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1. 发明申请

US20120259123A1 AMINOPYRIDINE COMPOUND 审中-公开
标题翻译：氨基吡啶化合物
公开(公告)号：US20120259123A1
公开(公告)日：2012-10-11
申请号：US13518824
申请日：2010-12-24
申请人： Ryo Iwamura , Masayuki Tanaka , Tetsushi Katsube , Nobuhiko Shibakawa , Manabu Shigetomi , Eiji Okanari , Tomoko Kanda , Yasunori Tokunaga , Hiroshi Fujiwara
发明人： Ryo Iwamura , Masayuki Tanaka , Tetsushi Katsube , Nobuhiko Shibakawa , Manabu Shigetomi , Eiji Okanari , Tomoko Kanda , Yasunori Tokunaga , Hiroshi Fujiwara
IPC分类号： C07D213/72 , C07D409/12 , C07D401/02 , C07D409/14
CPC分类号： C07D213/74 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, a medical composition containing the same, and a medical composition for the treatment or prophylaxis of respiratory diseases or glaucoma.
摘要翻译：本发明涉及由式（I）表示的化合物或其药学上可接受的盐，含有该化合物的医药组合物和用于治疗或预防呼吸系统疾病或青光眼的医药组合物。

2. 发明申请

US20090036453A1 Pyrrolopyridazinone Compound 失效
公开(公告)号：US20090036453A1
公开(公告)日：2009-02-05
申请号：US12087864
申请日：2007-01-16
申请人： Masahiko Hagihara , Masayuki Tanaka , Tetsushi Katsube , Makoto Okudo , Noriaki Iwase , Manabu Shigetomi , Tomoko Kanda , Takayuki Nakanishi
发明人： Masahiko Hagihara , Masayuki Tanaka , Tetsushi Katsube , Makoto Okudo , Noriaki Iwase , Manabu Shigetomi , Tomoko Kanda , Takayuki Nakanishi
IPC分类号： A61K31/5025 , C07D487/02 , A61P11/00 , A61P9/00 , A61P37/00
CPC分类号： C07D487/04
摘要： The present invention discloses a pyrrolopyridazinone compound represented by the formula (1): wherein R1 represents C1-C2 alkyl group or halogeno C1-C2 alkyl group, R2 repersents C3-C5 cycloalkyl group, (C3-C5 cycloalkyl)C1-C2 alkyl group or C1-C3 alkyl group, R3 represents hydrogen atom, or methylene group or cis-vinylene group for forming substituted oxygen-containing hetero ring in combination with group —O—R2, R4 represents hydrogen atom, halogen atom, C1-C8 alkyl group, C2-C6 alkenyl group, C2-C6 alkynyl group, hydroxy C3-C6 alkenyl group, hydroxy C3-C6 alkynyl group, C1-C6 alkyl group substituted by substituent(s) selected from Substituent group (a), C3-C6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), “C1-C3 alkyl group which is substituted by C3-C6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), and which may be substituted by a hydroxy group”, an aromatic ring group or heteroaromatic ring group each of which may be substituted by a substituent(s) selected from Substituent group (c) or “C1-C2 alkyl group which is substituted by aromatic ring group or heteroaromatic ring group each of which may be substituted by group(s) selected from Substituent group (c), and which may be substituted by a hydroxy group”, Substituent group (a) represents a halogen atom, hydroxy group, cyano group, carboxy group, C1-C5 alkoxy group, halogeno C1-C4 alkoxy group, C3-C6 cycloalkoxy group, (C3-C6 cycloalkyl)C1-C2 alkoxy group, C1-C4 alkoxycarbonyl group, C2-C4 alkanoyl group, C2-C4 alkanoyloxy group or C1-C4 alkyl-substituted amino group, Substituent group (b) represents a hydroxy group or a halogen atom, Substituent group (c) represents a halogen atom, a hydroxy group, a cyano group, a nitro group, a carboxy group, C1-C5 alkoxy group, C1-C4 alkoxycarbonyl group, C2-C4 alkanoyloxy group, C1-C4 alkyl-substituted amino group or a C1-C4 alkyl group which may be substituted by a substituent(s) selected from the group consisting of (a halogen atom, a hydroxy group and a carboxy group), or a pharmaceutically acceptable salt thereof.

3. 发明授权

US08450319B2 Pyrrolopyridazinone compound 失效
标题翻译：吡咯并哒嗪酮化合物
公开(公告)号：US08450319B2
公开(公告)日：2013-05-28
申请号：US12087864
申请日：2007-01-16
申请人： Masahiko Hagihara , Masayuki Tanaka , Tetsushi Katsube , Makoto Okudo , Noriaki Iwase , Manabu Shigetomi , Tomoko Kanda , Takayuki Nakanishi
发明人： Masahiko Hagihara , Masayuki Tanaka , Tetsushi Katsube , Makoto Okudo , Noriaki Iwase , Manabu Shigetomi , Tomoko Kanda , Takayuki Nakanishi
IPC分类号： C07D487/04 , A61K31/5025 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention discloses a pyrrolopyridazinone compound represented by the formula (1): useful, for example, as an anti-inflammatory agent or an inhibitor of respiratory tract contraction.
摘要翻译：本发明公开了由式（1）表示的吡咯并哒嗪酮化合物：例如可用作抗炎剂或呼吸道收缩抑制剂。

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