申请日：2006-12-05
申请人： Amir Arav , Victor Rzepakovsky , Uri Meir
发明人： Amir Arav , Victor Rzepakovsky , Uri Meir
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0268 , A01N1/0284
摘要： A method for changing the temperature of a sample from an initial temperature via an intermediate temperature to a final temperature, one of the initial and final temperatures being above the freezing point of the sample and the other being below the freezing point is provided. The method is for changing the temperature of a sample having minimal dimension in each of two mutually perpendicular cross-sections exceeding 0.5 centimeters, and at least one of the cross-sections having an outer zone and an inner zone.
摘要翻译：提供了将样品从初始温度经由中间温度改变到最终温度的方法，其中初始温度和最终温度之一高于样品的凝固点，另一个温度低于凝固点。该方法是用于在两个相互垂直的横截面中的每一个超过0.5厘米的范围内改变具有最小尺寸的样品的温度，并且至少一个横截面具有外部区域和内部区域。

3. 发明授权

US08580487B2 Methods of preserving functionality of an organ, preserving fertility of a patient undergoing a treatment expected to cause sterility and assuring a supply of viable gametes for future use 失效
公开(公告)号：US08580487B2
公开(公告)日：2013-11-12
申请号：US11102728
申请日：2005-04-11
申请人： Amir Arav , Yehudit Natan , Saar Yavin , Uri Meir , Udi Damari
发明人： Amir Arav , Yehudit Natan , Saar Yavin , Uri Meir , Udi Damari
IPC分类号： A01N1/02
CPC分类号： A01N1/0284 , A01N1/02
摘要： A method of preserving functionality of an organ. The method includes removing a whole organ and associated vasculature, cryo-preserving the whole organ, allowing a period of time to elapse, thawing the whole organ including vasculature and introducing the whole organ into a recipient so that the organ is supplied with blood by vasculature belonging to the recipient. Further disclosed is a method of preserving fertility of a patient undergoing a treatment expected to cause sterility. The method include removing a whole gonadal organ from the patient, cryo-preserving the whole gonadal organ, conducting the treatment and waiting for an effect thereof to subside, thawing the whole gonadal organ and introducing the whole gonadal organ where it is supplied with blood by the vasculature system of the patient. Further disclosed is a method of assuring a supply of viable gametes for future use, the method includes removing a whole gonadal organ from a patient, cryo-preserving the whole gonadal organ, waiting until viable gametes are desired by the patient, thawing the organ and introducing the gonadal organ into the patient so that it is supplied with blood by a vasculature system belonging to the patient.

4. 发明授权

US07659111B2 Method for freezing viable cells 失效
标题翻译：冻存活细胞的方法
公开(公告)号：US07659111B2
公开(公告)日：2010-02-09
申请号：US10488414
申请日：2002-09-05
申请人： Uri Meir , Yoram Amsalem , Yehudit Natan , Amir Arav
发明人： Uri Meir , Yoram Amsalem , Yehudit Natan , Amir Arav
IPC分类号： C12M1/02 , F25D13/06
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0278 , B01L3/5082 , B01L7/5255 , B01L2300/1894 , F25D3/02 , F26B5/06 , Y10S435/809
摘要： A method and a device for improved freezing of biological containing living cells is disclosed. Directional cooling coupled with agitation, preferably rotation, of the vessel containing the biological sample allows for the freezing of large volume samples at much greater rates than before. Whether a sample is large or not, the greater thermal homogeneity during the freezing process as well as the resulting crystal morphology yield a frozen sample which is exceptionally suited for lyophilization.
摘要翻译：公开了一种改善生物体内活细胞冻结的方法和装置。与包含生物样品的容器的搅动，优选旋转的定向冷却允许以比以前更高的速率冷冻大体积样品。无论样品是否大，冷冻过程中的热均匀性以及所得的晶体形态都会产生非常适合冷冻干燥的冷冻样品。

5. 发明申请

US20060057555A1 Method and system for controlling the development of biological entities 审中-公开
标题翻译：控制生物实体发展的方法和制度
公开(公告)号：US20060057555A1
公开(公告)日：2006-03-16
申请号：US10519093
申请日：2003-06-29
申请人： Udi Damari , Amir Shaham , Ginadi Shaham , Uri Meir
发明人： Udi Damari , Amir Shaham , Ginadi Shaham , Uri Meir
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： B01L7/54 , A01N1/02 , A01N1/0242 , C12M21/06 , C12M23/50 , C12M41/14 , C12M41/34 , C12M41/48 , F25C1/20 , F25D3/02 , F25D3/11 , F25D25/005 , F26B5/06 , G01N1/42 , G16H10/40
摘要： A method and system are presented for use in controlling the processing of components, e.g. biological entities. Each component is assigned with a unique machine readable identification mark. Data records are provided representative of matching sets of the identification marks relating to at least two associated components. Each component-containing holder may be provided with the unique machine readable identification mark assigned to the biological entity in the holder. This enables to identify whether the biological entities to be processed relate to the matching set or not.
摘要翻译：提供了一种方法和系统，用于控制组件的处理，例如，生物实体。每个组件都分配有一个唯一的机器可读识别标记。数据记录被提供代表与至少两个关联组件有关的识别标记的匹配集合。每个含组件的保持器可以设置有分配给保持器中的生物实体的独特的机器可读识别标记。这使得能够识别待处理的生物实体是否与匹配集相关。

6. 发明申请

US20090258085A1 Emulsions and methods of their production 审中-公开
标题翻译：乳液及其生产方法
公开(公告)号：US20090258085A1
公开(公告)日：2009-10-15
申请号：US12382467
申请日：2009-03-17
申请人： Uri Meir Bach , Zeev Maor
发明人： Uri Meir Bach , Zeev Maor
IPC分类号： A61K8/06 , A61K33/00 , A61P17/00
CPC分类号： A61K33/00 , A61K8/06 , A61K8/922 , A61K8/965 , A61Q19/00 , A61Q19/08
摘要： An emulsion including Dead Sea water is provided, as well as methods for making and using such an emulsion. The emulsion can also include a structured surfactant.
摘要翻译：提供了包括死海水的乳液，以及制备和使用这种乳液的方法。乳液也可以包括结构化表面活性剂。

7. 发明申请

US20050175975A1 Methods of preserving functionality of an organ, preserving fertility of a patient undergoing a treatment expected to cause sterility and assuring a supply of viable gametes for future use 失效
标题翻译：维持器官功能的方法，保持经历预期会导致不育的治疗的患者的生育能力，并确保为将来使用提供可行的配子
公开(公告)号：US20050175975A1
公开(公告)日：2005-08-11
申请号：US11102728
申请日：2005-04-11
申请人： Amir Arav , Yehudit Natan , Saar Yavin , Uri Meir , Udi Damari
发明人： Amir Arav , Yehudit Natan , Saar Yavin , Uri Meir , Udi Damari
IPC分类号： A01N1/02
CPC分类号： A01N1/0284 , A01N1/02
摘要： A method of preserving functionality of an organ. The method includes removing a whole organ and associated vasculature, cryo-preserving the whole organ, allowing a period of time to elapse, thawing the whole organ including vasculature and introducing the whole organ into a recipient so that the organ is supplied with blood by vasculature belonging to the recipient. Further disclosed is a method of preserving fertility of a patient undergoing a treatment expected to cause sterility. The method include removing a whole gonadal organ from the patient, cryo-preserving the whole gonadal organ,conducting the treatment and waiting for an effect thereof to subside, thawing the whole gonadal organ and introducing the whole gonadal organ where it is supplied with blood by the vasculature system of the patient. Further disclosed is a method of assuring a supply of viable gametes for future use, the method includes removing a whole gonadal organ from a patient, cryo-preserving the whole gonadal organ, waiting until viable gametes are desired by the patient, thawing the organ and introducing the gonadal organ into the patient so that it is supplied with blood by a vasculature system belonging to the patient.
摘要翻译：一种维持器官功能的方法。该方法包括去除整个器官和相关的脉管系统，冷冻保存整个器官，允许一段时间过去，解冻整个器官，包括脉管系统，并将整个器官引入受体，以便通过脉管系统为器官提供血液属于收件人。进一步公开的是保持经历预期导致不育的治疗的患者的生育能力的方法。该方法包括从患者身上清除整个性腺器官，冷冻保存整个性腺器官，进行治疗并等待其效果，使整个性腺器官融化，解冻，并将其中所有供血的性腺器官引入患者的脉管系统。进一步公开了一种确保供应可行配子以供将来使用的方法，该方法包括从患者中去除整个性腺器官，冷冻保存整个性腺器官，等待患者期望可食性配子，解冻器官和将性腺器官引入患者，使其由属于患者的脉管系统供给血液。

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