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1. 发明申请

US20220265832A1 THIXOTROPIC DELIVERY SYSTEMS 有权
公开(公告)号：US20220265832A1
公开(公告)日：2022-08-25
申请号：US17637713
申请日：2020-06-25
申请人： UNIVERSITY OF MONTANA
发明人： Monica Serban
IPC分类号： A61K47/36 , A61K47/34 , A61K31/496 , A61K31/407 , A61K9/06 , A61K47/24
摘要： The present disclosure provides compositions comprising a hydrolyzed tetraethyl orthosilicate (TEOS) and at least one macromolecule selected from the group consisting of hyaluronan and silk fibroin and methods of making thereof. The disclosure further provides methods of using the composition for delivery of an active agent and for treatment of diseases and disorders. Also provided are delivery devices and kits comprising the disclosed composition.

2. 发明申请

US20210199656A1 Apparatus and Method for the Detection of Bioaerosols 有权
公开(公告)号：US20210199656A1
公开(公告)日：2021-07-01
申请号：US17271494
申请日：2019-08-30
申请人： University of Montana
发明人： Aaron Cody Youngbull , Timothy Burgin
IPC分类号： G01N33/569 , G01N15/06 , G01N1/22 , G01N33/543
摘要： An autonomous bioaerosol sampling and detection system and method adapted to provide real-time detection and identification of bio-organisms in aerosols without human intervention.

3. 发明授权

US10227332B2 T-type calcium channel modulator and uses thereof 有权
公开(公告)号：US10227332B2
公开(公告)日：2019-03-12
申请号：US15518473
申请日：2015-10-15
申请人： UTI Limited Partnership , University of Montana
发明人： Gerald Werner Zamponi , Philippe Diaz
IPC分类号： C07D209/88 , C07D403/12 , C07D401/12
摘要： The present invention provides T-type calcium channel modulators and methods for producing and using the same. In some embodiments, compounds of the invention are of the formula: where R1 is selected from the group consisting of alkyl, alkenyl, polyether, alkoxy and cycloalkyl; X is selected from the group consisting of methylene, —C(═O)—[NR4]a—, —C(═S)—, and —S(═O)b; R2 is selected from the group consisting of heterocycloalkyl and heteroaryl; R3 is selected from the group consisting of alkyl, alkenyl, polyether, alkoxy, cycloalkyl, —NR5R6, —C(═O)NR5R6, —C(═O)ORa (where Ra is alkyl, typically C1-C8 alkyl, often C2-C6 alkyl, and in one particular embodiment Ra is tert-butyl), and —SO2NR5R6; R4 is hydrogen, alkyl, or a nitrogen protecting group; each of R5 and R6 are independently selected from the group consisting of hydrogen and alkyl; a is 0 or 1; b is 1 or 2; n=1 to 3; and m=0 to 1.

4. 发明授权

US09499472B2 Aspartylamide inhibitors of excitatory amino acid transporters 有权
标题翻译：兴奋性氨基酸转运蛋白的天冬氨酰胺抑制剂
公开(公告)号：US09499472B2
公开(公告)日：2016-11-22
申请号：US14382508
申请日：2013-03-05
申请人： THE UNIVERSITY OF MONTANA
发明人： John M. Gerdes , Richard J. Bridges , Syed K. Ahmed , Sarjubhai Patel
IPC分类号： A61K51/00 , A61M36/14 , C07C69/635 , C07C237/04 , C07B59/00 , A61K51/04 , C07C67/317 , C07F7/22
CPC分类号： C07C69/635 , A61K51/04 , C07B59/001 , C07B2200/05 , C07C67/317 , C07C237/04 , C07C2603/18 , C07F7/2208
摘要： The compounds of the invention are inhibitors of excitatory amino acid transporters (EAAT) that penetrate the blood-brain barrier to access the central nervous system. The compounds of the invention follow the structural formula: or a salt, ester or prodrug thereof, wherein X is a halogen, such as fluorine, or a radionuclide, such as fluorine-18. The compounds and methods described herein can be used for the treatment of, e.g., neurodegenerative disorders (e.g., amyotrophic lateral sclerosis), ischemia, spinal cord injury, and traumatic brain injury in a patient (e.g., a human). The invention further provides compounds and methods for the synthesis and use of radiographic tracers to diagnose and follow the progression of such disorders.

5. 发明申请

US20160200703A1 NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE 有权
标题翻译：细胞色素P450 26新戊酸羟化酶的新型特异性抑制剂
公开(公告)号：US20160200703A1
公开(公告)日：2016-07-14
申请号：US14912479
申请日：2014-08-20
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , UNIVERSITY OF MONTANA
发明人： Philippe DIAZ , Nina ISOHERRANEN , Brian BUTTRICK , Nicolas GUILLOTEAU
IPC分类号： C07D339/06 , C07C323/65 , C07C69/616 , C07C59/72 , C07C59/86 , C07C59/54 , C07C229/44 , C07C229/42 , C07D317/30 , C07C69/738 , C07C323/62 , C07C69/734
CPC分类号： C07D317/30 , C07C57/50 , C07C59/54 , C07C59/72 , C07C59/86 , C07C69/616 , C07C69/73 , C07C69/734 , C07C69/738 , C07C229/42 , C07C229/44 , C07C317/44 , C07C323/62 , C07C323/65 , C07C2602/10 , C07C2602/28 , C07C2603/74 , C07D339/06
摘要： The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions comprise compounds of formula (I). A repreid50000060307390 IB/345 nullsents aryl optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, and C1-C6 haloalkoxy; X is a bond, —CH2—, —CHR5—, —C═CHR4—, —NR4—, —N═O—R4—, —O—, —S—, —SO—, —SO2—, —C(O)—, or —C(NR4)—, or X is of formula (a), (b) or (c), wherein each n is independently 1, 2, or 3; each R4 is independently hydrogen or C1-6 alkyl; R5 is independently hydrogen, C1-6 alkyl, or —OR6, where R6 is selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyL C3-12 cycloalkyl, heterocyclyl, aryl, arylC1-6 alkyl, heteroaryl, or heteroarylC1-6 alkyl; Y is C1-6 alkylene, C2-6 alkenylene, or C2-6 alkylylene moiety.
摘要翻译：本公开一般涉及用于治疗通过抑制CYP26介导的视黄酸代谢而改善的疾病的组合物和方法。组合物包含式（I）的化合物。氰基，硝基，C 1-6烷基，C 1-6卤代烷基，-NH 2，-NH（C 1 -C 6烷基），C 1 -C 6卤代烷基，，-N（C 1 -C 6烷基）2，-OH，C 1 -C 6烷氧基和C 1 -C 6卤代烷氧基; X是键，-CH 2 - ， - CHR 5 - ， - C = CHR 4 - ， - NR 4 - ， - N = O-R 4 - ， - O - ， - S - ， - SO - ， - SO 2 - O） - 或-C（NR 4） - 或X具有式（a），（b）或（c），其中每个n独立地为1,2或3; 每个R 4独立地是氢或C 1-6烷基; R5独立地是氢，C1-6烷基或-OR6，其中R6选自氢，C1-6烷基，C2-6烯基，C2-6炔基C3-12环烷基，杂环基，芳基，芳基C1- 6烷基，杂芳基或杂芳基C 1-6烷基; Y是C 1-6亚烷基，C 2-6亚烯基或C 2-6亚烷基部分。

6. 发明授权

US09315624B2 Hydroxypolyamide gel forming agents 有权
公开(公告)号：US09315624B2
公开(公告)日：2016-04-19
申请号：US14107297
申请日：2013-12-16
申请人： THE UNIVERSITY OF MONTANA
发明人： Donald E. Kiely , Tyler N. Smith
IPC分类号： C08G69/26 , C08G69/28 , C08J3/075 , A01N25/04 , A61K47/34 , C05G3/00 , C08K3/22 , C08K3/26 , C08K3/28 , C08K3/32 , C08K5/05 , C08K5/21 , C08K5/41 , C08L5/00 , C08L77/06 , C08L89/00
CPC分类号： C08G69/28 , A01N25/04 , A61K47/34 , C05B7/00 , C05C5/02 , C05C9/00 , C05G3/0064 , C05G3/0076 , C08G69/26 , C08G69/265 , C08J3/075 , C08J2377/06 , C08K3/22 , C08K3/26 , C08K3/28 , C08K3/32 , C08K5/05 , C08K5/21 , C08K5/41 , C08K2003/324 , C08L5/00 , C08L77/06 , C08L89/00 , C08L2201/54 , C08L2201/56 , C08L2203/02
摘要： Hydroxypolyamides, hydroxypolyamide products, and post-hydroxypolyamides are disclosed as gel forming agents. Hydroxypolyamides and post-hydroxypolyamides are prepared from known methods. Hydroxypolyamide products are produced from a modified polymerization procedure which utilizes strong base for deprotonation of ammonium salts from the esterification of stoichiometrically equivalent polyacid:polyamine salts. The hydroxypolyamide products are capable of gel formation at lower concentrations than hydroxypolyamides and post-hydroxypolyamides from the known methods of preparation, and are therefore superior gel forming agents.

7. 发明申请

US20150368213A1 Novel Inhibitors of System Xc- 审中-公开
标题翻译：新型抑制剂Xc-
公开(公告)号：US20150368213A1
公开(公告)日：2015-12-24
申请号：US14744707
申请日：2015-06-19
申请人： The University of Montana, Missoula, MT
发明人： Nicholas R. Natale , Richard J. Bridges , Sarjubhai A. Patel , Nathan S. Duncan , Matthew J. Weaver , Mariusz P. Gajewski
IPC分类号： C07D261/08 , C07C311/42 , A61K49/00 , C07D261/18 , A61K51/04
CPC分类号： C07D261/08 , A61K49/0052 , A61K51/0453 , C07C311/42 , C07D261/18
摘要： The present invention is directed to novel inhibitors of system Xc−, also known as the cystine/glutamate antiporter. The present invention is further directed to methods of treating and detecting cancer that overexpresses system Xc− which includes but is not limited to gliomas (including glioblastoma), triple negative breast cancer, and bladder cancer. The present invention is further directed to methods of treating seizures including epileptic seizures.
摘要翻译：本发明涉及系统Xc-，也称为胱氨酸/谷氨酸反转录酶的新型抑制剂。本发明还涉及治疗和检测过表达系统Xc的癌症的方法，其包括但不限于神经胶质瘤（包括成胶质细胞瘤），三阴性乳腺癌和膀胱癌。本发明还涉及治疗癫痫发作的方法，包括癫痫发作。

8. 发明授权

US09162959B2 Method of oxidation using nitric acid 有权
标题翻译：使用硝酸的氧化方法
公开(公告)号：US09162959B2
公开(公告)日：2015-10-20
申请号：US14150633
申请日：2014-01-08
申请人： The University of Montana
发明人： Donald E. Kiely , Kirk R. Hash, Sr.
IPC分类号： C07C51/00 , C07C51/27
CPC分类号： C07C51/27 , C07C51/00 , C07C59/285
摘要： A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids. Oxidation of some carbohydrates by this process can produce one or more of their corresponding acid forms. The process is carried out at moderate temperatures, typically in the range of 20° C. to 45° C. in a closed reactor, with oxygen gas being introduced into the reaction chamber as needed in order to sustain the reaction. Computer controlled reactors allow for careful and reproducible control of reaction parameters. Nitric acid can be recovered by a distillation/evaporation process, or by diffusion dialysis, the aqueous solution made basic with inorganic hydroxide, and the residual inorganic nitrate removed using a filtration (nanofiltration) device. The method eliminates issues of thermal control of the oxidation, release of nitrogen into the atmosphere, and post-reaction difficulties in the removal of nitric acid and inorganic nitrates.
摘要翻译：使用使用氧和硝酸作为辅助氧化剂的受控硝酸方法将经受硝酸氧化的有机化合物氧化成其相应的羧酸。通过该方法氧化一些碳水化合物可以产生一种或多种相应的酸形式。该方法在中等温度下进行，通常在封闭反应器中在20℃至45℃的范围内，根据需要将氧气引入反应室，以维持反应。计算机控制的反应器允许仔细和可重复地控制反应参数。硝酸可以通过蒸馏/蒸发过程或通过扩散透析回收，水溶液用无机氢氧化物制成碱性，并且使用过滤（纳滤）装置除去残留的无机硝酸盐。该方法消除了氧化的热控制，氮气释放到大气中的问题，以及去除硝酸和无机硝酸盐的后反应困难。

9. 发明申请

US20150023878A1 Novel Aspartylamide Inhibitors of Excitatory Amino Acid Transporters 审中-公开
标题翻译：兴奋性氨基酸转运蛋白的新型天冬氨酰胺抑制剂
公开(公告)号：US20150023878A1
公开(公告)日：2015-01-22
申请号：US14382508
申请日：2013-03-05
申请人： THE UNIVERSITY OF MONTANA
发明人： John M. Gerdes , Richard J. Bridges , Syed K. Ahmed , Sarjubhai Patel
IPC分类号： C07C69/635 , C07C67/317 , C07F7/22 , A61K51/04 , C07B59/00
CPC分类号： C07C69/635 , A61K51/04 , C07B59/001 , C07B2200/05 , C07C67/317 , C07C237/04 , C07C2603/18 , C07F7/2208
摘要： The compounds of the invention are inhibitors of excitatory amino acid transporters (EAAT) that penetrate the blood-brain barrier to access the central nervous system. The compounds of the invention follow the structural formula: or a salt, ester or prodrug thereof, wherein X is a halogen, such as fluorine, or a radionuclide, such as fluorine-18. The compounds and methods described herein can be used for the treatment of, e.g., neurodegenerative disorders (e.g., amyotrophic lateral sclerosis), ischemia, spinal cord injury, and traumatic brain injury in a patient (e.g., a human). The invention further provides compounds and methods for the synthesis and use of radiographic tracers to diagnose and follow the progression of such disorders.
摘要翻译：本发明的化合物是穿透血脑屏障进入中枢神经系统的兴奋性氨基酸转运蛋白（EAAT）的抑制剂。本发明的化合物遵循以下结构式：或其盐，酯或前药，其中X为卤素，如氟，或放射性核素如氟-18。本文所述的化合物和方法可用于治疗例如患者（例如人）中的神经变性疾病（例如肌萎缩性侧索硬化），缺血，脊髓损伤和创伤性脑损伤。本发明还提供了用于合成和使用放射照相示踪剂以诊断和跟踪这些疾病进展的化合物和方法。

10. 发明申请

US20140358462A1 APPARATUSES AND METHODS FOR TESTING ELECTROCHEMICAL CELLS BY MEASURING FREQUENCY RESPONSE 审中-公开
标题翻译：通过测量频率响应测试电化学电池的方法和方法
公开(公告)号：US20140358462A1
公开(公告)日：2014-12-04
申请号：US14296321
申请日：2014-06-04
申请人： Battelle Energy Alliance, LLC , Montana Tech of the University of Montana , Qualtech Systems, Inc.
发明人： Jon P. Christophersen , John L. Morrison , William H. Morrison , Patrick A. Bald
IPC分类号： G01R31/36
CPC分类号： G01R31/392 , G01R31/389
摘要： Real-time battery impedance spectra are acquired by stimulating a battery or battery system with a signal generated as a sum of sine signals at related frequencies. An impedance measurement device can be used to interface between the battery system and a host computer for generating the signals. The impedance measurement device may be calibrated to adapt the response signal to more closely match other impedance measurement techniques. The impedance measurement device may be adapted to operate at mid-range voltages of about 50 volts and high-range voltages up to about 300 volts.
摘要翻译：通过以相关频率的正弦信号的和产生的信号来刺激电池或电池系统来获取实时电池阻抗谱。阻抗测量装置可用于在电池系统和主计算机之间进行接口以产生信号。可以校准阻抗测量装置以使响应信号更适应其他阻抗测量技术。阻抗测量装置可以适于在约50伏的中等范围电压和高达约300伏的高范围电压下工作。

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