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1. 发明授权

US08034928B2 Fluorescence assays with improved sensitivity 有权
标题翻译：荧光检测灵敏度提高
公开(公告)号：US08034928B2
公开(公告)日：2011-10-11
申请号：US12426997
申请日：2009-04-21
申请人： Ronald T. Raines , Sunil S. Chandran , Timothy E. Glass , Luke D. Lavis
发明人： Ronald T. Raines , Sunil S. Chandran , Timothy E. Glass , Luke D. Lavis
IPC分类号： C07D407/00 , C07D493/00 , C07D273/00
CPC分类号： C12Q1/34 , C07D493/10 , C09B11/24 , C09B19/00 , G01N33/581 , G01N33/582 , G01N2333/916 , G01N2333/924
摘要： Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more molecules of interest, such as proteins, peptides or nucleic acids. The blocking group(s) is released from the latent fluorescent compound by reaction with a trigger, forming the fluorescent molecule which can be detected. Also provided herein are methods of using latent fluorescent compounds to detect triggers.
摘要翻译：提供了包含具有一个或多个连接基团和任选的一个或多个含脲基团的荧光分子的潜在荧光化合物。含尿素基团可用于进一步连接一种或多种感兴趣的分子，例如蛋白质，肽或核酸。通过与触发剂反应，阻断基团从潜在荧光化合物释放，形成可被检测的荧光分子。本文还提供了使用潜伏荧光化合物来检测触发剂的方法。

2. 发明授权

US06586256B1 Chemical sensors and method of use 失效
标题翻译：化学传感器及使用方法
公开(公告)号：US06586256B1
公开(公告)日：2003-07-01
申请号：US09562202
申请日：2000-05-02
申请人： Timothy E. Glass , Joseph Raker , Ricardo Moran
发明人： Timothy E. Glass , Joseph Raker , Ricardo Moran
IPC分类号： G01N2164
CPC分类号： G01N21/6428 , G01N2021/7786
摘要： Chemical sensor compositions and methods for quantifying analytes are described. The chemical sensors include analyte-binding moieties and reporter moieties covalently attached to a framework including two trityl groups connected by a linear spacer such as ethyne or butadiyne. The sensors chelate an analyte across the acetylene axis of the molecule to stabilize the molecule in an eclipsed rotamer conformation. This conformation causes the sensors to emit a measurable signal. Also disclosed are methods of making the chemical sensors, methods of using the chemical sensors, and kits for quantifying analytes using the chemical
摘要翻译：描述了用于定量分析物的化学传感器组合物和方法。化学传感器包括共价连接到框架上的分析物结合部分和报道部分，其包括通过线性间隔物例如乙炔或丁二炔连接的两个三苯甲基。传感器通过分子的乙炔轴螯合分析物，以将分子稳定在黯淡的旋转异构体构象中。这种构造使得传感器发出可测量的信号。还公开了制备化学传感器的方法，使用化学传感器的方法以及使用该化学品定量分析物的试剂盒

3. 发明申请

US20090299061A1 FLUORESCENCE ASSAYS WITH IMPROVED SENSITIVITY 有权
标题翻译：具有提高灵敏度的荧光测定
公开(公告)号：US20090299061A1
公开(公告)日：2009-12-03
申请号：US12426997
申请日：2009-04-21
申请人： Ronald T. RAINES , Sunil S. Chandran , Timothy E. Glass , Luke D. Lavis
发明人： Ronald T. RAINES , Sunil S. Chandran , Timothy E. Glass , Luke D. Lavis
IPC分类号： C07D295/00 , C07D307/94
CPC分类号： C12Q1/34 , C07D493/10 , C09B11/24 , C09B19/00 , G01N33/581 , G01N33/582 , G01N2333/916 , G01N2333/924
摘要： Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more molecules of interest, such as proteins, peptides or nucleic acids. The blocking group(s) is released from the latent fluorescent compound by reaction with a trigger, forming the fluorescent molecule which can be detected. Also provided herein are methods of using latent fluorescent compounds to detect triggers.
摘要翻译：提供了包含具有一个或多个连接基团和任选的一个或多个含脲基团的荧光分子的潜在荧光化合物。含尿素基团可用于进一步连接一种或多种感兴趣的分子，例如蛋白质，肽或核酸。通过与触发剂反应，阻断基团从潜在荧光化合物释放，形成可被检测的荧光分子。本文还提供了使用潜伏荧光化合物来检测触发剂的方法。

4. 发明授权

US07534902B2 Fluorescence assays with improved sensitivity 有权
标题翻译：荧光检测灵敏度提高
公开(公告)号：US07534902B2
公开(公告)日：2009-05-19
申请号：US10988979
申请日：2004-11-15
申请人： Ronald T. Raines , Sunil S. Chandran , Timothy E. Glass , Luke D. Lavis
发明人： Ronald T. Raines , Sunil S. Chandran , Timothy E. Glass , Luke D. Lavis
IPC分类号： C07D311/82 , C07D311/78 , C07D311/88
CPC分类号： C12Q1/34 , C07D493/10 , C09B11/24 , C09B19/00 , G01N33/581 , G01N33/582 , G01N2333/916 , G01N2333/924
摘要： Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more molecules of interest, such as proteins, peptides or nucleic acids. The blocking group(s) is released from the latent fluorescent compound by reaction with a trigger, forming the fluorescent molecule which can be detected. Also provided herein are methods of using latent fluorescent compounds to detect triggers.
摘要翻译：提供了包含具有一个或多个连接基团和任选的一个或多个含脲基团的荧光分子的潜在荧光化合物。含尿素基团可用于进一步连接一种或多种感兴趣的分子，例如蛋白质，肽或核酸。通过与触发剂反应，阻断基团从潜在荧光化合物释放，形成可被检测的荧光分子。本文还提供了使用潜伏荧光化合物来检测触发剂的方法。

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