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1. 发明申请

US20160282367A1 METHODS FOR CALIBRATED ION MOBILITY ANALYSIS AND USES THEREOF 审中-公开
标题翻译：用于校准离子电动力分析的方法及其用途
公开(公告)号：US20160282367A1
公开(公告)日：2016-09-29
申请号：US15036901
申请日：2014-11-25
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO MMERCIALIZATION
发明人： Jay HEINECKE , Patrick Moore HUTCHINS
IPC分类号： G01N33/92 , C12Q1/26
CPC分类号： G01N33/92 , C12Q1/26 , G01N33/6893 , G01N2333/775
摘要： The present invention relates to improved ion mobility analysis (IMA) methods that can accurately quantify particle concentration in a sample solution. Specifically, reference particles of known solution-phase concentration are used for calibration. In addition, by exploiting spectral deconvolution techniques, the concentrations of subpopulations within the particles can also be accurately quantified. The improved IMA methods permit, for the first time, the quantification of absolute concentrations of HDL particles and subpopulations thereof in a biological sample. The correlations of HDL particle concentrations and conditions such as LCAT deficiency and cardiovascular diseases have been established. Accordingly, the present invention also provide methods to determine whether a subject is at risk to develop or is suffering from these conditions by using HDL particle concentration as a clinical metric.
摘要翻译：本发明涉及可以准确量化样品溶液中的颗粒浓度的改进的离子迁移率分析（IMA）方法。具体地，使用已知溶液相浓度的参比颗粒进行校准。此外，通过利用光谱去卷积技术，也可以精确量化颗粒内亚群的浓度。改进的IMA方法首次允许定量生物样品中HDL颗粒及其亚群的绝对浓度。已经建立了HDL颗粒浓度与LCAT缺陷和心血管疾病等相关因素。因此，本发明还提供了通过使用HDL颗粒浓度作为临床量度来确定受试者是否处于发展风险或正在遭受这些病症的方法。

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