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1. 发明授权

US09993529B2 Stable formulations of a hyaluronan-degrading enzyme 有权
公开(公告)号：US09993529B2
公开(公告)日：2018-06-12
申请号：US13507262
申请日：2012-06-15
申请人： Tzung-Horng Yang , Daniel Edward Vaughn , Michael James Labarre , Christopher L. Caster , Francois Nicol , Donghyun Kim
发明人： Tzung-Horng Yang , Daniel Edward Vaughn , Michael James Labarre , Christopher L. Caster , Francois Nicol , Donghyun Kim
IPC分类号： C07K14/62 , C12N9/24 , A61K38/28 , A61K47/02 , C07K5/06 , C07K5/068 , A61K38/47 , A61K9/00
CPC分类号： A61K38/28 , A61K9/0019 , A61K38/47 , A61K47/02 , C07K5/06 , C07K5/06086 , C07K14/62 , C12N9/2402 , C12Y302/01035
摘要： Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).

2. 发明申请

US20050163783A1 Purification and preferential synthesis of binding molecules 有权
标题翻译：结合分子的纯化和优先合成
公开(公告)号：US20050163783A1
公开(公告)日：2005-07-28
申请号：US10880320
申请日：2004-06-28
申请人： Gary Braslawsky , Scott Glaser , Tzung-Horng Yang , Jennifer Hopp , Paul Chinn
发明人： Gary Braslawsky , Scott Glaser , Tzung-Horng Yang , Jennifer Hopp , Paul Chinn
IPC分类号： A61K39/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/30 , C12N15/62 , A61K39/395 , C07H21/04 , C12N5/06
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/624 , C07K2319/00
摘要： The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
摘要翻译：本发明描述了分离或优先合成二聚体的方法，二聚体通过至少一个链间二硫键连接，二聚体不通过至少一个链间二硫键与包含两种类型的多肽二聚体的混合物连接。这些形式可以使用疏水相互作用色谱法彼此分离。此外，本发明涉及连接导致通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的二聚体的优先生物合成的肽。本发明还涉及其中大多数二聚体通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的组合物。本发明还涉及新颖的结合分子，例如包含连接本发明的肽。

3. 发明申请

US20130011378A1 Stable formulations of a hyaluronan-degrading enzyme 审中-公开
标题翻译：透明质酸降解酶的稳定制剂
公开(公告)号：US20130011378A1
公开(公告)日：2013-01-10
申请号：US13507263
申请日：2012-06-15
申请人： Tzung-Horng Yang , Daniel Edward Vaughn , Michael James Labarre , Christopher L. Caster , Francois Nicol , Donghyun Kim
发明人： Tzung-Horng Yang , Daniel Edward Vaughn , Michael James Labarre , Christopher L. Caster , Francois Nicol , Donghyun Kim
IPC分类号： A61K38/47 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0019 , A61K38/47 , A61K47/02 , C07K5/06 , C07K5/06086 , C07K14/62 , C12N9/2402 , C12Y302/01035
摘要： Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).
摘要翻译：提供的是作为透明质酸降解酶的稳定制剂或者是速效胰岛素和透明质酸降解酶（包括重组人PH20（rHuPH20））的稳定配方的组合物。

4. 发明授权

US07700097B2 Purification and preferential synthesis of binding molecules 有权
标题翻译：结合分子的纯化和优先合成
公开(公告)号：US07700097B2
公开(公告)日：2010-04-20
申请号：US10880320
申请日：2004-06-28
申请人： Gary R. Braslawsky , Scott Glaser , Tzung-Horng Yang , Jennifer Hopp , Paul Chinn
发明人： Gary R. Braslawsky , Scott Glaser , Tzung-Horng Yang , Jennifer Hopp , Paul Chinn
IPC分类号： A61K39/00 , C12P21/08 , C07K16/28 , C07K16/18
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/624 , C07K2319/00
摘要： The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
摘要翻译：本发明描述了分离或优先合成二聚体的方法，二聚体通过至少一个链间二硫键连接，二聚体不通过至少一个链间二硫键与包含两种类型的多肽二聚体的混合物连接。这些形式可以使用疏水相互作用色谱法彼此分离。此外，本发明涉及连接导致通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的二聚体的优先生物合成的肽。本发明还涉及其中大多数二聚体通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的组合物。本发明还涉及新颖的结合分子，例如包含连接本发明的肽。

5. 发明申请

US20090041758A1 MODIFIED BINDING MOLECULES COMPRISING CONNECTING PEPTIDES 有权
标题翻译：包含连接肽的修饰的结合分子
公开(公告)号：US20090041758A1
公开(公告)日：2009-02-12
申请号：US12100375
申请日：2008-04-09
申请人： Scott Glaser , Mitchell Reff , Tzung-Horng Yang , Xiufeng Wu , Paul Chinn
发明人： Scott Glaser , Mitchell Reff , Tzung-Horng Yang , Xiufeng Wu , Paul Chinn
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C07K16/00 , A61P35/00 , A61P37/00 , A61P29/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/624 , C07K2319/00
摘要： The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
摘要翻译：本发明描述了分离或优先合成二聚体的方法，二聚体通过至少一个链间二硫键连接，二聚体不通过至少一个链间二硫键与包含两种类型的多肽二聚体的混合物连接。这些形式可以使用疏水相互作用色谱法彼此分离。此外，本发明涉及连接导致通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的二聚体的优先生物合成的肽。本发明还涉及其中大多数二聚体通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的组合物。本发明还涉及新颖的结合分子，例如包含连接本发明的肽。

6. 发明申请

US20060182740A1 Buffered formulations for concentrating antibodies and methods of use thereof 审中-公开
标题翻译：用于浓缩抗体的缓冲制剂及其使用方法
公开(公告)号：US20060182740A1
公开(公告)日：2006-08-17
申请号：US10518434
申请日：2003-06-23
申请人： Tzung-Horng Yang , Michael Bacica , Michael Labarre
发明人： Tzung-Horng Yang , Michael Bacica , Michael Labarre
IPC分类号： A61K39/395
CPC分类号： C07K16/065 , A61K9/0019 , A61K39/39591 , A61K47/12 , A61K47/183 , C07K16/00
摘要： The present invention provides a method for producing a concentrated antibody preparation that includes the steps of: (a) obtaining an initial antibody preparation that is an aqueous solution of antibodies and histidine or acetate buffer at a concentration in the range of from about 2 mM to about 48 mM; and (b) subjecting the antibody preparation to membrane filtration so as to remove water and buffer but not antibodies from the antibody preparation, thereby producing an antibody preparation having a higher concentration of antibodies than the initial antibody preparation. The concentrated antibody preparations produced by the method have lower viscosity and are more stable than those of other formulations. The invention further includes concentrated antibody preparations produced by the method, pharmaceutical compositions made using such preparations, and therapeutic methods in which such pharmaceutical compositions are administered to treat diseases.
摘要翻译：本发明提供了一种生产浓缩抗体制剂的方法，其包括以下步骤：（a）获得初始抗体制剂，其为浓度为约2mM至约2mM的组合或乙酸盐缓冲液的抗体水溶液约48mM; 和（b）使抗体制剂进行膜过滤以从抗体制剂中除去水和缓冲剂而不是抗体，从而产生具有比初始抗体制备更高的抗体浓度的抗体制剂。通过该方法制备的浓缩抗体制剂具有较低的粘度，并且比其它配方更稳定。本发明还包括通过该方法制备的浓缩抗体制剂，使用这种制剂制备的药物组合物，以及其中施用这些药物组合物以治疗疾病的治疗方法。

7. 发明授权

US08603473B2 Modified binding molecules comprising connecting peptides 有权
标题翻译：包含连接肽的修饰的结合分子
公开(公告)号：US08603473B2
公开(公告)日：2013-12-10
申请号：US12100375
申请日：2008-04-09
申请人： Scott Glaser , Mitchell Reff , Tzung-Horng Yang , Xiufeng Wu , Paul Chinn
发明人： Scott Glaser , Mitchell Reff , Tzung-Horng Yang , Xiufeng Wu , Paul Chinn
IPC分类号： C07K16/46 , C07K16/00 , C07K19/00 , C07K16/22 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/624 , C07K2319/00
摘要： The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
摘要翻译：本发明描述了分离或优先合成二聚体的方法，二聚体通过至少一个链间二硫键连接，二聚体不通过至少一个链间二硫键与包含两种类型的多肽二聚体的混合物连接。这些形式可以使用疏水相互作用色谱法彼此分离。此外，本发明涉及连接导致通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的二聚体的优先生物合成的肽。本发明还涉及其中大多数二聚体通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的组合物。本发明还涉及新颖的结合分子，例如包含连接本发明的肽。

8. 发明申请

US20130022588A1 Stable formulations of a hyaluronan-degrading enzyme related applications 有权
标题翻译：稳定配方的透明质酸降解酶相关应用
公开(公告)号：US20130022588A1
公开(公告)日：2013-01-24
申请号：US13507262
申请日：2012-06-15
申请人： Tzung-Horng Yang , Daniel Edward Vaughn , Michael James Labarre , Christopher L. Caster , Francois Nicol , Donghyun Kim
发明人： Tzung-Horng Yang , Daniel Edward Vaughn , Michael James Labarre , Christopher L. Caster , Francois Nicol , Donghyun Kim
IPC分类号： A61K38/47 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0019 , A61K38/47 , A61K47/02 , C07K5/06 , C07K5/06086 , C07K14/62 , C12N9/2402 , C12Y302/01035
摘要： Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).
摘要翻译：提供的是作为透明质酸降解酶的稳定制剂或者是速效胰岛素和透明质酸降解酶（包括重组人PH20（rHuPH20））的稳定配方的组合物。

9. 发明申请

US20050163782A1 Modified binding molecules comprising connecting peptides 审中-公开
标题翻译：包含连接肽的修饰的结合分子
公开(公告)号：US20050163782A1
公开(公告)日：2005-07-28
申请号：US10880028
申请日：2004-06-28
申请人： Scott Glaser , Mitchell Reff , Tzung-Horng Yang , Xiufeng Wu , Paul Chinn
发明人： Scott Glaser , Mitchell Reff , Tzung-Horng Yang , Xiufeng Wu , Paul Chinn
IPC分类号： A61K39/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/30 , C12N15/62 , A61K39/395 , C07H21/04 , C12N5/06
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/624 , C07K2319/00
摘要： The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
摘要翻译：本发明描述了分离或优先合成二聚体的方法，二聚体通过至少一个链间二硫键连接，二聚体不通过至少一个链间二硫键与包含两种类型的多肽二聚体的混合物连接。这些形式可以使用疏水相互作用色谱法彼此分离。此外，本发明涉及连接导致通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的二聚体的优先生物合成的肽。本发明还涉及其中大多数二聚体通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的组合物。本发明还涉及新颖的结合分子，例如包含连接本发明的肽。

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