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1. 发明授权

US5766864A Method of measuring interferon acitivity 失效
标题翻译：测量干扰素活性的方法
公开(公告)号：US5766864A
公开(公告)日：1998-06-16
申请号：US551613
申请日：1995-11-01
申请人： Kazuko Uno , Tsunataro Kishida , Keiji Fujioka , Yoshihiro Takada , Takayuki Sato
发明人： Kazuko Uno , Tsunataro Kishida , Keiji Fujioka , Yoshihiro Takada , Takayuki Sato
IPC分类号： C12N5/08 , C12Q1/02 , C12Q1/25 , C12Q1/42 , G01N33/68
CPC分类号： G01N33/6866
摘要： A method of measuring the activity of interferon-.alpha., .beta. or .omega., which comprises bringing a sample containing interferon into contact with a cell and determining an induced protein is provided.
摘要翻译：一种测量干扰素-α，β或ω的活性的方法，其包括使含有干扰素的样品与细胞接触并测定诱导的蛋白质。

2. 发明授权

US5662900A Method of increasing interferon production in humans 失效
标题翻译：增加人类干扰素生产的方法
公开(公告)号：US5662900A
公开(公告)日：1997-09-02
申请号：US666745
申请日：1996-06-19
申请人： Tsunataro Kishida
发明人： Tsunataro Kishida
IPC分类号： A61K35/74 , A61P37/00 , A61P37/04 , A61P43/00 , A01N63/00 , C12N1/20
CPC分类号： A61K35/747 , Y10S435/855
摘要： A composition containing powdered Lactobacillus brevis subsp. coagulans is used to enhance the immunological functions of a patient, particularly with respect to increasing interferon production, 2-5A synthetase activity and Natural Killer activity.
摘要翻译：含有粉状短乳杆菌（Lactobacillus brevis）亚种的组合物凝固酶用于增强患者的免疫功能，特别是关于增加干扰素产生量，2-5A合成酶活性和自然杀伤活性。

3. 发明授权

US07501274B2 Lactic acid bacteria with immunoregulating activities 有权
标题翻译：具有免疫调节活性的乳酸菌
公开(公告)号：US07501274B2
公开(公告)日：2009-03-10
申请号：US11094576
申请日：2005-03-31
申请人： Yuji Nonaka , Takayuki Izumo , Kaoru Akatani , Atsuko Kishi , Tsunataro Kishida
发明人： Yuji Nonaka , Takayuki Izumo , Kaoru Akatani , Atsuko Kishi , Tsunataro Kishida
IPC分类号： A23C9/12 , C12N1/02 , C12N1/04 , C12N1/20
CPC分类号： C12N1/20 , C12R1/225 , Y10S435/853
摘要： The invention provides novel lactic acid bacteria having immunoregulating activities and usable in food and drinks, medicaments, and other applications. Specifically, the invention provides novel lactic acid bacteria separated from “Shibazuke,” one kind of traditional Kyoto pickles, and having immunoregulating activities. The lactic acid bacteria of the present invention belong to Lactobacillus pentosus.
摘要翻译：本发明提供具有免疫调节活性的新型乳酸菌，可用于食品和饮料，药物和其它应用。具体地说，本发明提供了从“Shibazuke”分离出来的新型乳酸菌，这是一种传统的京都泡菜，具有免疫调节作用。本发明的乳酸菌属于戊糖乳杆菌。

4. 发明申请

US20050266545A1 Lactic acid bacteria with immunoregualting activites 有权
标题翻译：具有免疫反应活性的乳酸菌
公开(公告)号：US20050266545A1
公开(公告)日：2005-12-01
申请号：US11094576
申请日：2005-03-31
申请人： Yuji Nonaka , Takayuki Izumo , Kaoru Akatani , Atsuko Kishi , Tsunataro Kishida
发明人： Yuji Nonaka , Takayuki Izumo , Kaoru Akatani , Atsuko Kishi , Tsunataro Kishida
IPC分类号： A23C9/123 , A23L1/28 , A23L1/30 , A61K35/74 , A61P37/02 , A61P37/04 , C12N1/20 , C12R1/225
CPC分类号： C12N1/20 , C12R1/225 , Y10S435/853
摘要： The invention provides novel lactic acid bacteria having immunoregulating activities and usable in food and drinks, medicaments, and other applications. Specifically, the invention provides novel lactic acid bacteria separated from “Shibazuke,” one kind of traditional Kyoto pickles, and having immunoregulating activities. The lactic acid bacteria of the present invention belong to Lactobacillus pentosus.
摘要翻译：本发明提供具有免疫调节活性的新型乳酸菌，可用于食品和饮料，药物和其它应用。具体地说，本发明提供了从“Shibazuke”分离出来的新型乳酸菌，这是一种传统的京都泡菜，具有免疫调节作用。本发明的乳酸菌属于戊糖乳杆菌。

5. 发明授权

US5846928A Method for treating cancer patients 失效
标题翻译：治疗癌症患者的方法
公开(公告)号：US5846928A
公开(公告)日：1998-12-08
申请号：US691122
申请日：1996-08-01
申请人： Tsunataro Kishida
发明人： Tsunataro Kishida
IPC分类号： A61K35/12 , C12N5/0783 , A01N37/18
CPC分类号： C12N5/0646 , A61K2035/124 , C12N2501/24
摘要： A new immunotherapy to cancer patients is provided. In the therapy, lymphocytes collected from a patient by leukopheresis are treated with interferon-.alpha. in vitro for a short period of term and then returned to the patient intravenously. According to the therapy, reduction in sensitivity of tumor cells to natural killer-cell lysis due to administration of interferon-.alpha. is eliminated, the activities of NK cell and 2-5AS and interferon-producing capacity can be enhanced, a large amount of lymphocytes can be activated directly in vitro with the dose of optimally adjusted to the patient, none of side effects are found, and any other potentiators and comodulaators, which may not be allowed to use in vivo, can be added to the lymphocytes and removed therefrom before returning to the patient.
摘要翻译：提供了一种针对癌症患者的新型免疫治疗方法。在治疗中，通过白细胞采集从患者收集的淋巴细胞在体外用干扰素-α短期治疗，然后静脉内返回给患者。根据该疗法，消除了由于施用干扰素-α而导致的肿瘤细胞对自然杀伤细胞裂解的敏感性降低，NK细胞和2-5AS的活性和干扰素产生能力的增强，大量的淋巴细胞可以直接在体外激活以患者最佳调整的剂量，没有发现副作用，并且可以在淋巴细胞中加入可能不允许在体内使用的任何其它增效剂和调节物，并从中除去其中返回病人。

6. 发明授权

US5556785A Lactobacillus used to enhance immunological functions 失效
标题翻译：乳杆菌用于增强免疫功能
公开(公告)号：US5556785A
公开(公告)日：1996-09-17
申请号：US141599
申请日：1993-10-27
申请人： Tsunataro Kishida
发明人： Tsunataro Kishida
IPC分类号： A61K35/74 , A61P37/00 , A61P37/04 , A61P43/00 , C12B1/24 , C12B1/225
CPC分类号： A61K35/747 , Y10S435/855
摘要： A composition containing powdered Lactobacillus brevis subsp. coagulans is used to enhance the immunological functions of a patient, particularly with respect to increasing interferon production, 2-5A synthetase activity and Natural Killer activity.
摘要翻译：含有粉状短乳杆菌（Lactobacillus brevis）亚种的组合物凝固酶用于增强患者的免疫功能，特别是关于增加干扰素产生量，2-5A合成酶活性和自然杀伤活性。

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