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1. 发明授权

US08828416B2 Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：拓扑替康与雷帕霉素组合的局部血管输送，以防止血管损伤后的再狭窄
公开(公告)号：US08828416B2
公开(公告)日：2014-09-09
申请号：US10796397
申请日：2004-03-09
申请人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
发明人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
IPC分类号： A61F2/00 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/434 , A61L2420/08 , C08L27/12 , C08L33/02
摘要： Medical devices, in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，用于递送可植入医疗装置的装置可以被修改，以在展开期间减少对可植入医疗装置的损害。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

2. 发明授权

US08652502B2 Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送曲古抑菌素A单独或与西罗莫司联合，以防止血管损伤后再狭窄
公开(公告)号：US08652502B2
公开(公告)日：2014-02-18
申请号：US10742346
申请日：2003-12-19
申请人： Robert Falotico , Tom Jay Parry , Jonathon Zhong Zhao
发明人： Robert Falotico , Tom Jay Parry , Jonathon Zhong Zhao
IPC分类号： A61F13/00 , A61F2/00 , A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/434 , C08L27/16 , C08L27/20
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

3. 发明授权

US07806924B2 Implantable structures for local vascular delivery of cladribine in combination with rapamycin for restenosis 有权
标题翻译：用于局部血管输送的克拉屈滨与雷帕霉素联合用于再狭窄的植入式结构
公开(公告)号：US07806924B2
公开(公告)日：2010-10-05
申请号：US10780596
申请日：2004-02-18
申请人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
发明人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/45 , A61L2420/08 , C08L33/02 , C08L27/12
摘要： Medical devices, and in particular implantable structures, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization.
摘要翻译：可以涂覆医疗装置，特别是可植入结构，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。

4. 发明授权

US08852556B2 Animal model for evaluating vasomotor response in vivo 有权
标题翻译：用于评估体内血管舒缩反应的动物模型
公开(公告)号：US08852556B2
公开(公告)日：2014-10-07
申请号：US12603360
申请日：2009-10-21
申请人： Tom Jay Parry , Bruce P. Damiano , Edward C. Giardino , Margery A. Connelly
发明人： Tom Jay Parry , Bruce P. Damiano , Edward C. Giardino , Margery A. Connelly
IPC分类号： A61K49/00
CPC分类号： A61K49/0008
摘要： A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a central ear artery of said rabbit in comparison with the baseline diameter of the vessel lumen of said central ear artery of said rabbit, said baseline diameter being measured prior to the administration of said compound.
摘要翻译：用于评估化合物对体内血管舒缩反应的影响的方法包括以下步骤：将所述化合物给予兔子，并测量所述兔子的中枢动脉的血管腔的直径与血管腔的基线直径相比的所述兔的所述中枢动脉，所述基线直径在施用所述化合物之前测量。

5. 发明授权

US07303758B2 Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送霉酚酸与雷帕霉素联合，以防止血管损伤后的再狭窄
公开(公告)号：US07303758B2
公开(公告)日：2007-12-04
申请号：US10761032
申请日：2004-01-20
申请人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
发明人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
IPC分类号： A61F2/00 , A61F2/06
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/21 , A61L2300/416 , A61L2420/08 , C08L27/16 , C08L27/20
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

6. 发明授权

US07875282B2 Coated medical device for local vascular delivery of Panzem® in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：用于Panzem®与雷帕霉素组合的局部血管输送的涂层医疗装置，以防止血管损伤后的再狭窄
公开(公告)号：US07875282B2
公开(公告)日：2011-01-25
申请号：US10805736
申请日：2004-03-22
申请人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
发明人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
IPC分类号： A61F13/00 , A61F2/00 , A61K31/70 , A61K31/56
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/43 , A61L2300/45 , A61L2300/608 , A61L2420/08
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

7. 发明申请

US20100189654A1 ANIMAL MODEL FOR EVALUATING VASOMOTOR RESPONSE IN VIVO 有权
标题翻译：用于评估VIVO中VASOMOTOR反应的动物模型
公开(公告)号：US20100189654A1
公开(公告)日：2010-07-29
申请号：US12603360
申请日：2009-10-21
申请人： Tom Jay Parry , Bruce P. Damiano , Edward C. Giardino , Margery A. Connelly
发明人： Tom Jay Parry , Bruce P. Damiano , Edward C. Giardino , Margery A. Connelly
IPC分类号： A61K49/00
CPC分类号： A61K49/0008
摘要： A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a central ear artery of said rabbit in comparison with the baseline diameter of the vessel lumen of said central ear artery of said rabbit, said baseline diameter being measured prior to the administration of said compound.
摘要翻译：用于评估化合物对体内血管舒缩反应的影响的方法包括以下步骤：将所述化合物给予兔子，并测量所述兔子的中枢动脉的血管腔的直径与血管腔的基线直径相比的所述兔的所述中枢动脉，所述基线直径在施用所述化合物之前测量。

8. 发明授权

US07695731B2 Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送依托泊苷与雷帕霉素联合，以防止血管损伤后的再狭窄
公开(公告)号：US07695731B2
公开(公告)日：2010-04-13
申请号：US10805722
申请日：2004-03-22
申请人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
发明人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/43 , A61L2300/45 , A61L2300/608 , A61L2420/08
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

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