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1. 发明授权

US07822193B2 Estimation method and apparatus 失效
标题翻译：估计方法和装置
公开(公告)号：US07822193B2
公开(公告)日：2010-10-26
申请号：US11083469
申请日：2005-03-18
申请人： Yuriy Zakharov , Timothy Conrad Tozer
发明人： Yuriy Zakharov , Timothy Conrad Tozer
IPC分类号： H04M9/08
CPC分类号： H04M9/082
摘要： A method and apparatus for producing an estimate of the acoustic response an environment. The method comprises receiving a first signal, and a second signal including a part of the first signal. The first and second signals are combined to produce a third signal. The first signal is combined with itself to produce a fourth signal. A plurality of weighted means of said third signal are computed and summed to produce a plurality of first summations. A plurality of weighted means of said fourth signal are computed and summed to produce a plurality of second summations. Said estimate is generated from said first and second summations.
摘要翻译：一种用于产生对环境的声学响应的估计的方法和装置。该方法包括接收第一信号和包括第一信号的一部分的第二信号。第一和第二信号被组合以产生第三信号。第一信号与其自身组合以产生第四信号。计算所述第三信号的多个加权装置并相加以产生多个第一和。计算所述第四信号的多个加权装置并相加以产生多个第二和。所述估计是从所述第一和第二求和产生的。

2. 发明申请

US20080021512A1 Nerve stimulation and blocking for treatment of gastrointestinal disorders 有权
标题翻译：神经刺激和阻塞用于治疗胃肠道疾病
公开(公告)号：US20080021512A1
公开(公告)日：2008-01-24
申请号：US11891770
申请日：2007-08-13
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译：通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。电刺激包括在刺激部位施加刺激信号。在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。

3. 发明申请

US20070213771A1 Regional anesthetic 有权
标题翻译：区域麻醉
公开(公告)号：US20070213771A1
公开(公告)日：2007-09-13
申请号：US11370967
申请日：2006-03-07
申请人： Robert Spinner , David Martin , Timothy Conrad
发明人： Robert Spinner , David Martin , Timothy Conrad
IPC分类号： A61N1/00
CPC分类号： A61M19/00 , A61B18/02 , A61B2018/0212 , A61N1/36017 , A61N1/36021
摘要： A method and apparatus are disclosed for anesthetizing a region of a patient's body. The method includes identifying a target nerve which, upon activation, anesthetizes a region of a patient's body including a surgical site. The target nerve is located and an active site of a nerve blocking apparatus is placed in proximity to the nerve. The nerve blocking apparatus is activated to block neural propagation along the nerve. The activation of the nerve blocking apparatus is maintained during a surgical procedure at the surgical site.
摘要翻译：公开了用于麻醉患者身体区域的方法和装置。该方法包括识别目标神经，其在激活时麻醉患者身体的包括手术部位的区域。定位目标神经，将神经阻滞装置的活动部位置于神经附近。神经阻断装置被激活以阻断沿着神经的神经传播。在手术部位的手术过程中，保持神经阻滞装置的活化。

4. 发明申请

US20070135856A1 Bulimia treatment 有权
标题翻译：暴食症治疗
公开(公告)号：US20070135856A1
公开(公告)日：2007-06-14
申请号：US11656121
申请日：2007-01-22
申请人： Mark knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC分类号： A61N1/32
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
摘要翻译：至少部分由至少部分由迷走神经活动支配至少一个患者的多个器官的患者的障碍中的至少一种通过包括将神经刺激器载体定位在患者的身体器官周围的方法来治疗，器官由至少一个迷走神经树干支配。电极设置在载体上并位于迷走神经干线处。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。该信号可以是阻塞或刺激信号。

5. 发明申请

US20050268919A1 Pharyngeal tissue fixation 有权
标题翻译：咽组织固定
公开(公告)号：US20050268919A1
公开(公告)日：2005-12-08
申请号：US11196690
申请日：2005-08-03
申请人： Mark Knudson , Timothy Conrad
发明人： Mark Knudson , Timothy Conrad
IPC分类号： A61F2/00 , A61F2/20 , A61F5/56 , A61M31/00 , A61M37/00
CPC分类号： A61F5/56 , A61F2/0077 , A61F2/20 , A61M31/002 , A61M37/00
摘要： A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.
摘要翻译：通过将膨胀器构件插入气道并将膨胀器构件的有效部分定位成与待治疗的咽壁的部分相对，来治疗患者的咽壁。膨胀器构件被启动以将壁部分向外推动到向外移位的位置。然后使膨胀器构件停止，同时将壁部分留在向外放置的位置，并且膨胀器构件从所述气道中移除。治疗的另一方面包括在压缩壁的部分之后稳定咽壁的至少一部分。

6. 发明申请

US20050098184A1 Resorbable airway implant 失效
标题翻译：可再吸气气道植入
公开(公告)号：US20050098184A1
公开(公告)日：2005-05-12
申请号：US11011741
申请日：2004-12-14
申请人： Timothy Conrad , Mark Knudson
发明人： Timothy Conrad , Mark Knudson
IPC分类号： A61F5/56 , A61B19/00
CPC分类号： A61F5/566
摘要： A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. The implant has multiple fibers braided along a length of the implant.
摘要翻译：用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。植入物嵌入软腭以改变动态反应。植入物沿着植入物的长度编织多根纤维。

7. 发明申请

US20060189840A1 Transmyocardial delivery of cardiac wall tension relief 审中-公开
标题翻译：心肌壁心肌张力释放的心肌传递
公开(公告)号：US20060189840A1
公开(公告)日：2006-08-24
申请号：US11061010
申请日：2005-02-18
申请人： Robert Walsh , Timothy Conrad
发明人： Robert Walsh , Timothy Conrad
IPC分类号： A61M1/10 , A61F2/00
CPC分类号： A61F2/2481 , A61M1/1053 , A61M1/1056 , A61M1/1068 , A61M1/12 , A61M2205/0266
摘要： A method for treating a disease of the heart such as congestive heart failure includes forming an access opening from a heart chamber into a pericardial space defined between an epicardial surface of the heart and a pericardium opposing the epicardial surface. A cardiac support member is deployed into said pericardial space through said access opening with said cardiac support member selected to engage an epicardial surface of said heart and relieve a wall tension of said heart.
摘要翻译：用于治疗心脏疾病如充血性心力衰竭的方法包括将心室的进入口形成到心外膜表面和与心外膜表面相对的心包之间的心包空间。心脏支撑构件通过所述进入开口部署到所述心包空间中，所述心脏支撑构件被选择为接合所述心脏的心外膜表面并减轻所述心脏的壁张力。

8. 发明申请

US20050268923A1 Injection sleep apnea treatment 有权
标题翻译：注射睡眠呼吸暂停治疗
公开(公告)号：US20050268923A1
公开(公告)日：2005-12-08
申请号：US11197271
申请日：2005-08-03
申请人： Mark Knudson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Katherine Tweden , Timothy Conrad
IPC分类号： A61F2/00 , A61F5/56 , A61B19/00
CPC分类号： A61F5/56 , A61F2/0059
摘要： A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.
摘要翻译：患者的上呼吸道状况如打鼾和睡眠呼吸暂停通过选择在组织内选择用于有限迁移的颗粒材料并促进组织对该材料的纤维化反应来治疗。将大量颗粒材料注入组织区域以使组织结构变硬。

9. 发明申请

US20050251255A1 Treatment for sleep apnea or snoring 有权
标题翻译：治疗睡眠呼吸暂停或打鼾
公开(公告)号：US20050251255A1
公开(公告)日：2005-11-10
申请号：US11179184
申请日：2005-07-12
申请人： Anja Metzger , Brian Erickson , John Sopp , Mark Knudson , Timothy Conrad
发明人： Anja Metzger , Brian Erickson , John Sopp , Mark Knudson , Timothy Conrad
IPC分类号： A61F2/00 , A61F2/20 , A61F5/56 , A61M31/00 , A61M37/00
CPC分类号： A61F5/56 , A61F2/04 , A61F2/20 , A61F2002/046 , A61M31/002 , A61M37/00
摘要： A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.
摘要翻译：具有至少部分地围绕和限定气道的患者的咽壁的咽气道通过选择尺寸设置成植入在咽壁的粘膜层上或下方并且横向于所述壁延伸的植入物来治疗。植入物具有用于植入物的机械特征，至少与由植入物引起的纤维化组织反应相结合，以加强所述咽壁以抵抗径向塌陷。将植入物植入到垂直于气道纵轴的咽壁中。

10. 发明申请

US20050038484A1 Controlled vagal blockage therapy 有权
标题翻译：受控迷走神经阻滞治疗
公开(公告)号：US20050038484A1
公开(公告)日：2005-02-17
申请号：US10881045
申请日：2004-06-30
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC分类号： A61N1/05 , A61N1/32 , A61N1/34 , A61N1/36 , A61N1/18
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
摘要翻译：用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。将电信号施加到电极以调节迷走神经活性。电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。电信号的应用被停止。重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。

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