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1. 发明授权

US11052158B2 Delivery of urea to cells of the macula and retina using liposome constructs 有权
公开(公告)号：US11052158B2
公开(公告)日：2021-07-06
申请号：US16326195
申请日：2017-08-18
申请人： Troy Bremer
发明人： Troy Bremer
IPC分类号： A61K9/127 , A61K31/17 , A61K47/69 , A61K9/00 , A61P27/02
摘要： Provided are liposome constructs for delivery of urea to the vitreoretinal interface of the eye. The liposome constructs are agglomerates of small lamellar vesicles (SUVs) and have a greater density than the vitreal fluid, such that they sink to the back of the eye rather than dispersing throughout the vitreous.

2. 发明申请

US20070092888A1 Diagnostic markers of hypertension and methods of use thereof 审中-公开
标题翻译：高血压的诊断标记及其使用方法
公开(公告)号：US20070092888A1
公开(公告)日：2007-04-26
申请号：US11435051
申请日：2006-05-15
申请人： Cornelius Diamond , Albert Man , Troy Bremer
发明人： Cornelius Diamond , Albert Man , Troy Bremer
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G16B40/00 , Y02A90/26
摘要： The present invention relates to methods for the diagnosis and evaluation of cardiovascular illness, particularly hypertension treatment. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for hypertension treatment and one or more non-specific markers for hypertension treatment. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. Algorithms for determining proper treatment are disclosed. A diagnostic kit for a panel of said markers is disclosed. In various aspects, the invention provides methods for the early detection and differentiation of hypertension treatment. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.
摘要翻译：本发明涉及用于诊断和评估心血管疾病，特别是高血压治疗的方法。特别地，分析患者测试样品中含有一种或多种用于高血压治疗的特异性标志物和一种或多种用于高血压治疗的非特异性标志物的标记组的成员的存在和量。公开了用于组装用于这种诊断和评价的标记物的各种标记。公开了用于确定适当处理的算法。公开了一种用于所述标记物组的诊断试剂盒。在各方面，本发明提供了用于早期检测和分化高血压治疗的方法。本发明的方法提供快速，灵敏和特异性的测定，其可以大大增加可以接受有益治疗和治疗的患者数量，降低与错误诊断相关的成本，并提供有关患者预后的重要信息。

3. 发明申请

US20050177035A1 Implantable biosensor and methods of use thereof 有权
标题翻译：植入式生物传感器及其使用方法
公开(公告)号：US20050177035A1
公开(公告)日：2005-08-11
申请号：US11013997
申请日：2004-12-16
申请人： Elliot Botvinick , Troy Bremer
发明人： Elliot Botvinick , Troy Bremer
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/1473 , A61B5/14532 , A61B5/1455 , A61B5/1459 , A61B5/14865 , A61B5/1495
摘要： Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
摘要翻译：本文提供了稳定的氧传递基质，其包含固定在整个稳定的氧传输基质中的可逆氧结合蛋白，例如血红蛋白。稳定的氧传输基质用于输送氧并且可以用作分析物传感器（例如植入式葡萄糖传感器）的氧传输区域和反应区域。可逆结合蛋白也可以作为分析物传感器内的氧探针起作用。

4. 发明申请

US20190184030A1 Delivery of Urea to Cells of the Macula and Retina Using Liposome Constructs 审中-公开
公开(公告)号：US20190184030A1
公开(公告)日：2019-06-20
申请号：US16326195
申请日：2017-08-18
申请人： Troy Bremer
发明人： Troy Bremer
IPC分类号： A61K47/69 , A61K31/17 , A61K9/00 , A61P27/02
CPC分类号： A61K47/6911 , A61K9/0019 , A61K9/0048 , A61K9/127 , A61K9/1271 , A61K31/17 , A61K47/6917 , A61P27/02
摘要： Provided are liposome constructs for delivery of urea to the vitreoretinal interface of the eye. The liposome constructs are agglomerates of small lamellar vesicles (SUVs) and have a greater density than the vitreal fluid, such that they sink to the back of the eye rather than dispersing throughout the vitreous.

5. 发明申请

US20120003639A1 CANCER BIOMARKERS AND METHODS OF USE THEREOF 审中-公开
标题翻译：癌症生物标志物及其使用方法
公开(公告)号：US20120003639A1
公开(公告)日：2012-01-05
申请号：US13094729
申请日：2011-04-26
申请人： KARLA KERLIKOWSKE , THEA D. TLSTY , MONA L. GAUTHIER , HAL K. BERMAN , TROY BREMER , ANNETTE M. MOLINARO
发明人： KARLA KERLIKOWSKE , THEA D. TLSTY , MONA L. GAUTHIER , HAL K. BERMAN , TROY BREMER , ANNETTE M. MOLINARO
IPC分类号： G01N33/574 , C12Q1/68 , C12Q1/02
CPC分类号： G01N33/57415
摘要： Embodiments are provided for characterizing a biological sample. In some embodiments, one can estimate the risk that a subject with ductal carcinoma in situ will have a subsequent DCIS event and/or invasive cancers.
摘要翻译：提供了用于表征生物样品的实施例。在一些实施方案中，可以估计具有导管原位癌的受试者将具有随后的DCIS事件和/或侵入性癌症的风险。

6. 发明申请

US20110307427A1 Molecular markers predicting response to adjuvant therapy, or disease progression, in breast cancer 审中-公开
标题翻译：预测乳腺癌中辅助治疗或疾病进展的反应的分子标记
公开(公告)号：US20110307427A1
公开(公告)日：2011-12-15
申请号：US13199068
申请日：2011-08-18
申请人： Steven Linke , Troy Bremer , Comelius Diamond
发明人： Steven Linke , Troy Bremer , Comelius Diamond
IPC分类号： G06N5/02 , G06F15/18
CPC分类号： G01N33/57415 , G01N2800/52 , G01N2800/56 , G16B20/00 , G16B25/00 , G16B40/00
摘要： Predicting response to adjuvant therapy or predicting disease progression in breast cancer is realized by (1) first obtaining a breast cancer test sample from a subject; (2) second obtaining clinicopathological data from said breast cancer test sample; (3) analyzing the obtained breast cancer test sample for presence or amount of (a) one or more molecular markers of hormone receptor status, one or more growth factor receptor markers, (b) one or more tumor suppression/apoptosis molecular markers; and (c) one or more additional molecular markers both proteomic and non-proteomic that are indicative of breast cancer disease processes; and then (4) correlating (a) the presence or amount of said molecular markers and, with (b) clinicopathological data from said tissue sample other than the molecular markers of breast cancer disease processes. A kit of (1) a panel of antibodies; (2) one or more gene amplification assays; (3) first reagents to assist said antibodies with binding to tumor samples; (4) second reagents to assist in determining gene amplification; permits, when applied to a breast cancer patient's tumor tissue sample, (A) permits observation, and determination, of a numerical level of expression of each individual antibody, and gene amplification; whereupon (B) a computer algorithm, residing on a computer can calculate a prediction of treatment outcome for a specific treatment for breast cancer, or future risk of breast cancer progression.
摘要翻译：预测乳腺癌辅助治疗或预测疾病进展的反应是通过以下方式实现的：（1）首先从受试者获得乳腺癌试验样品; （2）第二次从所述乳腺癌试验样品获得临床病理资料; （3）分析获得的乳腺癌试验样品的存在或量（a）一种或多种激素受体状态的分子标记，一种或多种生长因子受体标记，（b）一种或多种肿瘤抑制/凋亡分子标记; 和（c）指示乳腺癌疾病过程的一种或多种另外的蛋白质组学和非蛋白质组学的分子标记物; 然后（4）将（a）所述分子标记的存在或量与（b）来自所述组织样本的除了乳腺癌疾病过程的分子标记之外的临床病理学数据相关联。（1）一组抗体的试剂盒; （2）一个或多个基因扩增测定; （3）协助所述抗体与肿瘤样品结合的第一试剂; （4）辅助确定基因扩增的第二试剂; 允许当应用于乳腺癌患者的肿瘤组织样品时，（A）允许观察和确定每个单独抗体的数字表达水平和基因扩增; 因此（B）驻留在计算机上的计算机算法可以计算乳腺癌特异性治疗或乳腺癌进展的未来风险的治疗结果的预测。

7. 发明申请

US20060275844A1 Diagnostic markers of breast cancer treatment and progression and methods of use thereof 审中-公开
标题翻译：乳腺癌治疗和进展的诊断标记及其使用方法
公开(公告)号：US20060275844A1
公开(公告)日：2006-12-07
申请号：US11407169
申请日：2006-04-18
申请人： Steven Linke , Troy Bremer , Cornelius Diamond
发明人： Steven Linke , Troy Bremer , Cornelius Diamond
IPC分类号： G01N33/574 , G06F19/00 , G06Q10/00
CPC分类号： G01N33/57415 , G01N2800/52 , G06Q50/24 , Y02A90/22 , Y02A90/26
摘要： To maximize both the life expectancy and quality of life of patients with operable breast cancer, it is important to predict adjuvant treatment outcome and likelihood of progression before treatment. A machine-learning based method is used to develop a cross-validated model to predict (1) the outcome of adjuvant treatment, particularly endocrine treatment outcome, and (2) likelihood of cancer progression before treatment. The model includes standard clinicopathological features, as well as molecular markers collected using standard immunohistochemistry and fluorescence in situ hybridization. The model significantly outperforms the St. Gallen Consensus guidelines and the Nottingham Prognostic Index, thus providing a clinically useful and cost-effective prognostic for breast cancer patients.
摘要翻译：为了最大限度地提高可手术乳腺癌患者的预期寿命和生活质量，重要的是预测辅助治疗结果和治疗前进展的可能性。使用基于机器学习的方法开发交叉验证模型，以预测（1）辅助治疗的结果，特别是内分泌治疗结果，和（2）治疗前癌症进展的可能性。该模型包括标准临床病理特征，以及使用标准免疫组化和荧光原位杂交收集的分子标记。该模型显着优于圣加仑共识指南和诺丁汉预后指数，从而为乳腺癌患者提供临床上有用且具有成本效益的预后。

8. 发明申请

US20050176057A1 Diagnostic markers of mood disorders and methods of use thereof 审中-公开
标题翻译：情绪障碍的诊断标记及其使用方法
公开(公告)号：US20050176057A1
公开(公告)日：2005-08-11
申请号：US11080218
申请日：2005-03-14
申请人： Troy Bremer , Cornelius Diamond
发明人： Troy Bremer , Cornelius Diamond
IPC分类号： A61K31/00 , C12Q1/68 , G06F19/00 , A61K31/551 , G01N33/48 , G01N33/50
CPC分类号： A61K31/00 , A61K31/19 , A61K31/53 , A61K31/551 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/5082 , G01N2800/304 , G16B20/00 , G16B30/00 , G16B40/00 , G16H50/20 , Y02A90/26
摘要： The present invention relates to methods for the diagnosis, evaluation, and treatment of mood disorders, particularly bipolar disorder. In particular, patient test samples are analyzed for the presence and amount of members of a panel of biallelic markers comprising one or more specific markers for bipolar treatment and one or more non-specific markers for bipolar treatment. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. Algorithms for determining proper treatment are disclosed. A diagnostic kit for a panel of said markers is disclosed. In various aspects, the invention provides methods for the early detection and differentiation of mood disorders or bipolar treatment. Methods for screening therapeutic compounds for mood disorders are disclosed. The invention (1) gives methods providing rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, thereby reducing the costs associated with incorrect diagnosis, and (2) provides methods for improved therapies.
摘要翻译：本发明涉及用于诊断，评估和治疗情绪障碍，特别是双相情感障碍的方法。特别地，分析患者测试样品中包含用于双相治疗的一种或多种特异性标记物和用于双相治疗的一种或多种非特异性标志物的双重标志物组的成员的存在和量。公开了用于组装用于这种诊断和评价的标记物的各种标记。公开了用于确定适当处理的算法。公开了一种用于所述标记物组的诊断试剂盒。在各方面，本发明提供了用于情绪障碍或双相治疗的早期检测和分化的方法。公开了筛选情绪障碍治疗化合物的方法。本发明（1）提供了提供快速，灵敏和特异性测定的方法，其可以大大增加可以接受有益治疗和治疗的患者数量，从而降低与错误诊断相关的成本，以及（2）提供改善疗法的方法。

9. 发明申请

US20210353770A1 Delivery of Urea to Cells of the Macula and Retina Using Liposome Constructs 有权
公开(公告)号：US20210353770A1
公开(公告)日：2021-11-18
申请号：US17334278
申请日：2021-05-28
申请人： Troy Bremer
发明人： Troy Bremer
IPC分类号： A61K47/69 , A61K9/00 , A61K9/127 , A61P27/02 , A61K31/17
摘要： Provided are liposome constructs for delivery of urea to the vitreoretinal interface of the eye. The liposome constructs are agglomerates of small lamellar vesicles (SUVs) and have a greater density than the vitreal fluid, such that they sink to the back of the eye rather than dispersing throughout the vitreous.

10. 发明申请

US20060241365A1 Implantable Biosensor and Methods of Use Thereof 有权
标题翻译：可植入生物传感器及其使用方法
公开(公告)号：US20060241365A1
公开(公告)日：2006-10-26
申请号：US11427641
申请日：2006-06-29
申请人： Elliot Botvinick , Troy Bremer
发明人： Elliot Botvinick , Troy Bremer
IPC分类号： A61B5/05 , C12Q1/00 , C12Q1/54 , A61B5/00 , G01F1/64 , G01N27/26
CPC分类号： A61B5/1473 , A61B5/14532 , A61B5/1455 , A61B5/1459 , A61B5/14865 , A61B5/1495
摘要： Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
摘要翻译：本文提供了稳定的氧传递基质，其包含固定在整个稳定的氧传输基质中的可逆氧结合蛋白，例如血红蛋白。稳定的氧传输基质用于输送氧并且可以用作分析物传感器（例如植入式葡萄糖传感器）的氧传输区域和反应区域。可逆结合蛋白也可以作为分析物传感器内的氧探针起作用。

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