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1. 发明申请

US20080254464A1 Identification of genetic markers of biological age and metabolism 审中-公开
标题翻译：鉴定生物年龄和代谢的遗传标记
公开(公告)号：US20080254464A1
公开(公告)日：2008-10-16
申请号：US11974837
申请日：2006-11-20
申请人： Richard H. Weindruch , Tomas A. Prolla , Cheol-Koo Lee
发明人： Richard H. Weindruch , Tomas A. Prolla , Cheol-Koo Lee
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q2600/158
摘要： A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid that have been predetermined by either increase or decrease in response to biological aging of the organ, tissue or cell. A method of obtaining biomarkers of aging is also disclosed. This method comprises the step of comparing a gene expression profile of a young multicellular organism subject's organ, tissue or cells; a gene expression profile from a chronologically aged subject's organ, tissue or cell; and a gene expression profile from a chronologically aged but biologically younger subject's organ, tissue or cell and identifying gene expression alterations that are observed when comparing the young subjects and the chronologically aged subjects and are not observed or reduced in magnitude when comparing the young subjects and the chronologically aged but biologically younger subjects.
摘要翻译：公开了一种测量多细胞生物体的生物学年龄的方法。在一个实施方案中，该方法包括以下步骤：获得从生物的器官，组织或细胞分离的核酸样品，并确定核酸内的一组序列的表达模式，其通过响应于器官，组织或细胞的生物衰老。还公开了一种获得老化生物标志物的方法。该方法包括比较年轻多细胞生物受试者的器官，组织或细胞的基因表达谱的步骤; 来自时间顺序老化的受试者的器官，组织或细胞的基因表达谱; 以及来自时间年龄但生物较年轻的受试者的器官，组织或细胞的基因表达谱，并鉴定当比较年轻受试者和按时间顺序老化的受试者时观察到的基因表达改变，并且当比较年轻受试者和按时间顺序老化但生物学较年轻的科目。

2. 发明授权

US07126040B2 Mouse model for aging 有权
标题翻译：老鼠模型老化
公开(公告)号：US07126040B2
公开(公告)日：2006-10-24
申请号：US11119099
申请日：2005-04-29
申请人： Tomas A. Prolla , Gregory C. Kujoth
发明人： Tomas A. Prolla , Gregory C. Kujoth
IPC分类号： A01K67/27 , G01N33/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2267/03
摘要： A mouse model for mammalian aging is disclosed. In one embodiment, the invention comprises a mouse having a genomic mutation in the exonuclease domain II (ExoII) of a mitochondrial DNA polymerase gamma (PolG) gene, wherein the mutation leads to high levels of mutations in polymerase mtDNA.
摘要翻译：公开了哺乳动物老化的小鼠模型。在一个实施方案中，本发明包括在线粒体DNA聚合酶γ（PolG）基因的外切核酸酶结构域II（ExoII）中具有基因组突变的小鼠，其中突变导致聚合酶mtDNA中的高水平突变。

3. 发明授权

US06569624B1 Identification of genetic markers of biological age and metabolism 有权
标题翻译：鉴定生物年龄和代谢的遗传标记
公开(公告)号：US06569624B1
公开(公告)日：2003-05-27
申请号：US09630567
申请日：2000-08-08
申请人： Richard H. Weindruch , Tomas A. Prolla , Cheol-Koo Lee
发明人： Richard H. Weindruch , Tomas A. Prolla , Cheol-Koo Lee
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q2600/158
摘要： A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid that have been predetermined by either increase or decrease in response to biological aging of the organ, tissue or cell. A method of obtaining biomarkers of aging is also disclosed. This method comprises the step of comparing a gene expression profile of a young multicellular organism subject's organ, tissue or cells; a gene expression profile from a chronologically aged subject's organ, tissue or cell; and a gene expression profile from a chronologically aged but biologically younger subject's organ, tissue or cell and identifying gene expression alterations that are observed when comparing the young subjects and the chronologically aged subjects and are not observed or reduced in magnitude when comparing the young subjects and the chronologically aged but biologically younger subjects.
摘要翻译：公开了一种测量多细胞生物体的生物学年龄的方法。在一个实施方案中，该方法包括以下步骤：获得从生物的器官，组织或细胞分离的核酸样品，并确定核酸内的一组序列的表达模式，其通过响应于器官，组织或细胞的生物衰老。还公开了一种获得老化生物标志物的方法。该方法包括比较年轻多细胞生物受试者的器官，组织或细胞的基因表达谱的步骤; 来自时间顺序老化的受试者的器官，组织或细胞的基因表达谱; 以及来自时间年龄但生物较年轻的受试者的器官，组织或细胞的基因表达谱，并鉴定当比较年轻受试者和按时间顺序老化的受试者时观察到的基因表达改变，并且当比较年轻受试者和按时间顺序老化但生物学较年轻的科目。

4. 发明申请

US20100247530A1 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PRESBYCUSIS 审中-公开
标题翻译：用于预防和治疗PRESBYCUSIS的组合物和方法
公开(公告)号：US20100247530A1
公开(公告)日：2010-09-30
申请号：US12727902
申请日：2010-03-19
申请人： Shinichi Someya , Tomas A. Prolla
发明人： Shinichi Someya , Tomas A. Prolla
IPC分类号： A61K39/395 , C07H21/02 , C12N15/11 , A61P25/00 , A61P27/16
CPC分类号： C07K16/40 , C12N15/1135 , C12N2310/11 , C12N2310/14
摘要： The present invention provides compositions and methods for preventing and treating presbycusis. In particular, the present invention provides compositions and methods for preventing and treating presbycusis by inhibiting Bak.
摘要翻译：本发明提供了预防和治疗老年性耳聋的组合物和方法。特别地，本发明提供了通过抑制Bak来预防和治疗老年性耳聋的组合物和方法。

5. 发明授权

US07041449B2 Methods of screening for compounds that inhibit expression of biomarker sequences differentially expressed with age in mice 失效
标题翻译：筛选抑制小鼠与年龄差异表达的生物标志物序列表达的化合物的方法
公开(公告)号：US07041449B2
公开(公告)日：2006-05-09
申请号：US10098205
申请日：2002-03-15
申请人： Tomas A. Prolla , Richard H. Weindruch , Cheol-Koo Lee , Tsuyoshi Kayo
发明人： Tomas A. Prolla , Richard H. Weindruch , Cheol-Koo Lee , Tsuyoshi Kayo
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6809 , C12Q1/6876 , C12Q2600/158
摘要： A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment, the method comprises the steps of: (a) obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell, wherein the nucleic acid is RNA or a cDNA copy of RNA and (b) determining the gene expression pattern of at least one of the genes selected from the group consisting of M21050, Z49204, U49430, K02782, X58861, X66295, M22531, X67809, U19118, M64086, M63695, U39066, X92590, X56518, AA182189, X16493, U20344, X16834, X82648, D00754, D16313, L38971 and X15789.
摘要翻译：公开了一种测量多细胞生物体的生物学年龄的方法。在一个实施方案中，该方法包括以下步骤：（a）获得从生物的器官，组织或细胞分离的核酸样品，其中核酸是RNA或RNA的cDNA拷贝，（b）确定基因表达选自M21050，Z49204，U49430，K02782，X58861，X66295，M22531，X67809，U19118，M64086，M63695，U39066，X92590，X56518，AA182189，X16493，U20344，X16834等的至少一种基因的图案， X82648，D00754，D16313，L38971和X15789。

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