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1. 发明授权

US4824842A Cinnamoyl piperidines and thiomorpholine and cerebral protection compositions 失效
标题翻译：肉桂酰哌啶和硫代吗啉和脑保护组合物
公开(公告)号：US4824842A
公开(公告)日：1989-04-25
申请号：US829382
申请日：1986-02-13
申请人： Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
发明人： Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
IPC分类号： A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P25/28 , C07D211/16 , C07D211/22 , C07D211/46 , C07D265/30 , C07D265/32 , C07D279/12 , C07D295/18 , C07D295/185
CPC分类号： C07D265/30 , C07D211/16 , C07D211/22 , C07D279/12 , C07D295/185
摘要： Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen, methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.
摘要翻译：通式（I）的化合物其中：X为卤素或三氟甲基; R1是氢，卤素或三氟甲基; R2是氢，甲基或羟甲基; R3是氢或低级烷基; Y为亚甲基，被低级烷基或羟基取代的亚甲基，亚磺酰基，磺酰基，氧或硫，表现出脑保护作用，适用于治疗脑缺血和脑缺氧。可以通过用合适的肉桂酰氯将适当的哌啶或吗啉酰化，并且如果需要氧化反应产物，可以制备化合物。

2. 发明授权

US06355283B1 Process for making soybean curd bread 失效
标题翻译：制作豆腐面包的方法
公开(公告)号：US06355283B1
公开(公告)日：2002-03-12
申请号：US09655864
申请日：2000-09-06
申请人： Toyofumi Yamada , Isao Moriya
发明人： Toyofumi Yamada , Isao Moriya
IPC分类号： A21D202
CPC分类号： A21D13/064 , A21D2/02 , A21D2/362
摘要： A process for making a soybean curd bread which comprises adding magnesium chloride to a soybean milk having a predetermined solid content and at a temperature of about 60° C. to 90° C. to prepare homogeneously emulsified soybean curd, adding a bread dough composed of wheat flour, yeast, seasonings and water to prepare a soybean curd bread dough, stirring and mixing the soybean curd bread to ferment the soybean curd bread dough, with fermentation being promoted by utilizing the property of magnesium chloride contained in the soybean curd bread dough to prepare a fermented soybean curd bread dough and baking the fermented soybean curd bread dough.
摘要翻译：一种制造豆腐面包的方法，其包括向具有预定固体含量的豆浆中加入氯化镁并在约60℃至90℃的温度下制备均匀乳化的大豆凝乳，加入由小麦面粉，酵母，调味料和水，制备大豆凝乳面包面团，搅拌和混合豆腐面包发酵豆腐面包面团，通过利用大豆凝乳面包面团中含有的氯化镁的性质促进发酵制备发酵豆腐面包面团，烘烤发酵豆腐面包面团。

3. 发明授权

US4804750A Production of water-soluble chitin-oligomers by partial hydrolysis of chitin 失效
标题翻译：通过几丁质的部分水解生产水溶性几丁质寡聚物
公开(公告)号：US4804750A
公开(公告)日：1989-02-14
申请号：US940358
申请日：1986-12-11
申请人： Tatsumi Nishimura , Eiichi Eto , Toyofumi Yamada
发明人： Tatsumi Nishimura , Eiichi Eto , Toyofumi Yamada
IPC分类号： B01J19/10 , C07H1/08 , C07H3/00 , C07H3/06 , C07H5/06 , C07H13/06 , C08B37/08 , C08L1/00
CPC分类号： C07H3/06 , C08B37/003
摘要： Tetra-N-acetyl-chitotetraose, penta-N-acetylchitopentaose and hexa-N-acetyl-chitohexaose, ones of the water-soluble chitin-oligomers, may be obtained in improved yields, when finely ground chitin is quickly and intimately mixed with a concentrated hydrohalogenic acid containing a particular proportion of the hydrogen halide per a unit quantity of the chitin under the irradiation with ultrasonic waves and also under the agitation by mechanical stirrer, followed by hydrolyzing the chitin in the resulting homogeneous mixture comprising the chitin and the concentrated hydrohalogenic acid while said homogeneous mixture is further continuously irradiated with the ultrasonic waves and also agitated by the mechanical stirrer. From the aqueous phase of the hydrolyzed reaction mixture are recovered the desired water-soluble chitin-oligomers which are each useful as an immunopotentiating, antitumor agent or antifungal, antibacterial agent.
摘要翻译：四乙酰基四聚四糖，五-N-乙酰氨基四糖和六-N-乙酰基六氢六糖，其中一种水溶性几丁质 - 低聚物，可以以提高的产率获得，当细磨几丁质与在超声波照射下，还在机械搅拌器的搅拌下，每单位量的几丁质含有特定比例的卤化氢的浓缩氢卤酸，然后水解所得到的均匀混合物中的几丁质，所述混合物包含壳多糖和浓缩的氢卤素酸，同时所述均匀混合物用超声波进一步连续照射，并且还通过机械搅拌器搅拌。从水解的反应混合物的水相中回收所需的水溶性几丁质寡聚体，其各自可用作免疫增强剂，抗肿瘤剂或抗真菌抗菌剂。

4. 发明授权

US4962107A Agent for cerebral protection 失效
标题翻译：脑保护剂
公开(公告)号：US4962107A
公开(公告)日：1990-10-09
申请号：US321692
申请日：1989-03-10
申请人： Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
发明人： Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
IPC分类号： A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P25/28 , C07D211/16 , C07D211/22 , C07D211/46 , C07D265/30 , C07D265/32 , C07D279/12 , C07D295/18 , C07D295/185
CPC分类号： C07D265/30 , C07D211/16 , C07D211/22 , C07D279/12 , C07D295/185
摘要： Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.

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