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1. 发明申请

US20140255414A1 DIAGNOSTIC ANTIBODY ASSAY 有权
标题翻译：诊断抗体测定
公开(公告)号：US20140255414A1
公开(公告)日：2014-09-11
申请号：US14280919
申请日：2014-05-19
申请人： Martin Kleinschmidt , Stephan Schilling , Jens-Ulrich Rahfeld , Kristin Ebermann , Hans-Ulrich Demuth
发明人： Martin Kleinschmidt , Stephan Schilling , Jens-Ulrich Rahfeld , Kristin Ebermann , Hans-Ulrich Demuth
IPC分类号： C07K16/18 , G01N33/68
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.
摘要翻译：用于诊断淀粉样变性，特别是阿尔茨海默病的新型诊断测定法和相关方面。特别地，提供单克隆抗体和抗体测定。

2. 发明授权

US08486940B2 Inhibitors 有权
公开(公告)号：US08486940B2
公开(公告)日：2013-07-16
申请号：US12880369
申请日：2010-09-13
申请人： Ulrich Heiser , Daniel Ramsbeck , Robert Sommer , Antje Meyer , Torsten Hoffmann , Livia Boehme , Hans-Ulrich Demuth
发明人： Ulrich Heiser , Daniel Ramsbeck , Robert Sommer , Antje Meyer , Torsten Hoffmann , Livia Boehme , Hans-Ulrich Demuth
IPC分类号： A61K31/535 , A61K31/497 , A61K31/42 , A61K31/415 , A61K31/40 , C07D211/06 , C07D265/30 , C07D241/02 , C07D263/02 , C07D233/02
CPC分类号： C07D403/04 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K45/06 , C07D235/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

3. 发明申请

US20130116290A1 Use of Dipeptidyl Peptidase IV Effectors for Normalizing the Blood Glucose Level in Mammals 审中-公开
标题翻译：使用二肽基肽酶IV效应物来调节哺乳动物血糖水平
公开(公告)号：US20130116290A1
公开(公告)日：2013-05-09
申请号：US13458484
申请日：2012-04-27
申请人： Hans-Ulrich Demuth , Fred Rosche , Joem Schmidt , Robert P. Pauly , Christopher H.S. McIntosh , Ray A. Pederson
发明人： Hans-Ulrich Demuth , Fred Rosche , Joem Schmidt , Robert P. Pauly , Christopher H.S. McIntosh , Ray A. Pederson
IPC分类号： A61K31/426
CPC分类号： A61K31/426 , A61K9/0019 , A61K9/0053 , A61K31/00 , A61K31/40 , A61K31/401
摘要： The present invention comprises the use of activity-reducing effectors of dipeptidyl peptidase (DP IV) and DP IV-analogous enzyme activity in the blood of a mammal to lower elevated post-prandial and basal blood glucose levels in mammalian organisms. The invention further comprises the use of activity-reducing effectors of dipeptidyl peptidase (DP IV) and DP IV-analogous enzyme activity in the blood of a mammal to increase the half-life of incretins in vivo.
摘要翻译：本发明包括使用哺乳动物血液中二肽基肽酶（DP IV）的活性降低作用剂和DP IV类似酶活性降低哺乳动物生物体内升高的餐后和基础血糖水平。本发明还包括在哺乳动物的血液中使用二肽基肽酶（DP IV）的活性降低效应物和DP IV-类似酶活性以增加体内胰岛素的半衰期。

4. 发明申请

US20120070444A1 IN VIVO SCREENING MODELS FOR TREATMENT OF isoQC-RELATED DISORDERS 审中-公开
标题翻译：用于治疗等质量相关疾病的生殖器筛查模型
公开(公告)号：US20120070444A1
公开(公告)日：2012-03-22
申请号：US13225033
申请日：2011-09-02
申请人： Sigrid Graubner , Reinhard Sedlmeier , Andreas Becker , Stephan Schilling , Holger Cynis , Hans-Ulrich Demuth
发明人： Sigrid Graubner , Reinhard Sedlmeier , Andreas Becker , Stephan Schilling , Holger Cynis , Hans-Ulrich Demuth
IPC分类号： A61K38/45 , C07K16/00 , A61K49/00 , A01K67/027 , A61P1/04 , A61P25/00 , A61P25/28 , A61P35/00 , A61P31/04 , A61P25/18 , A61P15/00 , A61P29/00 , A61P35/04 , A61P17/06 , A61P11/00 , A61P1/16 , A61P3/00 , A61P5/00 , C12N5/10
CPC分类号： A01K67/0278 , A01K67/0275 , A01K2217/052 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/0312 , A01K2267/0318 , C12N9/104 , C12N15/8509 , C12Y203/02005 , G01N33/5088 , G01N2333/9108 , G01N2500/10
摘要： A transgenic non-human animal for overexpressing isoQC, comprising cells containing a DNA transgene encoding human isoQC, characterized in that said human isoQC comprises the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 75% sequence identity to the amino acid sequence of SEQ ID NO: 1 or a fragment or derivative of the amino acid sequence of SEQ ID NO: 1. Additionally disclosed is a method of screening for biologically active agents that inhibit or promote isoQC.
摘要翻译：一种用于过表达isoQC的转基因非人动物，其包含含有编码人isoQC的DNA转基因的细胞，其特征在于所述人isoQC包含SEQ ID NO：1的氨基酸序列或与SEQ ID NO：1的氨基酸序列具有至少75％ SEQ ID NO：1的氨基酸序列或SEQ ID NO：1的氨基酸序列的片段或衍生物。另外公开了筛选抑制或促进isoQC的生物活性剂的方法。

5. 发明申请

US20110091910A1 NOVEL ASSAY 审中-公开
标题翻译：新的测定
公开(公告)号：US20110091910A1
公开(公告)日：2011-04-21
申请号：US12884403
申请日：2010-09-17
申请人： Martin Kleinschmidt , Claudia Goettlich , Hans-Ulrich Demuth
发明人： Martin Kleinschmidt , Claudia Goettlich , Hans-Ulrich Demuth
IPC分类号： G01N33/566
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： A novel method for detection of Aβ peptides, in particular in plasma, and to the use of Aβ peptides for diagnosis of Alzheimer's disease.
摘要翻译：一种新的A＆Bgr检测方法肽，特别是血浆中的肽，以及使用A＆bgr; 用于诊断阿尔茨海默氏病的肽。

6. 发明授权

US07667044B2 Compounds for the treatment of neurological disorders 失效
标题翻译：用于治疗神经障碍的化合物
公开(公告)号：US07667044B2
公开(公告)日：2010-02-23
申请号：US11290735
申请日：2005-11-30
申请人： André Niestroj , Ulrich Heiser , Ingo Schulz , Jens-Ulrich Rahfeld , Joachim Baer , Hans-Ulrich Demuth
发明人： André Niestroj , Ulrich Heiser , Ingo Schulz , Jens-Ulrich Rahfeld , Joachim Baer , Hans-Ulrich Demuth
IPC分类号： C07D277/00 , C07D207/00 , C07D295/00 , C07D409/00 , C07D411/00 , A01N43/78 , A01N43/36 , A61K31/425 , A61K31/40
CPC分类号： C07D417/06 , C07D417/14
摘要： The present invention relates to novel inhibitors of prolyl endopeptidase of formula 1 W—KCONH—X—CON—Y—CO—Z (1) wherein K, W, X, Y and Z are specified in the description. The compounds are useful for the treatment of diseases such as mild cognitive impairment (MCI), Alzheimer's disease, Down Syndrome, Parkinson disease and Chorea Huntington.
摘要翻译：本发明涉及式1的W-KCONH-X-CON-Y-CO-Z（1）的脯氨酰内肽酶的新型抑制剂，其中K，W，X，Y和Z在说明书中规定。该化合物可用于治疗诸如轻度认知障碍（MCI），阿尔茨海默病，唐氏综合症，帕金森病和霍乱金淋巴瘤等疾病。

7. 发明申请

US20100009337A1 NOVEL GENES RELATED TO GLUTAMINYL CYCLASE 有权
标题翻译：与谷氨酰胺循环相关的新基因
公开(公告)号：US20100009337A1
公开(公告)日：2010-01-14
申请号：US12497082
申请日：2009-07-02
申请人： Stephan Schilling , Holger Cynis , Jens-Ulrich Rahfeld , Hans-Ulrich Demuth
发明人： Stephan Schilling , Holger Cynis , Jens-Ulrich Rahfeld , Hans-Ulrich Demuth
IPC分类号： C12Q1/00
CPC分类号： C12N9/104 , C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.
摘要翻译：作为谷氨酰胺环化酶同功酶（QC，EC 2.3.2.5）的新型谷氨酰胺肽 - 转移酶样蛋白（QPCTL），以及编码这些同工酶的分离的核酸，所有这些都可用于发现新的治疗剂，用于测定环化酶活性，以及测定化合物对这些谷氨酰胺环化酶同工酶的抑制活性。

8. 发明申请

US20090149394A1 USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES 有权
标题翻译：使用谷氨酰胺和谷氨酸周期的影响
公开(公告)号：US20090149394A1
公开(公告)日：2009-06-11
申请号：US12182113
申请日：2008-07-29
申请人： Stephan Schilling , Torsten Hoffmann , Andre Johannes Niestroj , Hans-Ulrich Demuth , Ulrich Heiser
发明人： Stephan Schilling , Torsten Hoffmann , Andre Johannes Niestroj , Hans-Ulrich Demuth , Ulrich Heiser
IPC分类号： A61K38/06 , A61K31/131 , A61K31/095 , A61K31/426 , A61K31/40 , A61P25/00 , A61K31/4439 , A61K31/472 , A61K38/05
CPC分类号： A61K31/00 , A61K31/13 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K38/06 , A61K38/07 , A61K38/08
摘要： The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of diseases that can be treated by modulation of QC-activity, e.g. diseases selected from the group consisting of duodenal cancer with or w/o Heliobacter pylori infections, colorectal cancer, Zolliger-Ellison syndrome, Familial British Dementia and Familial Danish Dementia.
摘要翻译：本发明提供了哺乳动物谷氨酰胺酰化环化酶（QC，EC 2.3.2.5）的新生理底物，QC的新效应物以及包含这些效应物的这些效应物和药物组合物的用途，用于治疗可以通过调节QC- 活动，例如选自由具有或不具有幽门螺旋杆菌感染的十二指肠癌，结肠直肠癌，佐立格 - 埃利森综合征，家族性英国痴呆和家族性丹麦痴呆组成的组的疾病。

9. 发明申请

US20080153892A1 Inhibitors of Glutaminyl Cyclase 有权
标题翻译：谷氨酰胺酰化酶抑制剂
公开(公告)号：US20080153892A1
公开(公告)日：2008-06-26
申请号：US12046520
申请日：2008-03-12
申请人： Stephan Schilling , Andre J. Niestroj , Ulrich Heiser , Mirko Buchholz , Hans-Ulrich Demuth
发明人： Stephan Schilling , Andre J. Niestroj , Ulrich Heiser , Mirko Buchholz , Hans-Ulrich Demuth
IPC分类号： A61K31/415
CPC分类号： C07D207/08 , A61K31/00 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4192 , C07D207/10 , C07D207/12 , C07D207/16 , C07D207/20 , C07D207/22 , C07D207/24 , C07D231/04 , C07D231/06 , C07D233/02 , C07D233/06 , C07D233/28 , C07D233/42 , C07D233/54 , C07D249/04 , C07D249/08 , C07D249/10 , C07D257/04 , C07D261/04 , C07D263/04 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/185 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07F9/572 , C07F9/59 , C07F9/6506 , C07F9/6561
摘要： Compounds that act as inhibitors of QC including those represented by the general formulae 1 to 9: and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Corea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia
摘要翻译：作为QC抑制剂的化合物，包括由通式1至9表示的化合物及其组合，用于治疗神经元疾病，特别是阿尔茨海默氏病，唐氏综合征，帕金森病，柯达亨廷顿病，致病精神病，精神分裂症，食物摄取受损睡眠觉醒，能量代谢障碍的稳态调节，自主神经功能障碍，激素平衡受损，调节受损，体液，高血压，发烧，睡眠失调，厌食，焦虑相关障碍，包括抑郁症，癫痫发作，药物戒断和酒精中毒，神经变性疾病包括认知功能障碍和痴呆

10. 发明授权

US07374449B2 Electrical contact element and contact arrangement 有权
标题翻译：电接触元件和接触装置
公开(公告)号：US07374449B2
公开(公告)日：2008-05-20
申请号：US11563218
申请日：2006-11-27
申请人： Ulrich Demuth , Rolf Hruby
发明人： Ulrich Demuth , Rolf Hruby
IPC分类号： H01R4/24
CPC分类号： H01R4/245 , H01R4/2454
摘要： A contact arrangement comprises an electrical contact element including a plate member with a contact slot configured to receive an electrically insulated conductor. The plate member has first and second plate arms extending there from that delimit the contact slot. At least one retaining element extends from a plane of the plate member configured to secure the electrical contact element in a housing. The retaining element has first and second retaining surfaces arranged at a fixed angle to each other. The fixed angle is less than 180 degrees. A housing has a contact accommodating chamber that receives the electrical contact element. The contact accommodating chamber has first and second conductor receiving openings and a wall. The retaining element engaging the wall when the electrical contact element is positioned in the contact accommodating chamber.
摘要翻译：接触装置包括电接触元件，该电接触元件包括板构件，其具有构造成接收电绝缘导体的接触槽。板构件具有从限定接触槽的位置延伸的第一和第二板臂。至少一个保持元件从构造成将电接触元件固定在壳体中的板构件的平面延伸。保持元件具有以彼此固定的角度布置的第一和第二保持表面。固定角度小于180度。壳体具有容纳电接触元件的接触容纳室。接触容纳室具有第一和第二导体接收开口和壁。当电接触元件位于接触容纳室中时，保持元件与壁接合。

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