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1. 发明申请

US20050038049A1 Compounds that induce neuronal differentiation in embryonic stem cells 有权
标题翻译：在胚胎干细胞中诱导神经元分化的化合物
公开(公告)号：US20050038049A1
公开(公告)日：2005-02-17
申请号：US10829804
申请日：2004-04-22
申请人： Sheng Ding , Tom Wu , Nathanael Gray , Peter Schultz
发明人： Sheng Ding , Tom Wu , Nathanael Gray , Peter Schultz
IPC分类号： A61K20060101 , A61K31/519 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention provides a novel class of compounds and compositions that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3β, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-β, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to the use of the compounds of the invention as potent inducers of neurogenesis in embryonic stem cells.
摘要翻译：本发明提供了一类新颖的化合物和组合物，其可用于治疗或预防与激酶相关的疾病或病症，特别是GSK-3β，c-Abl，HER-1，HER-2，KDR，Flt-3，c -Raf-1，PDGFR-β，c-Kit，Flt-4，Flt-1，Tek，c-src，CDK1，PDK1，FGFR-1，FGFR-2，Fer，MAP3K13，EPHA7和c-Met激酶。本发明还涉及本发明化合物在胚胎干细胞中作为神经发生的有效诱导剂的用途。

2. 发明授权

US07943649B2 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权
标题翻译： 2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂
公开(公告)号：US07943649B2
公开(公告)日：2011-05-17
申请号：US12288947
申请日：2008-10-24
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
IPC分类号： A61K31/4184 , A61K31/5377 , C07D235/02 , C07D413/14
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译：本发明包括式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。

3. 发明授权

US07711122B2 Method and apparatus for cryptographic key storage wherein key servers are authenticated by possession and secure distribution of stored keys 有权
标题翻译：用于加密密钥存储的方法和装置，其中密钥服务器通过拥有和安全分发所存储的密钥进行认证
公开(公告)号：US07711122B2
公开(公告)日：2010-05-04
申请号：US10093881
申请日：2002-03-08
申请人： Robert Allen , Robert A. Jerdonek , John Wang , Tom Wu
发明人： Robert Allen , Robert A. Jerdonek , John Wang , Tom Wu
IPC分类号： H04L9/08 , H04L9/32
CPC分类号： H04L9/083 , H04L9/0825 , H04L9/0897 , H04L9/3228
摘要： A key management system includes secured data stored on a first system secured by a control key stored securely on a key server. The secured data is secured against attacks such as unauthorized use, modification or access, where authorization to access the secured data is determined by knowledge of an access private key of an access key pair. When an authorized user is to access the secured data, the first system generates a request to the key server, signed with the access private key, wherein the request is for a decryption control key and the request includes a one-time public key of a key pair generated by the first system for the request. The first system can decrypt the decryption control key from the response, using a one-time private key. The first system can then decrypt the secured data with the decryption control key remaining secured in transport.
摘要翻译：密钥管理系统包括存储在由安全地存储在密钥服务器上的控制密钥保护的第一系统上的安全数据。安全数据是针对诸如未授权使用，修改或访问之类的攻击而进行的，其中访问安全数据的授权通过访问密钥对的访问私钥的知识来确定。当授权用户访问安全数据时，第一系统生成对密钥服务器的请求，该密钥服务器用访问私钥签名，其中该请求是用于解密控制密钥，并且该请求包括一个一次性公开密钥密钥对由第一个系统生成的请求。第一系统可以使用一次性私钥从响应中解密解密控制密钥。然后，第一系统可以利用解密控制密钥在传输中保持固定来解密安全数据。

4. 发明申请

US20100172504A1 METHOD AND APPARATUS FOR CRYPTOGRAPHIC KEY STORAGE WHEREIN KEY SERVERS ARE AUTHENTICATED BY POSSESSION AND SECURE DISTRIBUTION OF STORED KEYS 有权
标题翻译：关键服务器的存储关键存储的方法和装置由存储卡的安装和安全分配进行认证
公开(公告)号：US20100172504A1
公开(公告)日：2010-07-08
申请号：US12723480
申请日：2010-03-12
申请人： Robert Allen , Robert A. Jerdonek , John Wang , Tom Wu
发明人： Robert Allen , Robert A. Jerdonek , John Wang , Tom Wu
IPC分类号： H04L9/08 , H04L9/32
CPC分类号： H04L9/083 , H04L9/0825 , H04L9/0897 , H04L9/3228
摘要： A key management system includes secured data stored on a first system secured by a control key stored securely on a key server. The secured data is secured against attacks such as unauthorized use, modification or access, where authorization to access the secured data is determined by knowledge of an access private key of an access key pair. When an authorized user is to access the secured data, the first system generates a request to the key server, signed with the access private key, wherein the request is for a decryption control key and the request includes a one-time public key of a key pair generated by the first system for the request. The first system can decrypt the decryption control key from the response, using a one-time private key. The first system can then decrypt the secured data with the decryption control key remaining secured in transport.
摘要翻译：密钥管理系统包括存储在由安全地存储在密钥服务器上的控制密钥保护的第一系统上的安全数据。安全数据是针对诸如未授权使用，修改或访问之类的攻击而进行的，其中访问安全数据的授权通过访问密钥对的访问私钥的知识来确定。当授权用户访问安全数据时，第一系统生成对密钥服务器的请求，该密钥服务器用访问私钥签名，其中该请求是用于解密控制密钥，并且该请求包括一个密钥对由第一个系统生成的请求。第一系统可以使用一次性私钥从响应中解密解密控制密钥。然后，第一系统可以利用解密控制密钥在传输中保持固定来解密安全数据。

5. 发明申请

US20070208017A1 2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权
标题翻译：作为mPGES-1抑制剂的2-（苯基或杂环）-1H-苯并[9,10-d]咪唑
公开(公告)号：US20070208017A1
公开(公告)日：2007-09-06
申请号：US11374288
申请日：2005-11-23
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4245 , A61K31/4188 , C07D403/14 , C07D413/14
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译：本发明包括式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。

6. 发明授权

US07253166B2 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells 有权
标题翻译： 6-苯基-7H-吡咯并[2,3-d]嘧啶化合物，其诱导胚胎干细胞中的神经元分化
公开(公告)号：US07253166B2
公开(公告)日：2007-08-07
申请号：US10829804
申请日：2004-04-22
申请人： Sheng Ding , Tom Wu , Nathanael S. Gray , Peter Schultz
发明人： Sheng Ding , Tom Wu , Nathanael S. Gray , Peter Schultz
IPC分类号： C07D413/10 , C07D487/04 , A61K31/519 , A61K31/5355 , A61P25/28
CPC分类号： C07D487/04
摘要： The invention provides a novel class of compounds and compositions of Formula I: in which R1, R2 and R3 are defined herein, that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3β, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-β, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to the use of the compounds of the invention as potent inducers of neurogenesis in embryonic stem cells.
摘要翻译：本发明提供了一类新颖的式I化合物和组合物，其中R 1，R 2和R 3是本文定义的，可用于治疗或预防与激酶相关的疾病或病症，特别是GSK-3β，c-Abl，HER-1，HER-2，KDR，Flt-3，c-Raf-1，PDGFR-β， Kit，Flt-4，Flt-1，Tek，c-src，CDK1，PDK1，FGFR-1，FGFR-2，Fer，MAP3K13，EPHA7和c-Met激酶。本发明还涉及本发明化合物在胚胎干细胞中作为神经发生的有效诱导剂的用途。

7. 发明授权

US07361582B2 Method of forming a damascene structure with integrated planar dielectric layers 有权
标题翻译：用集成平面介质层形成镶嵌结构的方法
公开(公告)号：US07361582B2
公开(公告)日：2008-04-22
申请号：US11670720
申请日：2007-02-02
申请人： Tom Wu , Sasson Somekh , Chien Chiang
发明人： Tom Wu , Sasson Somekh , Chien Chiang
IPC分类号： H01L21/44
CPC分类号： H01L21/7684 , C25D3/02 , C25D3/38 , C25D5/22 , C25D5/34 , C25D7/123 , C25D17/001 , H01L21/3212 , H01L21/32125
摘要： Methods are provided for forming a circuit component on a workpiece substrate. The methods comprise the steps of depositing a dielectric material over the substrate; etching a pattern through the dielectric material to expose a portion of the substrate; depositing a barrier metal over the dielectric material and the exposed portion of the substrate; depositing a conductive metal over the barrier metal, the deposited conductive metal having a thickness sufficient to fill the etched pattern; planarizing the conductive metal to form a planar metal layer; and polishing the metal layer and the barrier metal in a single polishing step using an abrasive-free polish until the dielectric material surrounding the pattern is exposed.
摘要翻译：提供了用于在工件基板上形成电路部件的方法。该方法包括以下步骤：在衬底上沉积电介质材料; 蚀刻通过介电材料的图案以暴露基底的一部分; 在介电材料和基板的暴露部分上沉积阻挡金属; 在阻挡金属上沉积导电金属，沉积的导电金属具有足以填充蚀刻图案的厚度; 平面化导电金属以形成平坦的金属层; 并且在单次抛光步骤中使用无研磨抛光剂抛光金属层和阻挡金属，直到暴露图案周围的电介质材料。

8. 发明申请

US20070123033A1 Method of Forming A Damascene Structure with Integrated Planar Dielectric Layers 有权
标题翻译：用集成平面介电层形成镶嵌结构的方法
公开(公告)号：US20070123033A1
公开(公告)日：2007-05-31
申请号：US11670720
申请日：2007-02-02
申请人： Tom Wu , Sasson Somekh , Chien Chiang
发明人： Tom Wu , Sasson Somekh , Chien Chiang
IPC分类号： H01L21/4763
CPC分类号： H01L21/7684 , C25D3/02 , C25D3/38 , C25D5/22 , C25D5/34 , C25D7/123 , C25D17/001 , H01L21/3212 , H01L21/32125
摘要： Methods are provided for forming a circuit component on a workpiece substrate. The methods comprise the steps of depositing a dielectric material over the substrate; etching a pattern through the dielectric material to expose a portion of the substrate; depositing a barrier metal over the dielectric material and the exposed portion of the substrate; depositing a conductive metal over the barrier metal, the deposited conductive metal having a thickness sufficient to fill the etched pattern; planarizing the conductive metal to form a planar metal layer; and polishing the metal layer and the barrier metal in a single polishing step using an abrasive-free polish until the dielectric material surrounding the pattern is exposed.
摘要翻译：提供了用于在工件基板上形成电路部件的方法。该方法包括以下步骤：在衬底上沉积电介质材料; 蚀刻通过介电材料的图案以暴露基底的一部分; 在介电材料和基板的暴露部分上沉积阻挡金属; 在阻挡金属上沉积导电金属，沉积的导电金属具有足以填充蚀刻图案的厚度; 平面化导电金属以形成平坦的金属层; 并且在单次抛光步骤中使用无磨料抛光剂抛光金属层和阻挡金属，直到暴露图案周围的电介质材料。

9. 发明授权

US08290165B2 Method and apparatus for cryptographic key storage wherein key servers are authenticated by possession and secure distribution of stored keys 有权
标题翻译：用于加密密钥存储的方法和装置，其中密钥服务器通过拥有和安全分发所存储的密钥进行认证
公开(公告)号：US08290165B2
公开(公告)日：2012-10-16
申请号：US12723480
申请日：2010-03-12
申请人： Robert Allen , Robert A. Jerdonek , John Wang , Tom Wu
发明人： Robert Allen , Robert A. Jerdonek , John Wang , Tom Wu
IPC分类号： H04L9/00
CPC分类号： H04L9/083 , H04L9/0825 , H04L9/0897 , H04L9/3228
摘要： A key management system includes secured data stored on a first system secured by a control key stored securely on a key server. The secured data is secured against attacks such as unauthorized use, modification or access, where authorization to access the secured data is determined by knowledge of an access private key of an access key pair. When an authorized user is to access the secured data, the first system generates a request to the key server, signed with the access private key, wherein the request is for a decryption control key and the request includes a one-time public key of a key pair generated by the first system for the request. The first system can decrypt the decryption control key from the response, using a one-time private key. The first system can then decrypt the secured data with the decryption control key remaining secured in transport.
摘要翻译：密钥管理系统包括存储在由安全地存储在密钥服务器上的控制密钥保护的第一系统上的安全数据。安全数据是针对诸如未授权使用，修改或访问之类的攻击而进行的，其中访问安全数据的授权通过访问密钥对的访问私钥的知识来确定。当授权用户访问安全数据时，第一系统生成对密钥服务器的请求，该密钥服务器用访问私钥签名，其中该请求是用于解密控制密钥，并且该请求包括一个密钥对由第一个系统生成的请求。第一系统可以使用一次性私钥从响应中解密解密控制密钥。然后，第一系统可以利用解密控制密钥在传输中保持固定来解密安全数据。

10. 发明申请

US20090075998A1 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权
标题翻译： 2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂
公开(公告)号：US20090075998A1
公开(公告)日：2009-03-19
申请号：US12288947
申请日：2008-10-24
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/4439 , A61K31/4245 , A61K31/501 , A61K31/41
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译：本发明包括式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。

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