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1. 发明申请

US20090299036A1 AGENT FOR PREVENTING ARTERIOSCLEROSIS, AGENT FOR SUPPRESSING VASCULAR INTIMAL THICKENING AND AGENT FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION 审中-公开
标题翻译：用于预防神经功能障碍的药剂，用于抑制血管内增生的药剂和用于改善血管内皮功能的药剂
公开(公告)号：US20090299036A1
公开(公告)日：2009-12-03
申请号：US12279240
申请日：2007-02-14
申请人： Tatsuhiko Hirota , Teppei Nakamura , Kohji Ohki , Akihiro Masuyama , Toshiaki Takano , Toshikazu Yoshikawa , Yuji Naito , Hiroshi Ichikawa , Satomi Akagiri
发明人： Tatsuhiko Hirota , Teppei Nakamura , Kohji Ohki , Akihiro Masuyama , Toshiaki Takano , Toshikazu Yoshikawa , Yuji Naito , Hiroshi Ichikawa , Satomi Akagiri
IPC分类号： C07K5/08 , C07D207/16 , C07K14/47
CPC分类号： C07K5/0808 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/081 , C07K14/4732 , C12R1/225
摘要： There is provided an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis or the like. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.
摘要翻译：提供了具有对血管内皮功能的改善作用和对血管内膜增厚的抑制作用以及具有优异安全性，改善与血管内皮相关的功能的动脉硬化预防中的至少一种的药剂，其具有预防与血管内皮功能相关的各种疾病和抑制血管内膜增厚，并且可以预期对动脉硬化等提供预防效果。本发明的药剂含有：（a）Xaa-Pro-Pro，（b）含有Xaa-Pro-Pro或其浓缩物的动物乳酪蛋白的水解产物，或（c）发酵产物含有Ile-Pro-Pro和/或Val-Pro-Pro，其通过用瑞士乳杆菌种的细菌菌株发酵含有乳蛋白的原料而获得。

2. 发明授权

US06268903B1 Method of adjusting projection optical apparatus 失效
标题翻译：调整投影光学装置的方法
公开(公告)号：US06268903B1
公开(公告)日：2001-07-31
申请号：US08581016
申请日：1996-01-03
申请人： Hiroshi Chiba , Toshikazu Yoshikawa
发明人： Hiroshi Chiba , Toshikazu Yoshikawa
IPC分类号： H01L21027
CPC分类号： G03F7/706 , G02B27/0025 , G03F7/70308
摘要： A method adjusts optical performance of a projection optical system for projecting an image of a first object onto a second object. An optical member is provided having a predetermined optical surface, at a predetermined position of the projection optical system. Measurement is made of an aberration having a random aberration component in the projection optical system including the optical member at the predetermined position. A correction shape is obtained to correct the random aberration component. The correction shape is then formed on a correction optical member, and that correction optical member is arranged at the predetermined position of the projection optical system.
摘要翻译：一种调整用于将第一物体的图像投影到第二物体上的投影光学系统的光学性能的方法。在投影光学系统的预定位置处提供具有预定光学表面的光学构件。测量在包括光学构件的投影光学系统中在预定位置处具有随机像差分量的像差。获得校正形状以校正随机像差分量。然后在校正光学构件上形成校正形状，并且校正光学构件布置在投影光学系统的预定位置处。

3. 发明申请

US20120035096A1 AGENT FOR PREVENTING ARTERIOSCLEROSIS, AGENT FOR SUPPRESSING VASCULAR INTIMAL THICKENING AND AGENT FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION 审中-公开
标题翻译：用于预防神经功能障碍的药剂，用于抑制血管内增生的药剂和用于改善血管内皮功能的药剂
公开(公告)号：US20120035096A1
公开(公告)日：2012-02-09
申请号：US13278284
申请日：2011-10-21
申请人： Tatsuhiko HIROTA , Teppei NAKAMURA , Kohji OHKI , Akihiro MASUYAMA , Toshiaki TANAKO , Toshikazu YOSHIKAWA , Yuji NAITO , Hiroshi ICHIKAWA , Satomi AKAGIRI
发明人： Tatsuhiko HIROTA , Teppei NAKAMURA , Kohji OHKI , Akihiro MASUYAMA , Toshiaki TANAKO , Toshikazu YOSHIKAWA , Yuji NAITO , Hiroshi ICHIKAWA , Satomi AKAGIRI
IPC分类号： A61K38/06 , A61P9/10
CPC分类号： C07K5/0808 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/081 , C07K14/4732 , C12R1/225
摘要： There is provided an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis or the like. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.
摘要翻译：提供了具有对血管内皮功能的改善作用和对血管内膜增厚的抑制作用以及具有优异安全性，改善与血管内皮相关的功能的动脉硬化预防中的至少一种的药剂，其具有预防与血管内皮功能相关的各种疾病和抑制血管内膜增厚，并且可以预期对动脉硬化等提供预防效果。本发明的药剂含有：（a）Xaa-Pro-Pro，（b）含有Xaa-Pro-Pro或其浓缩物的动物乳酪蛋白的水解产物，或（c）发酵产物含有Ile-Pro-Pro和/或Val-Pro-Pro，其通过用瑞士乳杆菌种的细菌菌株发酵含有乳蛋白的原料而获得。

4. 发明授权

US06518250B2 Agent for preventing and curing hindrance of ischemic reperfusion 失效
标题翻译：预防和治疗缺血再灌注障碍的药物
公开(公告)号：US06518250B2
公开(公告)日：2003-02-11
申请号：US09993194
申请日：2001-11-14
申请人： Toshikazu Yoshikawa , Hironobu Murase , Norimasa Yoshida
发明人： Toshikazu Yoshikawa , Hironobu Murase , Norimasa Yoshida
IPC分类号： A61K3170
CPC分类号： C07H17/065 , A61K31/704 , A61K31/7048 , C07H15/26 , Y10S514/824 , Y10S514/878 , Y10S514/925 , Y10S514/926
摘要： An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: [wherein R1, R2, R3, and R4 independently denote a hydrogen atom or a lower alkyl group, R5 denotes a hydrogen atom, a lower alkyl group, or a lower acyl group, X denotes a monosaccharide residue or an oligosaccharide residue which may have a lower alkyl group or a lower acyl group substituted for the hydrogen atom of the hydroxyl group of the saccharide residue, n denotes an integer of 0-6, and m denotes an integer of 1-6]. The agent, even in a small dosage, acts safely and effectively on the affected part and allows the hindrances of ischemic reperfusion induced in heart, stomach, small intestine, liver, spleen, kidney, brain, and skin, and the hindrance induced during the transplantation of an internal organ to be prevented and cured.
摘要翻译：公开了预防和治疗缺血再灌注障碍的药剂，其作为其活性成分是由以下通式表示的色原肌糖苷：其中R1，R2，R3和R4独立地表示氢原子或低级烷基 R5表示氢原子，低级烷基或低级酰基，X表示可以具有低级烷基或低级酰基取代羟基的氢原子的单糖残基或寡糖残基糖残基，n表示0-6的整数，m表示1-6的整数]。即使在小剂量下，该药物对患部的安全有效地起作用，并且允许在心脏，胃，小肠，肝脏，脾脏，肾脏，脑和皮肤中诱导的缺血再灌注障碍，以及在移植内脏器官以防止和治愈。

5. 发明授权

US06377333B1 Method of adjusting projection optical apparatus 有权
标题翻译：调整投影光学装置的方法
公开(公告)号：US06377333B1
公开(公告)日：2002-04-23
申请号：US09721955
申请日：2000-11-27
申请人： Hiroshi Chiba , Toshikazu Yoshikawa
发明人： Hiroshi Chiba , Toshikazu Yoshikawa
IPC分类号： H01L21027
CPC分类号： G03F7/706 , G02B27/0025 , G03F7/70308
摘要： This invention relates to an adjusting method for correcting the random component of distortion of a projection optical apparatus without performing complicated assembly and adjustment. This adjusting method has the first step of measuring the residual distortion component of a projection optical system having a predetermined target member in its optical path, the second step of calculating, based on the measurement result of the first step, the surface shape of the target member to cancel the residual distortion component, the third step of removing the target member from the projection optical system and machining the target member so as to have the surface shape calculated in the second step, and the fourth step of inserting the target member machined in the third step into the optical path of the projection optical system.
摘要翻译：本发明涉及一种用于校正投影光学装置的失真的随机分量而不进行复杂的组装和调整的调整方法。该调整方法具有测量其光路中具有预定目标构件的投影光学系统的残余失真分量的第一步骤，基于第一步骤的测量结果计算目标的表面形状的第二步骤构件，以消除残余变形分量，从投影光学系统移除目标构件并加工目标构件以便具有在第二步骤中计算的表面形状的第三步骤，以及将被加工成的目标构件插入的第四步骤投影光学系统光路的第三步。

6. 发明授权

US06174864B1 Methods for the prevention or treatment of inflammatory bowel diseases 有权
标题翻译：预防或治疗炎症性肠病的方法
公开(公告)号：US06174864B1
公开(公告)日：2001-01-16
申请号：US09319647
申请日：1999-08-09
申请人： Toshikazu Yoshikawa , Norimasa Yoshida , Hironobu Murase
发明人： Toshikazu Yoshikawa , Norimasa Yoshida , Hironobu Murase
IPC分类号： A61K3170
CPC分类号： A61K31/7048 , A61K31/353 , C07H15/26
摘要： A preventive and curative agent for inflammatory bowel diseases is disclosed which has as an active ingredient thereof a chromanol glucoside represented by the following general formula (1) (wherein R1, R2, R3, and R4 represent identically or differently either a hydrogen atom or a lower alkyl group, R5 represents a hydrogen atom, a lower alkyl group, or a lower acyl group, X represents a monosaccharide residue or an oligosaccharide residue having the hydrogen atom in the hydroxyl group thereof optionally substituted with a lower alkyl group or a lower acyl group, n represents an integer of 0-6, and m represents an integer of 1-6). Owing to the use, as an active ingredient, of the chromanol glucoside excelling in water solubility and possessing an oxidization resisting action and a free radical resisting action, the agent can conspicuously repress the lesion of an inflammatory bowel disease and prominently ameriolate the condition of disease. It can be manufactured into an aqueous preparation containing the active ingredient in a high concentration and, therefore, act effectively on the seat of disease at a low application rate, and prevent and cure the inflammatory bowel diseases. It further allows very safe use because it entails no side effect.
摘要翻译：公开了一种炎性肠病的预防和治疗剂，其具有作为其活性成分的由以下通式（1）表示的色原烷醇葡糖苷（其中R1，R2，R3和R4表示相同或不同的氢原子或低级烷基，R5表示氢原子，低级烷基或低级酰基，X表示其羟基中的氢原子任选被低级烷基或低级酰基取代的单糖残基或寡糖残基基团，n表示0-6的整数，m表示1-6的整数）。作为活性成分，使用水溶性优异且具有抗氧化作用和自由基的色原烷醇葡萄糖苷抵抗作用，该药物可以显着抑制炎性肠病的病变，显着地使病情恶化。可以以高浓度将其制成含有活性成分的含水制剂，因此以低施用率有效地作用于疾病所在地，并预防和治愈炎症性肠病。它进一步允许非常安全的使用，因为它不会有副作用。

7. 发明授权

US5238931A Inflammatory bowel disease preventive and curative agent containing zinc L-carnosine salt as active ingredient 失效
标题翻译：含有锌锌盐酸盐作为活性成分的预防感冒和预防剂
公开(公告)号：US5238931A
公开(公告)日：1993-08-24
申请号：US726273
申请日：1991-07-05
申请人： Toshikazu Yoshikawa , Tomoyuki Yoneda , Yasuhiro Nishimura
发明人： Toshikazu Yoshikawa , Tomoyuki Yoneda , Yasuhiro Nishimura
IPC分类号： C07D233/64 , A61K31/415 , A61K38/04 , A61P1/00 , A61P29/00
CPC分类号： A61K38/04 , A61K31/415 , Y10S514/867
摘要： An agent for the prevention and treatment of inflammatory bowel disease (IBD) containing at least one of zinc L-carnosine salts and complexes as an active ingredient. A use of the zinc L-carnosine salts or complexes and a therapeutic method of IBD by using the same are also disclosed.

8. 发明授权

US4103057A Duplicate thermoplastic plates, matrices useful therefor and methods of manufacturing the same 失效
标题翻译：重复的热塑性板，有用的基体及其制造方法
公开(公告)号：US4103057A
公开(公告)日：1978-07-25
申请号：US699213
申请日：1976-06-24
申请人： Yasuyuki Takimoto , Toshikazu Yoshikawa
发明人： Yasuyuki Takimoto , Toshikazu Yoshikawa
IPC分类号： C08F2/00 , B41C3/06 , B41D7/00 , B41N1/12 , B41N11/00 , C08F2/48 , C08F290/00 , C08F299/00 , C08L47/00 , G03F7/038 , B41D7/02
CPC分类号： B41N1/12 , B41C3/06 , Y10T428/24479 , Y10T428/24612 , Y10T428/25 , Y10T428/252 , Y10T428/258 , Y10T428/31899 , Y10T428/31931 , Y10T428/31993
摘要： Duplicate thermoplastic plates are composed of a composition comprising a 1,2-polybutadiene having a crystallinity of about 10-30% and an intrinsic viscosity of greater than about 0.7. Matrices against which the duplicate thermoplastic plates are molded are formed of material containing said 1,2-PBD and a photoinitiator or a thermo-curable catalyst. The duplicate thermoplastic plates and matrices can give a high duration and reproducibility from an original pattern bearing design or image in relief, and they are molded with ease and in a great amount without difficulty. The use of the thermoplastic plates or matrices can provide a good releasability from the matrix against which the said plates are molded and from the original pattern against which the matrices are formed.
摘要翻译：重复的热塑性板由包含结晶度为约10-30％，特性粘度大于约0.7的1,2-聚丁二烯的组合物组成。重复的热塑性板被模制的基体由含有所述1,2- PBD和光引发剂或热可固化催化剂的材料形成。复制的热塑性板材和基质可以从原始图案轴承设计或图像浮雕中提供高持续时间和重现性，并且它们容易且大量成型而没有困难。使用热塑性板或基质可以提供从所述板模制的基质和形成基质的原始图案的良好的剥离性。

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