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1. 发明申请

US20070208007A1 Amine-Based Compound and Use Thereof 有权
标题翻译：胺类化合物及其用途
公开(公告)号：US20070208007A1
公开(公告)日：2007-09-06
申请号：US10591722
申请日：2005-03-10
申请人： Atsushi Saitou , Shigeyuki Kikumoto , Masahiro Ono , Ryo Matsui , Masashi Yamamoto , Tomohiro Sawa , Shigeru Suzuki , Mikiro Yanaka
发明人： Atsushi Saitou , Shigeyuki Kikumoto , Masahiro Ono , Ryo Matsui , Masashi Yamamoto , Tomohiro Sawa , Shigeru Suzuki , Mikiro Yanaka
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/4745 , A61K31/428 , A61K31/4184 , C07D403/02 , C07D413/02
CPC分类号： C07D403/12 , C07D263/64 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): where X represents O, CH2, C(═O), NR11, or CHR35 and D represents a group represented by the following formula (6): where Q represents a single bond, NR12, or a group represented by the formula (13): and Y represents a group represented by the following formula (7): where z represents a substitutable monocyclic or polycyclic aromatic ring; and B represents —NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.
摘要翻译：由下式（1）表示的新型胺化合物，对HIV，风湿病，癌症转移等病毒感染性疾病有效; 通常，A 1和A 2表示氢原子或可取代的单环或多环杂芳族环，W表示可取代的苯环或由下式（10 ）或（11）：其中X表示O，CH 2，C（-O），NR 11或CHR 35，D表示由下式（6）表示的基团：其中Q表示单键，NR 12或式（13）表示的基团：Y表示由下式（ 7）：其中z表示可取代的单环或多环芳环; 而B代表-NR 25 R 26; 在上式中的R 1至R 26中的R 1表示氢原子，烷基，烯基或炔基。

2. 发明授权

US07026488B2 Antitumor agents and process for producing the same 有权
标题翻译：抗肿瘤剂及其制备方法
公开(公告)号：US07026488B2
公开(公告)日：2006-04-11
申请号：US10484726
申请日：2002-08-29
申请人： Hiroshi Maeda , Tomohiro Sawa
发明人： Hiroshi Maeda , Tomohiro Sawa
IPC分类号： C07D209/56 , C07D53/00
CPC分类号： C07D487/22 , A61K47/60
摘要： Anticancer agents which contain as the active ingredient, a heme oxygenase inhibitory metalloporphyrin derivatives which are conjugated with amphipathic or water-soluble polymers (in particular, Zn-protoporphyrin (ZnPP) conjugated with polyethylene glycol). Because of being conjugated to amphipathic or water-soluble polymers, such as polyethylene glycol, the active ingredient can be administered by intravenous injection and can exert a remarkable anticancer effect owing to tumor selective delivery.
摘要翻译：含有作为活性成分的抗癌剂，与两亲性或水溶性聚合物（特别是与聚乙二醇缀合的锌原卟啉（ZnPP））缀合的血红素氧合酶抑制性金属卟啉衍生物。由于与两亲性或水溶性聚合物（例如聚乙二醇）缀合，可以通过静脉内注射施用活性成分，并且由于肿瘤选择性递送而具有显着的抗癌作用。

3. 发明授权

US06857495B2 Inflatable external airbag system 失效
标题翻译：充气外部气囊系统
公开(公告)号：US06857495B2
公开(公告)日：2005-02-22
申请号：US10064973
申请日：2002-09-05
申请人： Tomohiro Sawa
发明人： Tomohiro Sawa
IPC分类号： B62D25/10 , B60R21/00 , B60R21/16 , B60R21/34 , B60R21/36
CPC分类号： B60R21/36
摘要： An inflatable external airbag system adapted to securely deploy an airbag along a windshield from a rear portion of a hood with little or no influence of wind direction and/or wind pressure around the top of a running vehicle. The hood includes a front portion and a rear portion. The rear portion includes a deployment direction regulating member. The front and rear portions of the hood may be coupled together via a hinge. As the airbag inflates, the rear hood portion pivots upwardly to a predetermined angle to hang over the airbag just like a flap thereby regulating the deployment direction of the airbag to deflect the deployment toward the windshield.
摘要翻译：一种可充气的外部安全气囊系统，其适于沿着挡风玻璃的后部从挡风玻璃的后部可靠地部署气囊，同时风向和/或围绕行驶车辆的顶部的风压几乎没有影响。罩包括前部和后部。后部包括展开方向调节构件。罩的前部和后部可以通过铰链连接在一起。当安全气囊膨胀时，后罩部分向上枢转到预定角度，以像挡片一样悬挂在安全气囊上，从而调节安全气囊的展开方向以将展开偏向挡风玻璃。

4. 发明申请

US20050012458A1 Bulb-shaped electrodeless fluorescent lamp and electrodeless discharge lamp lighting device 失效
标题翻译：灯泡状无极荧光灯和无电极放电灯照明装置
公开(公告)号：US20050012458A1
公开(公告)日：2005-01-20
申请号：US10490924
申请日：2003-06-27
申请人： Takeshi Arakawa , Akira Hochi , Tomohiro Sawa , Mitsuharu Kawasaki
发明人： Takeshi Arakawa , Akira Hochi , Tomohiro Sawa , Mitsuharu Kawasaki
IPC分类号： H01J61/35 , H01J65/04 , H01J63/04 , H01J17/16
CPC分类号： H01J65/048 , H01J61/35
摘要： An electrodeless self-ballasted fluorescent lamp includes: a luminous bulb 1 having a cavity portion 15; an induction coil 3 inserted in the cavity portion 15; a ballast 4 electrically connected to the induction coil 3; and a base 7, wherein the luminous bulb 1, the ballast 4 and the base 7 are configured as one unit. The luminous bulb 1 includes an approximately spherical outer tube 12 and an inner tube 11. At least the surface of the upper hemisphere of the outer tube 12 is coated with a silicone rubber 10 having the property of transmitting light.
摘要翻译：无电极自镇流荧光灯包括：具有空腔部分15的发光管1; 插入空腔部分15中的感应线圈3; 电连接到感应线圈3的镇流器4; 以及基座7，其中发光管1，镇流器4和基座7被配置为一个单元。发光管1包括大致球形的外管12和内管11.至少外管12的上半球的表面涂覆有具有透光特性的硅橡胶10。

5. 发明授权

US06716426B1 Antitumor agents 有权
标题翻译：抗肿瘤剂
公开(公告)号：US06716426B1
公开(公告)日：2004-04-06
申请号：US09536017
申请日：2000-03-27
申请人： Hiroshi Maeda , Tomohiro Sawa , Takaaki Akaike
发明人： Hiroshi Maeda , Tomohiro Sawa , Takaaki Akaike
IPC分类号： A61K3843
CPC分类号： C12Y117/03002 , A61K31/522 , A61K38/44 , A61K47/60 , C12N11/08 , A61K2300/00
摘要： An antitumor agent, which is a combination of an oxidoreductase, such as xanthine oxidase chemically conjugated to a polymer such as poly ethylene glycol, for initial administration and accumulation in the tumor tissue followed by administration of a substrate for the oxidoreductase which releases reactive oxygen species. Improved tumor selective cytotoxic activity results.
摘要翻译：一种抗肿瘤剂，其是氧化还原酶，例如与聚乙二醇等聚合物化学偶联的黄嘌呤氧化酶的组合，用于初始给药并在肿瘤组织中积累，随后施用释放活性氧的氧化还原酶底物。改善肿瘤选择性细胞毒活性。

6. 发明申请

US20100282100A1 WATER-METACHROMATIC FABRIC SHEET 审中-公开
标题翻译：水彩织物
公开(公告)号：US20100282100A1
公开(公告)日：2010-11-11
申请号：US12811403
申请日：2008-12-26
申请人： Norimasa Okuda , Tomohiro Sawa
发明人： Norimasa Okuda , Tomohiro Sawa
IPC分类号： B41M1/12 , B32B5/02
CPC分类号： C09D11/02 , A63H33/22 , B41M1/12 , B41M1/30 , B41M3/00 , C09D11/50 , D06P1/004 , Y10T442/20
摘要： An object of the present invention is to provide a water-metachromatic fabric sheet having a color range of gradation in similar colors, for example, from a light blue region in the dried state to a dark blue region in the water-containing state. As a solution, a mixture layer containing porous particulate aluminum silicate and a colorant is printed on a surface of a fabric, wherein the mixture layer has a second mixture layer prepared by dispersing and fixing porous particulate aluminum silicate and a colorant in a binder resin and a first mixture layer prepared by dispersing and fixing porous particulate aluminum silicate and a colorant in a binder resin.
摘要翻译：本发明的目的是提供一种具有类似颜色的渐变色彩范围的水 - 异色织物片，例如从干燥状态的浅蓝色区域到含水状态的深蓝色区域。作为解决方案，在织物表面上印刷含有多孔颗粒状硅酸铝和着色剂的混合物层，其中混合物层具有通过将多孔颗粒状硅酸铝和着色剂分散并固定在粘合剂树脂中而制备的第二混合物层，通过将多孔粒状硅酸铝和着色剂分散并固定在粘合剂树脂中而制备的第一混合物层。

7. 发明授权

US07208036B2 Water-based pigment-containing ink composition for central core type marking pen 有权
标题翻译：用于中心芯型标记笔的含水基颜料的油墨组合物
公开(公告)号：US07208036B2
公开(公告)日：2007-04-24
申请号：US10482570
申请日：2002-07-01
申请人： Hidetoshi Fukuo , Naoshi Murata , Makoto Hirotani , Tomohiro Sawa
发明人： Hidetoshi Fukuo , Naoshi Murata , Makoto Hirotani , Tomohiro Sawa
IPC分类号： C09D11/16
CPC分类号： C09D11/17 , B43K8/02 , C09D11/16 , C09D11/18
摘要： A central core type marking pen which has an ink storage portion of a central core and a pen tip connected thereto, wherein the central core contains a water-based pigment-containing ink composition which contains a thickening agent and exhibits, at 20° C., a viscosity of not less than 45 mPa·s and not greater than 12 mPa·s when a stress of 0.01 and a stress of 10 Pa are applied, respectively.
摘要翻译：具有中央芯的墨水储存部分和与其连接的笔尖的中央芯型标记笔，其中中心芯含有含有增稠剂并含有20℃的水性含颜料的油墨组合物分别施加应力为0.01，应力为10Pa时，粘度为45mPa·s以上12mPa·s以下。

8. 发明申请

US20110172212A1 AMINE-BASED COMPOUND AND USE THEREOF 审中-公开
标题翻译：基于胺的化合物及其用途
公开(公告)号：US20110172212A1
公开(公告)日：2011-07-14
申请号：US13051248
申请日：2011-03-18
申请人： Atsushi SAITOU , Shigeyuki Kikumoto , Masahiro Ono , Ryo Matsui , Masashi Yamamoto , Tomohiro Sawa , Shigeru Suzuki , Mikiro Yanaka
发明人： Atsushi SAITOU , Shigeyuki Kikumoto , Masahiro Ono , Ryo Matsui , Masashi Yamamoto , Tomohiro Sawa , Shigeru Suzuki , Mikiro Yanaka
IPC分类号： A61K31/4178 , C07D403/12 , C07D403/14 , A61K31/4184 , C07D233/64 , A61K31/417 , C07D403/06 , A61K31/5513 , C07D401/12 , A61K31/4439 , C07D401/14 , A61K31/4725 , C07D471/04 , A61K31/437 , A61K31/454 , A61K31/4709 , C07D413/14 , A61K31/5377 , C07D405/14 , A61P29/00 , A61P35/04 , A61P31/12 , A61P31/18
CPC分类号： C07D403/12 , C07D263/64 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): where X represents O, CH2, C(═O), NR11, or CHR35 and D represents a group represented by the following formula (6): [Formula 4] -Q-Y—B (6) where Q represents a single bond, NR12, or a group represented by the formula (13): and Y represents a group represented by the following formula (7): [Formula 6] —(CR18R19)m3- or —(CR20R21)m4-z-(CR22R23)m5- (7) where z represents a substitutable monocyclic or polycyclic aromatic ring; and B represents —NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.
摘要翻译：由下式（1）表示的新型胺化合物，对HIV，风湿病，癌症转移等病毒感染性疾病有效; 通常，A1和A2表示氢原子或可取代的单环或多环杂芳环，W表示可取代的苯环或由下式（10）或（11）表示的任何基团：其中X表示O，CH 2，C（= O），NR 11或CHR 35，D表示由下式（6）表示的基团：[式4] -QY-B（6）其中Q表示单键，NR12或由式（13）表示的基团）：Y表示由下式（7）表示的基团：[式6] - （CR18R19）m3-或 - （CR20R21）m4-z-（CR22R23）m5-（7）其中z表示可取代的单环或多环芳环; B代表-NR25R26; 上式中的R 1至R 26表示氢原子，烷基，烯基或炔基。

9. 发明授权

US07514076B2 Antitumor agents 失效
标题翻译：抗肿瘤剂
公开(公告)号：US07514076B2
公开(公告)日：2009-04-07
申请号：US11485970
申请日：2006-07-14
申请人： Hiroshi Maeda , Tomohiro Sawa , Takaaki Akaike
发明人： Hiroshi Maeda , Tomohiro Sawa , Takaaki Akaike
IPC分类号： A61K38/44 , A61K47/34
CPC分类号： C12Y117/03002 , A61K31/522 , A61K38/44 , A61K45/06 , A61K47/60 , C12N11/08 , A61K2300/00
摘要： An antitumor agent, which is a combination of an oxidoreductase, such as xanthine oxidase chemically conjugated to a polymer such as poly ethylene glycol, for initial administration and accumulation in the tumor tissue followed by administration and of a substrate for the oxidoreductase which releases reactive oxygen species. Improved tumor selective cytotoxic activity results.
摘要翻译：抗肿瘤剂，其是氧化还原酶，例如与聚乙二醇等聚合物化学偶联的黄嘌呤氧化酶的组合，用于初始给药并在肿瘤组织中积累，然后施用，以及释放活性氧的氧化还原酶底物种类。改善肿瘤选择性细胞毒活性。

10. 发明授权

US07468400B2 Aqueous glittering ink composition 失效
标题翻译：水性闪光油墨组合物
公开(公告)号：US07468400B2
公开(公告)日：2008-12-23
申请号：US11016368
申请日：2004-12-17
申请人： Yasuyuki Yoshimura , Naoshi Murata , Yuki Yamamoto , Tomohiro Sawa
发明人： Yasuyuki Yoshimura , Naoshi Murata , Yuki Yamamoto , Tomohiro Sawa
IPC分类号： C09D11/18 , C08K9/02 , C08K3/40
CPC分类号： C09D11/16 , C09D5/36 , C09D11/18
摘要： The glittering ink composition of the present invention contains a glass flake pigment, a water-soluble resin, a water-soluble organic solvent and water as essential ingredients. The content of the glass flake pigment is 0.01-40% by weight relative to the total amount of the ink composition. Moreover, the ink composition contains a synthetic resin emulsion as a binder component for fixing the glass flake pigment to a handwriting or a coated film in 0.01-40% by weight in solids relative to the total amount of the ink composition. The synthetic resin emulsion has an anionic property or a nonionic property and its minimum film forming temperature is not higher than 20° C.
摘要翻译：本发明的闪光性油墨组合物含有玻璃鳞片颜料，水溶性树脂，水溶性有机溶剂和水作为必需成分。玻璃鳞片颜料的含量相对于油墨组合物的总量为0.01-40重量％。此外，油墨组合物含有作为粘合剂成分的合成树脂乳液，用于将玻璃鳞片颜料固定在手写或涂膜上，相对于油墨组合物的总量为0.01-40重量％的固体。合成树脂乳液具有阴离子性或非离子性，其最低成膜温度不高于20℃。

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