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1. 发明公开

US20240209456A1 METHODS AND COMPOSITIONS RELATED TO CELL-CYCLE RNA's 审中-公开
公开(公告)号：US20240209456A1
公开(公告)日：2024-06-27
申请号：US18557277
申请日：2022-04-25
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER , UNIVERSITY OF PORTSMOUTH
发明人： Daniel Geoffrey TENEN , Annalisa DI RUSCIO , Alexander K. EBRALIDZE , Colyn CRANE-ROBINSON , Simone UMMARINO
IPC分类号： C12Q1/6886 , C12Q1/6804 , C12Q1/6851 , C12Q1/6869
CPC分类号： C12Q1/6886 , C12Q1/6804 , C12Q1/6869 , C12Q1/6851 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： The present disclosure relates to compositions and methods of treating cancer in a subject in need thereof, relating to a specific non-coding RNA (ncRNA)-S Phase Early RNAs (SPEARs) or inhibitors thereof.

2. 发明申请

US20210038730A1 PEPTIDE NANOFIBERS 有权
公开(公告)号：US20210038730A1
公开(公告)日：2021-02-11
申请号：US17045085
申请日：2019-04-02
申请人： UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION
发明人： Aikaterini LALATSA , Diane LEITE
IPC分类号： A61K47/42 , A61K47/64 , C07K7/06 , A61K31/337 , A61K31/495 , A61K31/704
摘要： a nanofiber comprising a peptide GPCR modulator conjugated to a lipophilic moiety where in the peptide-lipophilic moiety conjugate comprises a poly(proline) type II helix structure.

3. 发明申请

US20220099685A1 METHOD 有权
公开(公告)号：US20220099685A1
公开(公告)日：2022-03-31
申请号：US17426058
申请日：2020-01-28
申请人： University of Portsmouth Higher Education Corporation
发明人： John Young , Sepinoud Firouzmand
IPC分类号： G01N33/68 , G01N33/573 , G01N33/94 , G01N33/50 , A61K31/4025 , A61K31/216 , A61K31/137 , A61K31/4725 , A61K31/46 , A61K31/453 , A61K31/445 , A61K31/222 , A61K31/426 , A61P13/10
摘要： The invention provides a method of diagnosing overactive bladder disorder (OAB), the method comprising: measuring the concentrations of one or more of adenosine triphosphate (ATP), acetylcholine (ACh), nitric oxide (NO) and interleukin 5 (IL-5) in a sample obtained from a subject; normalising the concentrations to the concentration of creatinine (Cr) in the sample; range standardising the normalised concentrations and subject's age to the following values: Age to 120 years old; ATP/Cr to 0.000001; ACh/Cr to 0.1; NO to 20000; IL-5/Cr to 100; wherein the likelihood of having OAB (pOAB)=1/1+e−x, where X=one or more of the following: (a) (−2.688±1.050)+5.472±2.098×subject's age+1.356±0.559×Gender (Female=1, Male=0)+(−7.998±40.273)×[IL-5/Cr]; (b) (−2.141±0.966)+4.506±1.902×subject's age+1.034±0.519×Gender (Female=1, Male=0)+(−5294.063±9075.456)×[ACh/Cr]; (c) (−2.825±1.072)+5.964±2.167×subject's age+1.312±0.562×Gender (Female=1, Male=0)+17.790±58.762×[IL-5/Cr]+(−9180.821±12700.057)×[ACh/Cr]; (d) (−2.993±1.197)+5.580±2.309×subject's age+1.724±0.719×Gender (Female=1, Male=0)+63.571±73.444×[IL-5/Cr]+(−0908.523±13606.752)×[ACh/Cr]+(−566.991±636.589)×[ATP/Cr]; (e) (−3.090±1.200)+5.393±2.256×subject's age+1.797±0.717×Gender (Female=1, Male=0)+34.767±56.331×[IL-5/Cr]+(−562.743±629.316)×[ATP/Cr]; or (f) (−2.650±1.067)+5.516±2.120×subject's age+1.389±0.583×Gender (Female=1, Male=0)+(−4.060±45.238)×[IL-5/Cr]+(−1.456±6.833)×[NO/Cr]; and wherein a pOAB above a threshold indicates that the subject has a high likelihood of having or developing OAB and a pOAB below a threshold indicates that the subject does not have OAB.

4. 发明申请

US20170349946A1 CELL ASSAY KIT AND METHOD 审中-公开
公开(公告)号：US20170349946A1
公开(公告)日：2017-12-07
申请号：US15527235
申请日：2015-10-23
申请人： UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION
发明人： Qian AN , Helen FILLMORE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6806 , C12Q2600/16
摘要： The application describes a cell line identification assay kit comprising: (a) one or more genotyping agents; (b) one or more rodent-specific agents; (c) one or more mycoplasma-specific markers; and optionally (d) one or more gender-specific markers.

5. 发明授权

US11208642B2 Microbial syringol utilization 有权
公开(公告)号：US11208642B2
公开(公告)日：2021-12-28
申请号：US16684206
申请日：2019-11-14
申请人： Alliance for Sustainable Energy, LLC , Montana State University , University of Portsmouth
发明人： Gregg Tyler Beckham , Jennifer DuBois , Melodie M. Machovina , Simon James Bradshaw Mallinson , John E. McGeehan , Christopher W. Johnson , Alexander William Meyers
IPC分类号： C12N9/16 , C12N9/42
摘要： Disclosed herein are compositions of non-naturally occurring enzymes to enable microbial syringol utilization with GcoAB.

6. 发明申请

US20210130894A1 Cell Assay Kit and Method 有权
公开(公告)号：US20210130894A1
公开(公告)日：2021-05-06
申请号：US17141828
申请日：2021-01-05
申请人： University of Portsmouth Higher Education Corporation
发明人： Qian An , Helen Fillmore
IPC分类号： C12Q1/6881 , C12Q1/6806
摘要： The application describes a cell line identification assay kit comprising: (a) one or more genotyping agents; (b) one or more rodent-specific agents; (c) one or more mycoplasma-specific markers; and optionally (d) one or more gender-specific markers.

7. 发明公开

US20230151340A1 PLASTIC DEGRADING FUSION PROTEINS AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：US20230151340A1
公开(公告)日：2023-05-18
申请号：US17921833
申请日：2021-05-10
申请人： Alliance for Sustainable Energy, LLC , University of Portsmouth
发明人： Gregg Tyler BECKHAM , Erika Marie ERICKSON , John E. MCGEEHAN
IPC分类号： C12N9/18 , C08J11/10 , B09B3/60
CPC分类号： C12N9/18 , C08J11/105 , B09B3/60 , C08J2367/02 , C07K2319/00 , B09B2101/75
摘要： The present disclosure relates to a non-naturally occurring enzyme that includes a first polypeptide that catalyzes the hydrolysis of a polyester to produce mono-(2-hydroxyethyl) terephthalate (MHET), a second polypeptide that catalyzes the cleavage of MHET to produce at least one of terephthalic acid or ethylene glycol, and a third polypeptide that links the first polypeptide with the second polypeptide.

8. 发明公开

US20240207914A1 POLYMER DEGRADING ENZYMES 审中-公开
公开(公告)号：US20240207914A1
公开(公告)日：2024-06-27
申请号：US18556064
申请日：2022-04-20
申请人： Alliance for Sustainable Energy, LLC , UNIVERSITY OF PORTSMOUTH
发明人： Erika Marie ERICKSON , Gregg Tyler BECKHAM , Japheth Emi GADO , John E. MCGEEHAN , Christina Marie PAYNE
IPC分类号： B09B3/60 , C12N1/20 , C12N9/18 , C12N15/70 , B09B101/75
CPC分类号： B09B3/60 , C12N1/20 , C12N9/18 , C12N15/70 , C12Y301/01 , B09B2101/75
摘要： Disclosed herein are PET hydrolase enzymes, and their nucleic acid and amino acid sequences. A number of candidates have been identified with detectable, quantifiable activity on PET and these enzymes possess desirable traits that are leveraged in the design and engineering of enzyme formulations targeted to degrade specific polymers. These enzymes have measurable PET degrading activity and, in an embodiment, may be active polyester polyurethanes.

9. 发明申请

US20210080473A1 URINE MARKERS AND FORMULA FOR DIAGNOSING OVERACTIVE BLADDER DISORDER 有权
公开(公告)号：US20210080473A1
公开(公告)日：2021-03-18
申请号：US16970327
申请日：2019-02-18
申请人： University of Portsmouth Higher Education Corporation
发明人： John S. Young , Sepinoud Firouzmand
IPC分类号： G01N33/68 , G16B40/00
摘要： The present invention relates to a method of diagnosing over active bladder disorder (OAB), the method comprising: measuring the concentrations of adenosine triphosphate (ATP), acetylcholine (ACh), nitrite, monocyte chemoattractant protein 1 (MCP-1) and interleukin 5 (IL-5) in a sample obtained from a subject; normalising the concentrations to the concentration of creatinine (Cr) in the sample; range standardising the normalised concentrations and subject's age to the following values: Age to 120 years old; ATP/Cr to 0.000001 mole/mgxdl−1; ACh/Cr to 0.1 mole/mgxdl−1; Nitrite to 200 nM/mgxdl−1; MCP-1/Cr to 100 pgxml−1/mgxdl−1; IL-5/Cr 100 pgxml-mgxdl−1; applying the normalised and range standardised concentrations to the following formula: Logit (p)=−1.738±1.404±4.985±2.914×subject's age+3315.959±5435.254×[ATP]/[Cr]+(−25204.194±20268.337)×[ACh]/[Cr]+26.799±32.967×[nitrite]/[Cr]+6.755±25.132 [MCP-1]/[Cr]+(−61.838±148.740) [IL-5]/[Cr] and calculating Logit; wherein a Logit value above a predetermined threshold indicates that the subject has OAB. Methods for monitoring the progression of OAB using the method, kits for use in the method and computer systems and programs configured to execute the method are also provided.

10. 发明申请

US20140087972A1 METHOD OF IMMOBILISING RNA ONTO A SURFACE 有权
标题翻译：将RNA固定在表面上的方法
公开(公告)号：US20140087972A1
公开(公告)日：2014-03-27
申请号：US14116390
申请日：2012-05-14
申请人： UNIVERSITY OF PORTSMOUTH
发明人： Anastasia Jane Callaghan
IPC分类号： C12N15/10
CPC分类号： C12N15/1093 , C12Q1/6837 , C12Q2525/205 , C12Q2563/131 , C12Q2565/515 , C12Q2521/119 , C12Q2525/143
摘要： The invention relates to a method of immobilising at least one RNA molecule onto a surface of a support comprising: i) providing a first support having a surface on which at least one DNA molecule is immobilised, wherein the DNA molecule encodes an RNA molecule and the encoded RNA molecule comprises a binding molecule; ii) providing a second support having a surface on which at least one binding partner for interacting with the binding molecule is immobilised; iii) arranging the first and second supports such that the surfaces displaying the immobilised molecules are in close proximity and substantially face each other, and contacting the DNA molecule immobilised on the surface of the first support with transcription reagents; and iv) carrying out a transcription reaction to generate the encoded RNA molecule, wherein the RNA molecule is directly immobilised onto the surface of the second support via an interaction between the binding molecule of the RNA molecule and the binding partner on the surface of the second support.
摘要翻译：本发明涉及将至少一种RNA分子固定在载体表面上的方法，其包括：i）提供具有表面的第一载体，其上至少固定有至少一个DNA分子，其中DNA分子编码RNA分子，编码的RNA分子包含结合分子; ii）提供具有其上固定有至少一个与结合分子相互作用的结合配偶体的表面的第二载体; iii）布置第一和第二支撑体，使得显示固定化分子的表面紧密相邻并且基本上彼此面对，并使固定在第一载体表面上的DNA分子与转录试剂接触; 和iv）进行转录反应以产生编码的RNA分子，其中所述RNA分子经由RNA分子的结合分子与第二支持物的表面上的结合配偶体之间的相互作用直接固定在第二支持体的表面上支持。

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