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1. 发明授权

US08669045B2 Method for inactivating viruses with slightly acidic arginine 有权
标题翻译：用微酸性精氨酸灭活病毒的方法
公开(公告)号：US08669045B2
公开(公告)日：2014-03-11
申请号：US12030321
申请日：2008-02-13
申请人： Hajime Koyama , Tsutomu Arakawa , Daisuke Ejima
发明人： Hajime Koyama , Tsutomu Arakawa , Daisuke Ejima
IPC分类号： C12Q1/70
CPC分类号： A01N47/44 , A23L3/3508 , A23V2002/00 , A61K31/198 , A61K2039/5252 , C12N7/00 , C12N7/04 , C12N7/06 , C12N2710/16663 , C12N2760/16163 , C12N2760/18863 , A23V2200/10 , A23V2250/0606
摘要： The present invention provides a method for conveniently producing a protein formulation in which viruses are inactivated, without impairing the quality of the obtained protein formulation, characterized by including the step of exposing the protein formulation contaminated with the viruses to a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5. The present invention also provides a virus inactivation method characterized by including the step of contacting a virus-containing object with a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5.
摘要翻译：本发明提供了一种方便地制备其中病毒灭活而不损害所获得的蛋白质制剂的质量的蛋白质制剂的方法，其特征在于包括将被病毒污染的蛋白质制剂暴露于0.1-2M的精氨酸，精氨酸衍生物或其混合物，将该水溶液调节至pH 3.5至5.本发明还提供了一种病毒灭活方法，其特征在于包括使病毒含有物体与0.1-2M水溶液接触的步骤的精氨酸，精氨酸衍生物或其混合物，将该水溶液调节至pH 3.5至5。

2. 发明授权

US08444990B2 Antibody-induced apoptosis 失效
公开(公告)号：US08444990B2
公开(公告)日：2013-05-21
申请号：US12901435
申请日：2010-10-08
申请人： Tsutomu Arakawa , Yoshiko Kita
发明人： Tsutomu Arakawa , Yoshiko Kita
IPC分类号： A61K39/00
CPC分类号： C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/82 , C07K2319/00
摘要： Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

3. 发明申请

US20120270782A1 FORMULATION FOR HGH AND RHIGF-1 COMBINATION 审中-公开
标题翻译： HGH和RHIGF-1组合的配方
公开(公告)号：US20120270782A1
公开(公告)日：2012-10-25
申请号：US13513858
申请日：2010-11-17
申请人： Enona Gopinath , Susan Park , Tsutomu Arakawa , Joël Richard , Fabio Fais
发明人： Enona Gopinath , Susan Park , Tsutomu Arakawa , Joël Richard , Fabio Fais
IPC分类号： A61K38/30 , A61P5/06
CPC分类号： A61K47/183 , A61K9/0019 , A61K9/19 , A61K38/27 , A61K38/30 , A61K47/02 , A61K47/10 , A61K47/26 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions. More particularly, the invention relates to formulations of growth hormone (GH) and insulin-like growth factor (IGF-1) combination compositions which provide stable pharmaceutical compositions without aggregation formation at a desirable pH, and to processes of preparation thereof.
摘要翻译：本发明涉及药物组合物。更具体地说，本发明涉及生产激素（GH）和胰岛素样生长因子（IGF-1）组合组合物的制剂，其提供稳定的药物组合物，而不需要在所需pH下形成聚集体，以及其制备方法。

4. 发明授权

US07811566B2 Antibody-induced apoptosis 有权
标题翻译：抗体诱导凋亡
公开(公告)号：US07811566B2
公开(公告)日：2010-10-12
申请号：US11981562
申请日：2007-10-30
申请人： Tsutomu Arakawa , Yoshiko Kita
发明人： Tsutomu Arakawa , Yoshiko Kita
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/82 , C07K2319/00
摘要： Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.
摘要翻译：公开了在Her2表达细胞中诱导凋亡的抗Her2抗体。该抗体用于“标记”Her2过表达的肿瘤以通过宿主免疫系统消除。还公开了产生抗体的杂交瘤细胞系，使用该抗体治疗癌症的方法和药物组合物。

5. 发明申请

US20090142359A1 Antibody-induced apoptosis 有权
公开(公告)号：US20090142359A1
公开(公告)日：2009-06-04
申请号：US11981562
申请日：2007-10-30
申请人： Tsutomu Arakawa , Yoshiko Kita
发明人： Tsutomu Arakawa , Yoshiko Kita
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/82 , C07K2319/00
摘要： Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

6. 发明申请

US20060286180A1 Lipolysis promoter and food and drink containing the same 审中-公开
标题翻译：脂解促进剂和含有相同的食物和饮料
公开(公告)号：US20060286180A1
公开(公告)日：2006-12-21
申请号：US11451399
申请日：2006-06-13
申请人： Yoko Suetake , Keishiro Yoshida , Susumu Shimura , Tsutomu Arakawa , Masahiro Tani
发明人： Yoko Suetake , Keishiro Yoshida , Susumu Shimura , Tsutomu Arakawa , Masahiro Tani
IPC分类号： A61K36/71 , A61K36/896 , A61K36/66 , A61K36/28
CPC分类号： A61K36/888 , A61K36/185 , A61K36/31 , A61K36/48 , A61K36/50 , A61K36/66 , A61K36/704 , A61K36/71 , A61K2300/00
摘要： [Problem to be solved] To provide a naturally-derived lipolysis promoter with high safety, which may promote the degradation of the accumulated adipose tissue to control, prevent, and ameliorate obesity to a satisfactory extent. [Solution] A lipolysis promoter containing one kind, or two or more kinds of plant bodies and/or extracts therefrom selected from the group consisting of Myristica fragrance, Symplocarpus foetidus, Escholzia california, Sparganium stoloniferum, Sanguinaria canadensis, Mahonia Aquifolium, Acorus gramineus, the fruit site of Musa paradiciaca, Cytisus scoparius, Hydrastis canadensis, Ficaria ranunculoides, Fumaria officinalis, Unonopsis floribunda, Nasturtium officinale, Nigella sativa, Urtica dioica, Capsella bursa-pastoris, and Polygonum bistorta as active ingredients.
摘要翻译： [待解决问题]提供具有高安全性的天然来源的脂肪分解促进剂，其可以促进累积的脂肪组织的降解以控制，预防和改善肥胖到令人满意的程度。 [解决方案]含有一种或两种以上植物体和/或其中提取物的脂肪分解促进剂，其选自肉豆蔻香料，苦苣菜，加利福尼亚加氏孢子，天竺葵，加拿大甘草，马鞭草，禾本科，野豌豆，水the，水葫芦，F ides ides is is is is a。。。。。。。a a a a a。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。

7. 发明申请

US20060160063A1 Method of screening physilogically active substance 审中-公开
标题翻译：物理活性物质筛选方法
公开(公告)号：US20060160063A1
公开(公告)日：2006-07-20
申请号：US10526369
申请日：2003-09-05
申请人： Iwao Katsuyama , Tsutomu Arakawa , Masao Tokunaga , Tadashi Yamamoto
发明人： Iwao Katsuyama , Tsutomu Arakawa , Masao Tokunaga , Tadashi Yamamoto
IPC分类号： C12Q1/18 , C12N1/18 , C12Q1/00
CPC分类号： C12Q1/025 , G01N2333/39
摘要： The present invention relates to a method of screening a physiologically active substance, comprising the steps of (1) contacting a transformed yeast with a test sample, wherein the transformed yeast is capable of expressing a heterogeneous protein, and shows a change in a growing state in an expression state of the protein as compared to that in a non-expression state of the protein; (2) culturing the yeast under conditions that the protein is capable of being expressed; and (3) measuring the growing state of the yeast, wherein the physiologically active substance is judged to be present in the test sample in a case where the growth of the yeast is lowered or improved in the presence of the test sample as compared to that in the absence of the test sample as a control; an yeast to be used in the method; a physiologically active substance obtainable by the method of screening as defined above; and a kit for screening a physiologically active substance, comprising the yeast as defined above.
摘要翻译：本发明涉及筛选生理活性物质的方法，包括以下步骤：（1）将转化的酵母与测试样品接触，其中转化的酵母能够表达异质蛋白质，并显示生长状态的变化与蛋白质的非表达状态相比，处于蛋白质的表达状态; （2）在能够表达蛋白质的条件下培养酵母; 和（3）测量酵母的生长状态，其中在测试样品存在下酵母生长降低或改善的情况下，判定生理活性物质存在于测试样品中在没有测试样本作为对照的情况下; 在该方法中使用的酵母; 通过如上定义的筛选方法可获得的生理活性物质; 和用于筛选生理活性物质的试剂盒，其包含如上定义的酵母。

8. 发明授权

US06384859B1 Methods for creating an image for a three-dimensional display, for calculating depth information and for image processing using the depth information 失效
标题翻译：用于创建用于三维显示的图像的方法，用于计算深度信息和使用深度信息进行图像处理
公开(公告)号：US06384859B1
公开(公告)日：2002-05-07
申请号：US08622047
申请日：1996-03-26
申请人： Yukinori Matsumoto , Hajime Terasaki , Kazuhide Sugimoto , Masazumi Katayama , Tsutomu Arakawa , Osamu Suzuki
发明人： Yukinori Matsumoto , Hajime Terasaki , Kazuhide Sugimoto , Masazumi Katayama , Tsutomu Arakawa , Osamu Suzuki
IPC分类号： H04N1300
CPC分类号： G06K9/20 , G06K9/32 , G06K2209/40 , G06T7/579 , G06T15/00 , G06T15/10 , G06T15/20 , G06T2207/10012 , G06T2207/10021 , H04N13/117 , H04N13/122 , H04N13/128 , H04N13/133 , H04N13/167 , H04N13/189 , H04N13/194 , H04N13/221 , H04N13/239 , H04N13/243 , H04N13/246 , H04N13/25 , H04N13/257 , H04N13/261 , H04N13/279 , H04N13/289 , H04N13/296 , H04N13/305 , H04N13/324 , H04N13/341 , H04N13/344 , H04N13/346 , H04N19/597 , H04N2013/0077 , H04N2013/0081 , H04N2013/0085 , H04N2013/0092
摘要： A method is proposed for automatically obtaining depth. information from a 2-D motion image, so as to create an image for a 3-D display. Further, methods are proposed for selecting appropriate frames for the calculation of the depth information, or discontinuing the calculation, and for conducting image., processing using the depth information. Examples of various types of image processing can be listed as including the creation of a viewfinder image seen from a different point, natural scaling operations to an image area, and separation of a desired image area. First, a motion information of an object on a screen is extracted by block matching or the like. Second, the actual movement of the object in the 3-D world is calculated. Since the viewfinder image is a projection of a 3-D space, it is possible to obtain the original 3-D movement of the object, based on the movements of a plurality of representative points through an inverse transformation, the representative points being provided in the viewfinder image. Resultantly, 3-D coordinates of this object are identified, so that depth information of the object is obtained. Afterwards, a parallax is calculated based on the depth information, so as to create right and left eye images from the input viewfinder image. Alternatively, image processing, such as separation of an object having a depth within a predetermined range, is carried out based on the depth information.
摘要翻译：提出一种自动获取深度的方法。来自2-D运动图像的信息，以便创建用于3D显示的图像。此外，提出了用于选择用于计算深度信息或者中断计算以及进行图像，使用深度信息的处理的适当帧的方法。可以将各种图像处理的示例列为包括从不同点看到的取景器图像的创建，对图像区域的自然缩放操作以及期望图像区域的分离。首先，通过块匹配等来提取屏幕上的对象的运动信息。其次，计算三维世界中物体的实际运动。由于取景器图像是3-D空间的投影，因此可以基于通过逆变换的多个代表点的移动来获得对象的原始3-D运动，代表点被提供在取景器图像。因此，识别该对象的3维坐标，从而获得对象的深度信息。之后，基于深度信息计算视差，以便从输入取景器图像创建右眼图像和左眼图像。或者，基于深度信息执行诸如将深度在预定范围内的对象分离的图像处理。

9. 发明授权

US5783186A Antibody-induced apoptosis 失效
公开(公告)号：US5783186A
公开(公告)日：1998-07-21
申请号：US568072
申请日：1995-12-05
申请人： Tsutomu Arakawa , Yoshiko Kita
发明人： Tsutomu Arakawa , Yoshiko Kita
IPC分类号： C12N15/02 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , A61P43/00 , C07K14/82 , C07K16/32 , C07K16/46 , C12N5/10 , C12N5/20 , C12P21/08 , C12R1/91 , C07K16/30 , C12N5/12
CPC分类号： C07K16/32 , C07K14/82 , A61K2039/505 , A61K38/00 , C07K2319/00
摘要： Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to "tag" Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

10. 发明授权

US5183917A 4,4'-bis(methacryloylthio)diphenylsulfide 失效
标题翻译： 4,4'-BIS（甲基丙烯酰氧基）二苯基酯
公开(公告)号：US5183917A
公开(公告)日：1993-02-02
申请号：US499421
申请日：1990-06-20
申请人： Satoshi Maruyama , Naoki Minorikawa , Tsutomu Arakawa , Haruo Yoshida , Hirotaka Tagoshi , Kazuto Abe
发明人： Satoshi Maruyama , Naoki Minorikawa , Tsutomu Arakawa , Haruo Yoshida , Hirotaka Tagoshi , Kazuto Abe
IPC分类号： C07C327/22 , C08F28/02
CPC分类号： C08F28/02 , C07C327/22
摘要： 4,4'-Bis(methacryloylthio)diphenylsulfide having the formula (I): ##STR1## and a curable composition characterized by comprising: (A) 4,4'-bis(methacryloylthio)diphenylsulfide having the above formula (I):(B) (i) another vinyl monomer copolymerizable with 4,4'-bis(methacryloylthio)diphenylsulfide having the above formula (I), and (ii) a polythiol represented by the formula (II):R-(SH).sub.n (II) wherein R is a polyvalent organic group and n represents an integer of 2 or more, wherein the content of the component (B)(i), when the component (B)(i) is present, in the total amount of said components (A), (B)(i) and (B)(ii) is 10 to 90% by weight, and the functional group equivalent ratio of the mercapto groups of the component (B)(ii), when the component (B)(ii) is present, to the methacryloyl groups of the component (A) is from 0.02 to 1.01, anda curable composition characterized by comprising:a prepolymer having a polythioether skeleton obtained by the addition reaction of(A) 4,4'-bis(methacryloylthio)diphenylsulfide having the above formula (I):(B) (ii) a polythiol having the formula (II):R-(SH).sub.n (II) wherein R is a polyvalent organic group composed of an aliphatic or aromatic hydrocarbon and n represents an integer of 2 or more, and(B) (i) another polymerizable monomer copolymerizable with 4,4'-bis(methacryloylthio)diphenylsulfide having the above formula (I).
摘要翻译： PCT No.PCT / JP89 / 01076 Sec。 371日期1990年6月20日 102（e）1990年6月20日PCT PCT日期：1989年10月20日PCT公布。出版物WO90 / 04587 日本1990年5月3日具有式（I）的4,4'-双（甲基丙烯酰硫基）二苯硫醚：（I）和可固化组合物，其特征在于包含：（A）4,4'-双（甲基丙烯酰硫基）上述式（I）：（B）（i）可与具有上述式（I）的4,4'-双（甲基丙烯酰硫基）二苯硫醚共聚的另一乙烯基单体，和（ii）由式（II）表示的多硫醇：R - （SH）n（II）其中R是多价有机基团，n表示2或更大的整数，其中当组分（B）（i）存在时，组分（B）（i）的含量，所述组分（A），（B）（i）和（B）（ii）的总量为10至90重量％，组分（B）（ii）的巯基官能团当量比当组分（B）（ii）存在时，组分（A）的甲基丙烯酰基为0.02至1.01，和一种可固化组合物，其特征在于包含：具有通过加成反应获得的聚硫醚骨架的预聚物具有上述式（I）的（A）4,4'-双（甲基丙烯酰硫基）二苯硫醚：（B）（ii）具有式（II）的多硫醇：R-（SH）n（II）其中R为由脂肪族或芳香族烃构成的多价有机基团，n表示2以上的整数，（B）（i）可与具有上述式（I）的4,4'-双（甲基丙烯酰硫基）二苯硫醚共聚的其他可聚合单体，。

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