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1. 发明授权

US07897257B2 Magnetic beads comprising an outer coating of hydrophilic porous polymer and method of making thereof 有权
标题翻译：包含亲水性多孔聚合物的外涂层的磁珠及其制造方法
公开(公告)号：US07897257B2
公开(公告)日：2011-03-01
申请号：US11911540
申请日：2006-04-13
申请人： Mathias Alterman , Andreas Axen , Gunnar Glad , Dag Lindstrom , Ulrika Meyer , Nils Norrman , Tobias Soderman
发明人： Mathias Alterman , Andreas Axen , Gunnar Glad , Dag Lindstrom , Ulrika Meyer , Nils Norrman , Tobias Soderman
IPC分类号： B32B5/16 , B05D7/00
CPC分类号： G01N33/54326 , H01F1/0054 , H01F1/36 , Y10T428/12014 , Y10T428/12028 , Y10T428/2998
摘要： The present invention relates to magnetic beads suitable for, for example, isolation of proteins, cells, and viruses and also for diagnostic applications and cell cultivation. The magnetic beads are composite beads with an inner core of metal particles, which are coated with an inert synthetic polymer and these are then enclosed in a hydrophilic porous polymer, preferably agarose. This provides porous biocompatible beads without metal leakage. The beads may be used for cell cultivation or for chromatography. When the beads are used for chromatography the agarose layer is preferably provided with ligands having affinity for selected biomolecules.
摘要翻译：本发明涉及适合于例如分离蛋白质，细胞和病毒以及用于诊断应用和细胞培养的磁珠。磁珠是具有金属颗粒内核的复合珠粒，其中涂有惰性合成聚合物，然后将其包封在亲水性多孔聚合物，优选琼脂糖中。这提供了多孔的生物相容珠，而没有金属泄漏。珠粒可用于细胞培养或色谱法。当珠子用于层析时，琼脂糖层优选具有对选定的生物分子具有亲和性的配体。

2. 发明申请

US20090281288A1 MATRIX FOR SEPARATION OF POLYETHERS AND METHOD OF SEPARATION 有权
标题翻译：用于分离聚合物的基质和分离方法
公开(公告)号：US20090281288A1
公开(公告)日：2009-11-12
申请号：US12506445
申请日：2009-07-21
申请人： JAMES VAN ALSTINE , Jan Bergstrom , Henrik Ihre , Tobias Soderman
发明人： JAMES VAN ALSTINE , Jan Bergstrom , Henrik Ihre , Tobias Soderman
IPC分类号： C07K1/14 , C07C29/74
CPC分类号： B01J20/3278 , B01D15/32 , B01D15/362 , B01D15/38 , B01D15/424 , B01J20/286 , B01J20/288 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/328
摘要： The present invention relates to a separation matrix comprised of a support to the surfaces of which polymer chains have been coupled, wherein each polymer chain presents recurring proton-donating groups and at least the surface of the support is substantially hydrophilic. In the most advantageous embodiment, the support is porous cross-linked agarose, the polymers are poly(acrylic acid) and the proton-donating groups are carboxyl groups. The matrix is useful e.g. to remove PEG from pegylated and/or native compounds in a liquid. Accordingly, the invention also encompasses a method, such as a chromatographic method, wherein the separation matrix according to the invention is used, for example as a pre-treatment of a reaction mixture that comprises unreacted PEG, pegylated proteins and native proteins.
摘要翻译：本发明涉及一种分离基质，其由其上已经连接有聚合物链的表面的载体组成，其中每个聚合物链呈现重复的质子供体基团，并且载体的至少表面基本上是亲水的。在最有利的实施方案中，载体是多孔交联琼脂糖，聚合物是聚（丙烯酸），质子供体基团是羧基。该矩阵是有用的。以从液体中的聚乙二醇化和/或天然化合物中除去PEG。因此，本发明还包括诸如色谱方法的方法，其中使用根据本发明的分离基质，例如作为包含未反应的PEG，聚乙二醇化蛋白质和天然蛋白质的反应混合物的预处理。

3. 发明申请

US20080138247A1 Liquid Detection and Confidence Determination 审中-公开
标题翻译：液体检测和置信度测定
公开(公告)号：US20080138247A1
公开(公告)日：2008-06-12
申请号：US11719078
申请日：2005-11-10
申请人： Mats Inganas , Tobias Soderman , Erik Hogstrand
发明人： Mats Inganas , Tobias Soderman , Erik Hogstrand
IPC分类号： G01J3/00 , B01J19/00 , G01N35/00
CPC分类号： G01N35/00069 , G01N35/08
摘要： A method and a system for grading the confidence of a result of an experiment that comprises one or more biological and/or chemical reactions and is carried out in a microchannel structure (110a) of a microfluidic device, said confidence determination comprises the steps of: i) detecting within each of at least one liquid detector segment of said microchannel structure (110a) the presence or absence of liquid and/or gas during a period of time for which it is known if liquid and/or gas shall be present and/or absent in the segment, and ii) assigning a lowered confidence to said result if the presence and/or absence of liquid and/or gas found in step (i) is deviating from what it shall be.
摘要翻译：一种用于对包括一种或多种生物和/或化学反应的实验结果的置信度进行分级并在微流体装置的微通道结构（110a）中进行）的方法和系统，所述置信度确定包括以下步骤：：i）在所述微通道结构（110a）的至少一个液体检测器段的每一个内检测液体和/或气体是否存在的一段时间内是否存在液体和/或气体和/或在该段中不存在，以及ii）如果在步骤（i）中发现的液体和/或气体的存在和/或不存在偏离了它将是什么，则对所述结果分配降低的置信度。

4. 发明授权

US07221783B2 Method and arrangement for reducing noise 有权
标题翻译：减少噪音的方法和装置
公开(公告)号：US07221783B2
公开(公告)日：2007-05-22
申请号：US10331399
申请日：2002-12-30
申请人： Tobias Soderman
发明人： Tobias Soderman
IPC分类号： G06K9/00
CPC分类号： G01N35/00069 , B01L3/5027 , G01N21/6402 , G01N21/6456 , G01N21/76 , G01N2035/00188
摘要： The present invention concerns a method and an arrangement for reducing noise in a substance raw data image containing noise. The method may comprise following steps in any order for removing different noise signals contributions step-by-step in any order in a substance raw data image: reducing background radiation; reducing peak disturbance; locating the detection area within the search area; moving binary artifacts; removing unwanted areas of the detection area; and applying default detection area in noisy images). The present invention also relates to a method and an arrangement for determining a measure of at least one substance.
摘要翻译：本发明涉及一种降低包含噪声的物质原始数据图像中的噪声的方法和装置。该方法可以包括以下步骤：以物质原始数据图像中任何顺序逐步去除不同噪声信号贡献的顺序：减少背景辐射; 减少峰值扰动; 将检测区域定位在搜索区域内; 移动二进制文物; 去除检测区域的不需要的区域; 并在噪声图像中应用默认检测区域）。本发明还涉及用于确定至少一种物质的量度的方法和装置。

5. 发明申请

US20070118490A1 Confidence determination 有权
标题翻译：信心决心
公开(公告)号：US20070118490A1
公开(公告)日：2007-05-24
申请号：US10555009
申请日：2004-06-30
申请人： Tobias Soderman , Mats Inganas
发明人： Tobias Soderman , Mats Inganas
IPC分类号： G06F15/18 , G06E1/00
CPC分类号： G06T7/0004 , B01L3/5027 , G06N3/02 , G06T7/0012 , G06T2207/10008 , G06T2207/20084
摘要： The present invention relates to a method, a system, a neural network and a computer program product for determining the quality of an analytical process, preferably the confidence value C. The analytical process is performed in a microchannel structure of a microfluidic device, from which data information of the analytic process is acquired by scanning at least one search area of the microchannel structure for signal data. Said search area comprises the result of the analytical process and said acquired data information is stored as an image, one image for each scanned search area.
摘要翻译：本发明涉及一种用于确定分析过程质量，优选置信度值C的方法，系统，神经网络和计算机程序产品。分析过程在微流体装置的微通道结构中进行，通过扫描用于信号数据的微通道结构的至少一个搜索区域来获取分析处理的数据信息。所述搜索区域包括分析处理的结果，并且所述获取的数据信息被存储为图像，每个扫描的搜索区域存储一个图像。

6. 发明授权

US08137559B2 Liquid clarification 失效
标题翻译：液体澄清
公开(公告)号：US08137559B2
公开(公告)日：2012-03-20
申请号：US12523322
申请日：2008-01-28
申请人： Michael Katzke , Ola Lind , Tobias Soderman , James Van Alstine
发明人： Michael Katzke , Ola Lind , Tobias Soderman , James Van Alstine
IPC分类号： B01D15/08
CPC分类号： A23L2/80 , A23L2/02 , B01D15/00 , B01J20/26 , B01J20/264 , B01J20/265 , C12H1/0424
摘要： The present invention relates to liquid clarification. More closely, the invention relates to beverage clarification, such as reduction of colloidal (not microbial) haze-causing substances in beer or related beverages such as wine, juices, flavorings etc. The method of the invention uses a hydrophilic surface for adsorption of haze-forming substances by hydrogen bonding interaction properties between the surface and the haze-forming substances.
摘要翻译：本发明涉及液体澄清。更具体地，本发明涉及饮料澄清，例如在啤酒或相关饮料如葡萄酒，果汁，调味料等中减少胶体（非微生物）雾状物质。本发明的方法使用亲水表面吸附雾度通过表面和雾状物质之间的氢键相互作用特性形成物质。

7. 发明申请

US20070292044A1 METHOD OF ANALYSING CELL SAMPLES, BY CREATING AND ANALYSING A RESULTANT IMAGE 有权
标题翻译：分析细胞样品的方法，通过创建和分析结果图像
公开(公告)号：US20070292044A1
公开(公告)日：2007-12-20
申请号：US11611934
申请日：2006-12-18
申请人： ERIK SLOGE , TOBIAS SODERMAN , LENNART BJORKESTEN
发明人： ERIK SLOGE , TOBIAS SODERMAN , LENNART BJORKESTEN
IPC分类号： G06K9/40
CPC分类号： G06K9/00127 , G06T7/0012
摘要： A method is provided for comparing multiple samples of cell extract containing a plurality of components. The method comprises the steps of preparing at least two samples of cell extract from at least two groups of cells and of exposing each of said sample of said cell extract to a different one of a set of matched markers, e.g. luminescent markers, to bind the marker to the cell extract to label the cell extract, each marker within said set of markers being capable of binding to the cell extract and can be individually detected from all other markers within said set. The samples are then mixed to form a mixture and said mixture is electrophoresed to separate the components within the cell extract. At least two electronic images of the electrophoresed mixture are obtained (I) by detection of the individual markers, each image being represented by detection of a marker different from the others. One resultant electronic image (Ires) of the obtained at least two electronic images is created (II) and analyzed in order to identify spot analysis areas (III). The identified spot analysis areas are applied on the respective at least two electronic images for evaluating said areas in order to detect spots representing components of said cell extracts (IV).
摘要翻译：提供了一种用于比较包含多个组分的细胞提取物的多个样品的方法。该方法包括以下步骤：从至少两组细胞制备细胞提取物的至少两个样品，并将每个所述细胞提取物的所述样品暴露于一组匹配的标记物，例如，将标记物结合到细胞提取物以标记细胞提取物，所述标记物组内的每个标记物能够结合细胞提取物，并且可以从所述组中的所有其它标记物单独检测。然后将样品混合以形成混合物，并将所述混合物电泳以分离细胞提取物内的组分。通过检测各个标记获得电泳混合物的至少两个电子图像（I），每个图像通过检测与其他标记不同的标记来表示。创建（II）获得的至少两个电子图像的一个结果电子图像（I），并分析以识别点分析区域（III）。所识别的斑点分析区域被应用于相应的至少两个电子图像，用于评估所述区域，以便检测表示所述细胞提取物（IV）的组分的斑点。

8. 发明授权

US07155050B1 Method of analyzing cell samples, by creating and analyzing a resultant image 有权
标题翻译：通过创建和分析所得图像来分析细胞样品的方法
公开(公告)号：US07155050B1
公开(公告)日：2006-12-26
申请号：US10129448
申请日：2000-10-31
申请人： Erik Sloge , Tobias Soderman , Lennart Bjorkesten
发明人： Erik Sloge , Tobias Soderman , Lennart Bjorkesten
IPC分类号： G06K9/00
CPC分类号： G06K9/00127 , G06T7/0012
摘要： A method is provided for comparing multiple samples of cell extract containing a plurality of components. The method comprises the steps of preparing at least two samples of cell extract from at least two groups of cells and of exposing each of said sample of said cell extract to a different one of a set of matched markers, e.g. luminescent markers, to bind the marker to the cell extract to label the cell extract, each marker within said set of markers being capable of binding to the cell extract and can be individually detected from all other markers within said set. The samples are then mixed to form a mixture and said mixture is electrophoresed to separate the components within the cell extract. At least two electronic images of the electrophoresed mixture are obtained (I) by detection of the individual markers, each image being represented by detection of a marker different from the others. One resultant electronic image (Ires) of the obtained at least two electronic images is created (II) and analyzed in order to identify spot analysis areas (III). The identified spot analysis areas are applied on the respective at least two electronic images for evaluating said areas in order to detect spots representing components of said cell extracts (IV).
摘要翻译：提供了一种用于比较包含多个组分的细胞提取物的多个样品的方法。该方法包括以下步骤：从至少两组细胞制备细胞提取物的至少两个样品，并将每个所述细胞提取物的所述样品暴露于一组匹配的标记物，例如，将标记物结合到细胞提取物以标记细胞提取物，所述标记物组内的每个标记物能够结合细胞提取物，并且可以从所述组中的所有其它标记物单独检测。然后将样品混合以形成混合物，并将所述混合物电泳以分离细胞提取物内的组分。通过检测各个标记获得电泳混合物的至少两个电子图像（I），每个图像通过检测与其他标记不同的标记来表示。创建（II）获得的至少两个电子图像的一个结果电子图像（I），并分析以识别点分析区域（III）。所识别的斑点分析区域被应用于相应的至少两个电子图像，用于评估所述区域，以便检测表示所述细胞提取物（IV）的组分的斑点。

9. 发明申请

US20050143477A1 Macroporous cross-linked polymer particles 审中-公开
标题翻译：大孔交联聚合物颗粒
公开(公告)号：US20050143477A1
公开(公告)日：2005-06-30
申请号：US10514857
申请日：2003-05-27
申请人： Tobias Soderman
发明人： Tobias Soderman
IPC分类号： C08F16/32 , B01D15/32 , B01J20/26 , B01J20/30 , C08F2/18 , C08F8/00 , C08F283/06 , C08J9/00
CPC分类号： G01N30/482 , B01D15/325 , B01J20/26 , B01J20/261 , B01J20/267 , B01J20/285 , B01J20/287 , B01J20/30 , B01J2220/54 , C08F283/06 , C08F216/125
摘要： The present invention relates to a method of producing one or more macroporous cross-linked polymer particles, comprising polymerizing via free radical initiation and cross-linking of bifunctional vinyl ether monomers in an inert solvent that includes ether groups. The invention also relates to particles so produced, which are useful as separation medium e.g. in RPC or, after suitable derivatisation, in other chromatographic methods.
摘要翻译：本发明涉及一种生产一种或多种大孔交联聚合物颗粒的方法，其包括通过自由基引发和双官能乙烯基醚单体在包括醚基团的惰性溶剂中的交联聚合。本发明还涉及如此制备的颗粒，其可用作分离介质，例如在RPC中，或在合适的衍生化之后，在其他色谱方法中。

10. 发明授权

US09377403B2 Adaptive linear filter for real time noise reduction in surface plasmon resonance sensorgrams 有权
标题翻译：自适应线性滤波器，用于表面等离子体共振传感图中的实时降噪
公开(公告)号：US09377403B2
公开(公告)日：2016-06-28
申请号：US13637389
申请日：2011-03-28
申请人： Tobias Soderman
发明人： Tobias Soderman
IPC分类号： G01N21/55 , G01N21/552
CPC分类号： G01N21/553 , G01N2201/12
摘要： A method for linear filtering of noise in a sensorgram generated from a surface plasmon resonance apparatus, the method comprising: providing a linear filter of variable length to filter an output signal in the sensorgram; and determining an optimal length of the linear filter based on a slope of the signal in the sensorgram and a locked interception linear error, LILE, detector.
摘要翻译：一种用于线性滤波从表面等离子体共振装置产生的传感图中的噪声的方法，所述方法包括：提供可变长度的线性滤波器以对传感图中的输出信号进行滤波; 并且基于传感图中的信号的斜率和锁定的截取线性误差LILE，检测器来确定线性滤波器的最佳长度。

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