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1. 发明申请

US20060173476A1 Coring device for preserving living tissue 有权
标题翻译：用于保存活组织的取心装置
公开(公告)号：US20060173476A1
公开(公告)日：2006-08-03
申请号：US11049410
申请日：2005-02-02
申请人： Gino Bradica , Timothy Ringeisen
发明人： Gino Bradica , Timothy Ringeisen
IPC分类号： A61B17/32
CPC分类号： A61B17/32053 , A61B17/1635 , A61B17/32002 , A61B2017/00464 , A61B2017/00858
摘要： Improved coring devices suitable for articular cartilage and bone, wherein the cutting device is capable of slicing through a tough protective tangential zone, delicately separating the shock absorbing columns of cells in the radial zone of the cartilage, and finally cutting into the hard underlying bone in a manner that preserves the viability of osteochondral cells. The coring device features an annulus having a flat annular cutting edge interrupted by at least one serration having neutral cutting angles. A method for concurrently removing cartilaginous and bony tissue using an improved coring device that preserves the viability of osteochondral cells.
摘要翻译：改进的适用于关节软骨和骨骼的取芯装置，其中切割装置能够穿过坚韧的保护性切向区域，精细地分离软骨的径向区域中的细胞的减震柱，并最终切割成硬的下面的骨骼一种保持骨软骨细胞活力的方法。取芯装置具有环形，其具有由至少一个具有中间切割角度的锯齿状物中断的平坦环形切割刃。使用改进的取芯装置同时去除软骨和骨组织的方法，其保持骨软骨细胞的活力。

2. 发明申请

US20070202148A1 HIGH DENSITY FIBROUS POLYMERS SUITABLE FOR IMPLANT 有权
标题翻译：适用于植入物的高密度纤维聚合物
公开(公告)号：US20070202148A1
公开(公告)日：2007-08-30
申请号：US11741611
申请日：2007-04-27
申请人： Timothy Ringeisen , William Wattengel
发明人： Timothy Ringeisen , William Wattengel
IPC分类号： A61F2/02 , B28B1/14
CPC分类号： A61L27/16 , A61B17/68 , A61B17/70 , A61B17/7062 , A61B17/72 , A61B2017/00526 , A61F2/0059 , A61F2/24 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/4241 , A61F2/44 , A61F2/4465 , A61F2002/30062 , A61F2002/4475 , A61F2002/4495 , A61F2210/0004 , A61F2310/00365 , A61L26/0033 , A61L26/008 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3616 , A61L27/3804 , A61L27/3834 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , C08H1/06 , C08K3/013 , C08L5/04 , C08L5/08 , C08L67/04 , C08L89/06 , C08L2205/16
摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
摘要翻译：本发明包括用于施用于组织部位以促进或促进新组织生长的可延展的，可生物降解的纤维组合物。本发明的一个方面是提供独特的机械和物理性质的纤维组分。本发明可以通过提供含有浆料的容器来产生，所述浆料包含多个天然或合成聚合物纤维和至少一种悬浮液，其中所述聚合物纤维基本均匀地分散并随机取向于整个悬浮液体积; 向包含所述浆料的所述容器施加力（例如离心），于是所述力用于使所述聚合物纤维迁移穿过悬浮液并聚集在容器的最远处，形成聚合物材料，所述聚合物材料包含聚合物纤维具有足够的长度并且足够粘稠，交错或互锁以阻止所述聚合物纤维的解离。

3. 发明申请

US20050246021A1 Compressed porous materials suitable for implant 有权
标题翻译：压缩多孔材料适合植入
公开(公告)号：US20050246021A1
公开(公告)日：2005-11-03
申请号：US10836740
申请日：2004-04-29
申请人： Timothy Ringeisen , Amanda Turner , Joseph DeMeo , Patrick Hearn , Robert McDade
发明人： Timothy Ringeisen , Amanda Turner , Joseph DeMeo , Patrick Hearn , Robert McDade
IPC分类号： A61F2/02 , A61F2/28 , A61F2/44 , A61L27/00 , A61L27/56
CPC分类号： A61B17/0642 , A61B17/7059 , A61B17/846 , A61B17/866 , A61F2/3094 , A61F2002/2817 , A61F2002/30014 , A61F2002/30032 , A61F2002/30036 , A61F2002/30062 , A61F2002/30235 , A61F2002/30563 , A61F2002/30578 , A61F2002/30677 , A61F2002/30904 , A61F2002/3092 , A61F2002/30971 , A61F2310/00293 , A61F2310/0097 , A61L27/56
摘要： A high strength porous polymeric material manufactured by a compression process is disclosed. The material results in a network of interconnected collapsed pores, which forces thin overlapping walls and passages to be created. The network provides permeable access for fluid migration throughout the material. The strength and/or permeability are advantageous for medical devices and implants.
摘要翻译：公开了一种通过压缩方法制造的高强度多孔聚合材料。该材料导致相互连接的塌陷孔的网络，这迫使薄的重叠壁和通道产生。网络为整个材料的流体迁移提供可渗透性。强度和/或渗透性对于医疗装置和植入物是有利的。

4. 发明申请

US20050123581A1 Compressed high density fibrous polymers suitable for implant 有权
标题翻译：适用于植入物的压缩高密度纤维聚合物
公开(公告)号：US20050123581A1
公开(公告)日：2005-06-09
申请号：US10729146
申请日：2003-12-04
申请人： Timothy Ringeisen , W. Wattengel
发明人： Timothy Ringeisen , W. Wattengel
IPC分类号： A61L15/32 , A61L27/24 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L28/00 , A61L31/04 , A61L31/10 , A61L31/14 , A61F13/00 , A61F2/00 , D01D5/30
CPC分类号： A61L31/141 , A61L27/502 , A61L31/10
摘要： An embodiment of the present invention may be made by the following steps: providing a mixture comprising a plurality of fibers, a lubricant, and a suspension fluid, with the suspension fluid filling a void space between said fibers and subjecting said mixture to at least one compressive force. The compressive force causes the migration and alignment of said fibers; and may remove substantially all of the suspension fluid from said mixture. The mixture may further comprise a biologically active agent, or a reinforcing agent.
摘要翻译：本发明的一个实施方案可以通过以下步骤制备：提供包含多种纤维，润滑剂和悬浮液的混合物，其中悬浮液填充所述纤维之间的空隙并使所述混合物至少一种压缩力。压缩力导致所述纤维的迁移和排列; 并且可以从所述混合物中基本上去除所有的悬浮液。混合物还可以包含生物活性剂或增强剂。

5. 发明申请

US20050075408A1 Method for making a porous polymeric material 有权
标题翻译：制造多孔聚合材料的方法
公开(公告)号：US20050075408A1
公开(公告)日：2005-04-07
申请号：US10948486
申请日：2004-09-23
申请人： Timothy Ringeisen , Scott Goldman
发明人： Timothy Ringeisen , Scott Goldman
IPC分类号： C08J9/28
CPC分类号： C08J9/0033 , A61L27/34 , A61L27/54 , B29C41/12 , B29C41/14 , B29C45/0001 , C08J9/0014 , C08J9/0023 , C08J9/0028 , C08J9/28 , C08J2201/054
摘要： Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second liquid is added to a polymer solution, the second liquid causing the solution to increase in viscosity. With sufficient polymer and second liquid present, the increase in viscosity can be up to that of a gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. A second material may be incorporated into the chambers, thereby creating a microstructure filling the voids of the macrostructure. A porous polymeric body manufactured by this process may incorporate biologically active agents, and which agents may be delivered in a time-staged delivery manner, where differing drugs may be delivered over differing periods.
摘要翻译：通过新的凝胶增强相分离技术产生多孔聚合物，其具有高度卷曲的多个开口或室，每个室由多个薄的平坦隔板限定。在优选的实施方案中，将第二液体加入到聚合物溶液中，使第二液体溶液增加粘度。当存在足够的聚合物和第二液体时，粘度的增加可以达到凝胶的增加。然后可以根据需要成型凝胶。随后的溶剂萃取离开具有限定形状的多孔聚合物体。多孔聚合物可用作医用假体，孔隙度允许相邻组织向内生长。可以将第二材料并入室中，从而产生填充宏观结构的空隙的微结构。通过该方法制造的多孔聚合体可以并入生物活性剂，并且哪些试剂可以按时间递送方式递送，其中不同的药物可以在不同的时期内递送。

6. 发明授权

US5855608A Device and methods for in vivo culturing of diverse tissue cells 失效
公开(公告)号：US5855608A
公开(公告)日：1999-01-05
申请号：US367510
申请日：1994-12-30
申请人： John H. Brekke , Timothy Ringeisen
发明人： John H. Brekke , Timothy Ringeisen
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/20 , C12N5/06 , A61K9/14
CPC分类号： A61F2/28 , A61L27/20 , A61F2/30756 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2250/0067
摘要： An anatomically specific, bioresorbable, implant device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment of using the implant device for facilitating the healing of a human joint lesion includes a cartilage region invested with an alginate microstructure joined with a subchondral bone region invested with a hyaluronan microstructure. The alginate selectively dispersed in the cartilage region enhances the environment for chondrocytes to grow articular cartilage. The hyaluronan selectively dispersed in the subchondral bone region enhances the environment for mesenchymal cells which migrate into that region's macrostructure and which differentiate into osteoblasts. The microstructures can be invested at varying concentrations in the regions. A hydrophobic barrier, strategically positioned within the subchondral bone region macrostructure, shields the chondrocytes from the oxygenated blood in subchondral cancellous bone. In the preferred form, the cartilage region includes a tangential zone including a network of intercommunicating void spaces having a horizontal orientation and in communication with synovial fluid and includes a radial zone including multiple void spaces oriented in both horizontal and vertical planes and providing intercommunication between the tangential zone and the subchondral bone region.

7. 发明申请

US20060217753A1 Coring device for preserving living tissue 有权
公开(公告)号：US20060217753A1
公开(公告)日：2006-09-28
申请号：US11356784
申请日：2006-02-17
申请人： Gino Bradica , Timothy Ringeisen
发明人： Gino Bradica , Timothy Ringeisen
IPC分类号： A61B17/32 , A61B17/14
CPC分类号： A61B17/32053 , A61B17/1635 , A61B17/32002 , A61B2017/00464 , A61B2017/00858
摘要： Improved coring devices suitable for articular cartilage and bone, wherein the cutting device is capable of slicing through a tough protective tangential zone, delicately separating the shock absorbing columns of cells in the radial zone of the cartilage, and finally cutting into the hard underlying bone in a manner that preserves the viability of osteochondral cells. The coring device features an annulus having a flat annular cutting edge interrupted by at least one serration having neutral cutting angles. A method for concurrently removing cartilaginous and bony tissue using an improved coring device that preserves the viability of osteochondral cells.

8. 发明申请

US20060002980A1 High density fibrous polymers suitable for implant 有权
标题翻译：适用于植入物的高密度纤维聚合物
公开(公告)号：US20060002980A1
公开(公告)日：2006-01-05
申请号：US11178175
申请日：2005-07-08
申请人： Timothy Ringeisen , William Wattengel
发明人： Timothy Ringeisen , William Wattengel
IPC分类号： A61F2/00 , A61K31/728
CPC分类号： A61L27/16 , A61B17/68 , A61B17/70 , A61B17/7062 , A61B17/72 , A61B2017/00526 , A61F2/0059 , A61F2/24 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/4241 , A61F2/44 , A61F2/4465 , A61F2002/30062 , A61F2002/4475 , A61F2002/4495 , A61F2210/0004 , A61F2310/00365 , A61L26/0033 , A61L26/008 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3616 , A61L27/3804 , A61L27/3834 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , C08H1/06 , C08K3/013 , C08L5/04 , C08L5/08 , C08L67/04 , C08L89/06 , C08L2205/16
摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
摘要翻译：本发明包括用于施用于组织部位以促进或促进新组织生长的可延展的，可生物降解的纤维组合物。本发明的一个方面是提供独特的机械和物理性质的纤维组分。本发明可以通过提供含有浆料的容器来产生，所述浆料包含多个天然或合成聚合物纤维和至少一种悬浮液，其中所述聚合物纤维基本均匀地分散并随机取向于整个悬浮液体积; 向包含所述浆料的所述容器施加力（例如离心），于是所述力用于使所述聚合物纤维迁移穿过悬浮液并聚集在容器的最远处，形成聚合物材料，所述聚合物材料包含聚合物纤维具有足够的长度并且足够粘稠，交错或互锁以阻止所述聚合物纤维的解离。

9. 发明申请

US20050186240A1 Gel suitable for implantation and delivery system 审中-公开
标题翻译：凝胶适用于植入和输送系统
公开(公告)号：US20050186240A1
公开(公告)日：2005-08-25
申请号：US10785665
申请日：2004-02-23
申请人： Timothy Ringeisen , William Wattengel
发明人： Timothy Ringeisen , William Wattengel
IPC分类号： A61L27/20 , A61L27/24 , A61L27/52 , A61L27/56 , A61K9/14
CPC分类号： A61L27/56 , A61L27/20 , A61L27/24 , A61L27/52 , C08L5/08
摘要： The invention concerns a dried form of a porous polymer gel material which may be rehydrated and placed under pressure or compression to induce solvation, thereby forming a high concentration gel, in the form of an injectable viscous putty or dough, which may be implantated in the body.
摘要翻译：本发明涉及干燥形式的多孔聚合物凝胶材料，其可以被再水化并置于压力或压缩下以诱导溶剂化，从而形成可注射粘性油灰或面团形式的高浓度凝胶，其可以植入在身体。

10. 发明申请

US20050085817A1 Compliant osteosynthesis fixation plate 有权
标题翻译：合格的骨接合固定板
公开(公告)号：US20050085817A1
公开(公告)日：2005-04-21
申请号：US10940117
申请日：2004-09-14
申请人： Timothy Ringeisen
发明人： Timothy Ringeisen
IPC分类号： A61B17/00 , A61B17/80 , A61L31/04 , A61L31/12 , A61L31/14 , A61L31/16 , A61L31/18 , A61B17/58
CPC分类号： A61B17/8061 , A61B17/80 , A61B17/8085 , A61B2017/00004 , A61L31/04 , A61L31/125 , A61L31/146 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/00
摘要： A bendable polymer tissue fixation device suitable to be implanted into a living body, consisting of a highly porous body, made from a polymer, the porous body having a plurality of pores, such that the device is capable of being smoothly bent, wherein the bending collapses a portion of the pores to form a radius curve, and the polymer fixation device is rigid enough to protect a tissue from shifting. Preferably, the polymer fixation device may be capable of being gradually resorbed by said living body. In one embodiment, the polymer fixation device consists of a plurality of layers distinguishable by various characteristics, such as structural or chemical properties. In another embodiment, the polymer fixation device may feature additional materials which serve to reinforce or otherwise alter the structure or physical characteristics of the device, or alternatively the additional materials serve to deliver therapies to the living being.
摘要翻译：一种可弯曲聚合物组织固定装置，适合于植入由聚合物制成的高度多孔体的活体中，所述多孔体具有多个孔，使得该装置能够平滑弯曲，其中弯曲塌陷一部分孔以形成半径曲线，并且聚合物固定装置足够刚性以保护组织免于移动。优选地，聚合物固定装置可能能够被所述活体逐渐吸收。在一个实施方案中，聚合物固定装置由可由各种特性区分的多个层组成，例如结构或化学性质。在另一个实施方案中，聚合物固定装置可以具有附加材料，其用于加强或以其它方式改变装置的结构或物理特性，或者替代地，附加材料用于向生物提供疗法。

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