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1. 发明申请

US20180106727A1 ULTRA-HIGH-SENSITIVE ASSAY OF PROTEIN AND NUCLEIC ACID AND KIT, AND NOVEL ENZYME SUBSTRATE 审中-公开
公开(公告)号：US20180106727A1
公开(公告)日：2018-04-19
申请号：US15845702
申请日：2017-12-18
申请人： Etsuro ITO , Satoshi WATABE , Toshiaki MIURA , Teruki YOSHIMURA
发明人： Etsuro ITO
IPC分类号： G01N21/78 , G01N21/25 , C12Q1/00 , C12Q1/34 , C12Q1/42 , C12Q1/28
CPC分类号： G01N21/78 , C12Q1/008 , C12Q1/28 , C12Q1/34 , C12Q1/42 , G01N21/25 , G01N2333/90209 , G01N2333/916 , G01N2333/924
摘要： Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.

2. 发明授权

US5312677A Latent looped yarn, a fabric made of the same, and a method for manufacturing the latent looped yarn 失效
标题翻译：潜环式纱线，由其制成的织物以及潜环式纱线的制造方法
公开(公告)号：US5312677A
公开(公告)日：1994-05-17
申请号：US804748
申请日：1991-12-11
申请人： Minoru Shiojima , Toshiaki Miura , Keitarou Nabeshima , Satoru Masuzaki
发明人： Minoru Shiojima , Toshiaki Miura , Keitarou Nabeshima , Satoru Masuzaki
IPC分类号： D02G1/18 , D03D15/04 , D03D3/00
CPC分类号： D02G1/18 , D02G3/34 , D03D15/04 , Y10T428/2924 , Y10T428/2976 , Y10T428/2978 , Y10T442/3065 , Y10T442/3114 , Y10T442/322
摘要： This invention relates to a latent looped yarn having loops produced by an eddy current treatment and once potentialized therein before a weaving operation and revealed in a fabric, after the yarns are woven therein at least as warp yarns, by heat treatment, to give the fabric a spunlike handling and high yarn density. This invention also provides a manufacturing method for producing the latent looped yarn and high density spunlike fabrics utilizing the latent looped yarn.
摘要翻译：本发明涉及一种潜环式纱线，其具有通过涡流处理产生的环路，并且在织造操作之前一度被潜在于其中，并且在织物中至少以经纱织造纱线之后通过热处理在织物中显露出来，以使织物旋转式处理和高纱线密度。本发明还提供了利用潜环式纱线生产潜环式纱线和高密度纺丝织物的制造方法。

3. 发明授权

US5459991A Composite crimped yarn and woven fabric 失效
标题翻译：复合卷曲纱和机织布
公开(公告)号：US5459991A
公开(公告)日：1995-10-24
申请号：US390519
申请日：1995-02-17
申请人： Keitaro Nabeshima , Minoru Wakabayashi , Toshiaki Miura
发明人： Keitaro Nabeshima , Minoru Wakabayashi , Toshiaki Miura
IPC分类号： D01H13/26 , D02G1/02 , D02G1/18 , D02G3/04 , D02G3/24 , D02G3/36 , D02G3/38 , D03D15/00
CPC分类号： D02G1/18 , D02G1/0206 , Y10T442/3081 , Y10T442/313
摘要： A composite crimped yarn comprising: at least two kinds of multifilament yarns, one of them being comprised of a crimped conjugate multifilament yarn comprising two kinds of polyester polymers different from each other in the heat shrinkability and positioned as a major component of the inner layer of the composite crimped yarn, the other of them being comprised of a crimped multifilament yarn of a single synthetic polymer and positioned as a major component in the outer layer of the composite crimped yarn. In the above, the length of the crimped multifilament yarn is 5 to 35% larger than that of the crimped conjugate multifilament yarn, part of the crimped multifilament yarn being migrated to the crimped conjugate multifilament yarn disposed in the inner layer and part of the crimped conjugate multifilament yarn being migrated to the crimped multifilament yarn disposed in the outer layer.
摘要翻译：一种复合卷曲纱线，包括：至少两种复丝纱线，其中一根纱线由包括两种在热收缩性彼此不同的聚酯聚合物的卷曲复合复丝纱线组成，并且被定位为复合卷曲纱线，另一个由单一合成聚合物的卷曲复丝纱线组成并且作为主要组分定位在复合卷曲纱线的外层中。在上述中，卷曲复丝纱线的长度比卷曲复合复丝纱线的长度大5〜35％，卷曲复丝纱线的一部分迁移到布置在内层中的卷曲复合复丝纱线，部分卷曲复合复丝纱线迁移到布置在外层中的卷曲复丝纱线。

4. 发明授权

US3967470A Apparatus for napping a circular knitted fabric 失效
标题翻译：用于打绒圆形针织物的装置
公开(公告)号：US3967470A
公开(公告)日：1976-07-06
申请号：US545999
申请日：1975-01-31
申请人： Toshiaki Miura , Tatsuya Ugajin , Masayoshi Inoue
发明人： Toshiaki Miura , Tatsuya Ugajin , Masayoshi Inoue
IPC分类号： D04B35/36 , D04B35/00
CPC分类号： D04B35/36
摘要： In apparatus for napping a circular knitted fabric between the knitting portion and the winding portion of a circular knitting machine, apparatus for napping the circular knitted fabric with emery in the form of a belt or the like. The invention includes a means for stretching the knitted fabric coursewise and an adjacent emery supporting base, an emery supporting frame structured to support said emery in the form of a belt or the like, and a driving portion provided to move said emery in a coursewise direction with respect to said circular knitted fabric while it is stretched coursewise.
摘要翻译：在圆形针织机的编织部和卷绕部之间对圆形针织物进行起毛的装置中，以带状或类似形式的金刚砂起绒圆形编织物的装置。本发明包括一种用于拉伸针织物和相邻的金刚砂支撑基座的装置，一种被构造成以带状或类似形式支撑所述金刚砂的金刚砂支撑框架，以及驱动部分，其设置成沿着沿着方向移动所述金刚砂相对于所述圆形针织物，同时被拉伸。

5. 发明申请

US20090050998A1 SEMICONDUCTOR DEVICE 有权
标题翻译：半导体器件
公开(公告)号：US20090050998A1
公开(公告)日：2009-02-26
申请号：US12193385
申请日：2008-08-18
申请人： Toshiaki MIURA
发明人： Toshiaki MIURA
IPC分类号： H01L27/146
CPC分类号： H01L31/1105 , H01L27/14681
摘要： In one embodiment of the present invention, a semiconductor device has a photodiode over a P-type substrate, an NPN transistor formed over the P-type substrate, an N−-type buried region provided right under the NPN transistor as being buried in the P-type substrate, and a P+-type buried region formed in the N+-type buried region.
摘要翻译：在本发明的一个实施例中，半导体器件在P型衬底上具有光电二极管，在P型衬底上形成的NPN晶体管，在NPN晶体管正下方设置的N型掩埋区， P型基板和形成在N +型掩埋区域中的P +型掩埋区域。

6. 发明授权

US5785802A Method and apparatus for single facer glue application adjustment 失效
标题翻译：单面胶应用调整方法及装置
公开(公告)号：US5785802A
公开(公告)日：1998-07-28
申请号：US613172
申请日：1996-03-08
申请人： Yukuharu Seki , Makoto Ando , Toshiaki Miura
发明人： Yukuharu Seki , Makoto Ando , Toshiaki Miura
IPC分类号： B31F1/28 , B65H23/188 , B65H37/04
CPC分类号： B31F1/2818 , B31F1/2831
摘要： To provide a single facer glue application adjusting method and apparatus which enable 1 to prevent occurrence of defective sheet accompanying with operation mistake like negligence of setting change of roll gap in a change of papers, 2 to improve appearance of corrugated board sheet and to enhance quality of strength etc. of same and 3 to decrease manufacturing cost of a glue application adjusting apparatus. A glue application roll 1 rotating at a circumferential velocity v.sub.1 different from that v.sub.2 of a downstream side corrugating roll (an upper corrugating roll) 9 is moved to touch the downstream side corrugating roll 9 via a core paper 11 and, upon variation in the circumferential velocity of each said roll caused thereby, a setting position of the glue application roll 1 to the downstream side corrugating roll 9 is adjusted, thus a gap between the glue application roll 1 and the downstream side corrugating roll 9 is maintained approximately at a thickness of the core paper 11.
摘要翻译：为了提供一种能够+ E，crc 1 + EE的单面胶应用调整方法和装置，用于防止随着操作错误的发生而出现故障，例如在纸张变化中设定辊间隙变化的疏忽，+ E，crc 2+ EE改善了瓦楞纸板的外观，并提高了相同和+ E，crc 3 + EE的强度等级，降低了胶水应用调节装置的制造成本。以与下游侧波纹辊（上部波纹辊）9的v2不同的周向速度v1旋转的胶合剂涂布辊1移动以经由芯纸11与下游侧波纹辊9接触，并且在周向由此导致每个所述辊的速度，调节涂胶辊1到下游侧波纹辊9的设置位置，从而将涂胶辊1和下游侧波纹辊9之间的间隙保持大致为核心文件11。

7. 发明授权

US5422171A Composite crimped yarn and woven fabric 失效
标题翻译：复合卷曲纱和机织布
公开(公告)号：US5422171A
公开(公告)日：1995-06-06
申请号：US192743
申请日：1994-02-07
申请人： Keitaro Nabeshima , Minoru Wakabayashi , Toshiaki Miura
发明人： Keitaro Nabeshima , Minoru Wakabayashi , Toshiaki Miura
IPC分类号： D01H13/26 , D02G1/02 , D02G1/18 , D02G3/04 , D02G3/24 , D02G3/36 , D02G3/38 , D03D15/00 , D03D3/00
CPC分类号： D02G1/18 , D02G1/0206 , Y10T442/3081 , Y10T442/313
摘要： A composite crimped yarn comprising: at least two kinds of multifilament yarns, one of them being comprised of a crimped conjugate multifilament yarn comprising two kinds of polyester polymers different from each other in the heat shrinkability and positioned as a major component of the inner layer of the composite crimped yarn, the other of them being comprised of a crimped multifilament yarn of a single synthetic polymer and positioned as a major component in the outer layer of the composite crimped yarn, In the above, the length of the crimped multifilament yarn is 5 to 35% larger than that of the crimped conjugate multifilament yarn, part of the crimped multifilament yarn being migrated to the crimped conjugate multifilament yarn disposed in the inner layer and part of the crimped conjugate multifilament yarn being migrated to the crimped multifilament yarn disposed in the outer layer.
摘要翻译：一种复合卷曲纱线，包括：至少两种复丝纱线，其中一根纱线由包括两种在热收缩性彼此不同的聚酯聚合物的卷曲复合复丝纱线组成，并且被定位为复合卷曲纱线，另一个由单一合成聚合物的卷曲复丝纱线组成并且作为主要组分定位在复合卷曲纱线的外层中。在上述中，卷曲复丝纱线的长度为5 比卷曲复合复丝纱线大35％，卷曲复丝纱线的一部分迁移到布置在内层中的卷曲复合复丝纱线，部分卷曲的复合复丝纱线被移动到布置在卷边中的卷曲复丝纱线外层。

8. 发明授权

US11221299B2 Ultra-high-sensitive assay of protein and nucleic acid and kit, and novel enzyme substrate 有权
公开(公告)号：US11221299B2
公开(公告)日：2022-01-11
申请号：US15845702
申请日：2017-12-18
申请人： Etsuro Ito , Satoshi Watabe , Toshiaki Miura , Teruki Yoshimura
发明人： Etsuro Ito
IPC分类号： G01N21/78 , G01N21/25 , C12Q1/00 , C12Q1/34 , C12Q1/42 , C12Q1/28
摘要： Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.

9. 发明授权

US08927209B2 Liver cancer methods and compositions 有权
标题翻译：肝癌方法和组成
公开(公告)号：US08927209B2
公开(公告)日：2015-01-06
申请号：US12528982
申请日：2008-03-01
申请人： Yoshihiko Hamamoto , Norio Iizuka , Toshiaki Miura , Toyoki Moribe , Masaaki Oka , Shigeru Tamatsukuri
发明人： Yoshihiko Hamamoto , Norio Iizuka , Toshiaki Miura , Toyoki Moribe , Masaaki Oka , Shigeru Tamatsukuri
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2523/125 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156
摘要： The present invention provides a novel method for detection of liver cancer. This method detects high-sensitively, high-specifically, simply and accurately liver cancer, especially that in early stage by identifying and/or quantifying methylation on particular genes and/or their DNA fragments in clinical specimens, and by combining said methylated DNA values with existing tumor marker values and/or DNA amounts in blood. This invention also detects a precancerous lesion, detects a risk of recurrence after treatment of liver cancer, detects malignancy of liver cancer and monitors progression of liver cancer with time by the same method. As for particular genes, BASP1 gene, SPINT2 gene, APC gene, CCND2 gene, CFTR gene, RASSF1 gene and SRD5A2 gene are mentioned.
摘要翻译：本发明提供一种检测肝癌的新方法。该方法通过鉴定和/或定量临床标本中特定基因和/或其DNA片段的甲基化，并将所述甲基化DNA值与血液中存在的肿瘤标志物值和/或DNA量。本发明还检测癌前病变，检测肝癌治疗后复发的风险，通过相同的方法随时间检测肝癌的恶性程度并监测肝癌的进展。对于特定基因，提及BASP1基因，SPINT2基因，APC基因，CCND2基因，CFTR基因，RASSF1基因和SRD5A2基因。

10. 发明申请

US20100304372A1 Liver Cancer Methods and Compositions 有权
标题翻译：肝癌方法和组成
公开(公告)号：US20100304372A1
公开(公告)日：2010-12-02
申请号：US12528982
申请日：2008-03-01
申请人： Yoshihiko Hamamoto , Norio Iizuka , Toshiaki Miura , Toyoki Moribe , Masaaki Oka , Shigeru Tamatsukuri
发明人： Yoshihiko Hamamoto , Norio Iizuka , Toshiaki Miura , Toyoki Moribe , Masaaki Oka , Shigeru Tamatsukuri
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2523/125 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156
摘要： The present invention provides a novel method for detection of liver cancer. This method detects high-sensitively, high-specifically, simply and accurately liver cancer, especially that in early stage by identifying and/or quantifying methylation on particular genes and/or their DNA fragments in clinical specimens, and by combining said methylated DNA values with existing tumor marker values and/or DNA amounts in blood. This invention also detects a precancerous lesion, detects a risk of recurrence after treatment of liver cancer, detects malignancy of liver cancer and monitors progression of liver cancer with time by the same method. As for particular genes, BASP1 gene, SPINT2 gene, APC gene, CCND2 gene, CFTR gene, RASSF1 gene and SRD5A2 gene are mentioned.
摘要翻译：本发明提供一种检测肝癌的新方法。该方法通过鉴定和/或定量临床标本中特定基因和/或其DNA片段的甲基化，并将所述甲基化DNA值与血液中存在的肿瘤标志物值和/或DNA量。本发明还检测癌前病变，检测肝癌治疗后复发的风险，通过相同的方法随时间检测肝癌的恶性程度并监测肝癌的进展。对于特定基因，提及BASP1基因，SPINT2基因，APC基因，CCND2基因，CFTR基因，RASSF1基因和SRD5A2基因。

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